Detailed information for compound 805239

Basic information

Technical information
  • TDR Targets ID: 805239
  • Name: 2-amino-4-(4-chlorophenyl)-6-methyl-5-oxo-4H- pyrano[5,6-c]quinoline-3-carbonitrile
  • MW: 363.797 | Formula: C20H14ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 3.24 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)Oc2c(C1c1ccc(cc1)Cl)c(=O)n(c1c2cccc1)C
  • InChi: 1S/C20H14ClN3O2/c1-24-15-5-3-2-4-13(15)18-17(20(24)25)16(14(10-22)19(23)26-18)11-6-8-12(21)9-7-11/h2-9,16H,23H2,1H3
  • InChiKey: NHHPCVKMDBNTCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-4-(4-chlorophenyl)-5-keto-6-methyl-4H-pyrano[5,6-c]quinoline-3-carbonitrile
  • A3625/0153745

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis AMP nucleosidase 0.0161 0.0733 0.5
Trypanosoma brucei uridine phosphorylase 0.0161 0.0733 0.0926
Schistosoma mansoni methylthioadenosine phosphorylase 0.0867 0.482 0.8192
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0067 0.011
Toxoplasma gondii hypothetical protein 0.0092 0.0335 0.0879
Echinococcus multilocularis arginine glutamic acid dipeptide (RE) repeats 0.0036 0.0014 0.0024
Loa Loa (eye worm) SET domain-containing protein 0.0152 0.068 0.0734
Echinococcus granulosus methylthioadenosine phosphorylase 0.0867 0.482 0.7888
Loa Loa (eye worm) hypothetical protein 0.0066 0.0184 0.0187
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.016 0.0732 0.1199
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0161 0.0733 0.5
Leishmania major C-8 sterol isomerase-like protein 0.0351 0.1834 0.3001
Loa Loa (eye worm) hypothetical protein 0.0368 0.1931 0.2111
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0037 0.002 0.0033
Echinococcus granulosus glutamate receptor NMDA 0.0075 0.0239 0.0391
Plasmodium vivax SET domain protein, putative 0.0173 0.0802 0.1313
Echinococcus granulosus metastasis associated protein 1 mta1 0.0036 0.0014 0.0024
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0161 0.0733 0.0733
Echinococcus multilocularis PWWP domain containing protein 2A 0.0092 0.0335 0.0548
Entamoeba histolytica hypothetical protein 0.0092 0.0335 0.0684
Loa Loa (eye worm) glutamate receptor 2 0.0038 0.0025 0.0012
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0867 0.482 0.7888
Echinococcus granulosus purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Schistosoma mansoni hypothetical protein 0.0187 0.0885 0.1505
Echinococcus granulosus purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0133 0.0576 0.0662
Echinococcus multilocularis histone h3 methyltransferase 0.1051 0.5884 0.9629
Echinococcus multilocularis polybromo 1 0.0036 0.0014 0.0024
Echinococcus multilocularis peregrin 0.0124 0.0521 0.0852
Trichomonas vaginalis set domain proteins, putative 0.1763 1 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Loa Loa (eye worm) hypothetical protein 0.0076 0.0243 0.0252
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0091 0.033 0.054
Echinococcus multilocularis nmda type glutamate receptor 0.0089 0.0321 0.0525
Schistosoma mansoni histone J3 methyltransferase 0.1051 0.5884 1
Schistosoma mansoni glutamate receptor kainate 0.0038 0.0025 0.0043
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0161 0.0733 0.2488
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0152 0.068 0.1114
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0036 0.0014 0.0025
Echinococcus multilocularis geminin 0.0187 0.0885 0.1449
Echinococcus multilocularis nmda type glutamate receptor 0.0082 0.0281 0.046
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.0006
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0161 0.0733 0.2488
Trichomonas vaginalis origin recognition complex subunit, putative 0.0036 0.0014 0.0014
Leishmania major histone-lysine N-methyltransferase, putative 0.0133 0.0576 0.0943
Brugia malayi ELM2 domain containing protein 0.0036 0.0014 0.0008
Loa Loa (eye worm) spermidine synthase 0.109 0.6111 0.6716
Loa Loa (eye worm) hypothetical protein 0.0125 0.0527 0.0565
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0659 0.3618 0.5793
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0161 0.0733 0.2488
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0133 0.0576 0.0662
Trypanosoma cruzi spermidine synthase, putative 0.109 0.6111 1
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0335 0.0255
Loa Loa (eye worm) hypothetical protein 0.0351 0.1834 0.2004
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0161 0.0733 0.1199
Schistosoma mansoni hypothetical protein 0.0092 0.0335 0.0569
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0992 0.5542 0.6089
Trypanosoma cruzi spermidine synthase, putative 0.109 0.6111 1
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0867 0.482 1
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0321 0.1662 0.2719
Toxoplasma gondii hypothetical protein 0.0133 0.0576 0.1513
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0161 0.0733 0.0926
Echinococcus multilocularis glutamate receptor 2 0.0046 0.0067 0.011
Echinococcus granulosus purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Schistosoma mansoni methylthioadenosine phosphorylase 0.0161 0.0733 0.1246
Brugia malayi CXXC zinc finger family protein 0.0306 0.1574 0.1725
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0173 0.0802 0.1313
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0291 0.149 0.2532
Loa Loa (eye worm) glutamate receptor 1 0.0038 0.0025 0.0012
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0315 0.1627 0.2764
Loa Loa (eye worm) SET domain-containing protein 0.0317 0.164 0.1791
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0447 0.2391 0.3723
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0067 0.011
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.004 0.0028
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0161 0.0733 0.5
Echinococcus granulosus purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Mycobacterium leprae probable uridine phosphorylase 0.0161 0.0733 0.5
Brugia malayi MTAP 0.0867 0.482 0.5298
Brugia malayi GATA zinc finger family protein 0.0036 0.0014 0.0008
Brugia malayi hypothetical protein 0.0092 0.0335 0.0361
Echinococcus granulosus PWWP domain containing protein 2A 0.0092 0.0335 0.0548
Loa Loa (eye worm) hypothetical protein 0.0179 0.0842 0.0911
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0867 0.482 0.5295
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0161 0.0733 0.0926
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0859 0.4774 1
Brugia malayi jmjC domain containing protein 0.0041 0.004 0.0036
Brugia malayi SET domain containing protein 0.0317 0.164 0.1797
Loa Loa (eye worm) CXXC zinc finger family protein 0.0306 0.1574 0.1718
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1606 0.9092 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0161 0.0733 0.0733
Plasmodium falciparum purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Echinococcus granulosus purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Loa Loa (eye worm) hypothetical protein 0.0368 0.1931 0.2111
Schistosoma mansoni protein arginine n-methyltransferase 0.016 0.0732 0.1245
Brugia malayi SET domain containing protein 0.0134 0.0582 0.0633
Loa Loa (eye worm) Carm1-pending protein 0.016 0.0732 0.0791
Echinococcus granulosus histone arginine methyltransferase CARMER 0.016 0.0732 0.1199
Echinococcus multilocularis purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Brugia malayi Glutamate receptor 1 precursor 0.0038 0.0025 0.002
Echinococcus granulosus metastasis associated protein MTA1 0.0036 0.0014 0.0024
Schistosoma mansoni cpg binding protein 0.0308 0.1584 0.2692
Echinococcus granulosus PWWP domain containing protein 2A 0.0092 0.0335 0.0548
Echinococcus granulosus spermidine synthase 0.109 0.6111 1
Schistosoma mansoni hepatoma derived growth factor 0.0092 0.0335 0.0569
Echinococcus multilocularis disco interacting protein 2 0.0315 0.1627 0.2662
Loa Loa (eye worm) hypothetical protein 0.0055 0.0123 0.012
Brugia malayi hypothetical protein 0.0368 0.1931 0.2118
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0692 0.3808 0.6231
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0046 0.0067 0.011
Onchocerca volvulus 0.0291 0.149 0.1195
Schistosoma mansoni hypothetical protein 0.0057 0.0136 0.0231
Schistosoma mansoni methylthioadenosine phosphorylase 0.0867 0.482 0.8192
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.0733 0.0733
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0659 0.3618 0.592
Schistosoma mansoni ATP-binding cassette transporter 0.0038 0.0025 0.0043
Brugia malayi hypothetical protein 0.0066 0.0184 0.0195
Echinococcus multilocularis purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Schistosoma mansoni glutamate receptor AMPA 0.0038 0.0025 0.0043
Schistosoma mansoni purine nucleoside phosphorylase 0.0161 0.0733 0.1246
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0447 0.2391 0.3912
Echinococcus multilocularis uridine phosphorylase 1 0.0161 0.0733 0.1199
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0317 0.164 0.2683
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0161 0.0733 0.0733
Onchocerca volvulus 0.0315 0.1627 0.1337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0238 0.1182 0.2009
Giardia lamblia UPL-1 0.0161 0.0733 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.0075 0.0239 0.0628
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0133 0.0576 0.0662
Echinococcus granulosus purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Schistosoma mansoni microtubule-associated protein tau 0.0766 0.4235 0.7197
Echinococcus granulosus nmda type glutamate receptor 0.0082 0.0281 0.046
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0092 0.0335 0.0255
Leishmania major methylthioadenosine phosphorylase, putative 0.0867 0.482 0.7888
Schistosoma mansoni cpg binding protein 0.0306 0.1574 0.2674
Echinococcus multilocularis metastasis associated protein 1 (mta1) 0.0036 0.0014 0.0024
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0107 0.0425 0.0695
Schistosoma mansoni glutamate receptor kainate 0.0038 0.0025 0.0043
Schistosoma mansoni purine nucleoside phosphorylase 0.0161 0.0733 0.1246
Echinococcus granulosus purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Leishmania major S-adenosylmethionine decarboxylase 0.0659 0.3618 0.592
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0447 0.2391 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0067 0.011
Trypanosoma cruzi spermidine synthase, putative 0.109 0.6111 1
Brugia malayi NNMT/PNMT/TEMT family protein 0.0992 0.5542 0.6093
Echinococcus multilocularis purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0413 0.0677
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.004 0.0068
Echinococcus multilocularis cpg binding protein 0.0308 0.1584 0.2592
Echinococcus granulosus glutamate NMDA receptor subunit 0.0091 0.033 0.054
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0161 0.0733 0.0412
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0161 0.0733 0.2488
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.016 0.0732 0.1924
Plasmodium vivax spermidine synthase, putative 0.109 0.6111 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.1182 0.1287
Schistosoma mansoni hypothetical protein 0.0092 0.0335 0.0569
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0659 0.3618 0.5793
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0107 0.0425 0.0695
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0659 0.3618 0.5793
Brugia malayi uridine phosphorylase family protein 0.0161 0.0733 0.0799
Brugia malayi SET domain containing protein 0.0054 0.0115 0.0119
Echinococcus multilocularis purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0867 0.482 0.7823
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0063 0.0103
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0413 0.0677
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0447 0.2391 0.3912
Trypanosoma cruzi spermidine synthase, putative 0.109 0.6111 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0351 0.1834 0.2011
Schistosoma mansoni suppressor of variegation 4-20-related 0.0152 0.068 0.1156
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0082 0.0281 0.0477
Brugia malayi Disco-interacting protein 2 homolog 0.0315 0.1627 0.1783
Schistosoma mansoni uridine phosphorylase 0.0161 0.0733 0.1246
Echinococcus multilocularis bromo adjacent y domain containing 1 0.0036 0.0014 0.0024
Echinococcus granulosus cpg binding protein 0.0308 0.1584 0.2592
Trypanosoma brucei C-8 sterol isomerase, putative 0.0351 0.1834 0.2784
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0036 0.0014 0.0025
Echinococcus multilocularis glutamate receptor 2 0.0038 0.0025 0.0042
Echinococcus granulosus hepatoma derived growth factor protein 0.0092 0.0335 0.0548
Echinococcus granulosus histone lysine methyltransferase setb 0.0238 0.1182 0.1935
Schistosoma mansoni glutamate receptor NMDA 0.0091 0.033 0.056
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0161 0.0733 0.2488
Treponema pallidum pfs protein (pfs) 0.0161 0.0733 0.5
Leishmania major modification methylase-like protein 0.0447 0.2391 0.3912
Brugia malayi jmjC domain containing protein 0.0105 0.0413 0.0447
Brugia malayi PWWP domain containing protein 0.0092 0.0335 0.0361
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0161 0.0733 0.0733
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0161 0.0733 0.5
Leishmania major hypothetical protein, conserved 0.0133 0.0576 0.0943
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0067 0.011
Brugia malayi polybromodomain protein 0.0036 0.0014 0.0008
Brugia malayi Carm1-pending protein 0.016 0.0732 0.0799
Echinococcus granulosus microtubule associated protein 2 0.0766 0.4235 0.693
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0161 0.0733 0.5
Schistosoma mansoni hypothetical protein 0.0092 0.0335 0.0569
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0036 0.0014 0.0025
Echinococcus granulosus uridine phosphorylase 1 0.0161 0.0733 0.1199
Mycobacterium ulcerans spermidine synthase 0.0859 0.4774 0.9885
Echinococcus multilocularis PWWP domain containing protein 2A 0.0092 0.0335 0.0548
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0161 0.0733 0.0799
Echinococcus multilocularis hepatoma derived growth factor protein 0.0092 0.0335 0.0548
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0659 0.3618 0.5793
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0173 0.0802 0.1363
Trichomonas vaginalis CDC6, putative 0.0036 0.0014 0.0014
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0161 0.0733 0.0733
Toxoplasma gondii DNA methyltransferase 2, putative 0.0447 0.2391 0.6279
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0335 0.0255
Echinococcus granulosus disco interacting protein 2 0.0315 0.1627 0.2662
Echinococcus granulosus SET and MYND domain containing protein 3 0.0078 0.0255 0.0417
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0867 0.482 0.7823
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0133 0.0576 0.0662
Echinococcus granulosus geminin 0.0187 0.0885 0.1449
Brugia malayi hypothetical protein 0.0092 0.0335 0.0361
Trypanosoma brucei histone-lysine n-methyltransferase 0.0133 0.0576 0.0662
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0133 0.0576 0.0662
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0867 0.482 0.7823
Echinococcus multilocularis glutamate receptor NMDA 0.0075 0.0239 0.0391
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0046 0.0067 0.011
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0067 0.011
Echinococcus multilocularis purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0067 0.011
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0447 0.2391 0.4063
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0161 0.0733 0.0733
Loa Loa (eye worm) uridine phosphorylase 0.0161 0.0733 0.0792
Loa Loa (eye worm) hypothetical protein 0.0119 0.0492 0.0526
Plasmodium falciparum spermidine synthase 0.109 0.6111 1
Leishmania major hypothetical protein, conserved 0.0133 0.0576 0.0943
Schistosoma mansoni uridine phosphorylase 0.0161 0.0733 0.1246
Toxoplasma gondii hypothetical protein 0.0692 0.3808 1
Leishmania major spermidine synthase 0.109 0.6111 1
Echinococcus granulosus histone h3 methyltransferase 0.1051 0.5884 0.9629
Loa Loa (eye worm) PWWP domain-containing protein 0.0092 0.0335 0.0353
Echinococcus granulosus polybromo 1 0.0036 0.0014 0.0024
Echinococcus granulosus DNA methyltransferase 2, putative 0.0447 0.2391 0.3912
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0194 0.0928 0.1519
Onchocerca volvulus 0.0368 0.1931 0.1652
Echinococcus granulosus nmda type glutamate receptor 0.0089 0.0321 0.0525
Schistosoma mansoni polybromo-1 0.0036 0.0014 0.0025
Toxoplasma gondii Purine nucleoside phosphorylase 0.0161 0.0733 0.1925
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0707 0.3892 0.7817
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.004 0.0065
Leishmania major nucleoside phosphorylase-like protein 0.0161 0.0733 0.1199
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.1051 0.5884 0.647
Schistosoma mansoni glutamate receptor kainate 0.0038 0.0025 0.0043
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.004 0.0068
Echinococcus granulosus glutamate receptor 2 0.0046 0.0067 0.011
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0659 0.3618 0.397
Brugia malayi Spermidine synthase 0.109 0.6111 0.6719
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0092 0.0335 0.0255
Brugia malayi hypothetical protein 0.0368 0.1931 0.2118
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0659 0.3618 0.5793
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0321 0.1662 0.2719
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0238 0.1182 0.2009
Leishmania major hypothetical protein, conserved 0.0092 0.0335 0.0548
Schistosoma mansoni jumonji domain containing protein 0.0084 0.0288 0.049
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0012
Schistosoma mansoni bromo adjacent homology domain containing 0.0036 0.0014 0.0025
Brugia malayi SET domain containing protein 0.0152 0.068 0.0741
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0133 0.0576 0.0662
Schistosoma mansoni glutamate receptor AMPA 0.0038 0.0025 0.0043
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0161 0.0733 0.0733
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0161 0.0733 0.0926
Entamoeba histolytica hypothetical protein 0.0161 0.0733 0.2488
Echinococcus multilocularis spermidine synthase 0.109 0.6111 1
Onchocerca volvulus 0.0306 0.1574 0.1282
Schistosoma mansoni hypothetical protein 0.0036 0.0014 0.0025
Echinococcus granulosus peregrin 0.0124 0.0521 0.0852
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0078 0.0255 0.0417
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0173 0.0802 0.2107
Loa Loa (eye worm) hypothetical protein 0.0315 0.1627 0.1776
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0029 0.0048
Brugia malayi Pre-SET motif family protein 0.021 0.1018 0.1113
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0093 0.0345 0.0564
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0161 0.0733 0.0733
Trypanosoma brucei transcription elongation factor s-II, putative 0.0092 0.0335 0.0255
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0238 0.1182 0.1935
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0161 0.0733 0.2488
Echinococcus multilocularis purine nucleoside phosphorylase 0.0161 0.0733 0.1199
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0447 0.2391 0.6279
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0659 0.3618 0.592
Schistosoma mansoni enhancer of zeste ezh 0.0317 0.164 0.2787
Brugia malayi Glutamate receptor 2 precursor 0.0038 0.0025 0.002
Toxoplasma gondii phosphorylase family protein 0.0161 0.0733 0.1925
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0092 0.0335 0.0255
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0447 0.2391 0.3912
Brugia malayi Pre-SET motif family protein 0.1606 0.9092 1
Schistosoma mansoni SET domain protein 0.0109 0.0435 0.0739
Schistosoma mansoni cpg binding protein 0.0308 0.1584 0.2692
Loa Loa (eye worm) hypothetical protein 0.1051 0.5884 0.6467
Loa Loa (eye worm) hypothetical protein 0.0092 0.0335 0.0353
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0317 0.164 0.2683
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0036 0.0014 0.0025
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0161 0.0733 0.5
Schistosoma mansoni glutamate receptor NMDA 0.0121 0.0502 0.0853
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0152 0.068 0.1114
Loa Loa (eye worm) hypothetical protein 0.0368 0.1931 0.2111
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0659 0.3618 0.3975
Schistosoma mansoni hepatoma derived growth factor 0.0092 0.0335 0.0569
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0188 0.0192
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0063 0.0103
Toxoplasma gondii phosphorylase family protein 0.0161 0.0733 0.1925
Echinococcus granulosus arginine glutamic acid dipeptide RE repeats 0.0036 0.0014 0.0024
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0093 0.0345 0.0564
Loa Loa (eye worm) hypothetical protein 0.0992 0.5542 0.6089
Schistosoma mansoni phd finger protein 0.0092 0.0335 0.0569
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0351 0.1834 0.2784
Echinococcus multilocularis microtubule associated protein 2 0.0766 0.4235 0.693
Echinococcus granulosus bromo adjacent y domain containing 1 0.0036 0.0014 0.0024
Echinococcus multilocularis metastasis associated protein MTA1 0.0036 0.0014 0.0024
Schistosoma mansoni hypothetical protein 0.0187 0.0885 0.1505
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0037 0.002 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.0733 0.0733
Loa Loa (eye worm) hypothetical protein 0.0992 0.5542 0.6089
Treponema pallidum uridine phosphorylase (udp) 0.0161 0.0733 0.5
Trypanosoma brucei spermidine synthase 0.109 0.6111 1
Onchocerca volvulus 0.0129 0.0549 0.0221

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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