Detailed information for compound 805339

Basic information

Technical information
  • TDR Targets ID: 805339
  • Name: 2'-amino-5-fluoro-1'-(4-methylphenyl)-2,5'-di oxospiro[1H-indole-3,4'-7,8-dihydro-6H-quinol ine]-3'-carbonitrile
  • MW: 414.432 | Formula: C24H19FN4O2
  • H donors: 2 H acceptors: 3 LogP: 2.82 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)N(c2ccc(cc2)C)C2=C(C31C(=O)Nc1c3cc(F)cc1)C(=O)CCC2
  • InChi: 1S/C24H19FN4O2/c1-13-5-8-15(9-6-13)29-19-3-2-4-20(30)21(19)24(17(12-26)22(29)27)16-11-14(25)7-10-18(16)28-23(24)31/h5-11H,2-4,27H2,1H3,(H,28,31)
  • InChiKey: UPKHYMLGAULQCR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-5'-fluoro-1-(4-methylphenyl)-2',5-dioxo-spiro[7,8-dihydro-6H-quinoline-4,3'-indoline]-3-carbonitrile
  • 2-amino-5'-fluoro-1-(4-methylphenyl)-2',5-dioxo-3-spiro[7,8-dihydro-6H-quinoline-4,3'-indoline]carbonitrile
  • 2-amino-5'-fluoro-2',5-diketo-1-(4-methylphenyl)spiro[7,8-dihydro-6H-quinoline-4,3'-indoline]-3-carbonitrile
  • 2'-amino-5-fluoro-1'-(4-methylphenyl)-2,5'-dioxo-spiro[1H-indole-3,4'-7,8-dihydro-6H-quinoline]-3'-carbonitrile
  • A3557/0150834

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine kinase 0.0074 0.0929 0.1035
Echinococcus granulosus tyrosine protein kinase ABL1 0.0074 0.0929 0.1035
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0057 0.0179 0.0179
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0058 0.024 0.0267
Schistosoma mansoni GTPase activating protein 0.0058 0.024 0.024
Brugia malayi SH3 domain containing protein 0.0057 0.0179 0.02
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Echinococcus granulosus expressed conserved protein 0.0058 0.024 0.0267
Echinococcus multilocularis tyrosine protein kinase Abl 0.0131 0.3321 0.3701
Onchocerca volvulus 0.0058 0.024 0.0812
Echinococcus granulosus tyrosine protein kinase Lyn 0.0131 0.3321 0.3701
Schistosoma mansoni C-fyn 0.0057 0.0179 0.0179
Brugia malayi SH2 domain containing protein 0.0058 0.024 0.0267
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0058 0.024 0.024
Schistosoma mansoni cell polarity protein 0.0057 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0179 0.0217
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0057 0.0179 0.02
Schistosoma mansoni tyrosine kinase 0.0131 0.3321 0.3321
Schistosoma mansoni voltage-gated potassium channel 0.0289 1 1
Echinococcus multilocularis nostrin 0.0057 0.0179 0.02
Echinococcus granulosus hypothetical protein 0.0058 0.024 0.0267
Onchocerca volvulus 0.0058 0.024 0.0812
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0179 0.5
Brugia malayi Variant SH3 domain containing protein 0.0057 0.0179 0.02
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0057 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0057 0.0179 0.02
Echinococcus multilocularis SHC transforming protein 3 0.0058 0.024 0.0267
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0058 0.024 0.0267
Onchocerca volvulus 0.0074 0.0929 1
Schistosoma mansoni sorbin 0.0057 0.0179 0.0179
Trypanosoma brucei conserved protein 0.0057 0.0179 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0179 0.5
Schistosoma mansoni tyrosine kinase 0.0131 0.3321 0.3321
Brugia malayi STAT protein, DNA binding domain containing protein 0.0058 0.024 0.0267
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0057 0.0179 0.02
Echinococcus granulosus tyrosine protein kinase Fyn 0.0131 0.3321 0.3701
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0868 0.0868
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0057 0.0179 0.02
Echinococcus multilocularis tensin 0.0058 0.024 0.0267
Schistosoma mansoni suppressor of cytokine signaling 0.0058 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0057 0.0179 0.0179
Echinococcus multilocularis tyrosine kinase 0.0074 0.0929 0.1035
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Schistosoma mansoni tyrosine kinase 0.0074 0.0929 0.0929
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0058 0.024 0.0267
Loa Loa (eye worm) hypothetical protein 0.0115 0.2632 0.2934
Brugia malayi Variant SH3 domain containing protein 0.0058 0.024 0.0267
Loa Loa (eye worm) SH2 domain-containing protein 0.0058 0.024 0.0267
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0247 0.8236 1
Schistosoma mansoni apoptosis stimulating of P53 0.0057 0.0179 0.0179
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0929 0.1035
Brugia malayi SH2 domain containing protein 0.0058 0.024 0.0267
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0131 0.3321 0.3701
Brugia malayi SRC-1 0.0131 0.3321 0.3701
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0131 0.3321 0.3321
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0929 0.1035
Schistosoma mansoni SH2A 0.0058 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0058 0.024 0.024
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0057 0.0179 0.02
Echinococcus multilocularis SH2 motif 0.0058 0.024 0.0267
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0131 0.3321 0.3701
Echinococcus multilocularis SH2 motif 0.0058 0.024 0.0267
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0265 0.8972 1
Echinococcus granulosus SHC transforming protein 3 0.0058 0.024 0.0267
Schistosoma mansoni tensin-related 0.0058 0.024 0.024
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0058 0.024 0.0267
Loa Loa (eye worm) TK/ABL protein kinase 0.0074 0.0929 0.1035
Brugia malayi Protein kinase domain containing protein 0.0074 0.0929 0.1035
Schistosoma mansoni tensin 0.0058 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0058 0.024 0.024
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0057 0.0179 0.02
Schistosoma mansoni tensin 0.0058 0.024 0.024
Brugia malayi SH2 domain containing protein 0.0058 0.024 0.0267
Onchocerca volvulus 0.0058 0.024 0.0812
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0058 0.024 0.0267
Schistosoma mansoni tyrosine kinase 0.0131 0.3321 0.3321
Echinococcus granulosus src region 0.0057 0.0179 0.02
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0929 0.1035
Echinococcus granulosus tyrosine protein kinase shark 0.0074 0.0929 0.1035
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0929 0.1035
Loa Loa (eye worm) hypothetical protein 0.0057 0.0179 0.02
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Schistosoma mansoni Dab2-interacting protein-like 0.0057 0.0179 0.0179
Echinococcus granulosus Spectrin alpha actinin 0.0057 0.0179 0.02
Echinococcus multilocularis tyrosine protein kinase Srms 0.0074 0.0929 0.1035
Brugia malayi Src substrate cortactin 0.0057 0.0179 0.02
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0058 0.024 0.0267
Brugia malayi Variant SH3 domain containing protein 0.0057 0.0179 0.02
Onchocerca volvulus 0.0058 0.024 0.0812
Echinococcus multilocularis c src tyrosine kinase 0.0131 0.3321 0.3701
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0131 0.3321 0.3701
Schistosoma mansoni hypothetical protein 0.0057 0.0179 0.0179
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0115 0.2632 0.2934
Echinococcus multilocularis transfer RNA-Ala 0.0057 0.0179 0.02
Schistosoma mansoni tyrosine kinase 0.0131 0.3321 0.3321
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Echinococcus multilocularis tyrosine protein kinase shark 0.0074 0.0929 0.1035
Brugia malayi Fes/CIP4 homology domain containing protein 0.0057 0.0179 0.02
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0265 0.8972 1
Echinococcus multilocularis intersectin 2 0.0057 0.0179 0.02
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0929 0.1035
Schistosoma mansoni growth factor receptor-bound protein 0.0115 0.2632 0.2632
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0057 0.0179 0.0179
Brugia malayi Protein kinase domain containing protein 0.0074 0.0929 0.1035
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0929 0.1035
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0057 0.0179 0.02
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0057 0.0179 0.02
Echinococcus granulosus SH2 motif 0.0058 0.024 0.0267
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0074 0.0929 0.1035
Brugia malayi hypothetical protein 0.0074 0.0929 0.1035
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Brugia malayi Myosin tail family protein 0.0057 0.0179 0.02
Brugia malayi Tyrosine-protein kinase abl-1 0.0131 0.3321 0.3701
Schistosoma mansoni dreadlocks/dock 0.0057 0.0179 0.0179
Brugia malayi Protein kinase domain containing protein 0.0074 0.0929 0.1035
Echinococcus multilocularis NCK adaptor protein 0.0115 0.2632 0.2934
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0179 0.0217
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Schistosoma mansoni shc transforming protein 0.0058 0.024 0.024
Echinococcus granulosus tyrosine protein kinase Blk 0.0074 0.0929 0.1035
Loa Loa (eye worm) hypothetical protein 0.0057 0.0179 0.02
Schistosoma mansoni tensin 0.0058 0.024 0.024
Schistosoma mansoni run and tbc1 domain containing 0.0057 0.0179 0.0179
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0074 0.0929 0.1035
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0058 0.024 0.0267
Echinococcus granulosus suppressor of cytokine signaling 7 0.0058 0.024 0.0267
Loa Loa (eye worm) protein-tyrosine kinase 0.0057 0.0179 0.02
Onchocerca volvulus 0.0074 0.0929 1
Echinococcus granulosus N chimaerin 0.0058 0.024 0.0267
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0058 0.024 0.024
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0058 0.024 0.0267
Onchocerca volvulus 0.0074 0.0929 1
Brugia malayi RhoGAP domain containing protein 0.0058 0.024 0.0267
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0131 0.3321 0.3701
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0179 0.5
Echinococcus multilocularis tensin 0.0058 0.024 0.0267
Echinococcus multilocularis expressed protein 0.0057 0.0179 0.02
Schistosoma mansoni tensin-related 0.0058 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0115 0.2632 0.2632
Echinococcus multilocularis SH2 motif 0.0058 0.024 0.0267
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0247 0.8236 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0131 0.3321 0.3701
Loa Loa (eye worm) hypothetical protein 0.0077 0.1028 0.1145
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0057 0.0179 0.02
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0131 0.3321 0.3701
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0929 0.1035
Brugia malayi tRNA modification GTPase TrmE family protein 0.0058 0.024 0.0267
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0058 0.024 0.0267
Schistosoma mansoni voltage-gated potassium channel 0.0077 0.1028 0.1028
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0058 0.024 0.0267
Brugia malayi Variant SH3 domain containing protein 0.0057 0.0179 0.02
Loa Loa (eye worm) TK protein kinase 0.0074 0.0929 0.1035
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0058 0.024 0.0267
Brugia malayi Variant SH3 domain containing protein 0.0115 0.2632 0.2934
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0058 0.024 0.0812
Loa Loa (eye worm) hypothetical protein 0.0057 0.0179 0.02
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0057 0.0179 0.0217
Brugia malayi Sex muscle abnormal protein 5 0.0115 0.2632 0.2934
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0057 0.0179 0.02
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0131 0.3321 0.3701
Schistosoma mansoni vav2 0.0058 0.024 0.024
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0077 0.1028 0.1145
Echinococcus granulosus suppressor of cytokine signaling 6 0.0058 0.024 0.0267
Leishmania major hypothetical protein, conserved 0.0057 0.0179 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0058 0.024 0.0267
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Onchocerca volvulus 0.0058 0.024 0.0812
Entamoeba histolytica protein kinase, putative 0.0058 0.024 0.0812
Schistosoma mansoni suppressor of cytokine signaling 0.0058 0.024 0.024
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0057 0.0179 0.02
Echinococcus granulosus intersectin 2 0.0057 0.0179 0.02
Echinococcus granulosus expressed protein 0.0057 0.0179 0.02
Echinococcus granulosus nostrin 0.0057 0.0179 0.02
Onchocerca volvulus 0.0074 0.0929 1
Onchocerca volvulus 0.0074 0.0929 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0074 0.0929 0.1035
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0131 0.3321 0.3701
Brugia malayi Variant SH3 domain containing protein 0.0057 0.0179 0.02
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0058 0.024 0.0267
Loa Loa (eye worm) STAT protein 0.0058 0.024 0.0267
Entamoeba histolytica SH2 domain containing protein 0.0058 0.024 0.0812
Brugia malayi Peripheral plasma membrane protein CASK 0.0057 0.0179 0.02
Schistosoma mansoni nck2/grb4 0.0115 0.2632 0.2632
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0057 0.0179 0.02
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0115 0.2632 0.2934
Brugia malayi Tensin 0.0058 0.024 0.0267
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0179 0.0217
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0131 0.3321 0.3701
Brugia malayi hypothetical protein 0.0058 0.024 0.0267
Brugia malayi cytokine inducible SH2-containing protein 5 0.0058 0.024 0.0267
Loa Loa (eye worm) thyroid receptor interactor 0.0057 0.0179 0.02
Schistosoma mansoni sorting nexin 0.0057 0.0179 0.0179
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0058 0.024 0.024
Brugia malayi Variant SH3 domain containing protein 0.0057 0.0179 0.02
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0077 0.1028 0.1145
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0057 0.0179 0.02
Loa Loa (eye worm) hypothetical protein 0.0057 0.0179 0.02
Brugia malayi Protein kinase domain containing protein 0.0074 0.0929 0.1035
Echinococcus multilocularis N chimaerin 0.0058 0.024 0.0267
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0057 0.0179 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0074 0.0929 0.1035
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0058 0.024 0.024
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0131 0.3321 0.3701
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0074 0.0929 1
Echinococcus granulosus fch and double sh3 domains protein 2 0.0057 0.0179 0.02
Brugia malayi Guanylate kinase family protein 0.0057 0.0179 0.02
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0058 0.024 0.0267
Echinococcus multilocularis voltage gated potassium channel 0.0077 0.1028 0.1145
Onchocerca volvulus 0.0074 0.0929 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0179 0.02
Schistosoma mansoni signal transduction protein lnk-related 0.0058 0.024 0.024
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0131 0.3321 0.3701
Echinococcus multilocularis Spectrin alpha actinin 0.0057 0.0179 0.02
Brugia malayi Variant SH3 domain containing protein 0.0115 0.2632 0.2934
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0058 0.024 0.0267
Echinococcus multilocularis 0.0058 0.024 0.0267
Echinococcus granulosus epidermal growth factor receptor kinase 0.0057 0.0179 0.02
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0077 0.1028 0.1145
Brugia malayi Variant SH3 domain containing protein 0.0057 0.0179 0.02
Echinococcus granulosus tensin 0.0058 0.024 0.0267
Echinococcus granulosus tyrosine protein kinase Src64B 0.0131 0.3321 0.3701
Schistosoma mansoni adapter molecule crk 0.0115 0.2632 0.2632
Echinococcus granulosus SH2 domain containing protein 7 0.0058 0.024 0.0267
Brugia malayi SH2 domain containing protein 0.0058 0.024 0.0267
Echinococcus granulosus c src tyrosine kinase 0.0131 0.3321 0.3701
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0265 0.8972 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0179 0.02
Brugia malayi Variant SH3 domain containing protein 0.0058 0.024 0.0267
Echinococcus multilocularis signal transduction protein lnk realted 0.0058 0.024 0.0267
Echinococcus granulosus endophilin A3 0.0057 0.0179 0.02
Brugia malayi SH2 domain containing protein 0.0058 0.024 0.0267
Echinococcus granulosus tyrosine protein kinase Src42A 0.0058 0.024 0.0267
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0058 0.024 0.0267
Echinococcus multilocularis SH2 domain containing protein 7 0.0058 0.024 0.0267
Loa Loa (eye worm) hypothetical protein 0.023 0.7495 0.8354
Brugia malayi SH2 domain containing protein 0.0074 0.0929 0.1035
Schistosoma mansoni growth factor receptor-bound protein 0.0115 0.2632 0.2632
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0131 0.3321 0.3701
Loa Loa (eye worm) hypothetical protein 0.0057 0.0179 0.02
Schistosoma mansoni formin binding protein and related proteins 0.0057 0.0179 0.0179
Schistosoma mansoni dynamin-associated protein 0.0057 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0179 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0179 0.0217
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0074 0.0929 0.1035
Echinococcus multilocularis growth factor receptor bound protein 2 0.0115 0.2632 0.2934
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0929 0.1035
Brugia malayi SH2 domain containing protein 0.0074 0.0929 0.1035
Echinococcus granulosus SH2 motif 0.0058 0.024 0.0267
Echinococcus granulosus voltage gated potassium channel 0.0077 0.1028 0.1145
Echinococcus granulosus growth factor receptor bound protein 2 0.0115 0.2632 0.2934
Echinococcus multilocularis endophilin A3 0.0057 0.0179 0.02
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0929 0.1035
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0058 0.024 0.0812
Brugia malayi protein-tyrosine kinase 0.0074 0.0929 0.1035
Loa Loa (eye worm) hypothetical protein 0.0057 0.0179 0.02
Brugia malayi Spectrin alpha chain 0.0057 0.0179 0.02
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0058 0.024 0.0812
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0179 0.0217
Echinococcus multilocularis tyrosine protein kinase Blk 0.0074 0.0929 0.1035
Loa Loa (eye worm) SH2 domain-containing protein 0.0058 0.024 0.0267
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0929 0.1035
Echinococcus granulosus SH2 domain containing adapter protein F 0.0058 0.024 0.0267
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0058 0.024 0.0267
Loa Loa (eye worm) hypothetical protein 0.0074 0.0929 0.1035
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0131 0.3321 0.3701
Brugia malayi protein-tyrosine kinase 0.0057 0.0179 0.02
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0058 0.024 0.0267
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Brugia malayi SH2 domain containing protein 0.0058 0.024 0.0267
Echinococcus granulosus tyrosine kinase 0.0074 0.0929 0.1035
Echinococcus granulosus NCK adaptor protein 0.0115 0.2632 0.2934
Brugia malayi Protein kinase domain containing protein 0.0074 0.0929 0.1035
Brugia malayi SH2 domain containing protein 0.0058 0.024 0.0267
Schistosoma mansoni voltage-gated potassium channel 0.0077 0.1028 0.1028
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0179 0.0217
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0265 0.8972 1
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0057 0.0179 0.0179
Schistosoma mansoni eps8-related protein 0.0057 0.0179 0.0179
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0074 0.0929 0.1035
Echinococcus granulosus tyrosine protein kinase Fyn 0.0131 0.3321 0.3701
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0267
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0131 0.3321 0.3701
Echinococcus granulosus signal transduction protein lnk realted 0.0058 0.024 0.0267
Schistosoma mansoni tyrosine kinase 0.0074 0.0929 0.0929
Loa Loa (eye worm) guanylate kinase 0.0057 0.0179 0.02
Onchocerca volvulus 0.0058 0.024 0.0812
Loa Loa (eye worm) SRC-1 0.0131 0.3321 0.3701
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0058 0.024 0.0267
Trichomonas vaginalis p67phox protein, putative 0.0057 0.0179 0.0217
Loa Loa (eye worm) p53BP2 0.0057 0.0179 0.02
Loa Loa (eye worm) SH2 domain-containing protein 0.0058 0.024 0.0267
Loa Loa (eye worm) hypothetical protein 0.0057 0.0179 0.02
Echinococcus granulosus tyrosine protein kinase Fyn 0.0131 0.3321 0.3701
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0057 0.0179 0.02

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.