Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.4355 | 0.4355 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.0213 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.0213 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0195 | 0.0195 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0213 | 0.5 |
Onchocerca volvulus | 0.0058 | 0.1522 | 0.5965 | |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0195 | 0.0195 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.6077 | 0.5999 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.6077 | 0.6077 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.6077 | 0.6077 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.6077 | 0.5999 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.6077 | 0.6077 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.4355 | 0.4355 |
Onchocerca volvulus | 0.0033 | 0.0564 | 0.1658 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0195 | 0.0195 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.1522 | 0.1522 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0082 | 0.2419 | 0.2268 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0195 | 0.0195 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0564 | 0.0376 |
Echinococcus granulosus | lamin | 0.0033 | 0.0564 | 0.0376 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.4355 | 0.4243 |
Onchocerca volvulus | 0.0033 | 0.0564 | 0.1658 | |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0213 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | carboxylesterase | 0.0134 | 0.4355 | 0.4355 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0023 | 0.0213 | 1 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.0213 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.4355 | 0.4355 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.4355 | 0.4355 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0564 | 0.0376 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0213 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0564 | 0.0376 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0564 | 0.0376 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.4355 | 0.4243 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0082 | 0.2419 | 0.2268 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.4355 | 0.4243 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0195 | 0.0195 |
Onchocerca volvulus | 0.0082 | 0.2419 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 0.4355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0195 | 0.0195 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0213 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.4355 | 0.4243 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0023 | 0.0213 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0564 | 0.0887 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.0213 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0564 | 0.0564 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0195 | 0.0195 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0023 | 0.0213 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0195 | 0.0195 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.6077 | 0.5999 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0542 | 0.0542 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0082 | 0.2419 | 0.2419 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.1522 | 0.3189 |
Echinococcus granulosus | carboxylesterase 5A | 0.0134 | 0.4355 | 0.4243 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0564 | 0.0564 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0023 | 0.0195 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0023 | 0.0195 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0564 | 0.0887 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0195 | 0.0195 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0082 | 0.2419 | 0.5346 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0564 | 0.0887 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0134 | 0.4355 | 0.4355 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0213 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0564 | 0.0376 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2419 | 0.2419 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0195 | 0.0195 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0195 | 0.0195 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.1522 | 0.3189 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0564 | 0.0564 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0213 | 0.5 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0195 | 0.0195 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0134 | 0.4355 | 0.4243 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0213 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.005 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.2818 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 12.5893 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.