Detailed information for compound 805396

Basic information

Technical information
  • TDR Targets ID: 805396
  • Name: 3-(3,5-dimethylpyrazol-1-yl)-N-(3-fluoropheny l)quinoxalin-2-amine
  • MW: 333.362 | Formula: C19H16FN5
  • H donors: 1 H acceptors: 3 LogP: 4.29 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)Nc1nc2ccccc2nc1n1nc(cc1C)C
  • InChi: 1S/C19H16FN5/c1-12-10-13(2)25(24-12)19-18(21-15-7-5-6-14(20)11-15)22-16-8-3-4-9-17(16)23-19/h3-11H,1-2H3,(H,21,22)
  • InChiKey: INBDJRYNKKTEHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(3,5-dimethyl-1-pyrazolyl)-N-(3-fluorophenyl)-2-quinoxalinamine
  • [3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2-yl]-(3-fluorophenyl)amine
  • ZINC01425850
  • A3600/0152542

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0078 0.0406 0.0406
Trichomonas vaginalis hypothetical protein 0.0182 0.1559 0.2629
Plasmodium falciparum thrombospondin-related anonymous protein 0.0045 0.004 0.068
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0078 0.0406 0.1334
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0077 0.0386 0.0468
Echinococcus granulosus neuropeptide s receptor 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0097 0.0611 0.2081
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0078 0.0406 0.0406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.0611 0.0598
Schistosoma mansoni c4b-binding protein beta chain 0.0078 0.0406 0.0393
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0097 0.0611 0.075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.0611 0.075
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus multilocularis protein will die slowly 0.0292 0.2782 0.3478
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0045 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0102 0.067 0.067
Trichomonas vaginalis WD repeat domain, putative 0.0292 0.2782 0.4708
Echinococcus granulosus neuropeptide Y receptor 0.0097 0.0611 0.0598
Brugia malayi hypothetical protein 0.0097 0.0611 0.0598
Echinococcus granulosus alpha 1A adrenergic receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis serotonin receptor 0.0097 0.0611 0.075
Brugia malayi Tachykinin-like peptides receptor 99D 0.0097 0.0611 0.0598
Echinococcus multilocularis neuropeptide receptor 0.0295 0.281 0.3513
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0078 0.0406 0.0406
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0097 0.0611 0.0598
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0728 0.0716
Loa Loa (eye worm) hypothetical protein 0.0078 0.0406 0.0406
Onchocerca volvulus 0.0097 0.0611 0.2081
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0097 0.0611 0.0598
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0122 0.011
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Echinococcus multilocularis beta adrenergic receptor kinase 0.0107 0.0728 0.0898
Schistosoma mansoni opsin-like receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0078 0.0406 0.0406
Trichomonas vaginalis cyclins, putative 0.0064 0.0245 0.0394
Loa Loa (eye worm) proprotein convertase 2 0.0223 0.2006 0.2006
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0045 0.004 0.0034
Loa Loa (eye worm) endoprotease bli-4 0.0942 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Brugia malayi von Willebrand factor type A domain containing protein 0.0045 0.004 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0045 0.004 0.068
Echinococcus granulosus somatostatin receptor 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0078 0.0406 0.1334
Echinococcus granulosus C type lectin domian containing protein 0.0078 0.0406 0.0393
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis 0.076 0.7976 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0045 0.004 0.0027
Echinococcus multilocularis neuropeptides capa receptor 0.0097 0.0611 0.075
Echinococcus multilocularis neuroendocrine convertase 2 0.0592 0.6111 0.7659
Echinococcus multilocularis sex peptide receptor 0.0097 0.0611 0.075
Loa Loa (eye worm) hypothetical protein 0.0078 0.0406 0.0406
Schistosoma mansoni histamine h1 receptor 0.0097 0.0611 0.0598
Schistosoma mansoni cyclin B3 0.0064 0.0245 0.0232
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Brugia malayi hypothetical protein 0.0078 0.0406 0.0393
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0097 0.0611 0.2081
Brugia malayi von Willebrand factor type A domain containing protein 0.0045 0.004 0.0027
Echinococcus multilocularis g protein coupled receptor 0.0097 0.0611 0.075
Echinococcus granulosus collagen alpha 1VII chain 0.0045 0.004 0.0027
Echinococcus granulosus cyclins 0.0064 0.0245 0.0232
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0097 0.0611 0.0611
Brugia malayi RE15519p 0.0097 0.0611 0.0598
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0097 0.0611 0.075
Schistosoma mansoni neuropeptide F-like receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis fmrfamide receptor 0.0097 0.0611 0.075
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0045 0.004 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.0611 0.075
Brugia malayi Sushi domain 0.0078 0.0406 0.0393
Echinococcus granulosus neuropeptides capa receptor 0.0097 0.0611 0.0598
Leishmania major cyclin 0.0102 0.067 1
Brugia malayi hypothetical protein 0.0097 0.0611 0.0598
Brugia malayi von Willebrand factor type A domain containing protein 0.0045 0.004 0.0027
Entamoeba histolytica hypothetical protein, conserved 0.0045 0.004 0.0406
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Giardia lamblia Cyclin A 0.0064 0.0245 0.0679
Brugia malayi sulfakinin receptor protein 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0097 0.0611 0.2081
Giardia lamblia Furin precursor putative serine protease 0.0182 0.1559 0.4533
Echinococcus granulosus c4b binding protein beta chain 0.0078 0.0406 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.0611 0.0598
Echinococcus granulosus tm gpcr rhodopsin 0.0097 0.0611 0.0598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.0611 0.075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.2006 0.3389
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.0611 0.075
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0097 0.0611 0.075
Entamoeba histolytica hypothetical protein 0.0045 0.004 0.0406
Plasmodium falciparum cyclin 0.0064 0.0245 0.5901
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Echinococcus granulosus cyclin B 0.0102 0.067 0.0658
Brugia malayi Serotonin receptor 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0292 0.2782 1
Brugia malayi Melatonin receptor type 1A 0.0097 0.0611 0.0598
Echinococcus multilocularis cyclin B 0.0102 0.067 0.0825
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0097 0.0611 0.0598
Schistosoma mansoni amine GPCR 0.0097 0.0611 0.0598
Loa Loa (eye worm) WD40 repeat protein 0.0292 0.2782 0.2782
Loa Loa (eye worm) hypothetical protein 0.037 0.364 0.364
Onchocerca volvulus 0.0097 0.0611 0.2081
Schistosoma mansoni neuropeptide receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Trichomonas vaginalis cyclin B, putative 0.0102 0.067 0.1117
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.004 0.0027
Brugia malayi hypothetical protein 0.0078 0.0406 0.0393
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.0611 0.0598
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0122 0.0122
Onchocerca volvulus 0.0097 0.0611 0.2081
Schistosoma mansoni cyclin B 0.0102 0.067 0.0658
Echinococcus multilocularis cyclins 0.0064 0.0245 0.0291
Brugia malayi hypothetical protein 0.0045 0.004 0.0027
Echinococcus granulosus fmrfamide receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0097 0.0611 0.075
Schistosoma mansoni opsin-like receptor 0.0097 0.0611 0.0598
Toxoplasma gondii hypothetical protein 0.0048 0.0073 0.1538
Echinococcus granulosus g protein coupled receptor 0.0097 0.0611 0.0598
Brugia malayi hypothetical protein 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0097 0.0611 0.2081
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0045 0.004 0.0027
Echinococcus granulosus serotonin receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0097 0.0611 0.0611
Brugia malayi putative neuropeptide receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.0611 0.075
Echinococcus granulosus dro:myosuppressin receptor 0.0097 0.0611 0.0598
Echinococcus granulosus cyclins 0.0064 0.0245 0.0232
Brugia malayi GnHR receptor homolog 0.0097 0.0611 0.0598
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0078 0.0406 0.0406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Onchocerca volvulus 0.0097 0.0611 0.2081
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0045 0.004 0.004
Echinococcus granulosus tachykinin peptides receptor 99D 0.0097 0.0611 0.0598
Schistosoma mansoni biogenic amine receptor 0.0097 0.0611 0.0598
Echinococcus granulosus orexin receptor type 2 0.0097 0.0611 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Schistosoma mansoni biogenic amine (5HT) receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis orexin receptor type 2 0.0097 0.0611 0.075
Trichomonas vaginalis cyclins, putative 0.0102 0.067 0.1117
Loa Loa (eye worm) CUTiclin-Like family member 0.0045 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0045 0.004 0.0045
Echinococcus granulosus tm gpcr rhodopsin 0.0097 0.0611 0.0598
Giardia lamblia G2/mitotic-specific cyclin B 0.0102 0.067 0.1927
Brugia malayi Cyclin, N-terminal domain containing protein 0.0102 0.067 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Brugia malayi hypothetical protein 0.0097 0.0611 0.0598
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0097 0.0611 0.0598
Brugia malayi neuropeptide F receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Brugia malayi hypothetical protein 0.0078 0.0406 0.0393
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0097 0.0611 0.0611
Echinococcus multilocularis cyclins 0.0064 0.0245 0.0291
Echinococcus granulosus allatostatin A receptor 0.0097 0.0611 0.0598
Schistosoma mansoni cyclins 0.0064 0.0245 0.0232
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.2006 0.3389
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Onchocerca volvulus 0.0102 0.067 0.2299
Echinococcus granulosus neuropeptide Y receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) melatonin receptor type 1A 0.0097 0.0611 0.0611
Schistosoma mansoni biogenic amine receptor 0.0097 0.0611 0.0598
Trichomonas vaginalis cyclins, putative 0.0102 0.067 0.1117
Brugia malayi Will die slowly protein 0.0292 0.2782 0.2773
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0097 0.0611 0.075
Brugia malayi Zona pellucida-like domain containing protein 0.0045 0.004 0.0027
Brugia malayi ORL1-like opioid receptor 0.0097 0.0611 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0573 0.5895 1
Onchocerca volvulus 0.0078 0.0406 0.1334
Echinococcus granulosus Furin 1 0.0223 0.2006 0.1996
Brugia malayi Cyclin, N-terminal domain containing protein 0.0064 0.0245 0.0232
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Brugia malayi G-protein coupled receptor 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0078 0.0406 0.1334
Trichomonas vaginalis cyclin A, putative 0.0102 0.067 0.1117
Entamoeba histolytica cyclin, putative 0.0102 0.067 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0406 0.0406
Echinococcus granulosus cyclin B3 1 0.0064 0.0245 0.0232
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.2006 0.3389
Onchocerca volvulus 0.0097 0.0611 0.2081
Brugia malayi von Willebrand Factor 0.0045 0.004 0.0027
Brugia malayi Dopamine receptor protein 1 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0077 0.0386 0.0386
Onchocerca volvulus 0.0097 0.0611 0.2081
Onchocerca volvulus 0.0097 0.0611 0.2081
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.0611 0.0598
Echinococcus multilocularis cyclins 0.0064 0.0245 0.0291
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0097 0.0611 0.2081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0122 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0097 0.0611 0.075
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Brugia malayi Cyclin, N-terminal domain containing protein 0.0102 0.067 0.0658
Echinococcus multilocularis neuropeptide s receptor 0.0097 0.0611 0.075
Echinococcus granulosus beta-adrenergic receptor kinase 0.0107 0.0728 0.0716
Trichomonas vaginalis cyclin D, putative 0.0064 0.0245 0.0394
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0077 0.0386 0.0373
Echinococcus multilocularis cyclins 0.0064 0.0245 0.0291
Echinococcus granulosus neuropeptide receptor 0.0097 0.0611 0.0598
Brugia malayi hypothetical protein 0.0078 0.0406 0.0393
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Giardia lamblia Hypothetical protein 0.0064 0.0245 0.0679
Onchocerca volvulus 0.0097 0.0611 0.2081
Echinococcus multilocularis g protein coupled receptor 0.0097 0.0611 0.075
Echinococcus granulosus biogenic amine 5HT receptor 0.0097 0.0611 0.0598
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0573 0.5895 1
Schistosoma mansoni neuropeptide receptor 0.0097 0.0611 0.0598
Schistosoma mansoni hypothetical protein 0.0097 0.0611 0.0598
Echinococcus granulosus cyclins 0.0064 0.0245 0.0232
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus granulosus 7TM GPCR rhodopsin 0.0097 0.0611 0.0598
Treponema pallidum hypothetical protein 0.0045 0.004 0.5
Trichomonas vaginalis cyclin B, putative 0.0102 0.067 0.1117
Brugia malayi celfurPC protein 0.076 0.7976 0.7973
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.0611 0.0598
Entamoeba histolytica cyclin family protein 0.0064 0.0245 0.3525
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Brugia malayi G protein-coupled receptor F59B2.13 0.0097 0.0611 0.0598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Brugia malayi von Willebrand factor type A domain containing protein 0.0045 0.004 0.0027
Brugia malayi Zona pellucida-like domain containing protein 0.0045 0.004 0.0027
Entamoeba histolytica cyclin family protein 0.0064 0.0245 0.3525
Schistosoma mansoni growth hormone secretagogue receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis neuropeptide receptor A26 0.0097 0.0611 0.075
Echinococcus multilocularis neuropeptide FF receptor 2 0.0097 0.0611 0.075
Onchocerca volvulus 0.0078 0.0406 0.1334
Echinococcus multilocularis Furin 1 0.0223 0.2006 0.2503
Trichomonas vaginalis cyclin B3, putative 0.0064 0.0245 0.0394
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0045 0.004 0.068
Echinococcus granulosus protein will die slowly 0.0292 0.2782 0.2773
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0097 0.0611 0.075
Schistosoma mansoni biogenic amine receptor 0.0097 0.0611 0.0598
Echinococcus granulosus neuropeptide FF receptor 2 0.0097 0.0611 0.0598
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Brugia malayi hypothetical protein 0.0097 0.0611 0.0598
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0182 0.1559 0.2629
Brugia malayi proprotein convertase 2 0.0592 0.6111 0.6106
Echinococcus granulosus sex peptide receptor 0.0097 0.0611 0.0598
Schistosoma mansoni hypothetical protein 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) G-protein coupled receptor 0.0097 0.0611 0.0611
Brugia malayi putative neuropeptide receptor NPR1 0.0097 0.0611 0.0598
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.0611 0.0598
Brugia malayi G-protein coupled receptor 0.0097 0.0611 0.0598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus granulosus neuropeptides capa receptor 0.0097 0.0611 0.0598
Brugia malayi hypothetical protein 0.0078 0.0406 0.0393
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0097 0.0611 0.075
Loa Loa (eye worm) CUTiclin family member 0.0045 0.004 0.004
Echinococcus granulosus voltage dependent calcium channel subunit 0.0045 0.004 0.0027
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0097 0.0611 0.075
Echinococcus multilocularis somatostatin receptor 0.0097 0.0611 0.075
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0078 0.0406 0.1334
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0097 0.0611 0.075
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.0013 0.0013
Onchocerca volvulus 0.0078 0.0406 0.1334
Echinococcus multilocularis serotonin receptor 0.0097 0.0611 0.075
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0097 0.0611 0.0598
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0097 0.0611 0.0598
Echinococcus granulosus g protein coupled receptor 0.0097 0.0611 0.0598
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0045 0.004 0.068
Brugia malayi neuropeptide F receptor 0.0097 0.0611 0.0598
Schistosoma mansoni hypothetical protein 0.0292 0.2782 0.2773
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.0611 0.075
Brugia malayi hypothetical protein 0.0097 0.0611 0.0598
Echinococcus granulosus hypothetical protein 0.0097 0.0611 0.0598
Schistosoma mansoni neuropeptide receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis fmrfamide receptor 0.0097 0.0611 0.075
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Echinococcus multilocularis c4b binding protein beta chain 0.0078 0.0406 0.0493
Echinococcus multilocularis cyclins 0.0064 0.0245 0.0291
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Trichomonas vaginalis cyclins, putative 0.0102 0.067 0.1117
Trichomonas vaginalis cyclin D, putative 0.0064 0.0245 0.0394
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Trichomonas vaginalis cyclin B, putative 0.0064 0.0245 0.0394
Echinococcus multilocularis g-protein coupled receptor 0.0097 0.0611 0.075
Echinococcus multilocularis cyclin B3 1 0.0064 0.0245 0.0291
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0182 0.1559 0.2629
Schistosoma mansoni adenoreceptor 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0097 0.0611 0.2081
Loa Loa (eye worm) hypothetical protein 0.0942 1 1
Echinococcus multilocularis cyclins 0.0064 0.0245 0.0291
Echinococcus granulosus biogenic amine 5HT receptor 0.0097 0.0611 0.0598
Schistosoma mansoni neuropeptide receptor 0.0295 0.281 0.2801
Echinococcus granulosus G protein coupled receptor 139 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.2006 0.3389
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0097 0.0611 0.075
Echinococcus multilocularis C type lectin domian containing protein 0.0078 0.0406 0.0493
Brugia malayi GCC2 and GCC3 family protein 0.0078 0.0406 0.0393
Toxoplasma gondii rhoptry neck protein RON9 0.0078 0.0406 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) neuropeptide F receptor 0.0097 0.0611 0.0611
Brugia malayi Dopamine receptor protein 2 0.0097 0.0611 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Brugia malayi G protein-coupled receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus granulosus peptide allatostatin:somatostatin 0.0097 0.0611 0.0598
Echinococcus multilocularis G-protein coupled receptor, putative 0.0097 0.0611 0.075
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0064 0.0245 0.0291
Onchocerca volvulus 0.0097 0.0611 0.2081
Trichomonas vaginalis cyclin B, putative 0.0102 0.067 0.1117
Plasmodium vivax SET domain protein, putative 0.0077 0.0386 0.9501
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus granulosus neuroendocrine convertase 2 0.0592 0.6111 0.6106
Giardia lamblia High cysteine membrane protein Group 2 0.035 0.3424 1
Trichomonas vaginalis cyclins, putative 0.0102 0.067 0.1117
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0097 0.0611 0.075
Treponema pallidum 76K protein 0.0045 0.004 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Onchocerca volvulus Neuropeptide F receptor homolog 0.0097 0.0611 0.2081
Trypanosoma cruzi CYC2-like cyclin, putative 0.0102 0.067 1
Echinococcus granulosus neuropeptide receptor 0.0295 0.281 0.2801
Entamoeba histolytica elongation factor-2 kinase, putative 0.0045 0.004 0.0406
Onchocerca volvulus 0.0078 0.0406 0.1334
Schistosoma mansoni amine GPCR 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Brugia malayi von Willebrand factor type A domain containing protein 0.0045 0.004 0.0027
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0097 0.0611 0.0611
Schistosoma mansoni hypothetical protein 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0097 0.0611 0.0598
Echinococcus granulosus g-protein coupled receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0097 0.0611 0.2081
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0102 0.067 0.067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.0611 0.075
Brugia malayi von Willebrand factor type A domain containing protein 0.0045 0.004 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0102 0.067 1
Echinococcus granulosus cyclin b3 0.0064 0.0245 0.0232
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.0611 0.0598
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0045 0.004 0.0034
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Plasmodium vivax thrombospondin-related anonymous protein 0.0045 0.004 0.068
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Brugia malayi hypothetical protein 0.0078 0.0406 0.0393
Loa Loa (eye worm) TYRA-2 protein 0.0097 0.0611 0.0611
Schistosoma mansoni hypothetical protein 0.0045 0.004 0.0027
Onchocerca volvulus 0.0097 0.0611 0.2081
Schistosoma mansoni hypothetical protein 0.0097 0.0611 0.0598
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.0611 0.0598
Echinococcus multilocularis neuropeptide receptor 0.0097 0.0611 0.075
Brugia malayi larval opioid receptor 0.0097 0.0611 0.0598
Trichomonas vaginalis cyclin B, putative 0.0102 0.067 0.1117
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0096 0.0606 0.0745
Plasmodium falciparum apical sushi protein 0.0078 0.0406 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.0611 0.075
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Onchocerca volvulus 0.0097 0.0611 0.2081
Schistosoma mansoni furin-1 (S08 family) 0.041 0.4087 0.4079
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0045 0.004 0.068
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.0611 0.0598
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0097 0.0611 0.075
Echinococcus granulosus neuropeptide receptor A26 0.0097 0.0611 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.0611 0.0598
Echinococcus multilocularis G protein coupled receptor 139 0.0295 0.281 0.3513
Brugia malayi follicle stimulating hormone receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0078 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0107 0.0728 0.0728
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Toxoplasma gondii microneme protein MIC2 0.0045 0.004 0.068
Echinococcus granulosus cyclins 0.0064 0.0245 0.0232
Brugia malayi Dopamine receptor 0.0097 0.0611 0.0598
Schistosoma mansoni amine GPCR 0.0097 0.0611 0.0598
Loa Loa (eye worm) G-protein coupled receptor 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Schistosoma mansoni neuropeptide f receptor 76f 0.0097 0.0611 0.0598
Toxoplasma gondii rhoptry neck protein RON1 0.0078 0.0406 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0573 0.5895 0.7387
Schistosoma mansoni neuropeptide F-like receptor 0.0097 0.0611 0.0598
Brugia malayi hypothetical protein 0.0078 0.0406 0.0393
Brugia malayi neuroendocrine convertase 1 precursor 0.0592 0.6111 0.6106
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis cyclins 0.0064 0.0245 0.0291
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Schistosoma mansoni opsin-like receptor 0.0097 0.0611 0.0598
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0064 0.0245 0.0232
Trypanosoma cruzi cyclin 6, putative 0.0102 0.067 1
Echinococcus multilocularis cyclin b3 0.0064 0.0245 0.0291
Brugia malayi von Willebrand factor type A domain containing protein 0.0045 0.004 0.0027
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0097 0.0611 0.075
Loa Loa (eye worm) neuropeptide F receptor 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0078 0.0406 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1559 0.2629
Echinococcus granulosus furin 0.0942 1 1
Brugia malayi hypothetical protein 0.0097 0.0611 0.0598
Schistosoma mansoni biogenic amine (5HT) receptor 0.0097 0.0611 0.0598
Trypanosoma brucei mitotic cyclin 6 0.0102 0.067 1
Brugia malayi hypothetical protein 0.0097 0.0611 0.0598
Schistosoma mansoni hypothetical protein 0.0045 0.004 0.0027
Trypanosoma cruzi cyclin, putative 0.0102 0.067 1
Schistosoma mansoni amine GPCR 0.0097 0.0611 0.0598
Echinococcus granulosus cyclins 0.0064 0.0245 0.0232
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.004
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0045 0.004 0.068
Entamoeba histolytica cyclin, putative 0.0064 0.0245 0.3525
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0045 0.004 0.068
Plasmodium falciparum SET domain protein, putative 0.0077 0.0386 0.9501
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0077 0.0386 0.0373
Echinococcus multilocularis dro:myosuppressin receptor 0.0097 0.0611 0.075
Echinococcus multilocularis allatostatin A receptor 0.0097 0.0611 0.075
Onchocerca volvulus 0.0078 0.0406 0.1334
Echinococcus multilocularis g protein coupled receptor 0.0097 0.0611 0.075
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0043 0.0013 0.0013
Trypanosoma cruzi cyclin, putative 0.0102 0.067 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.0013 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.2006 0.3389
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0245 0.0394
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0573 0.5895 0.589
Echinococcus granulosus 7tm_1 domain containing protein 0.0097 0.0611 0.0598
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0097 0.0611 0.0598
Trichomonas vaginalis cyclins, putative 0.0054 0.0132 0.0202
Schistosoma mansoni hypothetical protein 0.0182 0.1559 0.1548
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus multilocularis neuropeptide Y receptor 0.0097 0.0611 0.075
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0097 0.0611 0.0598
Brugia malayi pregnancy-associated plasma protein-A 0.0078 0.0406 0.0393
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.2006 0.3389
Echinococcus granulosus G protein coupled receptor kinase 1 0.0096 0.0606 0.0594
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0942 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0097 0.0611 0.075
Brugia malayi AKH receptor 0.0097 0.0611 0.0598
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0097 0.0611 0.0598
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0728 0.0716
Brugia malayi Protein set-1 0.0077 0.0386 0.0373
Brugia malayi hypothetical protein 0.0097 0.0611 0.0598
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0182 0.1559 0.2629
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0223 0.2006 0.1996
Brugia malayi hypothetical protein 0.0097 0.0611 0.0598
Onchocerca volvulus 0.0078 0.0406 0.1334
Schistosoma mansoni amine GPCR 0.0097 0.0611 0.0598
Toxoplasma gondii histone lysine methyltransferase SET8 0.0077 0.0386 0.9501
Echinococcus granulosus g protein coupled receptor 0.0097 0.0611 0.0598
Plasmodium vivax apical sushi protein, putative 0.0078 0.0406 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0097 0.0611 0.0598
Echinococcus multilocularis neuropeptide Y receptor 0.0097 0.0611 0.075
Echinococcus granulosus tm gpcr rhodopsin 0.0097 0.0611 0.0598
Loa Loa (eye worm) cyclin domain-containing protein 0.0064 0.0245 0.0245
Schistosoma mansoni myosin xvIII 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Brugia malayi Serotonin receptor 0.0097 0.0611 0.0598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0053 0.0122 0.0122
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0045 0.004 0.068
Entamoeba histolytica hypothetical protein, conserved 0.0045 0.004 0.0406

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.