TDR Targets

Basic information

Technical information

TDR Targets ID: 80548
Name: N-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl] phenyl]-2-(5-methyl-2-phenyl-1,3-oxazol-4-yl) acetamide
MW: 421.469 | Formula: C22H19N3O4S
H donors: 2 H acceptors: 4 LogP: 3.35 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1nc(oc1C)c1ccccc1)Nc1ccc(cc1)CC1SC(=O)NC1=O
InChi: 1S/C22H19N3O4S/c1-13-17(24-21(29-13)15-5-3-2-4-6-15)12-19(26)23-16-9-7-14(8-10-16)11-18-20(27)25-22(28)30-18/h2-10,18H,11-12H2,1H3,(H,23,26)(H,25,27,28)
InChiKey: DKSAHGHNBIUCKR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[(2,4-dioxothiazolidin-5-yl)methyl]phenyl]-2-(5-methyl-2-phenyl-oxazol-4-yl)acetamide
N-[4-[(2,4-dioxo-5-thiazolidinyl)methyl]phenyl]-2-(5-methyl-2-phenyl-4-oxazolyl)acetamide
N-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenyl]-2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethanamide
N-[4-[(2,4-diketothiazolidin-5-yl)methyl]phenyl]-2-(5-methyl-2-phenyl-oxazol-4-yl)acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	adenoreceptor	0.0005	0.0038	0.0038
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0038	0.0038
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0038	0.0038
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.1275	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0005	0.0038	0.0017
Brugia malayi	CXXC zinc finger family protein	0.0029	0.1488	0.1652
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.3582	0.4014
Schistosoma mansoni	myosin xvIII	0.0005	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0038	0.0038
Schistosoma mansoni	hypothetical protein	0.0169	1	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0038	0.0038
Schistosoma mansoni	opsin-like receptor	0.0005	0.0038	0.0038
Leishmania major	hypothetical protein, conserved	0.0025	0.1275	1
Echinococcus granulosus	tar DNA binding protein	0.0063	0.3582	0.3558
Loa Loa (eye worm)	melatonin receptor type 1A	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0706	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0038	0.0038
Brugia malayi	Dopamine receptor protein 2	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	neuropeptide F receptor	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.1275	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0182	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Echinococcus granulosus	smad	0.0008	0.0243	0.0205
Schistosoma mansoni	hypothetical protein	0.0005	0.0038	0.0038
Echinococcus granulosus	cpg binding protein	0.003	0.1587	0.1555
Brugia malayi	putative neuropeptide receptor NPR1	0.0005	0.0038	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0144	0.5
Brugia malayi	GnHR receptor homolog	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	growth hormone secretagogue receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0243	0.0205
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0288	0.0299
Echinococcus granulosus	Smad4	0.0008	0.0243	0.0205
Schistosoma mansoni	biogenic amine receptor	0.0005	0.0038	0.0038
Brugia malayi	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Brugia malayi	RE15519p	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0005	0.0038	0.0038
Echinococcus multilocularis	Smad4	0.0008	0.0243	0.0205
Brugia malayi	MH1 domain containing protein	0.0008	0.0243	0.0248
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0243	0.0243
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0288	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Brugia malayi	hypothetical protein	0.0005	0.0038	0.0017
Brugia malayi	follicle stimulating hormone receptor	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Onchocerca volvulus		0.0029	0.1488	0.1637
Schistosoma mansoni	opsin-like receptor	0.0005	0.0038	0.0038
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0005	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0005	0.0038	0.0017
Loa Loa (eye worm)	G-protein coupled receptor	0.0005	0.0038	0.0017
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.1275	0.2436
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	RNA binding protein	0.0063	0.3582	0.4014
Brugia malayi	hypothetical protein	0.0025	0.1275	0.1412
Brugia malayi	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0151	0.8891	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.3582	0.4014
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.1275	1
Brugia malayi	Melatonin receptor type 1A	0.0005	0.0038	0.0017
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0243	0.0243
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0435	0.0398
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0144	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0144	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	hypothetical protein	0.0169	1	1
Brugia malayi	MH2 domain containing protein	0.0008	0.0243	0.0248
Schistosoma mansoni	neuropeptide F-like receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	G-protein coupled receptor	0.0005	0.0038	0.0017
Loa Loa (eye worm)	Smad1	0.0008	0.0243	0.0248
Brugia malayi	ORL1-like opioid receptor	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.1275	1
Schistosoma mansoni	hypothetical protein	0.0005	0.0038	0.0038
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0005	0.0038	0.0017
Brugia malayi	sulfakinin receptor protein	0.0005	0.0038	0.0017
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.3582	0.4014
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	biogenic amine receptor	0.0005	0.0038	0.0038
Brugia malayi	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3582	0.3582
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0706	0.0706
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0005	0.0038	0.0038
Schistosoma mansoni	amine GPCR	0.0005	0.0038	0.0038
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0706	0.0671
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0038	0.0038
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0005	0.0038	0.0017
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0182	0.0145
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0243	0.0205
Onchocerca volvulus		0.0151	0.8891	1
Brugia malayi	Serotonin receptor	0.0005	0.0038	0.0017
Brugia malayi	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0038	0.0038
Schistosoma mansoni	cpg binding protein	0.003	0.1587	0.1587
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.3435	0.3435
Brugia malayi	G-protein coupled receptor	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.3582	0.3558
Echinococcus multilocularis	cpg binding protein	0.003	0.1587	0.1555
Brugia malayi	Smad1	0.0008	0.0243	0.0248
Schistosoma mansoni	neuropeptide f receptor 76f	0.0005	0.0038	0.0038
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0005	0.0038	0.0017
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0005	0.0038	0.0038
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0144	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0005	0.0038	0.0038
Schistosoma mansoni	biogenic amine receptor	0.0005	0.0038	0.0038
Brugia malayi	neuropeptide F receptor	0.0005	0.0038	0.0017
Loa Loa (eye worm)	neuropeptide F receptor	0.0005	0.0038	0.0017
Schistosoma mansoni	cpg binding protein	0.0029	0.1488	0.1488
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0144	0.5
Brugia malayi	hypothetical protein	0.0005	0.0038	0.0017
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0144	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Brugia malayi	Serotonin receptor	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0005	0.0038	0.0017
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0182	0.0145
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0243	0.0243
Trichomonas vaginalis	helicase, putative	0.0006	0.0144	0.5
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0005	0.0038	0.0017
Brugia malayi	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0144	0.5
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0243	0.0243
Brugia malayi	G protein-coupled receptor F59B2.13	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0182	0.0145
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0144	0.5
Brugia malayi	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0435	0.0398
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0706	0.0671
Schistosoma mansoni	amine GPCR	0.0005	0.0038	0.0038
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0243	0.0205
Schistosoma mansoni	opsin-like receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1275	0.1412
Brugia malayi	Dopamine receptor protein 1	0.0005	0.0038	0.0017
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.1275	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0144	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0144	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0005	0.0038	0.0038
Brugia malayi	hypothetical protein	0.0151	0.8891	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0706	0.0671
Brugia malayi	RNA binding protein	0.0063	0.3582	0.4014
Schistosoma mansoni	hypothetical protein	0.0005	0.0038	0.0038
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0005	0.0038	0.0017
Schistosoma mansoni	Smad4	0.0008	0.0243	0.0243
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0706	0.5
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0243	0.0205
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0182	0.0145
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0144	0.5
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0243	0.0248
Brugia malayi	G protein-coupled receptor	0.0005	0.0038	0.0017
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0706	0.0671
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0144	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0005	0.0038	0.0038
Schistosoma mansoni	neuropeptide F-like receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.1488	0.1652
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0005	0.0038	0.0017
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Brugia malayi	MH2 domain containing protein	0.0119	0.6972	0.7836
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0144	0.5
Brugia malayi	hypothetical protein	0.0016	0.0735	0.0803
Schistosoma mansoni	hypothetical protein	0.0005	0.0038	0.0038
Brugia malayi	AKH receptor	0.0005	0.0038	0.0017
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0706	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Brugia malayi	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0005	0.0038	0.0038
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0706	0.0671
Brugia malayi	neuropeptide F receptor	0.0005	0.0038	0.0017
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.3042	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	cpg binding protein	0.003	0.1587	0.1587
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0005	0.0038	0.0038
Brugia malayi	MH1 domain containing protein	0.0008	0.0243	0.0248
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0288	0.0251
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.1275	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.6972	0.7836
Schistosoma mansoni	smad	0.0008	0.0243	0.0243
Schistosoma mansoni	histamine h1 receptor	0.0005	0.0038	0.0038
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0144	0.5
Schistosoma mansoni	amine GPCR	0.0005	0.0038	0.0038
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0243	0.0248
Brugia malayi	larval opioid receptor	0.0005	0.0038	0.0017
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3582	0.3582
Brugia malayi	G-protein coupled receptor	0.0005	0.0038	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3582	0.3582
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0038	0.0038
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Echinococcus multilocularis	geminin	0.0169	1	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0281	0.0291
Loa Loa (eye worm)	TYRA-2 protein	0.0005	0.0038	0.0017
Brugia malayi	putative neuropeptide receptor	0.0005	0.0038	0.0017
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0706	0.0671
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0144	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0005	0.0038	0.0038
Schistosoma mansoni	hypothetical protein	0.0011	0.0435	0.0435
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.6972	0.7836
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3582	0.3582
Schistosoma mansoni	amine GPCR	0.0005	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Brugia malayi	TAR-binding protein	0.0063	0.3582	0.4014
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0038	0.0038
Echinococcus multilocularis	smad	0.0008	0.0243	0.0205
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0144	0.5
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.0017
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0005	0.0038	0.0038
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0005	0.0038	0.0038
Brugia malayi	MH2 domain containing protein	0.0008	0.0243	0.0248
Brugia malayi	hypothetical protein	0.0005	0.0038	0.0017
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0706	0.0771
Brugia malayi	Dopamine receptor	0.0005	0.0038	0.0017
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3582	0.3582
Schistosoma mansoni	amine GPCR	0.0005	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0144	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Normalization (functional)	= 16 %	In vivo euglycemic activity of the compound(administered by oral gavage) in C57/6J-ob/ob mice is measured by normalization of blood glucose levels at a dose of 2.5(mg/kg)	ChEMBL.	1588563
Normalization (functional)	= 16 %	In vivo euglycemic activity of the compound(administered by oral gavage) in C57/6J-ob/ob mice is measured by normalization of blood glucose levels at a dose of 2.5(mg/kg)	ChEMBL.	1588563
Normalization (functional)	= 64 %	In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice measured by normalization of blood glucose levels at a dose of 5 mg/kg.	ChEMBL.	1588563
Normalization (functional)	= 64 %	In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice measured by normalization of blood glucose levels at a dose of 5 mg/kg.	ChEMBL.	1588563

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL54731
PubChem: 15751812

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 80548