Detailed information for compound 80556

Basic information

Technical information
  • TDR Targets ID: 80556
  • Name: [(4-heptylanilino)-phosphonomethyl]phosphonic acid
  • MW: 365.299 | Formula: C14H25NO6P2
  • H donors: 5 H acceptors: 6 LogP: 2.02 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCc1ccc(cc1)NC(P(=O)(O)O)P(=O)(O)O
  • InChi: 1S/C14H25NO6P2/c1-2-3-4-5-6-7-12-8-10-13(11-9-12)15-14(22(16,17)18)23(19,20)21/h8-11,14-15H,2-7H2,1H3,(H2,16,17,18)(H2,19,20,21)
  • InChiKey: IGHWTRWWSFAETJ-UHFFFAOYSA-N  

Network

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Synonyms

  • [(4-heptylanilino)-phosphono-methyl]phosphonic acid
  • [[(4-heptylphenyl)amino]-phosphono-methyl]phosphonic acid
  • [[(4-heptylphenyl)amino]-phosphonomethyl]phosphonic acid
  • AIDS-257684
  • NSC725577
  • [(4-heptylphenyl)aminomethylene]-1,1-bisphosphonate (hydrate)
  • Phosphonic acid, [[(4-heptylphenyl)amino]methylene]bis-
  • AIDS257684

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi hexokinase, putative Curated by TDR Targets No references
Trypanosoma cruzi hexokinase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium falciparum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania donovani hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium knowlesi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Treponema pallidum hexokinase (hxk) Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 1 Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma japonicum ko:K00844 hexokinase [EC2.7.1.1], putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium vivax hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium yoelii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania braziliensis hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi Hexokinase family protein Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium parvum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 2 Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Neospora caninum cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related Get druggable targets OG5_126743 All targets in OG5_126743
Toxoplasma gondii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium hominis hexokinase i Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium berghei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Babesia bovis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase type II Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0076 0.0562
Trypanosoma brucei hexokinase 0.0192 0.0956 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0113 0.111
Echinococcus multilocularis lamin dm0 0.0029 0.0095 0.0212
Echinococcus granulosus hexokinase 0.0192 0.0956 0.2131
Brugia malayi MH2 domain containing protein 0.0016 0.0026 0.0087
Echinococcus granulosus dna polymerase eta 0.0083 0.0378 0.0842
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.004 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0024 0.008
Echinococcus granulosus chromobox protein 1 0.007 0.0307 0.0685
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0024 0.008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0023 0.0052
Loa Loa (eye worm) RNA binding protein 0.0188 0.0931 0.3141
Loa Loa (eye worm) hexokinase 0.006 0.0254 0.0858
Brugia malayi Pre-SET motif family protein 0.0029 0.0095 0.0322
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0244 0.0543
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0047 0.0186 0.1949
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.004 0.0089
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0861 0.4486 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.000000000021558 0.000000000072747
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0024 0.0053
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.004 0.0296
Onchocerca volvulus Hexokinase homolog 0.0121 0.0577 0.2128
Leishmania major DNA polymerase eta, putative 0.0043 0.0168 0.1693
Trypanosoma brucei hexokinase, putative 0.0192 0.0956 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0076 0.0717
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.018 0.0401
Loa Loa (eye worm) matrix metalloproteinase 0.0237 0.119 0.4017
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0008 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0023 0.0052
Trichomonas vaginalis chromobox protein, putative 0.007 0.0307 0.2286
Onchocerca volvulus 0.0336 0.1713 0.6313
Entamoeba histolytica hypothetical protein 0.0072 0.032 0.3348
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.00000000022545
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0047 0.0186 0.1949
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Brugia malayi nuclear hormone receptor 0.0016 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0237 0.119 0.4017
Trichomonas vaginalis pc-MYB2, putative 0.0047 0.0186 0.1386
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0439 0.4591
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.0244 0.2488
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0312
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0168 0.1693
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0113 0.0406
Trypanosoma cruzi hexokinase, putative 0.0192 0.0956 1
Toxoplasma gondii thioredoxin reductase 0.0094 0.0439 0.1581
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.004 0.0089
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0024 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0024 0.0053
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.12 0.405
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.000000000021558 0.000000000048052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.005
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0244 0.0822
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0024 0.008
Treponema pallidum hexokinase (hxk) 0.0192 0.0956 0.0853
Echinococcus multilocularis GPCR, family 2 0.0016 0.0023 0.0052
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.004 0.0089
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0244 0.0543
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.00000000022545
Echinococcus multilocularis hexokinase 0.0192 0.0956 0.2131
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0057 0.0244 0.0185
Schistosoma mansoni smad1 5 8 and 0.0016 0.0026 0.0057
Trichomonas vaginalis MYB72, putative 0.0047 0.0186 0.1386
Brugia malayi Thioredoxin reductase 0.0094 0.0439 0.1481
Schistosoma mansoni flap endonuclease-1 0.0023 0.0063 0.0139
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.004 0.0089
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0139 0.031
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0076 0.198
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1904 1 1
Onchocerca volvulus 0.0016 0.0024 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Trypanosoma brucei DNA polymerase eta, putative 0.0083 0.0378 0.3901
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0024 0.0053
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0095 0.0344
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.1206 0.155
Entamoeba histolytica hypothetical protein 0.0072 0.032 0.3348
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.004 0.0089
Echinococcus multilocularis dna polymerase kappa 0.0057 0.0244 0.0543
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.004 0.0134
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.004 0.0134
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0288 0.1463 0.4936
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0026 0.0057
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.004 0.0089
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0052
Trichomonas vaginalis C-MYB, putative 0.0047 0.0186 0.1386
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1174 0.8733
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0288 0.1463 0.1915
Trypanosoma brucei hexokinase 0.0192 0.0956 1
Entamoeba histolytica hexokinase 1 0.0192 0.0956 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Echinococcus granulosus GPCR family 2 0.0016 0.0023 0.0052
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0047 0.0188 0.0676
Echinococcus granulosus hexokinase 0.0192 0.0956 0.2131
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0023 0.0052
Echinococcus multilocularis Chromo domain 0.0011 0.000000000021558 0.000000000048052
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0113 0.3759
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Echinococcus granulosus Chromobox protein 3 0.0011 0.000000006517 0.000000014526
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0024 0.008
Brugia malayi Smad1 0.0016 0.0026 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Brugia malayi steroid hormone receptor 0.0016 0.0024 0.008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.018 0.0607
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0024 0.0053
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0113 0.118
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0113 0.0079
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0034 0.028
Toxoplasma gondii hexokinase 0.0192 0.0956 0.3445
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0168 0.0606
Schistosoma mansoni hypothetical protein 0.086 0.4483 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0026 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.1494
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0052
Schistosoma mansoni axis inhibition protein axin 0.0019 0.004 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0024 0.008
Onchocerca volvulus 0.015 0.0733 0.2702
Echinococcus granulosus sodium channel protein 0.0087 0.0397 0.0885
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0024 0.0088
Echinococcus multilocularis Chromobox protein 3 0.0011 0.000000006517 0.000000014526
Echinococcus granulosus Smad4 0.0016 0.0026 0.0057
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0023 0.0078
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0066 0.0494
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.1206 0.155
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0244 0.021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0439 0.0463
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0087 0.0397 0.0885
Onchocerca volvulus 0.0041 0.0156 0.0573
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.004 0.0089
Leishmania major DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.004 0.0134
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Echinococcus granulosus geminin 0.086 0.4483 0.9993
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.000000000021558 0.000000000072747
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0076 0.079
Mycobacterium leprae PROBABLE HYDROLASE 0.0288 0.1463 0.0632
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0284 0.0958
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0931 0.2076
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0204 0.0688
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0024 0.0053
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0023 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Brugia malayi Matrixin family protein 0.0237 0.119 0.4017
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0113 0.0079
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.000000000021558 0.000000000048052
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.0089
Echinococcus granulosus bloom syndrome protein 0.0024 0.0066 0.0148
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.004
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0024 0.0053
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0024 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Schistosoma mansoni DNA polymerase eta 0.0083 0.0378 0.0842
Brugia malayi ecdysteroid receptor 0.0016 0.0024 0.008
Entamoeba histolytica hypothetical protein 0.0011 0.000000000021558 0.00000000022545
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0113 0.111
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0076 0.0272
Onchocerca volvulus 0.0192 0.0956 0.3524
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0146 0.0538
Trypanosoma cruzi hexokinase, putative 0.0192 0.0956 1
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0113 0.0839
Loa Loa (eye worm) hypothetical protein 0.0061 0.0263 0.0887
Onchocerca volvulus 0.0237 0.119 0.4387
Trypanosoma brucei unspecified product 0.004 0.0149 0.1494
Echinococcus multilocularis expressed protein 0.0368 0.1885 0.4202
Plasmodium vivax hexokinase, putative 0.0192 0.0956 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0188 0.1395
Schistosoma mansoni hexokinase 0.0192 0.0956 0.2133
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0024 0.0053
Loa Loa (eye worm) glutaminase 2 0.0266 0.1345 0.4538
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0024 0.008
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000021558 0.000000000048085
Schistosoma mansoni hypothetical protein 0.0072 0.032 0.0714
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0076 0.079
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0284 0.2913
Echinococcus granulosus lamin 0.0029 0.0095 0.0212
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0244 0.2547
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0188 0.1395
Brugia malayi ImpB/MucB/SamB family protein 0.0083 0.0378 0.1274
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0162 0.1201
Echinococcus granulosus chromobox protein 1 0.007 0.0307 0.0685
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0095 0.0213
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0284 0.2913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.018 0.0401
Schistosoma mansoni hypothetical protein 0.086 0.4483 1
Brugia malayi SET domain containing protein 0.0012 0.0006 0.0019
Brugia malayi hypothetical protein 0.015 0.0733 0.2474
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0095 0.0321
Loa Loa (eye worm) hypothetical protein 0.015 0.0733 0.2474
Loa Loa (eye worm) matrixin family protein 0.0525 0.2713 0.9156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.004
Onchocerca volvulus 0.0029 0.0095 0.0351
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0024 0.0053
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0073 0.0689
Brugia malayi Pre-SET motif family protein 0.0205 0.1025 0.3457
Schistosoma mansoni smad1 5 8 and 0.0016 0.0026 0.0057
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0024 0.0053
Echinococcus multilocularis sodium channel protein 0.0087 0.0397 0.0885
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0113 0.111
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0113 0.111
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.004 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.012 0.0406
Plasmodium falciparum flap endonuclease 1 0.0026 0.0076 0.079
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.1206 0.155
Loa Loa (eye worm) hypothetical protein 0.0313 0.1593 0.5377
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0023 0.0079
Onchocerca volvulus 0.0192 0.0956 0.3524
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0244 0.0822
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0113 0.0406
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0024 0.0087
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.000000000021558 0.000000000072747
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.004 0.0089
Trichomonas vaginalis pc-MYB2, putative 0.0047 0.0186 0.1386
Plasmodium falciparum hexokinase 0.0192 0.0956 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Onchocerca volvulus 0.0029 0.0095 0.0351
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0076 0.0717
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0113 0.0251
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0244 0.2488
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.1159 0.3912
Plasmodium falciparum glutathione reductase 0.0094 0.0439 0.4591
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0244 0.0543
Leishmania major DNA damage repair protein, putative 0.0018 0.0034 0.028
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0139 0.031
Loa Loa (eye worm) hypothetical protein 0.0131 0.0633 0.2136
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Brugia malayi CHD4 protein 0.0011 0.000000000021558 0.000000000072747
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0113 0.118
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.004 0.0089
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0026 0.0057
Loa Loa (eye worm) hexokinase 0.0192 0.0956 0.3227
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0931 0.2076
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1367 0.7164 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0024 0.0053
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0067 0.0226
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0162 0.1201
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.0406
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0024 0.0053
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.1078 0.1369
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.004 0.0089
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0162 0.0595
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.032 0.0714
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.004 0.0134
Loa Loa (eye worm) TAR-binding protein 0.0188 0.0931 0.3141
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0026 0.0087
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0439 0.1481
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0034 0.0076
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.004 0.0134
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.1206 0.0209
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0095 0.0321
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.004 0.0089
Onchocerca volvulus 0.0234 0.1174 0.4328
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0095 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0024 0.0053
Entamoeba histolytica hypothetical protein 0.0019 0.004 0.0416
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.004 0.0089
Schistosoma mansoni smad 0.0016 0.0026 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.018 0.0401
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.004 0.0089
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0537 0.2776 0.2751
Loa Loa (eye worm) hexokinase type II 0.0192 0.0956 0.3227
Echinococcus granulosus flap endonuclease 1 0.0026 0.0076 0.0168
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1904 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.004 0.0089
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0024 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Brugia malayi MH1 domain containing protein 0.0016 0.0026 0.0087
Brugia malayi nuclear receptor NHR-88 0.0016 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Giardia lamblia Myb 1-like protein 0.0047 0.0188 0.7327
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.032 0.0714
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.1078 0.1369
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0026 0.0087
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0024 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0284 0.0633
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0024 0.0053
Onchocerca volvulus Matrix metalloproteinase homolog 0.0525 0.2713 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0024 0.008
Loa Loa (eye worm) Smad1 0.0016 0.0026 0.0087
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0047 0.0186 0.1949
Echinococcus multilocularis hexokinase 0.0192 0.0956 0.2131
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0025 0.0266
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0015 0.0033
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0284 0.2913
Onchocerca volvulus Matrilysin homolog 0.0525 0.2713 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0537 0.2776 0.2789
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.018 0.0401
Entamoeba histolytica hypothetical protein 0.0019 0.004 0.0416
Trichomonas vaginalis MYB, putative 0.0047 0.0188 0.1395
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0113 0.118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.018 0.0401
Brugia malayi follicle stimulating hormone receptor 0.0231 0.1159 0.3912
Echinococcus multilocularis chromobox protein 1 0.007 0.0307 0.0685
Echinococcus granulosus tar DNA binding protein 0.0188 0.0931 0.2075
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0537 0.2776 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Brugia malayi hypothetical protein 0.012 0.0574 0.1938
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0095 0.0213
Brugia malayi hypothetical protein 0.0019 0.004 0.0134
Brugia malayi hexokinase 0.0192 0.0956 0.3227
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0024 0.0053
Brugia malayi glutaminase DH11.1 0.0266 0.1345 0.4538
Brugia malayi Matrixin family protein 0.0237 0.119 0.4017
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0244 0.0543
Schistosoma mansoni hypothetical protein 0.0034 0.012 0.0268
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0113 0.0251
Mycobacterium ulcerans hydrolase 0.0288 0.1463 0.1434
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0024 0.008
Plasmodium falciparum thioredoxin reductase 0.0094 0.0439 0.4591
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.00000000022545
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0051 0.0534
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.004 0.0089
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0034 0.0357
Brugia malayi Hemopexin family protein 0.0336 0.1713 0.578
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0073 0.0762
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0066 0.0148
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0024 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.12 0.405
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0024 0.0087
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0439 0.4548
Echinococcus granulosus dna polymerase kappa 0.0057 0.0244 0.0543
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0188 0.0931 0.3141
Brugia malayi Matrixin family protein 0.0572 0.2963 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0113 0.111
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0024 0.008
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.0089
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.000000000021558 0.000000000048052
Echinococcus granulosus axis inhibition protein axin 0.0019 0.004 0.0089
Brugia malayi RNA recognition motif domain containing protein 0.0188 0.0931 0.3141
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0113 0.0252
Giardia lamblia DINP protein human, muc B family 0.0057 0.0244 1
Echinococcus multilocularis smad 0.0016 0.0026 0.0057
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0113 0.118
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0087 0.0397 0.4106
Onchocerca volvulus 0.0192 0.0956 0.3524
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.018 0.0401
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0024 0.0053
Loa Loa (eye worm) RecQ helicase 0.0024 0.0066 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0024 0.008
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0034 0.028
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.004 0.0089
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0024 0.008
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.032 0.0714
Brugia malayi Matrixin family protein 0.0237 0.119 0.4017
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0073 0.0689
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0076 0.0168
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.004 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0034 0.028
Trichomonas vaginalis chromobox protein, putative 0.007 0.0307 0.2286
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.1078 0.1369
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.004 0.0089
Loa Loa (eye worm) matrixin family protein 0.0572 0.2963 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.004 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0024 0.008
Entamoeba histolytica hypothetical protein 0.0072 0.032 0.3348
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0073 0.0762
Mycobacterium tuberculosis Probable reductase 0.0216 0.1078 0.1369
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.0089
Loa Loa (eye worm) hypothetical protein 0.0288 0.1463 0.4936
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.1078 0.1369
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0095 0.0321
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.004 0.0089
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0307 0.1037
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0931 0.2076
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0086 0.0637
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.1085
Echinococcus granulosus smad 0.0016 0.0026 0.0057
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1367 0.7164 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Echinococcus multilocularis lamin 0.0029 0.0095 0.0212
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0244 0.021
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0244 0.2488
Loa Loa (eye worm) glutathione reductase 0.0094 0.0439 0.1481
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0113 0.111
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.004 0.0089
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0066 0.0224
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0024 0.008
Loa Loa (eye worm) hexokinase 0.0192 0.0956 0.3227
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0086 0.0637
Brugia malayi PXA domain containing protein 0.0019 0.004 0.0134
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0034 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0024 0.008
Leishmania major hexokinase, putative 0.0192 0.0956 1
Brugia malayi Flap endonuclease-1 0.0026 0.0076 0.0255
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0113 0.111
Schistosoma mansoni chromobox protein 0.007 0.0307 0.0686
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0322
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0492
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0321
Leishmania major hexokinase, putative 0.0192 0.0956 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.0095 0.0212
Trypanosoma brucei trypanothione reductase 0.0094 0.0439 0.4548
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0244 0.2488
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0024 0.0053
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.000000000021558 0.00000000022545
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0024 0.0053
Echinococcus multilocularis geminin 0.086 0.4483 0.9993
Echinococcus multilocularis Smad4 0.0016 0.0026 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0931 0.2076
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0246
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0113 0.111
Leishmania major DNA polymerase eta, putative 0.0083 0.0378 0.3901
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0066 0.0494
Echinococcus multilocularis dna polymerase eta 0.0083 0.0378 0.0842
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Schistosoma mansoni Smad4 0.0016 0.0026 0.0057
Echinococcus multilocularis tar DNA binding protein 0.0188 0.0931 0.2075
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0023 0.0052
Trichomonas vaginalis glutaminase, putative 0.0266 0.1345 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.0244 0.1811
Brugia malayi hypothetical protein 0.0072 0.032 0.108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0083 0.0378 0.1274
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0931 0.2076
Echinococcus granulosus hexokinase type 2 0.0192 0.0956 0.2131
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0113 0.0839
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0047 0.0186 0.1949
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0284 0.2913
Schistosoma mansoni glutaminase 0.0266 0.1345 0.3
Plasmodium vivax SET domain protein, putative 0.0029 0.0095 0.0998
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Loa Loa (eye worm) hypothetical protein 0.005 0.0204 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.1494
Echinococcus granulosus lamin dm0 0.0029 0.0095 0.0212
Trypanosoma cruzi DNA polymerase eta, putative 0.0083 0.0378 0.3901
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0024 0.0053
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0073 0.0262
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0024 0.008
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0047 0.0186 0.1949
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.004 0.0089
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.004 0.0134
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0034 0.028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0121 0.0577 0.1948
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0024 0.008
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0284 0.0958
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.009 0.02
Brugia malayi MH2 domain containing protein 0.0016 0.0026 0.0087
Brugia malayi hypothetical protein 0.0019 0.004 0.0134
Brugia malayi MH2 domain containing protein 0.0239 0.12 0.405
Plasmodium falciparum glutathione reductase 0.0033 0.0113 0.118
Schistosoma mansoni smad1 5 8 and 0.0016 0.0026 0.0057
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0024 0.0053
Trypanosoma brucei unspecified product 0.0057 0.0244 0.2488
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0067 0.0226
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.004 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0034 0.028
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.0089
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0052
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0284 0.0633
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.004 0.0089
Plasmodium vivax hypothetical protein, conserved 0.0011 0.000000000021558 0.00000000022545
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Brugia malayi chromobox protein homolog 3 0.0039 0.0146 0.0492
Onchocerca volvulus 0.0121 0.0577 0.2128
Trichomonas vaginalis MYB3r3, putative 0.0047 0.0186 0.1386
Brugia malayi hexokinase type II 0.0061 0.0263 0.0887
Entamoeba histolytica hexokinase 2 0.0192 0.0956 1
Leishmania major DNA polymerase kappa, putative 0.0018 0.0034 0.028
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0439 0.0978
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Plasmodium falciparum thioredoxin reductase 0.0033 0.0113 0.118
Leishmania major hypothetical protein, conserved 0.0025 0.0073 0.0689
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.004 0.0134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0299 0.1517 0.3384
Schistosoma mansoni hypothetical protein 0.0336 0.1713 0.3821
Schistosoma mansoni lamin 0.0029 0.0095 0.0212
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0095 0.0213
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0026 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0024 0.0053
Onchocerca volvulus Matrilysin homolog 0.0237 0.119 0.4387
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0244 0.0185
Onchocerca volvulus 0.0031 0.0101 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0024 0.008
Schistosoma mansoni lamin 0.0029 0.0095 0.0212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.018 0.0401
Echinococcus multilocularis musashi 0.0029 0.0095 0.0212
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0034 0.028
Schistosoma mansoni coup transcription factor 0.0016 0.0024 0.0053
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0023 0.0078
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1025 0.3457
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0061 0.0263 0.0887
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0034 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0034 0.028
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0024 0.0053
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0073 0.0762
Brugia malayi polk-prov protein 0.0018 0.0034 0.0115
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0439 0.0978
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.004 0.0134
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0076 0.0255
Brugia malayi hypothetical protein 0.0025 0.0073 0.0246
Trypanosoma brucei unspecified product 0.004 0.0149 0.1494
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.1085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0026 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0034 0.028
Echinococcus granulosus axis inhibition protein axin 0.0019 0.004 0.0089
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0284 0.2969
Entamoeba histolytica hypothetical protein 0.0072 0.032 0.3348
Leishmania major trypanothione reductase 0.0094 0.0439 0.4548
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.000000000021558 0.000000000077661
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0204 0.0688
Loa Loa (eye worm) hypothetical protein 0.0237 0.119 0.4017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.018 0.0607
Brugia malayi hypothetical protein 0.0016 0.0026 0.0087
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0237 0.119 0.2655
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0076 0.0717
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0024 0.0053
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.000000000021558 0.000000000072747
Schistosoma mansoni chromobox protein 0.007 0.0307 0.0686
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0342
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0024 0.008
Onchocerca volvulus 0.0011 0.000000006517 0.000000024018
Echinococcus multilocularis hexokinase type 2 0.0192 0.0956 0.2131
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0537 0.2776 0.2694
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.1078 0.1369
Schistosoma mansoni hypothetical protein 0.0011 0.000000000021558 0.000000000048085
Echinococcus granulosus expressed protein 0.0368 0.1885 0.4202
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0015 0.0033
Brugia malayi Heterochromatin protein 1 0.007 0.0307 0.1037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.0089
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0095 0.0213
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.004 0.0134
Brugia malayi glutathione reductase 0.0094 0.0439 0.1481
Echinococcus multilocularis chromobox protein 1 0.007 0.0307 0.0685
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0034 0.0123
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0861 0.4486 1
Trichomonas vaginalis C-MYB, putative 0.0047 0.0186 0.1386
Loa Loa (eye worm) hexokinase 0.0121 0.0577 0.1949
Brugia malayi intermediate filament protein 0.0029 0.0095 0.0321
Brugia malayi PXA domain containing protein 0.0019 0.004 0.0134
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0073 0.0689
Echinococcus granulosus Chromo domain 0.0011 0.000000000021558 0.000000000048052
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0024 0.0087
Loa Loa (eye worm) hypothetical protein 0.0237 0.119 0.4017
Brugia malayi Hexokinase family protein 0.0192 0.0956 0.3227
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0008 0.0078
Loa Loa (eye worm) RGS-3 protein 0.0019 0.004 0.0134
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0113 0.111
Plasmodium vivax glutathione reductase, putative 0.0094 0.0439 0.4591
Brugia malayi TAR-binding protein 0.0188 0.0931 0.3141
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0284 0.0633
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.000000000021558 0.000000000048052
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0023 0.0079
Echinococcus multilocularis hexokinase 0.0192 0.0956 0.2131
Brugia malayi Matrixin family protein 0.0237 0.119 0.4017
Echinococcus granulosus hexokinase 0.0192 0.0956 0.2131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0024 0.008
Mycobacterium ulcerans glutaminase 0.0266 0.1345 0.1315
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0113 0.0079
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0113 0.0381
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0034 0.0123
Brugia malayi RNA binding protein 0.0188 0.0931 0.3141
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0024 0.008
Brugia malayi MH1 domain containing protein 0.0016 0.0026 0.0087
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1904 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0024 0.008
Schistosoma mansoni axis inhibition protein axin 0.0019 0.004 0.0089
Echinococcus granulosus intermediate filament protein 0.0029 0.0095 0.0212
Entamoeba histolytica hypothetical protein 0.0019 0.004 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.1494
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0204 0.0688
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0034 0.028
Loa Loa (eye worm) glutaminase 0.0266 0.1345 0.4538
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.0244 0.1811
Brugia malayi Hexokinase family protein 0.0121 0.0577 0.1949
Brugia malayi Hexokinase family protein 0.006 0.0254 0.0858
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0034 0.028
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0156 0.0347
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0095 0.0213
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000021558 0.000000000048085
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0115

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -5.84 Inhibitory activity against Trypanosoma cruzi hexokinase ChEMBL. 16392806
IC50 (binding) = -4 Inhibitory activity against FPPS in Leishmania major ChEMBL. 16392806
IC50 (binding) = 0.81 uM Inhibition of Trypanosoma cruzi hexokinase ChEMBL. 17329254
IC50 (binding) = 0.81 uM Inhibition of Trypanosoma cruzi hexokinase ChEMBL. 17329254
IC50 (binding) = 1.45 uM Inhibitory activity against Trypanosoma cruzi hexokinase ChEMBL. 16392806
IC50 (binding) = 1.45 uM Inhibitory activity against Trypanosoma cruzi hexokinase ChEMBL. 16392806
IC50 (functional) = 10 uM Cytotoxicity to Dictyostelium discoideum ChEMBL. 16392806
IC50 (functional) = 10 uM Cytotoxicity to Dictyostelium discoideum ChEMBL. 16392806
IC50 (functional) = 36.2 uM In vitro growth inhibition against Entamoeba histolytica ChEMBL. 14695831
IC50 (functional) = 36.2 uM In vitro growth inhibition against Entamoeba histolytica ChEMBL. 14695831
IC50 (binding) = 100 uM Inhibitory activity against Leishmania major Farnesyl diphosphate synthase ChEMBL. 14695831
IC50 (binding) >= 100 uM Inhibitory activity against FPPS in Leishmania major ChEMBL. 16392806
IC50 (binding) = 100 uM Inhibitory activity against Leishmania major Farnesyl diphosphate synthase ChEMBL. 14695831
IC50 (binding) >= 100 uM Inhibitory activity against FPPS in Leishmania major ChEMBL. 16392806
IC50 (functional) = 103 uM In vitro growth inhibition against Plasmodium falciparum ChEMBL. 14695831
IC50 (functional) = 103 uM In vitro growth inhibition against Plasmodium falciparum ChEMBL. 14695831
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli pTMV19 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli pTMV19 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate ChEMBL. 17149863
LD50 (ADMET) = 211 uM Toxicity evaluated against human nasopharyngeal carcinoma KB cell line ChEMBL. 14695831
LD50 (functional) = 211 uM Cytotoxicity in human nasopharyngeal carcinoma KB cell line ChEMBL. 16392806
LD50 (ADMET) = 211 uM Toxicity evaluated against human nasopharyngeal carcinoma KB cell line ChEMBL. 14695831
LD50 (functional) = 211 uM Cytotoxicity in human nasopharyngeal carcinoma KB cell line ChEMBL. 16392806
Log IC50 (binding) = 4 Inhibitory activity against FPPS in Leishmania major ChEMBL. 16392806
Log IC50 (binding) = 5.84 Inhibitory activity against Trypanosoma cruzi hexokinase ChEMBL. 16392806
Ratio LD50/IC50 (functional) = 147 Therapeutic index TI=LD50(KB)/IC50(TcHK) ChEMBL. 16392806
TI (ADMET) = 2.05 Therapeutic index was expressed as ratio of LD50 for KB cell line to IC50 against Plasmodium falciparum ChEMBL. 14695831
TI (ADMET) = 5.83 Therapeutic index was expressed as ratio of LD50 for KB cell line to IC50 against Entamoeba histolytica ChEMBL. 14695831

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Dictyostelium discoideum ChEMBL23 16392806

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 45814  
Annotator: millerja@u.washington.edu Comment: Compound structures shown in Figure 1 of referenced publication References: 16392806
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 36562  
Annotator: millerja@u.washington.edu Comment: Compound structures shown in Figure 1 of referenced publication References: 16392806
growth (GO:0040007) decreased (PATO:0000468) epimastigote (BTO:0000409) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 45814  
Annotator: millerja@u.washington.edu Comment: References: 17329254
growth (GO:0040007) decreased (PATO:0000468) epimastigote (BTO:0000409) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 36562  
Annotator: millerja@u.washington.edu Comment: References: 17329254

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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