Detailed information for compound 805782

Basic information

Technical information
  • TDR Targets ID: 805782
  • Name: 4-(2-chlorophenyl)-7,7-dimethyl-1-(5-prop-2-e nylsulfanyl-1,3,4-thiadiazol-2-yl)-3,4,6,8-te trahydroquinoline-2,5-dione
  • MW: 460.012 | Formula: C22H22ClN3O2S2
  • H donors: 0 H acceptors: 4 LogP: 4.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCSc1nnc(s1)N1C(=O)CC(C2=C1CC(C)(C)CC2=O)c1ccccc1Cl
  • InChi: 1S/C22H22ClN3O2S2/c1-4-9-29-21-25-24-20(30-21)26-16-11-22(2,3)12-17(27)19(16)14(10-18(26)28)13-7-5-6-8-15(13)23/h4-8,14H,1,9-12H2,2-3H3
  • InChiKey: ZNIHHLVEVFAPRD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(5-allylsulfanyl-1,3,4-thiadiazol-2-yl)-4-(2-chlorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydroquinoline-2,5-dione
  • 1-[5-(allylthio)-1,3,4-thiadiazol-2-yl]-4-(2-chlorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydroquinoline-2,5-dione
  • 1-[5-(allylthio)-1,3,4-thiadiazol-2-yl]-4-(2-chlorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydroquinoline-2,5-quinone
  • A3388/0143718

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.005 0.0138 0.2853
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.1328 1 0.5
Brugia malayi ORL1-like opioid receptor 0.005 0.0138 0.2853
Echinococcus multilocularis neuropeptides capa receptor 0.005 0.0138 0.2853
Echinococcus granulosus g protein coupled receptor 0.005 0.0138 0.2853
Trichomonas vaginalis cyclin B, putative 0.0077 0.0347 1
Echinococcus granulosus neuropeptides capa receptor 0.005 0.0138 0.2853
Schistosoma mansoni myosin xvIII 0.005 0.0138 0.2853
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0138 0.2853
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0097 0.2782
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis somatostatin receptor 0.005 0.0138 0.2853
Echinococcus granulosus neuropeptide FF receptor 2 0.005 0.0138 0.2853
Plasmodium vivax protein kinase Crk2 0.0045 0.0097 0.5
Brugia malayi Dopamine receptor 0.005 0.0138 0.2853
Echinococcus granulosus peptide allatostatin:somatostatin 0.005 0.0138 0.2853
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0097 0.2782
Echinococcus multilocularis neuropeptide Y receptor 0.005 0.0138 0.2853
Echinococcus multilocularis dro:myosuppressin receptor 0.005 0.0138 0.2853
Trypanosoma cruzi cyclin 6, putative 0.0077 0.0347 1
Loa Loa (eye worm) TYRA-2 protein 0.005 0.0138 0.2853
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0097 0.2003
Trichomonas vaginalis cyclins, putative 0.0077 0.0347 1
Brugia malayi putative neuropeptide receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.005 0.0138 0.2853
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0097 0.2003
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.005 0.0138 0.2853
Echinococcus granulosus biogenic amine 5HT receptor 0.005 0.0138 0.2853
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0097 0.2782
Schistosoma mansoni hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis g-protein coupled receptor 0.005 0.0138 0.2853
Schistosoma mansoni peptide (allatostatin)-like receptor 0.005 0.0138 0.2853
Echinococcus granulosus cyclin B 0.0077 0.0347 0.72
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.005 0.0138 0.2853
Schistosoma mansoni neuropeptide F-like receptor 0.005 0.0138 0.2853
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.005 0.0138 0.2853
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0138 0.2853
Trichomonas vaginalis cyclins, putative 0.0077 0.0347 1
Echinococcus granulosus sex peptide receptor 0.005 0.0138 0.2853
Echinococcus multilocularis g protein coupled receptor 0.005 0.0138 0.2853
Brugia malayi Serotonin receptor 0.005 0.0138 0.2853
Schistosoma mansoni neuropeptide receptor 0.005 0.0138 0.2853
Echinococcus granulosus alpha 1A adrenergic receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) norepinephrine transporter 0.0095 0.0482 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.005 0.0138 0.2853
Brugia malayi Serotonin receptor 0.005 0.0138 0.2853
Schistosoma mansoni neuropeptide F-like receptor 0.005 0.0138 0.2853
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.005 0.0138 0.2853
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0097 0.2782
Schistosoma mansoni neuropeptide receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus granulosus neuropeptides capa receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Schistosoma mansoni neuropeptide receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) melatonin receptor type 1A 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Brugia malayi Protein kinase domain containing protein 0.0045 0.0097 0.2003
Echinococcus multilocularis cyclin B 0.0077 0.0347 0.72
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) G-protein coupled receptor 0.005 0.0138 0.2853
Trypanosoma cruzi cyclin, putative 0.0077 0.0347 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0077 0.0347 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.005 0.0138 0.2853
Echinococcus multilocularis orexin receptor type 2 0.005 0.0138 0.2853
Brugia malayi hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus granulosus g-protein coupled receptor 0.005 0.0138 0.2853
Schistosoma mansoni amine GPCR 0.005 0.0138 0.2853
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0138 0.2853
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0138 0.2853
Echinococcus multilocularis G protein coupled receptor 139 0.005 0.0138 0.2853
Echinococcus multilocularis sex peptide receptor 0.005 0.0138 0.2853
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.005 0.0138 0.2853
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0097 0.2782
Echinococcus multilocularis serotonin transporter 0.0095 0.0482 1
Brugia malayi putative neuropeptide receptor NPR1 0.005 0.0138 0.2853
Brugia malayi RE15519p 0.005 0.0138 0.2853
Echinococcus multilocularis alpha 1A adrenergic receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.005 0.0138 0.2853
Onchocerca volvulus 0.0095 0.0482 1
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0138 0.2853
Brugia malayi G-protein coupled receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0138 0.2853
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.0077 0.0347 0.72
Brugia malayi neuropeptide F receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Schistosoma mansoni neuropeptide receptor 0.005 0.0138 0.2853
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0095 0.0482 1
Trichomonas vaginalis cyclin B, putative 0.0077 0.0347 1
Loa Loa (eye worm) neuropeptide F receptor 0.005 0.0138 0.2853
Echinococcus granulosus thyrotropin releasing hormone receptor 0.005 0.0138 0.2853
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.005 0.0138 0.2853
Echinococcus granulosus dro:myosuppressin receptor 0.005 0.0138 0.2853
Brugia malayi hypothetical protein 0.005 0.0138 0.2853
Trypanosoma brucei mitotic cyclin 6 0.0077 0.0347 1
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0138 0.2853
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0138 0.2853
Echinococcus multilocularis tachykinin peptides receptor 99D 0.005 0.0138 0.2853
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0097 0.2003
Brugia malayi sulfakinin receptor protein 0.005 0.0138 0.2853
Leishmania major cyclin 0.0077 0.0347 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0097 0.2003
Schistosoma mansoni growth hormone secretagogue receptor 0.005 0.0138 0.2853
Echinococcus granulosus g protein coupled receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Schistosoma mansoni alpha-1 adrenergic receptor 0.005 0.0138 0.2853
Schistosoma mansoni biogenic amine receptor 0.005 0.0138 0.2853
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Schistosoma mansoni histamine h1 receptor 0.005 0.0138 0.2853
Brugia malayi Cyclin, N-terminal domain containing protein 0.0077 0.0347 0.72
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.0045 0.0099 0.2053
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) solute carrier family 6 member 4 0.0095 0.0482 1
Brugia malayi hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.005 0.0138 0.2853
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Schistosoma mansoni opsin-like receptor 0.005 0.0138 0.2853
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0138 0.2853
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Brugia malayi G protein-coupled receptor 0.005 0.0138 0.2853
Schistosoma mansoni biogenic amine receptor 0.005 0.0138 0.2853
Treponema pallidum sodium- and chloride- dependent transporter 0.0095 0.0482 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus granulosus somatostatin receptor 0.005 0.0138 0.2853
Schistosoma mansoni amine GPCR 0.005 0.0138 0.2853
Brugia malayi larval opioid receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0138 0.2853
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0138 0.2853
Brugia malayi Melatonin receptor type 1A 0.005 0.0138 0.2853
Schistosoma mansoni opsin-like receptor 0.005 0.0138 0.2853
Schistosoma mansoni cyclin B 0.0077 0.0347 0.72
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.005 0.0138 0.2853
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0138 0.2853
Brugia malayi hypothetical protein 0.005 0.0138 0.2853
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0138 0.2853
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0138 0.2853
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.005 0.0138 0.2853
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0138 0.2853
Echinococcus multilocularis g protein coupled receptor 0.005 0.0138 0.2853
Schistosoma mansoni biogenic amine receptor 0.005 0.0138 0.2853
Schistosoma mansoni sodium/chloride dependent transporter 0.0095 0.0482 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Brugia malayi Serotonin/octopamine receptor family protein 7 0.005 0.0138 0.2853
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0097 0.2003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0138 0.2853
Schistosoma mansoni hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.0095 0.0482 1
Trichomonas vaginalis cyclins, putative 0.0077 0.0347 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.005 0.0138 0.2853
Echinococcus granulosus fmrfamide receptor 0.005 0.0138 0.2853
Entamoeba histolytica cyclin, putative 0.0077 0.0347 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis serotonin receptor 0.005 0.0138 0.2853
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0138 0.2853
Schistosoma mansoni biogenic amine (5HT) receptor 0.005 0.0138 0.2853
Echinococcus granulosus serotonin receptor 0.005 0.0138 0.2853
Schistosoma mansoni hypothetical protein 0.005 0.0138 0.2853
Onchocerca volvulus 0.0077 0.0347 0.6082
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.005 0.0138 0.2853
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.005 0.0138 0.2853
Brugia malayi AKH receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0138 0.2853
Brugia malayi hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis allatostatin A receptor 0.005 0.0138 0.2853
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.005 0.0138 0.2853
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0097 0.2003
Echinococcus multilocularis G-protein coupled receptor, putative 0.005 0.0138 0.2853
Echinococcus granulosus neuropeptide receptor A26 0.005 0.0138 0.2853
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.005 0.0138 0.2853
Echinococcus multilocularis neuropeptides capa receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0097 0.2003
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0138 0.2853
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0097 0.2003
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0138 0.2853
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.005 0.0138 0.2853
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0138 0.2853
Giardia lamblia G2/mitotic-specific cyclin B 0.0077 0.0347 1
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0097 0.2782
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0138 0.2853
Schistosoma mansoni amine GPCR 0.005 0.0138 0.2853
Trichomonas vaginalis cyclin A, putative 0.0077 0.0347 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis serotonin receptor 0.005 0.0138 0.2853
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.0095 0.0482 1
Trichomonas vaginalis cyclins, putative 0.0053 0.0159 0.4577
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.005 0.0138 0.2853
Trichomonas vaginalis cyclin B, putative 0.0077 0.0347 1
Echinococcus granulosus serotonin transporter 0.0095 0.0482 1
Brugia malayi hypothetical protein 0.005 0.0138 0.2853
Plasmodium falciparum protein kinase 5 0.0045 0.0097 1
Brugia malayi neuropeptide F receptor 0.005 0.0138 0.2853
Brugia malayi hypothetical protein 0.005 0.0138 0.2853
Brugia malayi follicle stimulating hormone receptor 0.005 0.0138 0.2853
Trypanosoma cruzi cyclin, putative 0.0077 0.0347 1
Echinococcus granulosus orexin receptor type 2 0.005 0.0138 0.2853
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0138 0.2853
Schistosoma mansoni opsin-like receptor 0.005 0.0138 0.2853
Schistosoma mansoni hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis fmrfamide receptor 0.005 0.0138 0.2853
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0097 0.2003
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus granulosus allatostatin A receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) G-protein coupled receptor 0.005 0.0138 0.2853
Brugia malayi Dopamine receptor protein 2 0.005 0.0138 0.2853
Trypanosoma cruzi CYC2-like cyclin, putative 0.0077 0.0347 1
Brugia malayi hypothetical protein 0.005 0.0138 0.2853
Echinococcus granulosus neuropeptide receptor 0.005 0.0138 0.2853
Echinococcus multilocularis neuropeptide receptor A26 0.005 0.0138 0.2853
Loa Loa (eye worm) neuropeptide F receptor 0.005 0.0138 0.2853
Schistosoma mansoni biogenic amine (5HT) receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Brugia malayi cell division control protein 2 homolog 0.0045 0.0097 0.2003
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0138 0.2853
Echinococcus granulosus biogenic amine 5HT receptor 0.005 0.0138 0.2853
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0138 0.2853
Echinococcus multilocularis neuropeptide receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis g protein coupled receptor 0.005 0.0138 0.2853
Brugia malayi GnHR receptor homolog 0.005 0.0138 0.2853
Echinococcus multilocularis neuropeptide Y receptor 0.005 0.0138 0.2853
Brugia malayi hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis neuropeptide receptor 0.005 0.0138 0.2853
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.005 0.0138 0.2853
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0097 0.2003
Brugia malayi hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0097 0.2003
Echinococcus multilocularis fmrfamide receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.0095 0.0482 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0138 0.2853
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.005 0.0138 0.2853
Schistosoma mansoni amine GPCR 0.005 0.0138 0.2853
Schistosoma mansoni adenoreceptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0095 0.0482 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus multilocularis biogenic amine (5HT) receptor 0.005 0.0138 0.2853
Echinococcus granulosus G protein coupled receptor 139 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.005 0.0138 0.2853
Echinococcus granulosus neuropeptide receptor 0.005 0.0138 0.2853
Echinococcus granulosus tachykinin peptides receptor 99D 0.005 0.0138 0.2853
Brugia malayi Cyclin, N-terminal domain containing protein 0.0077 0.0347 0.72
Echinococcus granulosus neuropeptide Y receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0097 0.2003
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.0097 0.5
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0097 0.2003
Brugia malayi Tachykinin-like peptides receptor 99D 0.005 0.0138 0.2853
Trichomonas vaginalis cyclin B, putative 0.0077 0.0347 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Loa Loa (eye worm) serotonin transporter b 0.0095 0.0482 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.005 0.0138 0.2853
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0138 0.2853
Echinococcus granulosus 7tm_1 domain containing protein 0.005 0.0138 0.2853
Echinococcus granulosus hypothetical protein 0.005 0.0138 0.2853
Schistosoma mansoni amine GPCR 0.005 0.0138 0.2853
Brugia malayi Dopamine receptor protein 1 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.0044 0.0093 0.1927
Echinococcus granulosus g protein coupled receptor 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.0077 0.0347 0.72
Echinococcus granulosus neuropeptide s receptor 0.005 0.0138 0.2853
Trichomonas vaginalis cyclins, putative 0.0077 0.0347 1
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0097 0.2782
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Brugia malayi G-protein coupled receptor 0.005 0.0138 0.2853
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.005 0.0138 0.2853
Schistosoma mansoni neuropeptide f receptor 76f 0.005 0.0138 0.2853
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.2853
Brugia malayi gonadotropin-releasing hormone receptor 2 0.005 0.0138 0.2853
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.1328 1 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.005 0.0138 0.2853
Echinococcus multilocularis neuropeptide s receptor 0.005 0.0138 0.2853

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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