Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.1273 | 0.6542 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0032 | 0.0252 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0035 | 0.0273 |
Onchocerca volvulus | 0.006 | 0.0032 | 0.0119 | |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.1873 | 1 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0032 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0035 | 0.0086 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.1873 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1273 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0707 | 0.5551 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0035 | 0.0086 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.1947 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.1273 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0024 | 0.7466 |
Onchocerca volvulus | 0.0182 | 0.0707 | 1 | |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0024 | 0.7466 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.1873 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0035 | 0.0273 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.1947 | 1 |
Brugia malayi | hypothetical protein | 0.0182 | 0.0707 | 0.5465 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.1273 | 0.6542 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.