Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2503 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.2503 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2503 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.2503 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2503 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.2503 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2503 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.2503 | 0.2503 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2503 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
F (ADMET) | = 10.6 % | Bioavailability in rat of PMEA prodrug | ChEMBL. | 8021925 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.