Detailed information for compound 807286

Basic information

Technical information
  • TDR Targets ID: 807286
  • Name: N-[(5E)-4-oxo-5-(phenylmethylidene)-2-sulfany lidene-1,3-thiazolidin-3-yl]benzenesulfonamid e
  • MW: 376.473 | Formula: C16H12N2O3S3
  • H donors: 1 H acceptors: 3 LogP: 3.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1S/C(=C/c2ccccc2)/C(=O)N1NS(=O)(=O)c1ccccc1
  • InChi: 1S/C16H12N2O3S3/c19-15-14(11-12-7-3-1-4-8-12)23-16(22)18(15)17-24(20,21)13-9-5-2-6-10-13/h1-11,17H/b14-11+
  • InChiKey: YMWXQEPXNNIXDH-SDNWHVSQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(5E)-4-oxo-5-(phenylmethylene)-2-thioxo-thiazolidin-3-yl]benzenesulfonamide
  • N-[(5E)-4-oxo-5-(phenylmethylene)-2-thioxo-3-thiazolidinyl]benzenesulfonamide
  • N-[(5E)-5-(benzylidene)-4-keto-2-thioxo-thiazolidin-3-yl]benzenesulfonamide
  • 5366-47-2
  • AIDS163406
  • ZINC01231002
  • BIM-0006523.P001
  • 5-(Phenylmethylene)-3-[(phenylsulfonyl)amino]-2-thioxo-1,3-thiazolidin-4-one
  • AIDS-163406

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum protoporphyrinogen oxidase 0.0118 0.0091 0.2153
Brugia malayi SWIRM domain containing protein 0.0049 0.0013 0.0013
Trypanosoma brucei Silent information regulator 2 related protein 3 0.01 0.007 0.0835
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0082 0.0102
Schistosoma mansoni integrin beta subunit 0.1484 0.1647 0.1647
Giardia lamblia Furin precursor putative serine protease 0.1762 0.1964 0.5363
Plasmodium vivax hypothetical protein, conserved 0.01 0.007 0.1658
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0058 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.01 0.007 0.007
Plasmodium falciparum transcriptional regulatory protein sir2a 0.01 0.007 0.1658
Leishmania major silent information regulator 2, putative 0.0675 0.0725 1
Entamoeba histolytica hypothetical protein 0.0049 0.0013 0.003
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0076 0.0043 0.0043
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.01 0.007 0.0087
Brugia malayi EGF-like domain containing protein 0.0081 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Loa Loa (eye worm) endoprotease bli-4 0.8818 1 1
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0233 0.0222 0.0222
Schistosoma mansoni integrin alpha-ps 0.0456 0.0476 0.0476
Loa Loa (eye worm) reprolysin 0.0044 0.0007 0.0007
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0125 0.0099 0.0239
Loa Loa (eye worm) sirtuin 4 0.01 0.007 0.007
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0531 0.0561 0.0561
Loa Loa (eye worm) carboxylesterase 0.0076 0.0043 0.0043
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0136 0.0112 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.0222 0.0222
Echinococcus multilocularis protein kinase c epsilon type 0.0089 0.0058 0.0073
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0233 0.0222 0.0278
Brugia malayi hypothetical protein 0.0069 0.0035 0.0035
Plasmodium falciparum plasmepsin V 0.0408 0.0421 1
Schistosoma mansoni SWI/SNF complex-related 0.0049 0.0013 0.0013
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0049 0.0013 0.0012
Giardia lamblia Hypothetical protein 0.0675 0.0725 0.1959
Giardia lamblia hypothetical protein 0.0081 0.0049 0.0101
Loa Loa (eye worm) hypothetical protein 0.0048 0.0012 0.0012
Onchocerca volvulus 0.0038 0 0.0003
Leishmania major subtilisin-like serine peptidase 0.0389 0.04 0.5036
Loa Loa (eye worm) hypothetical protein 0.058 0.0617 0.0617
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.04 0.0637
Loa Loa (eye worm) hypothetical protein 0.0531 0.0561 0.0561
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5395 0.6101 0.7633
Giardia lamblia Tenascin-like 0.0081 0.0049 0.0101
Giardia lamblia Tenascin-X 0.0081 0.0049 0.0101
Trichomonas vaginalis hypothetical protein 0.1762 0.1964 0.3204
Echinococcus granulosus growth factor receptor bound protein 2 0.0136 0.0112 0.0111
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0675 0.0725 0.0907
Onchocerca volvulus 0.0038 0 0.0003
Echinococcus granulosus integrin alpha ps 0.0519 0.0548 0.0548
Loa Loa (eye worm) hypothetical protein 0.0118 0.0091 0.0091
Onchocerca volvulus 0.0038 0 0.0003
Echinococcus granulosus neuroendocrine convertase 2 0.5575 0.6306 0.6306
Brugia malayi Carboxylesterase family protein 0.0076 0.0043 0.0043
Echinococcus multilocularis protein jagged 2 0.0081 0.0049 0.0061
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.007 0.007
Toxoplasma gondii subtilisin SUB1 0.0389 0.04 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0136 0.0112 0.0139
Toxoplasma gondii aspartyl protease ASP5 0.0372 0.038 0.9501
Echinococcus multilocularis acetylcholinesterase 0.0076 0.0043 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5395 0.6101 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0118 0.0091 0.5
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0094
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0675 0.0725 1
Toxoplasma gondii histone deacetylase SIR2 0.01 0.007 0.1747
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.01 0.007 0.0835
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0118 0.0091 0.2153
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1352 0.1496 0.1496
Loa Loa (eye worm) TK/ALK protein kinase 0.0069 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.8818 1 1
Brugia malayi Angiotensin-converting enzyme family protein 0.067 0.072 0.072
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0267 0.0261 0.0326
Trichomonas vaginalis WD repeat domain, putative 0.0286 0.0283 0.0444
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Loa Loa (eye worm) hypothetical protein 0.0081 0.0049 0.0049
Onchocerca volvulus 0.0069 0.0035 0.052
Loa Loa (eye worm) hypothetical protein 0.0081 0.0049 0.0049
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0389 0.04 0.04
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.01 0.007 0.0835
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0675 0.0725 1
Brugia malayi CHE-14 protein 0.011 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0069 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0282 0.0278 0.0278
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0675 0.0725 0.0725
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0725 0.0725
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0389 0.04 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Loa Loa (eye worm) integrin beta-2 0.2521 0.2828 0.2828
Brugia malayi Kelch motif family protein 0.0402 0.0414 0.0414
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0091 0.2153
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Schistosoma mansoni furin-1 (S08 family) 0.3813 0.4299 0.4299
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.01 0.007 0.007
Onchocerca volvulus 0.0389 0.04 0.5941
Schistosoma mansoni hypothetical protein 0.1762 0.1964 0.1964
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0675 0.0725 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Schistosoma mansoni amine oxidase 0.0118 0.0091 0.0091
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.067 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0167 0.0147 0.0147
Mycobacterium tuberculosis Conserved hypothetical protein 0.0118 0.0091 0.0632
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0118 0.0091 0.2153
Giardia lamblia Neurogenic locus notch-like protein 0.0081 0.0049 0.0101
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.007 0.0835
Echinococcus multilocularis integrin alpha ps 0.0456 0.0476 0.0596
Toxoplasma gondii subtilisin SUB12 0.0389 0.04 1
Echinococcus granulosus MAM 0.0069 0.0035 0.0035
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0389 0.04 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2407 0.3933
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0675 0.0725 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0118 0.0091 0.0632
Onchocerca volvulus 0.0286 0.0283 0.4201
Onchocerca volvulus 0.0172 0.0152 0.2259
Schistosoma mansoni site-1 peptidase (S08 family) 0.0389 0.04 0.04
Echinococcus multilocularis 0.0118 0.0091 0.0113
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.004 0.004
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0389 0.04 1
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0389 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0383 0.0393 0.0393
Onchocerca volvulus 0.0038 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.0118 0.0091 0.0091
Schistosoma mansoni integrin alpha-ps 0.0301 0.0299 0.0299
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Loa Loa (eye worm) WD40 repeat protein 0.0286 0.0283 0.0283
Brugia malayi amine oxidase, flavin-containing family protein 0.0167 0.0147 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.01 0.007 0.0087
Brugia malayi hypothetical protein 0.0118 0.0091 0.0091
Echinococcus granulosus protein will die slowly 0.0286 0.0283 0.0283
Loa Loa (eye worm) transcriptional regulator 0.01 0.007 0.007
Echinococcus multilocularis fibrillin 2 0.0081 0.0049 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2407 0.3933
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.04 0.0637
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.04 0.0637
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0049 0.0013 0.0015
Onchocerca volvulus 0.0069 0.0035 0.052
Brugia malayi Protein kinase domain containing protein 0.0069 0.0035 0.0035
Onchocerca volvulus 0.0038 0 0.0003
Giardia lamblia Tenascin-37 0.0081 0.0049 0.0101
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0267 0.0261 0.2912
Plasmodium vivax plasmepsin V, putative 0.0408 0.0421 1
Toxoplasma gondii subtilisin SUB8 0.0389 0.04 1
Echinococcus multilocularis integrin alpha ps 0.0519 0.0548 0.0685
Giardia lamblia High cysteine membrane protein Group 2 0.3243 0.3651 1
Echinococcus multilocularis neuroendocrine convertase 2 0.5575 0.6306 0.7889
Echinococcus granulosus lysine specific histone demethylase 1A 0.058 0.0617 0.0617
Entamoeba histolytica SWIRM domain protein 0.0049 0.0013 0.003
Brugia malayi Furin-like cysteine rich region family protein 0.0633 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0047 0.001 0.001
Loa Loa (eye worm) subtilase 0.0389 0.04 0.04
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.007 0.007
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0118 0.0091 0.2269
Trypanosoma brucei subtilisin peptidase 0.0389 0.04 0.545
Echinococcus granulosus Protein patched homolog 1 0.011 0.0082 0.0082
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Echinococcus multilocularis Furin 1 0.2151 0.2407 0.3011
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0118 0.0091 0.0632
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Brugia malayi hypothetical protein 0.0058 0.0023 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Mycobacterium tuberculosis Possible oxidoreductase 0.0118 0.0091 0.0632
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0118 0.0091 0.0632
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0246 0.0237 0.0237
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0094
Brugia malayi hypothetical protein 0.0047 0.001 0.001
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1762 0.1964 0.3204
Toxoplasma gondii subtilisin SUB6 0.0389 0.04 1
Brugia malayi Sex muscle abnormal protein 5 0.0136 0.0112 0.0112
Echinococcus granulosus furin 0.8818 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0633 0.0677 0.0847
Brugia malayi Will die slowly protein 0.0286 0.0283 0.0283
Brugia malayi Subtilase family protein 0.0389 0.04 0.04
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0267 0.0261 0.0261
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0046 0.001 0.001
Onchocerca volvulus 0.0038 0 0.0003
Trypanosoma cruzi subtilisin peptidase 0.0389 0.04 0.545
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0071 0.0038 0.0038
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1762 0.1964 0.3204
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0007 0.0007
Echinococcus multilocularis adam 0.0139 0.0115 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Brugia malayi proprotein convertase 2 0.5575 0.6306 0.6306
Schistosoma mansoni growth factor receptor-bound protein 0.0136 0.0112 0.0112
Brugia malayi EGF-like domain containing protein 0.0081 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.058 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.011 0.0082 0.0082
Schistosoma mansoni patched 1 0.011 0.0082 0.0082
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Giardia lamblia Transcriptional regulator, Sir2 family 0.01 0.007 0.0158
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2407 0.3933
Echinococcus granulosus protein kinase c epsilon type 0.0089 0.0058 0.0058
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0389 0.04 0.04
Echinococcus multilocularis carboxylesterase 5A 0.0076 0.0043 0.0053
Schistosoma mansoni growth factor receptor-bound protein 0.0136 0.0112 0.0112
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0094
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0091 0.2153
Loa Loa (eye worm) hypothetical protein 0.0267 0.0261 0.0261
Brugia malayi protein kinase C II. 0.0089 0.0058 0.0058
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0267 0.0261 0.3503
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Toxoplasma gondii histone deacetylase SIR2-like 0.01 0.007 0.1747
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0081 0.0049 0.006
Echinococcus granulosus integrin alpha ps 0.0219 0.0206 0.0206
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0118 0.0091 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0094
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5395 0.6101 0.6101
Schistosoma mansoni hypothetical protein 0.0069 0.0035 0.0035
Echinococcus granulosus integrin beta 2 0.1868 0.2084 0.2083
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0046 0.001 0.001
Mycobacterium ulcerans oxidoreductase 0.0118 0.0091 0.0632
Plasmodium vivax subtilisin-like serine protease, putative 0.0389 0.04 0.9493
Plasmodium vivax subtilisin-like protease 2, putative 0.0389 0.04 0.9493
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0267 0.0261 0.5782
Onchocerca volvulus 0.0629 0.0673 1
Giardia lamblia High cysteine protein 0.0081 0.0049 0.0101
Brugia malayi celfurPC protein 0.7056 0.7993 0.7993
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0044 0.0007 0.0007
Echinococcus multilocularis protein dispatched 1 0.011 0.0082 0.0102
Echinococcus multilocularis fibrillin 1 0.0111 0.0084 0.0104
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0389 0.04 1
Brugia malayi hypothetical protein 0.0383 0.0393 0.0393
Echinococcus granulosus fibrillin 2 0.0081 0.0049 0.0049
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0089 0.0058 0.0058
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0267 0.0261 0.0261
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0408 0.0421 0.5748
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.04 0.0637
Onchocerca volvulus 0.0038 0 0.0003
Giardia lamblia High cysteine protein 0.0081 0.0049 0.0101
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0389 0.04 0.04
Plasmodium falciparum subtilisin-like protease 3 0.0389 0.04 0.9493
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.01 0.007 0.007
Entamoeba histolytica SWIRM domain protein 0.0049 0.0013 0.003
Toxoplasma gondii subtilisin SUB4 0.0389 0.04 1
Echinococcus multilocularis membrane bound transcription factor site 1 0.0389 0.04 0.05
Schistosoma mansoni hypothetical protein 0.0069 0.0035 0.0035
Loa Loa (eye worm) proprotein convertase 2 0.2151 0.2407 0.2407
Onchocerca volvulus 0.0038 0 0.0003
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0048 0.0012 0.0012
Toxoplasma gondii subtilisin SUB7 0.0389 0.04 1
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0058 0.0058
Onchocerca volvulus 0.0048 0.0012 0.0174
Loa Loa (eye worm) hypothetical protein 0.0049 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0076 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Echinococcus granulosus chromatin regulatory protein sir2 0.0675 0.0725 0.0725
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0675 0.0725 0.1171
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0408 0.0421 0.5748
Echinococcus granulosus membrane bound transcription factor site 1 0.0389 0.04 0.04
Echinococcus multilocularis MAM 0.0069 0.0035 0.0044
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0267 0.0261 0.3503
Loa Loa (eye worm) hypothetical protein 0.0044 0.0007 0.0007
Echinococcus multilocularis serine:threonine protein kinase N2 0.0082 0.005 0.0062
Loa Loa (eye worm) hypothetical protein 0.0048 0.0012 0.0012
Echinococcus granulosus integrin alpha 3 0.0584 0.0622 0.0622
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0094
Echinococcus multilocularis integrin alpha 3 0.0584 0.0622 0.0778
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.007 0.0835
Giardia lamblia Sirtuin type 2 0.01 0.007 0.0158
Mycobacterium ulcerans monoamine oxidase 0.0118 0.0091 0.0632
Toxoplasma gondii histone lysine-specific demethylase 0.0118 0.0091 0.2269
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Schistosoma mansoni Lysine-specific histone demethylase 1 0.058 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0389 0.04 0.04
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Onchocerca volvulus 0.0081 0.0049 0.073
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0118 0.0091 0.2153
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0094
Schistosoma mansoni integrin alpha 0.0822 0.0893 0.0893
Loa Loa (eye worm) acetylcholinesterase 1 0.0076 0.0043 0.0043
Echinococcus granulosus epidermal growth factor receptor 0.0633 0.0677 0.0677
Loa Loa (eye worm) TK/EGFR protein kinase 0.0633 0.0677 0.0677
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0081 0.0049 0.0049
Brugia malayi Integrin alpha pat-2 precursor 0.0822 0.0893 0.0893
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5395 0.6101 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1762 0.1964 0.3204
Echinococcus multilocularis protein patched 0.011 0.0082 0.0102
Loa Loa (eye worm) hypothetical protein 0.0046 0.001 0.001
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0389 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0603 0.0644 0.0644
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2407 0.3933
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.04 0.0637
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0402 0.0414 0.0414
Schistosoma mansoni tyrosine kinase 0.0633 0.0677 0.0677
Entamoeba histolytica hypothetical protein, conserved 0.01 0.007 0.0835
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0389 0.04 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0118 0.0091 0.1127
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0389 0.04 1
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0082 0.0114
Echinococcus granulosus fibrillin 1 0.0084 0.0052 0.0052
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.007 0.007
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0389 0.04 0.04
Toxoplasma gondii hypothetical protein 0.0081 0.0049 0.1224
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0267 0.0261 0.3503
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0082 0.0082
Toxoplasma gondii subtilisin SUB11 0.0389 0.04 1
Schistosoma mansoni amine oxidase 0.0118 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0286 0.0283 0.0283
Brugia malayi EGF-like domain containing protein 0.0081 0.0049 0.0049
Echinococcus multilocularis protoporphyrinogen oxidase 0.0118 0.0091 0.0113
Toxoplasma gondii subtilisin SUB2 0.0389 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0629 0.0673 0.0673
Echinococcus granulosus Tolloid protein 1 0.0046 0.001 0.0009
Echinococcus multilocularis protein will die slowly 0.0286 0.0283 0.0354
Toxoplasma gondii subtilisin SUB10 0.0389 0.04 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0094
Loa Loa (eye worm) hypothetical protein 0.0301 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0069 0.0035 0.0035
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0118 0.0091 0.2153
Leishmania major UDP-galactopyranose mutase 0.0118 0.0091 0.0319
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.01 0.007 0.0158
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0725 0.0725
Echinococcus granulosus lysine specific histone demethylase 1A 0.0118 0.0091 0.0091
Trypanosoma brucei SIR2-like protein 4, putative 0.01 0.007 0.0835
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2151 0.2407 0.2407
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2407 0.3933
Plasmodium vivax NAD-dependent deacetylase, putative 0.01 0.007 0.1658
Plasmodium falciparum transcriptional regulatory protein sir2b 0.01 0.007 0.1658
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0675 0.0725 1
Plasmodium vivax subtilisin-like protease 1 0.0389 0.04 0.9493
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0389 0.04 0.05
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0007 0.0007
Brugia malayi SWIRM domain containing protein 0.0629 0.0673 0.0673
Trypanosoma cruzi UDP-galactopyranose mutase 0.0118 0.0091 0.1127
Schistosoma mansoni hypothetical protein 0.0219 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.3423 0.3856 0.3856
Plasmodium falciparum subtilisin-like protease 1 0.0389 0.04 0.9493
Echinococcus granulosus adam 0.0139 0.0115 0.0115
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0267 0.0261 0.0261
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.004 0.0411
Giardia lamblia Tenascin precursor 0.0081 0.0049 0.0101
Loa Loa (eye worm) transcriptional regulator 0.0675 0.0725 0.0725
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.011 0.0082 0.0082
Echinococcus granulosus sterol regulatory element binding protein 0.011 0.0082 0.0082
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0125 0.0099 0.0143
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0389 0.04 0.545
Onchocerca volvulus 0.0038 0 0.0003
Echinococcus multilocularis lysine specific histone demethylase 1A 0.058 0.0617 0.0772
Echinococcus multilocularis integrin alpha ps 0.0219 0.0206 0.0257
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0389 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Echinococcus multilocularis sterol regulatory element binding protein 0.011 0.0082 0.0102
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.007 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Echinococcus multilocularis integrin beta 2 0.1868 0.2084 0.2607
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0082 0.0082
Plasmodium falciparum subtilisin-like protease 2 0.0389 0.04 0.9493
Loa Loa (eye worm) integrin alpha pat-2 0.1071 0.1177 0.1177
Loa Loa (eye worm) hypothetical protein 0.0069 0.0035 0.0035
Echinococcus multilocularis chromatin regulatory protein sir2 0.0675 0.0725 0.0907
Echinococcus multilocularis Tolloid protein 1 0.0046 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Onchocerca volvulus 0.0038 0 0.0003
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0725 0.0725
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Trichomonas vaginalis hypothetical protein 0.0081 0.0049 0.006
Echinococcus granulosus acetylcholinesterase 0.0076 0.0043 0.0043
Loa Loa (eye worm) transcriptional regulator 0.01 0.007 0.007
Toxoplasma gondii subtilisin SUB9 0.0389 0.04 1
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0044 0.0007 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Brugia malayi neuroendocrine convertase 1 precursor 0.5575 0.6306 0.6306
Echinococcus granulosus carboxylesterase 5A 0.0076 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Giardia lamblia Neurogenic locus Notch protein precursor 0.0081 0.0049 0.0101
Echinococcus multilocularis 0.7056 0.7993 1
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0125 0.0099 0.0143
Brugia malayi NAD-dependent deacetylase SIRT1 0.01 0.007 0.007
Brugia malayi GCC2 and GCC3 family protein 0.0058 0.0022 0.0022
Echinococcus multilocularis acetylcholinesterase 0.0076 0.0043 0.0053
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0125 0.0099 0.0143
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8818 1 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0389 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0366 0.0373 0.0373
Brugia malayi Carboxylesterase family protein 0.0076 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0116 0.0089 0.0089
Brugia malayi EGF-like domain containing protein 0.0081 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0081 0.0049 0.0049
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.01 0.007 0.0087
Toxoplasma gondii SWIRM domain-containing protein 0.0049 0.0013 0.0308
Echinococcus granulosus acetylcholinesterase 0.0076 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.1762 0.1964 0.3204
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0094
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.01 0.007 0.007
Mycobacterium ulcerans dehydrogenase 0.0118 0.0091 0.0632
Schistosoma mansoni septate junction protein 0.0051 0.0015 0.0015
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0675 0.0725 0.1171
Loa Loa (eye worm) hypothetical protein 0.0076 0.0043 0.0043
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0408 0.0421 0.5748
Brugia malayi Integrin beta pat-3 precursor 0.2521 0.2828 0.2828
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.007 0.0094
Brugia malayi transcriptional regulator, Sir2 family protein 0.0675 0.0725 0.0725
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2407 0.3933
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.04 0.0637
Mycobacterium leprae Possible secreted protease 0.0389 0.04 1
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.007 0.007
Echinococcus granulosus c-Jun N-terminal kinases 0.0233 0.0222 0.0222
Brugia malayi Stress-activated protein kinase jnk-1 0.0233 0.0222 0.0222
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0389 0.04 1
Toxoplasma gondii subtilisin SUB5 0.0389 0.04 1
Echinococcus granulosus Furin 1 0.2151 0.2407 0.2407

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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