Detailed information for compound 807604

Basic information

Technical information
  • TDR Targets ID: 807604
  • Name: 1-(6-bicyclo[2.2.1]hept-2-enylmethyl)-4-[(3-b romo-4-methoxyphenyl)methyl]piperazine
  • MW: 391.345 | Formula: C20H27BrN2O
  • H donors: 0 H acceptors: 0 LogP: 3.9 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Br)CN1CCN(CC1)CC1CC2CC1C=C2
  • InChi: 1S/C20H27BrN2O/c1-24-20-5-3-16(12-19(20)21)13-22-6-8-23(9-7-22)14-18-11-15-2-4-17(18)10-15/h2-5,12,15,17-18H,6-11,13-14H2,1H3
  • InChiKey: YYBQGKNCXLPPSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(6-bicyclo[2.2.1]hept-2-enylmethyl)-4-[(3-bromo-4-methoxy-phenyl)methyl]piperazine
  • 1-(6-bicyclo[2.2.1]hept-2-enylmethyl)-4-(3-bromo-4-methoxy-benzyl)piperazine
  • Oprea1_323453
  • BIM-0009483.P001
  • CBMicro_009587
  • STK135473

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0026 0.0298
Onchocerca volvulus 0.0038 0.0026 0.0694
Schistosoma mansoni hypothetical protein 0.005 0.0055 0.0054
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0229 0.0498 0.9342
Echinococcus multilocularis tar DNA binding protein 0.0133 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0387 0.0888 1
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0261 0.026
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0058 0.0048
Trypanosoma brucei trypanothione reductase 0.009 0.0156 0.0407
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0026 0.0017
Plasmodium falciparum thioredoxin reductase 0.009 0.0156 0.0146
Mycobacterium tuberculosis Conserved protein 0.0038 0.0026 0.0318
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0037 0.0076
Loa Loa (eye worm) transcriptional regulator 0.0051 0.0058 0.0655
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0208 0.0207
Brugia malayi MH2 domain containing protein 0.0247 0.0542 0.6097
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0261 0.026
Plasmodium vivax thioredoxin reductase, putative 0.009 0.0156 0.0146
Echinococcus multilocularis thioredoxin glutathione reductase 0.0091 0.0157 0.0156
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0058 0.0048
Entamoeba histolytica hypothetical protein 0.0111 0.0208 0.0151
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0058 0.0048
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0037 0.0076
Leishmania major sir2-family protein-like protein 0.0051 0.0058 0.0048
Schistosoma mansoni chromatin regulatory protein sir2 0.0051 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0298
Loa Loa (eye worm) hypothetical protein 0.0028 0.0001 0.0014
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0026 0.0318
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.001 0.0009
Leishmania major trypanothione reductase 0.009 0.0156 0.0146
Loa Loa (eye worm) hypothetical protein 0.0126 0.0245 0.2757
Trypanosoma cruzi agmatinase, putative 0.1484 0.3595 1
Echinococcus multilocularis neuropeptide receptor A26 0.0477 0.1111 0.111
Loa Loa (eye worm) RNA binding protein 0.0133 0.0261 0.294
Loa Loa (eye worm) hypothetical protein 0.0126 0.0245 0.2757
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0364 0.0355
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0051 0.0058 0.0057
Onchocerca volvulus Huntingtin homolog 0.0126 0.0245 0.6706
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0387 0.0888 0.0886
Loa Loa (eye worm) TAR-binding protein 0.0133 0.0261 0.294
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0138 0.0136
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0051 0.0058 0.0923
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0026 0.0318
Trypanosoma cruzi arginase, putative 0.1484 0.3595 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0026 0.0318
Onchocerca volvulus 0.0038 0.0026 0.0694
Brugia malayi hypothetical protein 0.0111 0.0208 0.233
Brugia malayi RNA binding protein 0.0133 0.0261 0.293
Trypanosoma cruzi arginase, putative 0.1484 0.3595 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0387 0.0888 0.0879
Mycobacterium tuberculosis Probable dehydrogenase 0.0206 0.0441 0.8256
Loa Loa (eye worm) beta-lactamase 0.0038 0.0026 0.0298
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0026 0.0528
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0026 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0591 0.0581
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0325 0.6024
Schistosoma mansoni microtubule-associated protein tau 0.0737 0.1752 0.1751
Brugia malayi hypothetical protein 0.0244 0.0535 0.6023
Echinococcus multilocularis chromatin regulatory protein sir2 0.0051 0.0058 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.0247 0.0542 0.6103
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.006 0.014
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0058 0.0048
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.001 0.0009
Mycobacterium ulcerans beta-lactamase 0.0038 0.0026 0.0528
Echinococcus multilocularis neuropeptide s receptor 0.0477 0.1111 0.111
Brugia malayi TAR-binding protein 0.0133 0.0261 0.293
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0026 0.0318
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0026 0.0046
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0031 0.001 0.5
Loa Loa (eye worm) transcriptional regulator 0.0051 0.0058 0.0655
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0138 0.0136
Trypanosoma brucei SIR2-like protein 4, putative 0.0051 0.0058 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0591 0.0581
Brugia malayi beta-lactamase 0.0038 0.0026 0.0284
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0051 0.0058 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0026 0.0017
Mycobacterium ulcerans hypothetical protein 0.0038 0.0026 0.0528
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.0677 0.1861
Echinococcus granulosus microtubule associated protein 2 0.0737 0.1752 0.1751
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0138 0.0136
Trypanosoma cruzi trypanothione reductase, putative 0.009 0.0156 0.0407
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0206 0.0441 0.8256
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0298
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0051 0.0058 0.0135
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0387 0.0888 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0229 0.0498 0.9342
Schistosoma mansoni chromatin regulatory protein sir2 0.0051 0.0058 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0026 0.0017
Toxoplasma gondii histone deacetylase SIR2-like 0.0051 0.0058 0.331
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0051 0.0058 0.0135
Toxoplasma gondii ABC1 family protein 0.0038 0.0026 0.114
Mycobacterium tuberculosis Probable reductase 0.0206 0.0441 0.8256
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0026 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0388 0.0378
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0026 0.0025
Toxoplasma gondii thioredoxin reductase 0.009 0.0156 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0229 0.0498 0.9342
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0051 0.0058 0.0057
Treponema pallidum NADH oxidase 0.0031 0.001 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0208 0.0207
Toxoplasma gondii hypothetical protein 0.0049 0.0053 0.2936
Echinococcus multilocularis 0.4078 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0364 0.0355
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0261 0.026
Mycobacterium ulcerans Sir2-like regulatory protein 0.0051 0.0058 0.1532
Onchocerca volvulus 0.005 0.0055 0.1492
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0026 0.0017
Trypanosoma brucei agmatinase, putative 0.1484 0.3595 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.0533 1
Loa Loa (eye worm) transcriptional regulator 0.0051 0.0058 0.0655
Trichomonas vaginalis Arginase, putative 0.4078 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0298
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0058 0.0048
Brugia malayi Thioredoxin reductase 0.009 0.0156 0.1742
Toxoplasma gondii histone deacetylase SIR2 0.0051 0.0058 0.331
Brugia malayi glutathione reductase 0.009 0.0156 0.1742
Giardia lamblia Transcriptional regulator, Sir2 family 0.0051 0.0058 0.055
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0206 0.0441 0.8256
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0591 0.0581
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0364 0.0355
Loa Loa (eye worm) hypothetical protein 0.0083 0.0138 0.155
Giardia lamblia Sirtuin type 2 0.0051 0.0058 0.055
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0591 0.0581
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.001 0.0097
Echinococcus granulosus neuropeptide receptor A26 0.0477 0.1111 0.111
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0037 0.0076
Mycobacterium tuberculosis Conserved protein 0.0038 0.0026 0.0318
Entamoeba histolytica hypothetical protein 0.0111 0.0208 0.0151
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0058 0.0048
Echinococcus multilocularis microtubule associated protein 2 0.0737 0.1752 0.1751
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.001 0.5
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0001 0.0014
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0051 0.0058 0.0135
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0298
Brugia malayi beta-lactamase family protein 0.0038 0.0026 0.0284
Brugia malayi NAD-dependent deacetylase SIRT1 0.0387 0.0888 1
Plasmodium falciparum arginase 0.4078 1 1
Onchocerca volvulus Huntingtin homolog 0.0126 0.0245 0.6706
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0387 0.0888 0.0886
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0058 0.0048
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0138 0.1538
Brugia malayi transcriptional regulator, Sir2 family protein 0.0051 0.0058 0.0641
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0051 0.0058 0.0135
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0285 0.0275
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0026 0.0284
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0055 0.0611
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0051 0.0058 0.0048
Plasmodium falciparum glutathione reductase 0.009 0.0156 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.4078 1 1
Loa Loa (eye worm) glutathione reductase 0.009 0.0156 0.1753
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0206 0.0441 0.8256
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0037 0.0076
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.0535 0.0534
Loa Loa (eye worm) thioredoxin reductase 0.009 0.0156 0.1753
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0387 0.0888 0.0879
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.0261 0.293
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0001 0.0014
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0387 0.0888 0.0879
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0591 0.0581
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0026 0.0017
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0285 0.0767
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0026 0.0528
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.001 0.5
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0026 0.0318
Brugia malayi hypothetical protein 0.0126 0.0245 0.2747
Plasmodium vivax NAD-dependent deacetylase, putative 0.0051 0.0058 0.0048
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0051 0.0058 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0026 0.0046
Leishmania major arginase 0.4078 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0247 0.0542 0.6103
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0336 0.0762 0.8585
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0206 0.0441 0.8796
Schistosoma mansoni survival motor neuron protein 0.005 0.0055 0.0054
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.0591 0.665
Schistosoma mansoni chromatin regulatory protein sir2 0.0051 0.0058 0.0057
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0026 0.0318
Loa Loa (eye worm) hypothetical protein 0.0244 0.0535 0.6029
Plasmodium vivax glutathione reductase, putative 0.009 0.0156 0.0146
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0285 0.0767
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0026 0.0017
Entamoeba histolytica Arginase, putative 0.4078 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0364 0.0355
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0364 0.0355
Echinococcus granulosus arginase 2 mitochondrial 0.4078 1 1
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0051 0.0058 0.0048
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0298
Mycobacterium ulcerans NAD-dependent deacetylase 0.0051 0.0058 0.1532
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.0535 0.0534
Entamoeba histolytica hypothetical protein 0.0111 0.0208 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.4078 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0206 0.0441 0.8256
Echinococcus multilocularis arginase 2, mitochondrial 0.4078 1 1
Entamoeba histolytica hypothetical protein 0.0111 0.0208 0.0151
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0051 0.0058 0.0135
Trichomonas vaginalis esterase, putative 0.0038 0.0026 0.0017
Loa Loa (eye worm) sirtuin 4 0.0051 0.0058 0.0655
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0388 0.0378
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0261 0.026
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.009 0.0156 0.2789
Onchocerca volvulus 0.0083 0.0138 0.3753
Leishmania major agmatinase-like protein 0.1484 0.3595 0.3589
Leishmania major hypothetical protein, conserved 0.0038 0.0026 0.0017
Echinococcus granulosus thioredoxin glutathione reductase 0.0091 0.0157 0.0156
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0051 0.0058 0.0057
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0208 0.0207
Schistosoma mansoni chromatin regulatory protein sir2 0.0051 0.0058 0.0057
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0051 0.0058 0.0048
Brugia malayi transcriptional regulator, Sir2 family protein 0.0051 0.0058 0.0641
Schistosoma mansoni chromatin regulatory protein sir2 0.0051 0.0058 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0026 0.0046
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0364 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0364 0.0355
Echinococcus granulosus chromatin regulatory protein sir2 0.0051 0.0058 0.0057
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0051 0.0058 0.0057
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.0677 0.0668
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0591 0.0581
Schistosoma mansoni arginase 0.4078 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0026 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0364 0.0355
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0261 0.026
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.0261 0.294
Trypanosoma cruzi agmatinase, putative 0.1484 0.3595 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0229 0.0498 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0387 0.0888 0.0879
Onchocerca volvulus 0.0038 0.0026 0.0694
Mycobacterium ulcerans hypothetical protein 0.0159 0.0325 1
Echinococcus granulosus neuropeptide s receptor 0.0477 0.1111 0.111
Mycobacterium ulcerans lipase LipD 0.0038 0.0026 0.0528
Leishmania major silent information regulator 2, putative 0.0051 0.0058 0.0048
Brugia malayi beta-lactamase family protein 0.0038 0.0026 0.0284
Giardia lamblia Hypothetical protein 0.0051 0.0058 0.055
Echinococcus granulosus tar DNA binding protein 0.0133 0.0261 0.026
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0058 0.0048
Plasmodium vivax arginase, putative 0.4078 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0051 0.0058 0.0057
Schistosoma mansoni chromatin regulatory protein sir2 0.0387 0.0888 0.0886
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0026 0.0318
Brugia malayi transcriptional regulator, Sir2 family protein 0.0051 0.0058 0.0641
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0298
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.0677 0.1861
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.0677 0.1861
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.0591 0.6655
Schistosoma mansoni hypothetical protein 0.0111 0.0208 0.0207
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.001 0.0009
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0051 0.0058 0.0135

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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