Detailed information for compound 807614

Basic information

Technical information
  • TDR Targets ID: 807614
  • Name: N-(2,4-dichlorophenyl)-3-oxobutanamide
  • MW: 246.09 | Formula: C10H9Cl2NO2
  • H donors: 1 H acceptors: 2 LogP: 2.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1Cl)Cl)CC(=O)C
  • InChi: 1S/C10H9Cl2NO2/c1-6(14)4-10(15)13-9-3-2-7(11)5-8(9)12/h2-3,5H,4H2,1H3,(H,13,15)
  • InChiKey: YTKNYOWCICFXOW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dichlorophenyl)-3-oxo-butanamide
  • N-(2,4-dichlorophenyl)-3-keto-butyramide
  • 17223-66-4
  • ZINC00449426
  • 2',4'-Dichloroacetoacetanilide
  • EINECS 241-262-8
  • NSC132855
  • CBMicro_010211
  • BIM-0009951.P001
  • ST5443011

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis arginase 2, mitochondrial 0.1124 1 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0089 0.0074
Entamoeba histolytica hypothetical protein 0.0076 0.0631 0.0618
Echinococcus multilocularis twik family of potassium channels 0.0011 0.0053 0.0039
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0011 0.0053 0.0108
Echinococcus multilocularis 0.1124 1 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0011 0.0053 0.018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0205 0.0191
Trypanosoma brucei heat shock protein, putative 0.0035 0.0262 0.0689
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0078 0.0298
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0262 0.0689
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0199 0.0513
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0078 0.0178
Echinococcus multilocularis endoplasmin 0.0028 0.0199 0.0185
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0078 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0753 0.0753
Brugia malayi hypothetical protein 0.0128 0.1095 0.5021
Trypanosoma brucei heat shock protein, putative 0.0035 0.0262 0.0689
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Leishmania major hypothetical protein, conserved 0.0011 0.0053 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0074
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0011 0.0053 0.018
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0199 0.0186
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0089 0.0207
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Leishmania major potassium channel subunit-like protein 0.0011 0.0053 0.0039
Loa Loa (eye worm) hypothetical protein 0.0128 0.1095 0.5021
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0053 0.0108
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0011 0.0053 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0753 0.0753
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0262 0.0689
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0007 0.0014 0.0001
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0089 0.0207
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Onchocerca volvulus 0.0011 0.0053 0.0191
Brugia malayi hypothetical protein 0.0011 0.0053 0.018
Echinococcus multilocularis potassium channel subfamily K 8 0.0011 0.0053 0.0039
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0089 0.0345
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0221 0.0221
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0221 0.4418
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0199 0.0513
Loa Loa (eye worm) TWK-28 protein 0.0011 0.0053 0.018
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0089 0.0074
Brugia malayi CXXC zinc finger family protein 0.0031 0.0226 0.0982
Entamoeba histolytica Arginase, putative 0.1124 1 1
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0053 0.0053
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0053 0.004
Schistosoma mansoni cpg binding protein 0.0032 0.0241 0.0241
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0078 0.1373
Schistosoma mansoni calcium-activated potassium channel 0.0011 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Schistosoma mansoni endoplasmin 0.0035 0.0262 0.0262
Leishmania major hypothetical protein, conserved 0.0011 0.0053 0.0039
Plasmodium falciparum endoplasmin, putative 0.0021 0.0142 0.0128
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0007 0.0014 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0046 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0631 0.0618
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Echinococcus multilocularis twik family of potassium channels 0.0011 0.0053 0.0039
Onchocerca volvulus Huntingtin homolog 0.0128 0.1095 0.5312
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0078 0.1373
Toxoplasma gondii ion channel protein 0.0011 0.0053 0.083
Schistosoma mansoni calcium-activated potassium channel 0.0011 0.0053 0.0053
Plasmodium vivax endoplasmin, putative 0.0035 0.0262 0.0248
Plasmodium falciparum arginase 0.1124 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0262 0.0689
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Schistosoma mansoni hypothetical protein 0.0011 0.0053 0.0053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0221 0.0207
Brugia malayi Pre-SET motif family protein 0.003 0.0221 0.0958
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0053 0.004
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0089 0.159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0753 0.0753
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0089 0.159
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0011 0.0053 0.018
Trypanosoma brucei heat shock protein, putative 0.0035 0.0262 0.0689
Loa Loa (eye worm) hypothetical protein 0.003 0.0221 0.0958
Trypanosoma cruzi arginase, putative 0.0409 0.3607 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0221 0.0221
Echinococcus granulosus twik family of potassium channels 0.0011 0.0053 0.0039
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1795 0.8272
Brugia malayi hypothetical protein 0.0011 0.0053 0.018
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0134 0.0335
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0262 0.0248
Echinococcus granulosus cpg binding protein 0.0032 0.0241 0.0227
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0544 0.0544
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Plasmodium vivax heat shock protein, putative 0.0014 0.0078 0.0064
Trypanosoma cruzi heat shock protein, putative 0.0014 0.0078 0.0178
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0011 0.0053 0.018
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0199 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0053 0.004
Trypanosoma cruzi ion transport protein, putative 0.0011 0.0053 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0199 0.0186
Plasmodium vivax potassium channel, putative 0.0011 0.0053 0.0039
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0142 0.0129
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0074
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0262 0.0248
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0753 0.3433
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0053 0.0053
Onchocerca volvulus 0.0011 0.0053 0.0191
Schistosoma mansoni heat shock protein 0.0014 0.0078 0.0078
Trypanosoma brucei calcium-activated potassium channel, putative 0.0011 0.0053 0.0108
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0481 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Loa Loa (eye worm) hypothetical protein 0.0178 0.1545 0.7112
Schistosoma mansoni pyruvate dehydrogenase 0.0007 0.0014 0.0014
Echinococcus multilocularis heat shock protein 90 0.0035 0.0262 0.0248
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0142 0.0129
Onchocerca volvulus 0.003 0.0221 0.1014
Loa Loa (eye worm) uncoordinated protein 58 0.0011 0.0053 0.018
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Echinococcus granulosus heat shock protein 90 0.0028 0.0199 0.0185
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0078 0.0064
Brugia malayi hypothetical protein 0.0076 0.0631 0.2866
Trypanosoma cruzi ion transport protein, putative 0.0011 0.0053 0.0108
Plasmodium vivax potassium channel, putative 0.0011 0.0053 0.0039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Treponema pallidum heat shock protein 90 0.0028 0.0199 1
Echinococcus granulosus endoplasmin 0.0028 0.0199 0.0185
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Leishmania major calcium/potassium channel (CAKC), putative 0.0011 0.0053 0.0039
Onchocerca volvulus 0.0011 0.0053 0.0191
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0262 0.0689
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0029 0.0015
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.0199 0.7443
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0262 0.0689
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0221 0.0207
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0089 0.0207
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0011 0.0053 0.0039
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0011 0.0053 0.018
Trypanosoma brucei heat shock protein, putative 0.0035 0.0262 0.0689
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0011 0.0053 0.018
Trypanosoma brucei agmatinase, putative 0.0409 0.3607 1
Onchocerca volvulus Huntingtin homolog 0.0128 0.1095 0.5312
Echinococcus granulosus potassium channel subfamily K 8 0.0011 0.0053 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0053 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0029 0.0029
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0011 0.0053 0.018
Onchocerca volvulus 0.0011 0.0053 0.0191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0753 0.074
Schistosoma mansoni heat shock protein 0.0035 0.0262 0.0262
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Entamoeba histolytica hypothetical protein 0.0076 0.0631 0.0618
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0631 0.0618
Echinococcus granulosus twik family of potassium channels 0.0011 0.0053 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0221 0.0221
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0053 0.0053
Giardia lamblia Grp94/Hsp90 0.0028 0.0199 0.7443
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0011 0.0053 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.1124 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0262 1
Brugia malayi Endoplasmin precursor 0.0035 0.0262 0.115
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0074
Echinococcus multilocularis potassium channel subfamily K 0.0011 0.0053 0.0039
Echinococcus multilocularis heat shock protein 0.0035 0.0262 0.0248
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Plasmodium vivax SET domain protein, putative 0.003 0.0221 0.0207
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0078 0.0064
Schistosoma mansoni hypothetical protein 0.0438 0.3865 0.3865
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Echinococcus granulosus calcium activated potassium channel variant 0.0011 0.0053 0.0039
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0089 0.0345
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.0199 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0053 0.004
Giardia lamblia Hypothetical protein 0.0011 0.0053 0.1566
Schistosoma mansoni endoplasmin 0.0035 0.0262 0.0262
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0262 0.5304
Schistosoma mansoni arginase 0.1124 1 1
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Echinococcus granulosus Two pore potassium channel protein sup 9 0.019 0.1647 0.1636
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0262 0.115
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0631 0.0631
Echinococcus multilocularis dnaJ subfamily B 0.0438 0.3865 0.3856
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0011 0.0053 0.018
Onchocerca volvulus 0.0011 0.0053 0.0191
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.2167 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0089 0.0074
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Leishmania major arginase 0.1124 1 1
Loa Loa (eye worm) hypothetical protein 0.019 0.1647 0.7586
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0199 0.0185
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Echinococcus granulosus small conductance calcium activated potassium 0.0011 0.0053 0.0039
Echinococcus multilocularis small conductance calcium activated potassium 0.0011 0.0053 0.0039
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0011 0.0053 0.018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0753 0.3433
Trichomonas vaginalis receptor histidine kinase, putative 0.0007 0.0014 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0007 0.0014 0.5
Onchocerca volvulus 0.0011 0.0053 0.0191
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0029 0.0015
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0011 0.0053 0.018
Mycobacterium ulcerans ion transport protein 0.0011 0.0053 0.2104
Brugia malayi heat shock protein 90 0.0035 0.0262 0.115
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0089 0.0207
Leishmania major agmatinase-like protein 0.0409 0.3607 0.3598
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Onchocerca volvulus 0.0011 0.0053 0.0191
Trichomonas vaginalis Arginase, putative 0.1124 1 1
Loa Loa (eye worm) hypothetical protein 0.019 0.1647 0.7586
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0262 0.0689
Brugia malayi Pre-SET motif family protein 0.0206 0.1795 0.8272
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0053 0.004
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0089 0.4029
Loa Loa (eye worm) endoplasmin 0.0035 0.0262 0.115
Brugia malayi Hsp90 protein 0.0014 0.0078 0.0298
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Echinococcus granulosus potassium channel subfamily K 0.0011 0.0053 0.0039
Trichomonas vaginalis sensor histidine kinase, putative 0.0007 0.0014 0.0001
Trypanosoma brucei heat shock protein, putative 0.0035 0.0262 0.0689
Entamoeba histolytica hypothetical protein 0.0076 0.0631 0.0618
Trichomonas vaginalis receptor histidine kinase, putative 0.0007 0.0014 0.0001
Schistosoma mansoni cpg binding protein 0.0032 0.0241 0.0241
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0.0014 0.5
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0053 0.0053
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0046 0.0031
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.019 0.1647 0.1636
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0011 0.0053 0.018
Schistosoma mansoni twik family of potassium channels-related 0.019 0.1647 0.1647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0753 0.074
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0011 0.0053 0.018
Schistosoma mansoni calcium-activated potassium channel 0.0011 0.0053 0.0053
Echinococcus multilocularis potassium channel subfamily K 8 0.0011 0.0053 0.0039
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0011 0.0053 0.2104
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0011 0.0053 0.018
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.0199 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0011 0.0053 0.018
Echinococcus granulosus arginase 2 mitochondrial 0.1124 1 1
Echinococcus granulosus heat shock protein 0.0035 0.0262 0.0248
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0753 0.074
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0011 0.0053 0.018
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0.0014 0.5
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0089 0.0074
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0226 0.0982
Schistosoma mansoni hypothetical protein 0.0076 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0262 0.0248
Onchocerca volvulus 0.0235 0.2049 1
Echinococcus granulosus heat shock protein 90 0.0035 0.0262 0.0248
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0011 0.0053 0.0039
Mycobacterium ulcerans transmembrane cation transporter 0.0011 0.0053 0.2104
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0045 0.0141
Onchocerca volvulus 0.0011 0.0053 0.0191
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0011 0.0053 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Loa Loa (eye worm) hypothetical protein 0.0128 0.1095 0.5021
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0007 0.0014 0.0001
Leishmania major ion transport protein-like protein 0.0011 0.0053 0.0039
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0074
Leishmania major heat shock protein, putative 0.0014 0.0078 0.0064
Schistosoma mansoni heat shock protein 0.0035 0.0262 0.0262
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0014 0.0078 0.0064
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0089 0.0074
Echinococcus multilocularis calcium activated potassium channel variant 0.0011 0.0053 0.0039
Trypanosoma brucei heat shock protein, putative 0.0035 0.0262 0.0689
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0046 0.0146
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0011 0.0053 0.018
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0078 0.0315
Plasmodium falciparum potassium channel 0.0011 0.0053 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.1124 1 1
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0262 0.5304
Echinococcus granulosus potassium channel subfamily K 8 0.0011 0.0053 0.0039
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0199 1
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Trypanosoma cruzi agmatinase, putative 0.0409 0.3607 1
Entamoeba histolytica hypothetical protein 0.0076 0.0631 0.0618
Plasmodium vivax arginase, putative 0.1124 1 1
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0011 0.0053 0.018
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0053 0.0053
Schistosoma mansoni DNA topoisomerase II 0.0007 0.0014 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0221 0.0207
Schistosoma mansoni cpg binding protein 0.0031 0.0226 0.0226
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0262 0.0249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0753 0.074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0221 0.0221
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0078 0.0064
Toxoplasma gondii ion channel protein 0.0011 0.0053 0.083
Brugia malayi follicle stimulating hormone receptor 0.0248 0.2167 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0078 0.0065
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0011 0.0053 0.0039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0262 0.0689
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0015
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0011 0.0053 0.018
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Onchocerca volvulus 0.0031 0.0226 0.1039
Plasmodium falciparum heat shock protein 90 0.0035 0.0262 0.0248
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0199 0.0185
Schistosoma mansoni hypothetical protein 0.0011 0.0053 0.0053
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Plasmodium vivax heat shock protein 90, putative 0.0014 0.0078 0.0064
Brugia malayi isocitrate dehydrogenase 0.0015 0.0089 0.0345
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0011 0.0053 0.018
Echinococcus multilocularis cpg binding protein 0.0032 0.0241 0.0227
Echinococcus granulosus dnaJ subfamily B 0.0438 0.3865 0.3856
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2049 0.2039
Leishmania major heat shock protein 83-1 0.0035 0.0262 0.0248
Trypanosoma brucei heat shock protein, putative 0.0035 0.0262 0.0689
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0007 0.0014 0.0001
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.019 0.1647 0.7586
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Trypanosoma cruzi arginase, putative 0.0409 0.3607 1
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0262 0.0689
Trypanosoma brucei heat shock protein, putative 0.0035 0.0262 0.0689
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0007 0.0014 0.0001
Trypanosoma cruzi agmatinase, putative 0.0409 0.3607 1
Loa Loa (eye worm) TWK-7 protein 0.0011 0.0053 0.018
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0011 0.0053 0.0108
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0199 0.0186
Plasmodium falciparum potassium channel 0.0011 0.0053 0.0039
Echinococcus multilocularis heat shock protein 90 0.0028 0.0199 0.0185
Trichomonas vaginalis DNA topoisomerase II, putative 0.0007 0.0014 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.018

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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