Detailed information for compound 807671

Basic information

Technical information
  • TDR Targets ID: 807671
  • Name: 4-dimethylamino-5-methyl-1,1-di(phenyl)hex-2- yn-1-ol
  • MW: 307.429 | Formula: C21H25NO
  • H donors: 1 H acceptors: 1 LogP: 4.18 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(N(C)C)C#CC(c1ccccc1)(c1ccccc1)O)C
  • InChi: 1S/C21H25NO/c1-17(2)20(22(3)4)15-16-21(23,18-11-7-5-8-12-18)19-13-9-6-10-14-19/h5-14,17,20,23H,1-4H3
  • InChiKey: MOYQRHPXYJSAIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-Dimethylamino-5-methyl-1,1-diphenyl-hex-2-yn-1-ol
  • BAS 03200189
  • STOCK1S-01911
  • Oprea1_094552
  • CBMicro_014466
  • Oprea1_164735
  • AG-670/34887022

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha tubulin 0.0276 0.6086 0.606
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0084 0.1776 0.286
Loa Loa (eye worm) hypothetical protein 0.0211 0.4638 0.762
Echinococcus granulosus Smad4 0.0009 0.009 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.1395 0.1338
Echinococcus multilocularis tubulin alpha chain 0.0276 0.6086 0.606
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1121 0.1842
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0781 0.0721
Echinococcus granulosus beta tubulin 0.0149 0.3224 0.318
Trichomonas vaginalis tubulin epsilon chain, putative 0.0276 0.6086 1
Echinococcus granulosus tubulin alpha chain 0.0276 0.6086 0.606
Treponema pallidum cell division protein FtsZ 0.0064 0.1337 0.5
Schistosoma mansoni alpha tubulin 0.0276 0.6086 0.606
Echinococcus multilocularis Tubulin beta 2C chain 0.0149 0.3224 0.318
Schistosoma mansoni hypothetical protein 0.0017 0.0279 0.0215
Brugia malayi MH1 domain containing protein 0.0009 0.009 0.0148
Echinococcus multilocularis Tubulin alpha 1 chain 0.0276 0.6086 0.606
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0599 0.0984
Trypanosoma brucei epsilon tubulin 0.0149 0.3224 0.3974
Loa Loa (eye worm) tubulin beta chain 0.0064 0.1337 0.2197
Echinococcus multilocularis tubulin alpha 3 chain 0.0276 0.6086 0.606
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.009 0.0025
Trypanosoma cruzi epsilon tubulin, putative 0.0149 0.3224 0.3974
Leishmania major epsilon tubulin, putative 0.0149 0.3224 0.3974
Loa Loa (eye worm) tubulin gamma chain 0.0149 0.3224 0.5298
Echinococcus multilocularis tubulin alpha 1C chain 0.0276 0.6086 0.606
Schistosoma mansoni tubulin subunit epsilon 0.0149 0.3224 0.318
Trichomonas vaginalis tubulin alpha chain, putative 0.0149 0.3224 0.5259
Trypanosoma brucei alpha tubulin 0.0276 0.6086 1
Schistosoma mansoni tubulin subunit beta 0.0064 0.1337 0.128
Trypanosoma brucei epsilon tubulin 0.0149 0.3224 0.3974
Trichomonas vaginalis tubulin epsilon chain, putative 0.0149 0.3224 0.5259
Echinococcus granulosus Tubulin alpha 1 chain 0.0276 0.6086 0.606
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0064 0.1337 0.0212
Echinococcus granulosus tubulin beta 4A class IVa 0.0149 0.3224 0.318
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0279 0.0215
Echinococcus multilocularis short transient receptor potential channel 6 0.0071 0.1476 0.142
Plasmodium vivax tubulin alpha chain, putative 0.0276 0.6086 1
Schistosoma mansoni transient receptor potential channel 0.0107 0.2288 0.2238
Plasmodium vivax tubulin gamma chain, putative 0.0149 0.3224 0.3974
Echinococcus granulosus tubulin alpha chain 0.0276 0.6086 0.606
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0279 0.0215
Toxoplasma gondii beta tubulin 0.0149 0.3224 0.4102
Brugia malayi hypothetical protein 0.004 0.0778 0.1279
Echinococcus granulosus tubulin subunit TubB 0.0276 0.6086 0.606
Trichomonas vaginalis tubulin beta chain, putative 0.0276 0.6086 1
Brugia malayi tubulin alpha-2 chain 0.0276 0.6086 1
Trypanosoma brucei epsilon tubulin 0.0149 0.3224 0.3974
Echinococcus granulosus transient receptor potential ion channel A 0.0103 0.2208 0.2157
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0731 0.1202
Loa Loa (eye worm) tubulin alpha 2 0.0211 0.4638 0.762
Brugia malayi Tubulin beta-1 chain 0.0149 0.3224 0.5298
Brugia malayi Tubulin alpha chain 0.0064 0.1337 0.2197
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Leishmania major alpha tubulin 0.0276 0.6086 1
Echinococcus granulosus Tubulin beta 2C chain 0.0149 0.3224 0.318
Trichomonas vaginalis tubulin, putative 0.0149 0.3224 0.5259
Trichomonas vaginalis tubulin alpha chain, putative 0.0084 0.1776 0.286
Leishmania major alpha tubulin 0.0276 0.6086 1
Entamoeba histolytica tubulin alpha chain, putative 0.0276 0.6086 1
Echinococcus multilocularis tubulin epsilon chain 0.0149 0.3224 0.318
Loa Loa (eye worm) hypothetical protein 0.0055 0.1121 0.1842
Echinococcus granulosus transient receptor potential gamma protein 0.0107 0.2288 0.2238
Trypanosoma brucei beta tubulin 0.0149 0.3224 0.3974
Plasmodium vivax tubulin alpha chain, putative 0.0276 0.6086 1
Schistosoma mansoni hypothetical protein 0.0038 0.0731 0.067
Schistosoma mansoni tubulin subunit alpha 0.0276 0.6086 0.606
Trichomonas vaginalis tubulin, putative 0.0084 0.1776 0.286
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Brugia malayi alpha-tubulin 0.0276 0.6086 1
Leishmania major alpha tubulin 0.0276 0.6086 1
Trypanosoma brucei alpha tubulin 0.0276 0.6086 1
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1337 0.2133
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Loa Loa (eye worm) beta-tubulin 0.0149 0.3224 0.5298
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Schistosoma mansoni tubulin subunit alpha 0.0276 0.6086 0.606
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.009 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0778 0.0718
Schistosoma mansoni transient receptor potential channel 0.0071 0.1476 0.142
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Brugia malayi Cell division protein ftsZ 0.0064 0.1337 0.2197
Trichomonas vaginalis tubulin beta chain, putative 0.0276 0.6086 1
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Trichomonas vaginalis tubulin gamma chain, putative 0.0149 0.3224 0.5259
Echinococcus multilocularis hypothetical protein 0.0276 0.6086 0.606
Schistosoma mansoni hypothetical protein 0.0017 0.0279 0.0215
Loa Loa (eye worm) alpha-tubulin 0.0276 0.6086 1
Entamoeba histolytica tubulin family protein 0.0149 0.3224 0.4608
Schistosoma mansoni tubulin subunit delta 0.0064 0.1337 0.128
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.009 0.0025
Brugia malayi Tubulin gamma chain 0.0149 0.3224 0.5298
Brugia malayi Tubulin beta chain 0.0084 0.1776 0.2918
Echinococcus multilocularis tubulin delta chain 0.0064 0.1337 0.128
Schistosoma mansoni cpg binding protein 0.0032 0.0599 0.0537
Echinococcus granulosus tubulin epsilon chain 0.0149 0.3224 0.318
Echinococcus multilocularis Tubulin beta 2C chain 0.0149 0.3224 0.318
Giardia lamblia Beta tubulin 0.0149 0.3224 0.3974
Echinococcus granulosus tubulin alpha chain 0.0276 0.6086 0.606
Echinococcus granulosus GPCR family 2 0.0017 0.0279 0.0215
Loa Loa (eye worm) alpha-tubulin 0.0276 0.6086 1
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Echinococcus multilocularis dnaJ subfamily B 0.045 1 1
Echinococcus multilocularis tubulin subunit beta 0.0149 0.3224 0.318
Mycobacterium leprae cell division protein FtsZ 0.0064 0.1337 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.284 0.4667
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0064 0.1337 0.5
Trypanosoma cruzi alpha tubulin, putative 0.0276 0.6086 1
Loa Loa (eye worm) Smad1 0.0009 0.009 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1337 0.2133
Schistosoma mansoni tubulin subunit beta 0.0149 0.3224 0.318
Schistosoma mansoni smad 0.0009 0.009 0.0025
Echinococcus granulosus tubulin alpha 0.0149 0.3224 0.318
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0279 0.0458
Giardia lamblia Gamma tubulin 0.0149 0.3224 0.3974
Trichomonas vaginalis tubulin beta chain, putative 0.0149 0.3224 0.5259
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0064 0.1337 0.0212
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0279 0.0215
Echinococcus granulosus tubulin alpha 1C chain 0.0276 0.6086 0.606
Echinococcus multilocularis smad 0.0009 0.009 0.0025
Brugia malayi MH2 domain containing protein 0.0009 0.009 0.0148
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Trichomonas vaginalis tubulin alpha chain, putative 0.0149 0.3224 0.5259
Leishmania major alpha tubulin 0.0276 0.6086 1
Echinococcus multilocularis tubulin alpha chain 0.0276 0.6086 0.606
Echinococcus granulosus short transient receptor potential channel 6 0.0071 0.1476 0.142
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.284 0.4667
Echinococcus granulosus alpha tubulin 0.0276 0.6086 0.606
Echinococcus multilocularis Tubulin alpha 1 chain 0.0276 0.6086 0.606
Schistosoma mansoni tubulin subunit beta 0.0149 0.3224 0.318
Echinococcus multilocularis short transient receptor potential channel 6 0.0071 0.1476 0.142
Leishmania major alpha tubulin 0.0276 0.6086 1
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Brugia malayi beta-tubulin, identical 0.0149 0.3224 0.5298
Trichomonas vaginalis tubulin beta chain, putative 0.0276 0.6086 1
Giardia lamblia Alpha-tubulin 0.0276 0.6086 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1121 0.1842
Plasmodium vivax tubulin beta chain, putative 0.0149 0.3224 0.3974
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0149 0.3224 0.4102
Loa Loa (eye worm) tubulin alpha-3 chain 0.0192 0.4199 0.6899
Entamoeba histolytica tubulin gamma chain 0.0149 0.3224 0.4608
Echinococcus granulosus Tubulin beta 2C chain 0.0149 0.3224 0.318
Echinococcus granulosus smad 0.0009 0.009 0.0025
Schistosoma mansoni hypothetical protein 0.0017 0.0279 0.0215
Echinococcus multilocularis cpg binding protein 0.0033 0.0639 0.0578
Loa Loa (eye worm) BEN-1 protein 0.0149 0.3224 0.5298
Echinococcus multilocularis Tubulin alpha 1 chain 0.0276 0.6086 0.606
Leishmania major alpha tubulin 0.0276 0.6086 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0781 0.1284
Echinococcus multilocularis tubulin alpha chain 0.0276 0.6086 0.606
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0108 0.0044
Schistosoma mansoni tubulin subunit alpha 0.0276 0.6086 0.606
Echinococcus multilocularis Tubulin beta 2C chain 0.0149 0.3224 0.318
Loa Loa (eye worm) tubulin beta-2A chain 0.0149 0.3224 0.5298
Giardia lamblia Alpha-tubulin 0.0276 0.6086 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0149 0.3224 0.318
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0276 0.6086 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.139 1
Onchocerca volvulus 0.0084 0.1776 1
Entamoeba histolytica tubulin family protein 0.0149 0.3224 0.4608
Trypanosoma brucei alpha tubulin 0.0276 0.6086 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0701 0.1152
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0192 0.4199 0.6874
Trypanosoma cruzi beta tubulin, putative 0.0149 0.3224 0.3974
Echinococcus granulosus Tubulin alpha 1 chain 0.0276 0.6086 0.606
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Loa Loa (eye worm) tubulin alpha chain 0.0276 0.6086 1
Giardia lamblia Beta tubulin 0.0149 0.3224 0.3974
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0279 0.0458
Trypanosoma brucei beta tubulin 0.0149 0.3224 0.3974
Schistosoma mansoni tubulin subunit beta 0.0149 0.3224 0.318
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0778 0.0718
Loa Loa (eye worm) hypothetical protein 0.0038 0.0731 0.1202
Echinococcus granulosus peroxisome assembly protein 26 0.0276 0.6086 0.606
Brugia malayi Tubulin alpha-2 chain 0.0276 0.6086 1
Leishmania major alpha tubulin 0.0276 0.6086 1
Echinococcus granulosus tubulin gamma 1 chain 0.0149 0.3224 0.318
Leishmania major alpha tubulin 0.0276 0.6086 1
Echinococcus granulosus short transient receptor potential channel 6 0.0071 0.1476 0.142
Toxoplasma gondii alpha tubulin TUBA1 0.0276 0.6086 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0064 0.1337 0.2133
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.139 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.009 0.0025
Schistosoma mansoni tubulin subunit gamma 0.0149 0.3224 0.318
Schistosoma mansoni hypothetical protein 0.0017 0.0279 0.0215
Plasmodium falciparum tubulin gamma chain 0.0149 0.3224 0.3974
Brugia malayi CXXC zinc finger family protein 0.0032 0.0599 0.0984
Trypanosoma brucei beta tubulin 0.0149 0.3224 0.3974
Trichomonas vaginalis tubulin epsilon chain, putative 0.0276 0.6086 1
Loa Loa (eye worm) hypothetical protein 0.0192 0.4199 0.6899
Schistosoma mansoni tubulin subunit beta 0.0149 0.3224 0.318
Schistosoma mansoni tubulin subunit beta 0.0149 0.3224 0.318
Loa Loa (eye worm) tubulin alpha 2 0.0127 0.275 0.452
Brugia malayi MH1 domain containing protein 0.0009 0.009 0.0148
Loa Loa (eye worm) tubulin beta-1 chain 0.0149 0.3224 0.5298
Trichomonas vaginalis tubulin, putative 0.0064 0.1337 0.2133
Schistosoma mansoni cpg binding protein 0.0033 0.0639 0.0578
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0211 0.4638 0.762
Echinococcus multilocularis beta tubulin 0.0149 0.3224 0.318
Echinococcus granulosus Tubulin beta 2C chain 0.0149 0.3224 0.318
Trypanosoma brucei alpha tubulin, putative 0.0084 0.1776 0.0924
Trichomonas vaginalis tubulin epsilon chain, putative 0.0149 0.3224 0.5259
Trichomonas vaginalis tubulin, putative 0.0084 0.1776 0.286
Echinococcus granulosus tubulin beta 1 chain 0.0149 0.3224 0.318
Brugia malayi MH2 domain containing protein 0.0009 0.009 0.0148
Echinococcus multilocularis tubulin subunit TubB 0.0276 0.6086 0.606
Toxoplasma gondii beta-1 tubulin, putative 0.0149 0.3224 0.4102
Echinococcus multilocularis tubulin alpha chain 0.0276 0.6086 0.606
Echinococcus multilocularis tubulin alpha 0.0149 0.3224 0.318
Echinococcus granulosus tubulin alpha chain 0.0276 0.6086 0.606
Loa Loa (eye worm) hypothetical protein 0.0017 0.0279 0.0458
Schistosoma mansoni hypothetical protein 0.045 1 1
Schistosoma mansoni transient receptor potential channel 0.0071 0.1476 0.142
Leishmania major alpha tubulin 0.0276 0.6086 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.2288 0.376
Loa Loa (eye worm) tubulin alpha 2 0.0211 0.4638 0.762
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.139 0.1333
Loa Loa (eye worm) tubulin alpha chain 0.0276 0.6086 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.009 0.0025
Trypanosoma brucei alpha tubulin 0.0276 0.6086 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0276 0.6086 0.606
Echinococcus granulosus tubulin alpha 3 chain 0.0276 0.6086 0.606
Schistosoma mansoni transient receptor potential channel 4 0.0107 0.2288 0.2238
Echinococcus multilocularis tubulin beta 1 chain 0.0149 0.3224 0.318
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Loa Loa (eye worm) hypothetical protein 0.0067 0.1396 0.2294
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Echinococcus granulosus tubulin delta chain 0.0064 0.1337 0.128
Brugia malayi Transient-receptor-potential like protein 0.004 0.0781 0.1284
Trichomonas vaginalis tubulin alpha chain, putative 0.0084 0.1776 0.286
Schistosoma mansoni smad1 5 8 and 0.0009 0.009 0.0025
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.139 0.1333
Echinococcus granulosus tubulin alpha chain 0.0276 0.6086 0.606
Echinococcus granulosus Tubulin alpha 1 chain 0.0276 0.6086 0.606
Plasmodium falciparum alpha tubulin 2 0.0276 0.6086 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0108 0.0178
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0108 0.0044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0279 0.0215
Echinococcus multilocularis Tubulin beta 2C chain 0.0149 0.3224 0.318
Loa Loa (eye worm) tubulin alpha-2 chain 0.0276 0.6086 1
Echinococcus granulosus tubulin subunit beta 0.0149 0.3224 0.318
Trichomonas vaginalis tubulin gamma chain, putative 0.0149 0.3224 0.5259
Brugia malayi tubulin alpha chain - mouse 0.0276 0.6086 1
Brugia malayi MH2 domain containing protein 0.0131 0.284 0.4667
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0106 0.0174
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0211 0.4638 0.7601
Schistosoma mansoni smad1 5 8 and 0.0009 0.009 0.0025
Echinococcus granulosus tubulin alpha 3 chain 0.0276 0.6086 0.606
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.139 0.1333
Echinococcus granulosus Tubulin beta 2C chain 0.0149 0.3224 0.318
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0279 0.0458
Giardia lamblia Beta tubulin 0.0149 0.3224 0.3974
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0064 0.1337 0.2133
Trichomonas vaginalis tubulin gamma chain, putative 0.0149 0.3224 0.5259
Echinococcus multilocularis transient receptor potential ion channel A 0.0103 0.2208 0.2157
Echinococcus multilocularis peroxisome assembly protein 26 0.0276 0.6086 0.606
Brugia malayi Smad1 0.0009 0.009 0.0148
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.139 1
Plasmodium falciparum tubulin beta chain 0.0149 0.3224 0.3974
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Loa Loa (eye worm) BEN-1 protein 0.0149 0.3224 0.5298
Echinococcus multilocularis Smad4 0.0009 0.009 0.0025
Schistosoma mansoni hypothetical protein 0.004 0.0778 0.0718
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.009 0.0148
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.139 0.0111
Trichomonas vaginalis tubulin beta chain, putative 0.0276 0.6086 1
Trypanosoma brucei beta tubulin 0.0149 0.3224 0.3974
Toxoplasma gondii beta-tubulin, putative 0.0149 0.3224 0.4102
Echinococcus multilocularis tubulin gamma 1 chain 0.0149 0.3224 0.318
Schistosoma mansoni smad1 5 8 and 0.0009 0.009 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.139 1
Brugia malayi Tubulin alpha chain 0.0276 0.6086 1
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.139 0.0322
Echinococcus multilocularis tubulin alpha chain 0.0276 0.6086 0.606
Echinococcus multilocularis beta tubulin 0.0149 0.3224 0.318
Loa Loa (eye worm) tubulin beta-4 chain 0.0149 0.3224 0.5298
Plasmodium vivax tubulin epsilon chain, putative 0.0149 0.3224 0.3974
Schistosoma mansoni Smad4 0.0009 0.009 0.0025
Trichomonas vaginalis tubulin epsilon chain, putative 0.0064 0.1337 0.2133
Schistosoma mansoni alpha tubulin 0.0276 0.6086 0.606
Leishmania major alpha tubulin 0.0276 0.6086 1
Trichomonas vaginalis tubulin beta chain, putative 0.0084 0.1776 0.286
Leishmania major gamma-tubulin 0.0149 0.3224 0.3974
Brugia malayi Tubulin alpha-2 chain 0.0276 0.6086 1
Echinococcus granulosus beta tubulin 0.0149 0.3224 0.318
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.139 0.1333
Trypanosoma brucei beta tubulin 0.0149 0.3224 0.3974
Schistosoma mansoni tubulin subunit beta 0.0149 0.3224 0.318
Entamoeba histolytica tubulin alpha-1 chain 0.0276 0.6086 1
Brugia malayi Tubulin beta chain 0.0064 0.1337 0.2197
Trypanosoma cruzi epsilon tubulin, putative 0.0149 0.3224 0.3974
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0781 0.0721
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1121 0.1842
Leishmania major alpha tubulin 0.0276 0.6086 1
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0778 0.0718
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0149 0.3224 0.318
Loa Loa (eye worm) tubulin beta chain 0.0149 0.3224 0.5298
Trichomonas vaginalis tubulin beta chain, putative 0.0276 0.6086 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0149 0.3224 0.3974
Echinococcus granulosus tubulin alpha 1C chain 0.0276 0.6086 0.606
Trypanosoma brucei tubulin gamma chain 0.0149 0.3224 0.3974
Trichomonas vaginalis tubulin beta chain, putative 0.0276 0.6086 1
Loa Loa (eye worm) hypothetical protein 0.0276 0.6086 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0107 0.2288 0.2238
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.009 0.0148
Trichomonas vaginalis tubulin alpha chain, putative 0.0084 0.1776 0.286
Echinococcus multilocularis tubulin alpha 3 chain 0.0276 0.6086 0.606
Echinococcus granulosus Tubulin beta 2C chain 0.0149 0.3224 0.318
Echinococcus multilocularis GPCR, family 2 0.0017 0.0279 0.0215
Schistosoma mansoni tubulin subunit alpha 0.0064 0.1337 0.128
Leishmania major beta tubulin 0.0149 0.3224 0.3974
Plasmodium falciparum alpha tubulin 1 0.0276 0.6086 1
Toxoplasma gondii alpha-tubulin I, putative 0.0276 0.6086 1
Echinococcus granulosus cpg binding protein 0.0033 0.0639 0.0578
Schistosoma mansoni cpg binding protein 0.0033 0.0639 0.0578
Trypanosoma cruzi tubulin gamma chain 0.0149 0.3224 0.3974
Leishmania major alpha tubulin 0.0276 0.6086 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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