Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0139 | 0.0336 | 0.0925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.0336 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0842 | 0.3628 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.0336 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.0336 | 1 |
Echinococcus multilocularis | nibrin | 0.0139 | 0.0336 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0139 | 0.0336 | 1 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0139 | 0.0336 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.0008 | 0.0228 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.0336 | 1 |
Brugia malayi | topoisomerase | 0.0139 | 0.0336 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0139 | 0.0336 | 0.0328 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0139 | 0.0336 | 1 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0139 | 0.0336 | 0.0925 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2201 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0842 | 0.3628 | 1 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0139 | 0.0336 | 1 |
Onchocerca volvulus | 0.0139 | 0.0336 | 0.5 | |
Toxoplasma gondii | ATPase, AAA family protein | 0.0139 | 0.0336 | 0.0925 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0139 | 0.0336 | 1 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0139 | 0.0336 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0139 | 0.0336 | 1 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0139 | 0.0336 | 1 |
Treponema pallidum | DNA ligase (lig) | 0.0139 | 0.0336 | 0.5 |
Schistosoma mansoni | topbp1 | 0.0139 | 0.0336 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0139 | 0.0336 | 0.0925 |
Trichomonas vaginalis | rotamase, putative | 0.0069 | 0.0008 | 0.0228 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0139 | 0.0336 | 0.0925 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0139 | 0.0336 | 0.0328 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.0336 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.0336 | 0.0925 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0139 | 0.0336 | 0.0328 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0842 | 0.3628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2201 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0842 | 0.3628 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0842 | 0.3628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0842 | 0.3628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0139 | 0.0336 | 0.0328 |
Echinococcus granulosus | nibrin | 0.0139 | 0.0336 | 0.0328 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.0336 | 0.0925 |
Schistosoma mansoni | DNA ligase IV | 0.0139 | 0.0336 | 0.0328 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2201 | 1 | 1 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0139 | 0.0336 | 0.0328 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2201 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.2201 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2201 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2201 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2201 | 1 | 1 |
Brugia malayi | DKFZp564C0469 protein | 0.0139 | 0.0336 | 0.0328 |
Brugia malayi | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.0336 | 1 |
Schistosoma mansoni | topbp1 | 0.0139 | 0.0336 | 0.0328 |
Brugia malayi | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Brugia malayi | Dihydrofolate reductase | 0.2201 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.