Detailed information for compound 808508

Basic information

Technical information
  • TDR Targets ID: 808508
  • Name: 1-(4-methylphenyl)sulfonyl-4-[(2,3,4-trimetho xyphenyl)methyl]piperazine
  • MW: 420.522 | Formula: C21H28N2O5S
  • H donors: 0 H acceptors: 2 LogP: 2.65 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(ccc(c1OC)OC)CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C21H28N2O5S/c1-16-5-8-18(9-6-16)29(24,25)23-13-11-22(12-14-23)15-17-7-10-19(26-2)21(28-4)20(17)27-3/h5-10H,11-15H2,1-4H3
  • InChiKey: JKUZPKGXDBYTIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-methylphenyl)sulfonyl-4-(2,3,4-trimethoxybenzyl)piperazine
  • STK138305
  • 1-(Toluene-4-sulfonyl)-4-(2,3,4-trimethoxy-benzyl)-piperazine
  • BAS 02500709
  • BIM-0012879.P001
  • Oprea1_444877
  • CBMicro_012801
  • Oprea1_540571

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Loa Loa (eye worm) nuclear receptor NHR-67 0.0113 0.0462 0.1554
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0258 0.1169 0.1144
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Echinococcus granulosus geminin 0.017 0.0739 0.0713
Brugia malayi nuclear hormone receptor 0.0258 0.1169 0.4059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0258 0.1169 0.1144
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0258 0.1169 0.4059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0128 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0113 0.0462 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0018
Mycobacterium ulcerans hypothetical protein 0.0023 0.0023 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0139 0.0411
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0139 0.0112
Brugia malayi nuclear hormone receptor family member nhr-6 0.0113 0.0462 0.1554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0072 0.444
Brugia malayi ecdysteroid receptor 0.0602 0.2846 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0407 0.1358
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0258 0.1169 0.1144
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0113 0.0462 0.1554
Loa Loa (eye worm) hypothetical protein 0.0258 0.1169 0.4059
Schistosoma mansoni nuclear hormone receptor 0.0113 0.0462 0.0435
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0258 0.1169 0.1144
Brugia malayi Nuclear hormone receptor E75 0.0113 0.0462 0.1554
Schistosoma mansoni hypothetical protein 0.0047 0.0139 0.0112
Brugia malayi Nuclear hormone receptor E75 0.0113 0.0462 0.1554
Loa Loa (eye worm) transcription factor SMAD2 0.0358 0.1655 0.578
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0258 0.1169 0.1144
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0258 0.1169 0.1144
Onchocerca volvulus 0.008 0.0299 0.0978
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0128 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0258 0.1169 0.4059
Schistosoma mansoni nuclear receptor nhr-48 0.0113 0.0462 0.0435
Loa Loa (eye worm) hypothetical protein 0.0258 0.1169 0.4059
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0145 0.0616 0.059
Loa Loa (eye worm) hypothetical protein 0.0258 0.1169 0.4059
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0023 0.5
Schistosoma mansoni nuclear hormone receptor 0.0113 0.0462 0.0435
Brugia malayi intermediate filament protein 0.008 0.0299 0.0978
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0139 0.0112
Echinococcus granulosus Nuclear hormone receptor HR96 0.0113 0.0462 0.0435
Schistosoma mansoni nuclear hormone receptor 0.0258 0.1169 0.1144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0258 0.1169 0.4059
Schistosoma mansoni coup transcription factor 0.0258 0.1169 0.1144
Schistosoma mansoni lamin 0.008 0.0299 0.0272
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0258 0.1169 0.1144
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0258 0.1169 0.1144
Brugia malayi MH1 domain containing protein 0.0024 0.0028 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.556
Loa Loa (eye worm) hypothetical protein 0.0037 0.009 0.0237
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0637 0.2175
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0113 0.0462 0.1554
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0113 0.0462 0.0435
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0113 0.0462 0.1554
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0145 0.0616 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0096 0.6827
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0097 0.007
Schistosoma mansoni hypothetical protein 0.0047 0.0139 0.0112
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0258 0.1169 0.1144
Brugia malayi Smad1 0.0024 0.0028 0.0016
Echinococcus multilocularis lamin 0.008 0.0299 0.0272
Schistosoma mansoni intermediate filament proteins 0.008 0.0299 0.0272
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0462 0.0435
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0128 1
Echinococcus granulosus lamin 0.008 0.0299 0.0272
Onchocerca volvulus Bile acid receptor homolog 0.0602 0.2846 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0258 0.1169 0.4059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0072 0.444
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0637 0.2175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0072 0.444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.1138
Brugia malayi nuclear receptor RXR 0.0113 0.0462 0.1554
Schistosoma mansoni hypothetical protein 0.0047 0.0139 0.0112
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0023 0.5
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0128 0.0101
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0028 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.0145 0.0616 0.2099
Echinococcus granulosus Nuclear hormone receptor HR96 0.0113 0.0462 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0258 0.1169 0.4059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.004 0.1267
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0407 0.1358
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0258 0.1169 0.1144
Brugia malayi ecdysone receptor 0.0113 0.0462 0.1554
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Onchocerca volvulus 0.0113 0.0462 0.1554
Schistosoma mansoni hypothetical protein 0.0102 0.0407 0.038
Loa Loa (eye worm) DR-78 0.0113 0.0462 0.1554
Schistosoma mansoni hypothetical protein 0.0047 0.0139 0.0112
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0128 0.0372
Echinococcus multilocularis ecdysone induced protein 78C 0.0258 0.1169 0.1144
Echinococcus granulosus GPCR family 2 0.0047 0.0139 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0258 0.1169 0.4059
Brugia malayi MH2 domain containing protein 0.0358 0.1655 0.578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0097 0.0262
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0128 0.0101
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0128 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0118 0.0336
Brugia malayi nuclear hormone receptor family member odr-7 0.0113 0.0462 0.1554
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0258 0.1169 0.4059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0128 1
Echinococcus granulosus tumor protein p63 0.0338 0.1559 0.1536
Schistosoma mansoni lamin 0.008 0.0299 0.0272
Echinococcus granulosus FTZ F1 alpha 0.0258 0.1169 0.1144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0145 0.0616 0.059
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Schistosoma mansoni microtubule-associated protein tau 0.2067 1 1
Brugia malayi nuclear receptor RXR 0.0145 0.0616 0.2099
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0128 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0084 0.5742
Schistosoma mansoni nuclear receptor 0.0113 0.0462 0.0435
Brugia malayi hypothetical protein 0.0113 0.0462 0.1554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0128 1
Echinococcus multilocularis lamin dm0 0.008 0.0299 0.0272
Loa Loa (eye worm) hypothetical protein 0.0145 0.0616 0.2099
Brugia malayi hypothetical protein 0.0145 0.0616 0.2099
Giardia lamblia GTOR 0.0045 0.0128 0.5
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Loa Loa (eye worm) hypothetical protein 0.0602 0.2846 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0258 0.1169 0.4059
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0023 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0358 0.1655 0.578
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0258 0.1169 0.1144
Loa Loa (eye worm) hypothetical protein 0.0145 0.0616 0.2099
Onchocerca volvulus 0.0113 0.0462 0.1554
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0258 0.1169 0.4059
Brugia malayi hypothetical protein 0.0145 0.0616 0.2099
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0258 0.1169 0.4059
Echinococcus multilocularis geminin 0.017 0.0739 0.0713
Brugia malayi conserved hypotetical protein 0.0113 0.0462 0.1554
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0023 0.5
Loa Loa (eye worm) hypothetical protein 0.0258 0.1169 0.4059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.556
Echinococcus granulosus nuclear receptor nhr 48 0.0113 0.0462 0.0435
Loa Loa (eye worm) hypothetical protein 0.0145 0.0616 0.2099
Loa Loa (eye worm) hypothetical protein 0.0079 0.0292 0.0953
Onchocerca volvulus Protein ultraspiracle homolog 0.0258 0.1169 0.4059
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0023 0.5
Loa Loa (eye worm) hypothetical protein 0.0145 0.0616 0.2099
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0139 0.0411
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0013 0.0985
Loa Loa (eye worm) hypothetical protein 0.0037 0.009 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0258 0.1169 0.4059
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0113 0.0462 0.0435
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0023 0.5
Brugia malayi nuclear receptor NHR-88 0.0113 0.0462 0.1554
Brugia malayi Steroid receptor seven-up type 2 0.0258 0.1169 0.4059
Echinococcus granulosus thyroid hormone receptor alpha 0.0434 0.2028 0.2006
Echinococcus multilocularis GPCR, family 2 0.0047 0.0139 0.0112
Echinococcus multilocularis nuclear receptor nhr 48 0.0113 0.0462 0.0435
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0258 0.1169 0.4059
Loa Loa (eye worm) hypothetical protein 0.008 0.0299 0.0978
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0258 0.1169 0.4059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0258 0.1169 0.1144
Brugia malayi Nuclear hormone receptor-like 1 0.0258 0.1169 0.4059
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0139 0.0411
Loa Loa (eye worm) hypothetical protein 0.0258 0.1169 0.4059
Echinococcus multilocularis FTZ F1 alpha 0.0258 0.1169 0.1144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.556
Echinococcus multilocularis musashi 0.008 0.0299 0.0272
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0145 0.0616 0.2099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.004 0.1267
Schistosoma mansoni thyroid hormone receptor 0.0258 0.1169 0.1144
Schistosoma mansoni hypothetical protein 0.017 0.0739 0.0713
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.0299 0.0978
Brugia malayi MH2 domain containing protein 0.0024 0.0028 0.0016
Echinococcus granulosus ecdysone induced protein 78C 0.0258 0.1169 0.1144
Echinococcus granulosus intermediate filament protein 0.008 0.0299 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0056 0.2856
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0258 0.1169 0.1144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0258 0.1169 0.4059
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0145 0.0616 0.059
Loa Loa (eye worm) steroid hormone receptor 0.0579 0.2735 0.9607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.1138
Schistosoma mansoni RAR-like nuclear receptor 0.0258 0.1169 0.1144
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0118 0.0336
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0113 0.0462 0.0435
Brugia malayi nuclear receptor NHR-88 0.0258 0.1169 0.4059
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0023 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0128 0.0372
Schistosoma mansoni nuclear receptor 0.0113 0.0462 0.0435
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0023 0.5
Brugia malayi steroid hormone receptor 0.0579 0.2735 0.9607
Brugia malayi nuclear hormone receptor 0.0113 0.0462 0.1554
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0023 0.5
Brugia malayi MH1 domain containing protein 0.0024 0.0028 0.0016
Loa Loa (eye worm) Smad1 0.0024 0.0028 0.0016
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0113 0.0462 0.0435
Loa Loa (eye worm) hypothetical protein 0.0145 0.0616 0.2099
Schistosoma mansoni thyroid hormone receptor 0.0258 0.1169 0.1144
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0128 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Schistosoma mansoni retinoic acid receptor RXR 0.0258 0.1169 0.1144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0072 0.444
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0023 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.004 0.1267
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0084 0.6514
Loa Loa (eye worm) hypothetical protein 0.0113 0.0462 0.1554
Echinococcus multilocularis thyroid hormone receptor alpha 0.0258 0.1169 0.1144
Echinococcus multilocularis tumor protein p63 0.0338 0.1559 0.1536
Loa Loa (eye worm) hypothetical protein 0.0258 0.1169 0.4059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0258 0.1169 0.1144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0258 0.1169 0.4059
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.0299 0.0978
Brugia malayi tailless protein 0.0113 0.0462 0.1554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0072 0.444
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.015 0.0123
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0128 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0258 0.1169 0.4059
Onchocerca volvulus 0.0049 0.015 0.045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0258 0.1169 0.4059
Brugia malayi orphan nuclear receptor NR2E1 0.0113 0.0462 0.1554
Schistosoma mansoni hypothetical protein 0.017 0.0739 0.0713
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0258 0.1169 0.4059
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0258 0.1169 0.4059
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0258 0.1169 0.1144
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0258 0.1169 0.1144
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0258 0.1169 0.1144
Brugia malayi Nuclear hormone receptor-like 1 0.0145 0.0616 0.2099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0018
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0097 0.007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0258 0.1169 0.1144
Echinococcus granulosus lamin dm0 0.008 0.0299 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0072 0.444
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0258 0.1169 0.1144
Schistosoma mansoni zinc finger protein 0.0113 0.0462 0.0435
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0128 0.0101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0139 0.0411
Brugia malayi nuclear receptor NHR-67 0.0113 0.0462 0.1554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0258 0.1169 0.4059
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0113 0.0462 0.0435
Loa Loa (eye worm) hypothetical protein 0.0149 0.0637 0.2175
Brugia malayi MH2 domain containing protein 0.0024 0.0028 0.0016
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0139 0.0112
Onchocerca volvulus 0.0258 0.1169 0.4059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0051 0.2387
Onchocerca volvulus 0.008 0.0299 0.0978
Loa Loa (eye worm) hypothetical protein 0.0049 0.015 0.045
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0113 0.0462 0.1554
Loa Loa (eye worm) hypothetical protein 0.0258 0.1169 0.4059
Echinococcus multilocularis microtubule associated protein 2 0.2067 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0072 0.444
Loa Loa (eye worm) nuclear hormone receptor 0.0113 0.0462 0.1554
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0023 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0258 0.1169 0.4059
Brugia malayi hypothetical protein 0.0113 0.0462 0.1554
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0072 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0637 0.2175
Loa Loa (eye worm) intermediate filament protein 0.008 0.0299 0.0978
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0139 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.556
Schistosoma mansoni steroid hormone receptor ad4bp 0.0258 0.1169 0.1144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0258 0.1169 0.4059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0462 0.0435
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0028 0.0016
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0128 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0113 0.0462 0.0435
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0128 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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