Detailed information for compound 808742

Basic information

Technical information
  • TDR Targets ID: 808742
  • Name: N-[(5E)-5-[(4,5-dimethoxy-2-nitrophenyl)methy lidene]-4-oxo-1,3-thiazol-2-yl]benzenesulfona mide
  • MW: 449.458 | Formula: C18H15N3O7S2
  • H donors: 1 H acceptors: 5 LogP: 3.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C\2/SC(=NC2=O)NS(=O)(=O)c2ccccc2)c(cc1OC)[N+](=O)[O-]
  • InChi: 1S/C18H15N3O7S2/c1-27-14-8-11(13(21(23)24)10-15(14)28-2)9-16-17(22)19-18(29-16)20-30(25,26)12-6-4-3-5-7-12/h3-10H,1-2H3,(H,19,20,22)/b16-9+
  • InChiKey: DXPFGKPJCBOMGO-CXUHLZMHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(5E)-5-[(4,5-dimethoxy-2-nitro-phenyl)methylene]-4-oxo-thiazol-2-yl]benzenesulfonamide
  • N-[(5E)-5-[(4,5-dimethoxy-2-nitrophenyl)methylene]-4-oxo-2-thiazolyl]benzenesulfonamide
  • N-[(5E)-5-(4,5-dimethoxy-2-nitro-benzylidene)-4-keto-thiazol-2-yl]benzenesulfonamide
  • N-[(5E)-5-[(4,5-dimethoxy-2-nitro-phenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]benzenesulfonamide
  • ZINC01753440
  • ZINC02291294
  • MLS000530504
  • N-[5-(4,5-dimethoxy-2-nitrobenzylidene)-4-oxo-1,3-thiazolidin-2-ylidene]benzenesulfonamide
  • SMR000135482
  • BIM-0011712.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0276 0.2809 0.5182
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0122 0.0224
Leishmania major basic transcription factor 3a, putative 0.0042 0.0325 0.2222
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0276 0.2809 0.3219
Brugia malayi Ets-domain containing protein 0.0087 0.0805 0.1485
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0011 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0276 0.2809 0.4978
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0276 0.2809 0.5182
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0139 0.0951
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.005 0.0345
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0276 0.2809 0.3219
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0371 0.0821
Echinococcus granulosus hypothetical protein 0.0032 0.022 0.0252
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.013 0.126 0.1444
Schistosoma mansoni smad1 5 8 and 0.0025 0.014 0.0161
Brugia malayi conserved hypotetical protein 0.013 0.126 0.2324
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0288 0.0532
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0288 0.0532
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Schistosoma mansoni inositol monophosphatase 0.004 0.0298 0.0342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1876 0.2151
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.022 0.0252
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.022 0.0252
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.0368 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0023 0.0122 0.0122
Brugia malayi neuropeptide F receptor 0.0032 0.022 0.0406
Brugia malayi ecdysone receptor 0.013 0.126 0.2324
Trichomonas vaginalis DNA helicase recq, putative 0.0036 0.0255 0.0467
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus multilocularis protein C ets 2 0.0013 0.0011 0.0013
Brugia malayi nuclear receptor NHR-88 0.0276 0.2809 0.5182
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.022 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0325 0.0679
Echinococcus multilocularis serotonin receptor 0.0032 0.022 0.0252
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.0276 0.2809 0.5182
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0371 0.0685
Loa Loa (eye worm) hypothetical protein 0.006 0.0516 0.0951
Brugia malayi nuclear hormone receptor family member odr-7 0.013 0.126 0.2324
Brugia malayi MH1 domain containing protein 0.0025 0.014 0.0258
Toxoplasma gondii exonuclease III APE 0.0039 0.0288 0.1974
Schistosoma mansoni amine GPCR 0.0032 0.022 0.0252
Echinococcus multilocularis bloom syndrome protein 0.0049 0.0399 0.0457
Onchocerca volvulus Bile acid receptor homolog 0.0276 0.2809 0.4978
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.022 0.0252
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.022 0.0252
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0011 0.0013
Brugia malayi hypothetical protein 0.0146 0.1426 0.263
Loa Loa (eye worm) hypothetical protein 0.0276 0.2809 0.5182
Loa Loa (eye worm) beta-lactamase 0.0149 0.1461 0.2695
Schistosoma mansoni cpg binding protein 0.0037 0.0266 0.0304
Onchocerca volvulus 0.0522 0.5421 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0218 0.149
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.022 0.0252
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0122 0.0122
Echinococcus multilocularis dna polymerase eta 0.0077 0.0698 0.08
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.044 0.0504
Plasmodium vivax hypothetical protein, conserved 0.0149 0.1461 1
Mycobacterium tuberculosis Probable lipase LipE 0.0149 0.1461 0.1461
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0276 0.2809 0.3219
Schistosoma mansoni DNA helicase recq1 0.0032 0.0218 0.025
Brugia malayi nuclear receptor NHR-88 0.013 0.126 0.2324
Echinococcus granulosus geminin 0.0173 0.1715 0.1965
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.022 0.0252
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.022 0.0252
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0032 0.0218 0.0402
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0276 0.2809 0.3219
Echinococcus multilocularis translocator protein 0.0522 0.5421 0.6213
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0357 0.2441
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Entamoeba histolytica recQ family helicase, putative 0.0036 0.0255 0.6458
Loa Loa (eye worm) hypothetical protein 0.0077 0.0698 0.1287
Schistosoma mansoni inositol monophosphatase 0.004 0.0298 0.0342
Loa Loa (eye worm) hypothetical protein 0.0276 0.2809 0.5182
Loa Loa (eye worm) nuclear receptor NHR-67 0.013 0.126 0.2324
Echinococcus multilocularis GPCR, family 2 0.0019 0.0079 0.009
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0011 0.002
Schistosoma mansoni biogenic amine receptor 0.0032 0.022 0.0252
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0023 0.0122 0.0224
Brugia malayi MH2 domain containing protein 0.0365 0.3748 0.6914
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0371 0.2541
Schistosoma mansoni amine GPCR 0.0032 0.022 0.0252
Echinococcus multilocularis Nuclear hormone receptor HR96 0.013 0.126 0.1444
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0122 0.0833
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0276 0.2809 0.5182
Brugia malayi hypothetical protein 0.0211 0.2115 0.3901
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0805 0.1485
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.022 0.0252
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.013 0.126 0.1444
Loa Loa (eye worm) hypothetical protein 0.0149 0.1461 0.2695
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0011 0.0013
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.022 0.0252
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0371 0.0371
Echinococcus granulosus neuropeptide receptor 0.0032 0.022 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0276 0.2809 0.5182
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.003 0.0205
Echinococcus multilocularis g protein coupled receptor 0.0032 0.022 0.0252
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0276 0.2809 0.3219
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.1461 0.4144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.022 0.0252
Loa Loa (eye worm) nuclear receptor nhr-7B 0.013 0.126 0.2324
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0032 0.0218 0.025
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0022 0.0106 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0325 0.0679
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0325 0.2222
Loa Loa (eye worm) transcription factor SMAD2 0.0365 0.3748 0.6914
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.022 0.0406
Mycobacterium tuberculosis Conserved protein 0.0149 0.1461 0.1461
Schistosoma mansoni gabp alpha 0.0087 0.0805 0.0923
Echinococcus granulosus nuclear receptor nhr 48 0.013 0.126 0.1444
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.002
Leishmania major hypothetical protein, conserved 0.0149 0.1461 1
Brugia malayi Dopamine receptor 0.0032 0.022 0.0406
Schistosoma mansoni hypothetical protein 0.0308 0.3151 0.3611
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0139 0.3291
Loa Loa (eye worm) hypothetical protein 0.0241 0.2435 0.4493
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.022 0.0252
Echinococcus multilocularis g protein coupled receptor 0.0032 0.022 0.0252
Onchocerca volvulus 0.0035 0.0245 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) fli-1 protein 0.0265 0.2695 0.4972
Schistosoma mansoni thyroid hormone receptor 0.0276 0.2809 0.3219
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0325 0.2222
Echinococcus multilocularis solute carrier family 5 0.0046 0.0368 0.0422
Echinococcus multilocularis muscleblind protein 1 0.018 0.1792 0.2054
Schistosoma mansoni neuropeptide receptor 0.0032 0.022 0.0252
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.022 0.0252
Schistosoma mansoni hypothetical protein 0.0049 0.0398 0.0456
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0023 0.0122 0.0122
Brugia malayi hypothetical protein 0.0032 0.022 0.0406
Schistosoma mansoni cpg binding protein 0.0037 0.0266 0.0304
Trichomonas vaginalis glutaminase, putative 0.033 0.3381 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0276 0.2809 0.3219
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0139 0.2907
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0218 0.149
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.1911 0.219
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0371 0.0426
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0079 0.009
Echinococcus granulosus protein C ets 2 0.0013 0.0011 0.0013
Brugia malayi nuclear hormone receptor family member nhr-6 0.013 0.126 0.2324
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0032 0.0218 0.025
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0122 0.0224
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0194 0.1145
Echinococcus granulosus thyroid hormone receptor alpha 0.013 0.126 0.1444
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0398 0.0735
Loa Loa (eye worm) hypothetical protein 0.0156 0.1535 0.2832
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0183 0.021
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.044 0.0504
Trichomonas vaginalis chaperonin, putative 0.0025 0.0139 0.0112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.1461 0.1674
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0371 0.0426
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.014 0.0258
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0371 0.0425
Echinococcus multilocularis fmrfamide receptor 0.0032 0.022 0.0252
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0298 0.055
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.2435 0.2791
Brugia malayi hypothetical protein 0.0146 0.1426 0.263
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8725 1
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.022 0.0252
Brugia malayi mbt repeat family protein 0.0047 0.0371 0.0685
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.013 0.126 0.1999
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0522 0.5421 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0125 0.007
Leishmania major GTP-binding protein, putative 0.0021 0.0102 0.0699
Echinococcus multilocularis ecdysone induced protein 78C 0.0276 0.2809 0.3219
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0149 0.1461 0.1461
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0183 0.1253
Brugia malayi Serotonin receptor 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.042 0.4333 0.7994
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Trichomonas vaginalis esterase, putative 0.0149 0.1461 0.4144
Schistosoma mansoni retinoic acid receptor RXR 0.0276 0.2809 0.3219
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0146 0.1426 0.1634
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.014 0.0161
Leishmania major importin beta-1 subunit, putative 0.0023 0.0125 0.0856
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0122 0.0224
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0276 0.2809 0.5182
Echinococcus granulosus translocator protein 0.0522 0.5421 0.6213
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0146 0.1426 0.263
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0183 0.1253
Onchocerca volvulus 0.0522 0.5421 1
Echinococcus granulosus somatostatin receptor 0.0032 0.022 0.0252
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0288 0.7471
Brugia malayi MH1 domain containing protein 0.0025 0.014 0.0258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.022 0.0252
Schistosoma mansoni coup transcription factor 0.0276 0.2809 0.3219
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0139 0.0159
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0164 0.1125
Schistosoma mansoni adenoreceptor 0.0032 0.022 0.0252
Schistosoma mansoni blooms syndrome DNA helicase 0.0033 0.0225 0.0257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.1461 0.1674
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.022 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0205
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0288 0.1974
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.013 0.126 0.1444
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.022 0.0252
Leishmania major DNA damage repair protein, putative 0.0014 0.003 0.0205
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0102 0.0504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0276 0.2809 0.5182
Schistosoma mansoni DNA polymerase eta 0.0077 0.0698 0.08
Brugia malayi Steroid receptor seven-up type 2 0.0276 0.2809 0.5182
Schistosoma mansoni steroid hormone receptor ad4bp 0.0276 0.2809 0.3219
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.1876 0.3462
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.022 0.0252
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.003 0.0205
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0298 0.204
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.022 0.0252
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.044 0.0504
Loa Loa (eye worm) hypothetical protein 0.0149 0.1461 0.2695
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8725 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.1461 0.4144
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Mycobacterium tuberculosis Probable lipase LipD 0.0149 0.1461 0.1461
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Brugia malayi MH2 domain containing protein 0.0025 0.014 0.0258
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.022 0.0406
Echinococcus granulosus ecdysone induced protein 78C 0.0276 0.2809 0.3219
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0298 0.7766
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.022 0.0252
Echinococcus granulosus Smad4 0.0025 0.014 0.0161
Echinococcus multilocularis transcription factor btf3 0.0042 0.0325 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0122 0.0224
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0005 0.0006
Echinococcus granulosus solute carrier family 5 0.0046 0.0368 0.0422
Schistosoma mansoni nuclear hormone receptor 0.0276 0.2809 0.3219
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.022 0.0252
Schistosoma mansoni ran 0.0021 0.0102 0.0117
Echinococcus multilocularis neuropeptide receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0522 0.5421 1
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0139 0.0112
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0298 0.204
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0218 0.1491
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0146 0.1426 0.1634
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.022 0.0252
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0516 0.0951
Brugia malayi Nuclear hormone receptor-like 1 0.0146 0.1426 0.263
Brugia malayi hypothetical protein 0.0027 0.0164 0.0303
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.003 0.0205
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0005 0.0006
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.044 0.0504
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0254 0.1738
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Plasmodium falciparum importin beta, putative 0.0029 0.0183 0.4622
Echinococcus granulosus Nuclear hormone receptor HR96 0.013 0.126 0.1444
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0011 0.0013
Brugia malayi hypothetical protein 0.0032 0.022 0.0406
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.022 0.0252
Schistosoma mansoni thyroid hormone receptor 0.0276 0.2809 0.3219
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Schistosoma mansoni amine GPCR 0.0032 0.022 0.0252
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.1876 0.3462
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.014 0.0161
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0276 0.2809 0.3219
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0288 0.0331
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.022 0.0252
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0657 0.0753
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.2435 0.2791
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.002
Echinococcus granulosus allatostatin A receptor 0.0032 0.022 0.0252
Brugia malayi Disco-interacting protein 2 homolog 0.0023 0.0122 0.0224
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0036 0.0255 0.1747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0276 0.2809 0.5182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0053 0.044 0.0812
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1876 0.2151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.022 0.0252
Brugia malayi beta-lactamase 0.0149 0.1461 0.2695
Loa Loa (eye worm) hypothetical protein 0.0276 0.2809 0.5182
Schistosoma mansoni hypothetical protein 0.0032 0.022 0.0252
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0183 0.1253
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0288 0.1974
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0288 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0298 0.0598
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.022 0.0252
Brugia malayi putative neuropeptide receptor 0.0032 0.022 0.0406
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0032 0.0218 0.5673
Echinococcus granulosus sodium:glucose cotransporter 0.0046 0.0368 0.0422
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Brugia malayi Serotonin receptor 0.0032 0.022 0.0406
Onchocerca volvulus 0.0276 0.2809 0.4978
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8725 1
Schistosoma mansoni hypothetical protein 0.0032 0.022 0.0252
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.022 0.0252
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0102 0.0699
Schistosoma mansoni hypothetical protein 0.0019 0.0079 0.009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0276 0.2809 0.5182
Entamoeba histolytica hypothetical protein 0.0042 0.0325 0.8577
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0276 0.2809 0.5182
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0276 0.2809 0.5182
Schistosoma mansoni DNA helicase recq5 0.0032 0.0218 0.025
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0371 0.0426
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5121 0.587
Schistosoma mansoni sodium/solute symporter 0.0046 0.0368 0.0422
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0079 0.0145
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.003 0.0205
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0298 0.0342
Brugia malayi Smad1 0.0025 0.014 0.0258
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.022 0.0252
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.005 0.0345
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0187 0.1281
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0371 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.022 0.0252
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0139 0.0256
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0022 0.0106 0.0106
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0102 0.0188
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0371 0.0426
Brugia malayi neuropeptide F receptor 0.0032 0.022 0.0406
Brugia malayi Inositol-1 0.004 0.0298 0.055
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0102 0.0699
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.013 0.126 0.1444
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0298 0.0342
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0122 0.0224
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0224
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0023 0.0122 0.0833
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0146 0.1426 0.1634
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.1876 0.2151
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.022 0.0252
Echinococcus multilocularis high affinity choline transporter 1 0.042 0.4333 0.4967
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.022 0.0252
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0288 0.0568
Brugia malayi Bloom's syndrome protein homolog 0.0049 0.0399 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0276 0.2809 0.5182
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.022 0.0252
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0276 0.2809 0.3219
Brugia malayi steroid hormone receptor 0.0276 0.2809 0.5182
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.022 0.0252
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0371 0.0426
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.022 0.0406
Echinococcus granulosus sodium:glucose cotransporter 2 0.0046 0.0368 0.0422
Trichomonas vaginalis DNA helicase recq1, putative 0.0049 0.0399 0.0904
Loa Loa (eye worm) hypothetical protein 0.0149 0.1461 0.2695
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0139 0.0159
Brugia malayi hypothetical protein 0.0241 0.2435 0.4493
Loa Loa (eye worm) hypothetical protein 0.0146 0.1426 0.263
Loa Loa (eye worm) hypothetical protein 0.0032 0.0218 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0276 0.2809 0.5182
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.022 0.0406
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0079 0.0145
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.022 0.0252
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0006
Brugia malayi Nuclear hormone receptor E75 0.013 0.126 0.2324
Echinococcus multilocularis serotonin receptor 0.0032 0.022 0.0252
Schistosoma mansoni smad1 5 8 and 0.0025 0.014 0.0161
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0218 0.1491
Brugia malayi Nuclear hormone receptor E75 0.013 0.126 0.2324
Schistosoma mansoni transcription factor btf3 0.0042 0.0325 0.0372
Brugia malayi beta-lactamase family protein 0.0149 0.1461 0.2695
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0276 0.2809 0.3219
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0011 0.0013
Brugia malayi follicle stimulating hormone receptor 0.0032 0.022 0.0406
Schistosoma mansoni nuclear receptor nhr-48 0.013 0.126 0.1444
Schistosoma mansoni elf1 0.0013 0.0011 0.0013
Entamoeba histolytica hypothetical protein 0.0023 0.0125 0.2482
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus granulosus neuropeptide s receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Echinococcus granulosus disco interacting protein 2 0.0023 0.0122 0.0139
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0139 0.0951
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0325 0.0599
Leishmania major DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Mycobacterium ulcerans hypothetical protein 0.0014 0.003 0.0055
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.1911 0.219
Echinococcus multilocularis sex peptide receptor 0.0032 0.022 0.0252
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.022 0.0252
Echinococcus multilocularis snurportin 1 0.0308 0.3151 0.3611
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0046 0.0368 0.0422
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0371 0.0685
Trypanosoma brucei unspecified product 0.0047 0.0371 0.2541
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.022 0.0406
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0102 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Schistosoma mansoni nuclear hormone receptor 0.013 0.126 0.1444
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.022 0.0252
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.005 0.0345
Brugia malayi hypothetical protein 0.013 0.126 0.2324
Schistosoma mansoni amine GPCR 0.0032 0.022 0.0252
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0298 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0276 0.2809 0.3219
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.014 0.0161
Echinococcus granulosus dna polymerase kappa 0.0047 0.0371 0.0425
Schistosoma mansoni smad 0.0025 0.014 0.0161
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.022 0.0252
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0371 0.2541
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.022 0.0252
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0805 0.0923
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus multilocularis nuclear receptor nhr 48 0.013 0.126 0.1444
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.022 0.0406
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0046 0.0361 1
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.022 0.0252
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0254 0.0254
Brugia malayi polk-prov protein 0.0014 0.003 0.0055
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0371 0.0685
Echinococcus multilocularis Nuclear hormone receptor HR96 0.013 0.126 0.1444
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0522 0.5421 1
Schistosoma mansoni hypothetical protein 0.0494 0.5121 0.587
Brugia malayi hypothetical protein 0.0032 0.022 0.0406
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0149 0.1461 0.1461
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.022 0.0252
Brugia malayi CXXC zinc finger family protein 0.0035 0.0245 0.0451
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0164 0.4057
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0164 0.1125
Onchocerca volvulus 0.0149 0.1461 0.2386
Onchocerca volvulus 0.0522 0.5421 1
Schistosoma mansoni amine GPCR 0.0032 0.022 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0276 0.2809 0.5182
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.022 0.0406
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0298 0.204
Loa Loa (eye worm) hypothetical protein 0.0276 0.2809 0.5182
Echinococcus granulosus g protein coupled receptor 0.0032 0.022 0.0252
Brugia malayi hypothetical protein 0.013 0.126 0.2324
Loa Loa (eye worm) hypothetical protein 0.0149 0.1461 0.2695
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0288 0.0568
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.022 0.0252
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0276 0.2809 0.3219
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0011 0.002
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.022 0.0252
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0102 0.0117
Schistosoma mansoni biogenic amine receptor 0.0032 0.022 0.0252
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.022 0.0406
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0325 0.2222
Brugia malayi G-protein coupled receptor 0.0032 0.022 0.0406
Onchocerca volvulus 0.0522 0.5421 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.022 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.022 0.0252
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0276 0.2809 0.3219
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.022 0.0252
Brugia malayi Importin beta-1 subunit 0.0029 0.0183 0.0338
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0516 0.0951
Mycobacterium ulcerans glutaminase 0.033 0.3381 0.6238
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.014 0.0161
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0578
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.022 0.0406
Schistosoma mansoni hypothetical protein 0.0013 0.0011 0.0013
Trypanosoma brucei unspecified product 0.0032 0.0218 0.149
Schistosoma mansoni hypothetical protein 0.0032 0.022 0.0252
Schistosoma mansoni opsin-like receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0164 0.1125
Schistosoma mansoni hypothetical protein 0.0013 0.0011 0.0013
Mycobacterium tuberculosis Conserved protein 0.0149 0.1461 0.1461
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.1461 0.4144
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.1461 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0338
Brugia malayi Dopamine receptor protein 1 0.0032 0.022 0.0406
Schistosoma mansoni hypothetical protein 0.0019 0.0079 0.009
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0149 0.1461 0.2695
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.022 0.0252
Brugia malayi Melatonin receptor type 1A 0.0032 0.022 0.0406
Brugia malayi beta-NAC-like protein 0.0042 0.0325 0.0599
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.3151 0.5813
Leishmania major DNA polymerase eta, putative 0.0045 0.0357 0.2441
Onchocerca volvulus 0.0149 0.1461 0.2386
Schistosoma mansoni nuclear hormone receptor 0.013 0.126 0.1444
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0276 0.2809 0.3219
Schistosoma mansoni opsin-like receptor 0.0032 0.022 0.0252
Brugia malayi tailless protein 0.013 0.126 0.2324
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.014 0.0161
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0016 0.0044 0.0097
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0288 0.7574
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.022 0.0252
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.022 0.0252
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0276 0.2809 0.3219
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0288 0.0288
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.022 0.0252
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0325 0.8577
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.003 0.0205
Schistosoma mansoni high-affinity choline transporter 0.042 0.4333 0.4967
Brugia malayi AKH receptor 0.0032 0.022 0.0406
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.022 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0276 0.2809 0.5182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0224
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.022 0.0252
Echinococcus granulosus fmrfamide receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0149 0.1461 0.2695
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0139 0.0951
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.022 0.0252
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0325 0.8895
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0102 0.2178
Brugia malayi nuclear hormone receptor 0.013 0.126 0.2324
Brugia malayi beta-lactamase family protein 0.0149 0.1461 0.2695
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0011 0.0013
Brugia malayi MH1 domain containing protein 0.0014 0.0022 0.0041
Schistosoma mansoni neuropeptide receptor 0.0032 0.022 0.0252
Brugia malayi ORL1-like opioid receptor 0.0032 0.022 0.0406
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0149 0.1461 0.1461
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0313 0.0578
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0371 0.0685
Echinococcus granulosus dna polymerase eta 0.0077 0.0698 0.08
Mycobacterium ulcerans esterase/lipase LipP 0.0149 0.1461 0.2695
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.022 0.0252
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.003 0.0034
Schistosoma mansoni ets-related 0.0013 0.0011 0.0013
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0371 0.0371
Brugia malayi hypothetical protein 0.0032 0.022 0.0406
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.022 0.0252
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0164 0.1125
Brugia malayi Sodium:solute symporter family protein 0.0046 0.0368 0.0679
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0276 0.2809 0.5182
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.022 0.0252
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0298 0.0598
Loa Loa (eye worm) nuclear hormone receptor 0.013 0.126 0.2324
Echinococcus multilocularis smad 0.0025 0.014 0.0161
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0522 0.5421 1
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0288 0.1806
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0276 0.2809 0.5182
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.1461 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0371 0.2541
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0139 0.0256
Echinococcus granulosus bloom syndrome protein 0.0049 0.0399 0.0457
Echinococcus multilocularis beta LACTamase domain containing family member 0.0149 0.1461 0.1674
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0122 0.0122
Schistosoma mansoni cpg binding protein 0.0035 0.0245 0.028
Brugia malayi nuclear receptor NHR-67 0.013 0.126 0.2324
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0079 0.009
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0245 0.0451
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0303
Echinococcus granulosus orexin receptor type 2 0.0032 0.022 0.0252
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0139 0.0762
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0276 0.2809 0.5182
Trichomonas vaginalis DNA helicase recq, putative 0.0049 0.0399 0.0904
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.022 0.0406
Echinococcus granulosus g protein coupled receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.022 0.0406
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.003 0.0205
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0146 0.1426 0.1634
Echinococcus granulosus high affinity choline transporter 1 0.042 0.4333 0.4967
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.022 0.0252
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.022 0.0252
Brugia malayi G protein-coupled receptor 0.0032 0.022 0.0406
Schistosoma mansoni hypothetical protein 0.0041 0.0313 0.0359
Loa Loa (eye worm) inositol-1 0.004 0.0298 0.055
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.018 0.1792 0.3305
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.022 0.0252
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0164 0.0939
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.022 0.0252
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0023 0.0122 0.0139
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0516 0.0951
Schistosoma mansoni zinc finger protein 0.013 0.126 0.1444
Leishmania major hypothetical protein, conserved 0.0027 0.0164 0.1125
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0011 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0079 0.0145
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Entamoeba histolytica recQ family DNA helicase 0.0016 0.005 0.0202
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus granulosus muscleblind protein 0.018 0.1792 0.2054
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0276 0.2809 0.3219
Trypanosoma brucei unspecified product 0.0032 0.0218 0.149
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5121 0.587
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.022 0.0406
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0357 0.2441
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.022 0.0252
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0139 0.0159
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0125 0.0856
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Echinococcus multilocularis neuropeptide receptor 0.0032 0.022 0.0252
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) glutaminase 2 0.033 0.3381 0.6238
Loa Loa (eye worm) hypothetical protein 0.0146 0.1426 0.263
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0298 0.204
Echinococcus granulosus importin subunit beta 1 0.0029 0.0183 0.021
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0288 0.1974
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0139 0.3195
Schistosoma mansoni nuclear receptor 0.013 0.126 0.1444
Brugia malayi nuclear receptor RXR 0.0146 0.1426 0.263
Schistosoma mansoni smad1 5 8 and 0.0025 0.014 0.0161
Trypanosoma brucei hypothetical protein, conserved 0.0149 0.1461 1
Schistosoma mansoni ran 0.0021 0.0102 0.0117
Echinococcus granulosus Nuclear hormone receptor HR96 0.013 0.126 0.1444
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0298 0.204
Giardia lamblia DINP protein human, muc B family 0.0047 0.0371 1
Brugia malayi MH1 domain containing protein 0.0014 0.0022 0.0041
Brugia malayi hypothetical protein 0.0032 0.022 0.0406
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0371 0.0426
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.044 0.0504
Echinococcus granulosus cpg binding protein 0.0037 0.0266 0.0304
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.022 0.0406
Echinococcus granulosus neuropeptide receptor 0.0032 0.022 0.0252
Brugia malayi mbt repeat family protein 0.0047 0.0371 0.0685
Schistosoma mansoni Smad4 0.0025 0.014 0.0161
Echinococcus granulosus FTZ F1 alpha 0.0276 0.2809 0.3219
Brugia malayi Fli-1 protein 0.0265 0.2695 0.4972
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0011 0.0013
Schistosoma mansoni ets 0.0013 0.0011 0.0013
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0122 0.0122
Echinococcus granulosus smad 0.0025 0.014 0.0161
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0805 0.0923
Mycobacterium ulcerans hypothetical protein 0.0149 0.1461 0.2695
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Loa Loa (eye worm) hypothetical protein 0.0075 0.067 0.1236
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0371 0.2541
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0276 0.2809 0.5182
Brugia malayi nuclear receptor RXR 0.013 0.126 0.2324
Onchocerca volvulus Protein ultraspiracle homolog 0.0276 0.2809 0.4978
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.1876 0.2151
Loa Loa (eye worm) glutaminase 0.033 0.3381 0.6238
Echinococcus granulosus snurportin 1 0.0308 0.3151 0.3611
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.1876 0.2151
Echinococcus granulosus g-protein coupled receptor 0.0032 0.022 0.0252
Echinococcus multilocularis allatostatin A receptor 0.0032 0.022 0.0252
Echinococcus multilocularis muscleblind protein 0.018 0.1792 0.2054
Brugia malayi glutaminase DH11.1 0.033 0.3381 0.6238
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0139 0.0951
Schistosoma mansoni survival motor neuron protein 0.0049 0.0398 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Brugia malayi Cytochrome P450 family protein 0.0074 0.0667 0.123
Mycobacterium tuberculosis Probable esterase LipL 0.0149 0.1461 0.1461
Toxoplasma gondii ABC1 family protein 0.0149 0.1461 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0149 0.1461 0.1674
Loa Loa (eye worm) hypothetical protein 0.018 0.1792 0.3305
Loa Loa (eye worm) hypothetical protein 0.0046 0.0368 0.0679
Plasmodium vivax importin-beta 2, putative 0.0029 0.0183 0.107
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0276 0.2809 0.5182
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.1461 0.4144
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0036 0.0255 0.1747
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.022 0.0406
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0011 0.0013
Brugia malayi orphan nuclear receptor NR2E1 0.013 0.126 0.2324
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.013 0.126 0.1444
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0011 0.002
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.0368 0.2518
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0102 0.0699
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0276 0.2809 0.5182
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Brugia malayi nuclear hormone receptor 0.0276 0.2809 0.5182
Loa Loa (eye worm) steroid hormone receptor 0.0276 0.2809 0.5182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0145
Schistosoma mansoni RAR-like nuclear receptor 0.0276 0.2809 0.3219
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.022 0.0252
Leishmania major DNA polymerase eta, putative 0.0077 0.0698 0.4777
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.003 0.0205
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0698 0.4777
Brugia malayi GnHR receptor homolog 0.0032 0.022 0.0406
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0125 0.007
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0371 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.1461 0.4144
Mycobacterium ulcerans lipase LipD 0.0149 0.1461 0.2695
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0047 0.0371 0.0685
Brugia malayi TspO/MBR family protein 0.0522 0.5421 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0032 0.0218 0.5506
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0276 0.2809 0.3219
Mycobacterium ulcerans beta-lactamase 0.0149 0.1461 0.2695
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0023 0.0122 0.0833
Loa Loa (eye worm) Smad1 0.0025 0.014 0.0258
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0288 0.7802
Mycobacterium tuberculosis Probable hydrolase 0.0149 0.1461 0.1461
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0371 0.0821
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0276 0.2809 0.3219
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0371 0.0685
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0122 0.0224
Echinococcus granulosus sex peptide receptor 0.0032 0.022 0.0252
Schistosoma mansoni hypothetical protein 0.0173 0.1715 0.1965
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0125 0.007
Echinococcus granulosus transcription factor btf3 0.0042 0.0325 0.0372
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.022 0.0252
Onchocerca volvulus 0.0046 0.0368 0.0284
Echinococcus multilocularis somatostatin receptor 0.0032 0.022 0.0252
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0011 0.0013
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.003 0.0205
Schistosoma mansoni ap endonuclease 0.0039 0.0288 0.0331
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.013 0.126 0.1999
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.022 0.0252
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0011 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0288 0.1974
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0288 0.0331
Brugia malayi ecdysteroid receptor 0.0276 0.2809 0.5182
Brugia malayi hypothetical protein 0.0032 0.022 0.0406
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.022 0.0252
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0102 0.2114
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.022 0.0252
Echinococcus granulosus sodium:myo inositol cotransporter 0.0046 0.0368 0.0422
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Entamoeba histolytica Ran family GTPase 0.0021 0.0102 0.178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.022 0.0252
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0019 0.0079 0.009
Onchocerca volvulus 0.013 0.126 0.1999
Brugia malayi Nuclear hormone receptor-like 1 0.0276 0.2809 0.5182
Leishmania major DNA polymerase kappa, putative 0.0014 0.003 0.0205
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0079 0.009
Schistosoma mansoni hypothetical protein 0.0032 0.022 0.0252
Onchocerca volvulus 0.013 0.126 0.1999
Mycobacterium leprae Probable lipase LipE 0.0149 0.1461 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0032 0.0218 0.025
Loa Loa (eye worm) hypothetical protein 0.0149 0.1461 0.2695
Schistosoma mansoni neuropeptide receptor 0.0032 0.022 0.0252
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0298 0.0598
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0371 0.0425
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.014 0.0258
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.003 0.0205
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.013 0.126 0.2324
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0139 0.0159
Schistosoma mansoni myosin xvIII 0.0032 0.022 0.0252
Brugia malayi GH02984p 0.042 0.4333 0.7994
Schistosoma mansoni nuclear receptor 0.013 0.126 0.1444
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0325 0.0679
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0093
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Loa Loa (eye worm) DR-78 0.013 0.126 0.2324
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0149 0.1461 0.2695
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0698 0.4777
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.022 0.0252
Schistosoma mansoni ap endonuclease 0.0039 0.0288 0.0331
Echinococcus multilocularis geminin 0.0173 0.1715 0.1965
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0522 0.5421 0.6213
Echinococcus multilocularis FTZ F1 alpha 0.0276 0.2809 0.3219
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.022 0.0406
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0218 0.0402
Loa Loa (eye worm) MBCTL1 0.0053 0.044 0.0812
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.022 0.0406
Onchocerca volvulus 0.0049 0.0398 0.0342
Brugia malayi hypothetical protein 0.0032 0.022 0.0406
Echinococcus multilocularis Smad4 0.0025 0.014 0.0161
Loa Loa (eye worm) nuclear factor I 0.0014 0.0022 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.022 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.022 0.0252
Schistosoma mansoni hypothetical protein 0.0291 0.2969 0.3403
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.022 0.0252
Schistosoma mansoni neuropeptide receptor 0.0032 0.022 0.0252
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.044 0.0812
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.003 0.0205
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Loa Loa (eye worm) hypothetical protein 0.0276 0.2809 0.5182
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0371 0.0425
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.003 0.0205
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0041
Onchocerca volvulus 0.0047 0.0371 0.0291
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0011 0.002
Schistosoma mansoni opsin-like receptor 0.0032 0.022 0.0252
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0325 0.2059
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.013 0.126 0.1444
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.0368 0.0422
Brugia malayi larval opioid receptor 0.0032 0.022 0.0406
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0371 0.0425
Echinococcus multilocularis disco interacting protein 2 0.0023 0.0122 0.0139
Brugia malayi hypothetical protein 0.0018 0.0062 0.0115
Echinococcus granulosus g protein coupled receptor 0.0032 0.022 0.0252
Brugia malayi Muscleblind-like protein 0.018 0.1792 0.3305
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0036 0.0255 0.1747
Schistosoma mansoni hypothetical protein 0.0173 0.1715 0.1965
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0218 0.0402
Brugia malayi Dopamine receptor protein 2 0.0032 0.022 0.0406
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0164 0.4057
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.022 0.0252
Echinococcus multilocularis fmrfamide receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0149 0.1461 0.2695
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0371 0.2541
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.022 0.0406
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0079 0.009
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0698 0.1287
Schistosoma mansoni ets-related 0.0265 0.2695 0.3089
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0288 0.0532
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.022 0.0252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.013 0.126 0.1444
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0276 0.2809 0.3219
Brugia malayi MH2 domain containing protein 0.0025 0.014 0.0258
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0139 0.0256
Echinococcus granulosus GPCR family 2 0.0019 0.0079 0.009
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0022 0.0106 0.0106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.1876 0.2151
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.022 0.0252
Schistosoma mansoni inositol transporter 0.0046 0.0368 0.0422
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0276 0.2809 0.3219
Echinococcus multilocularis cpg binding protein 0.0037 0.0266 0.0304
Loa Loa (eye worm) MH2 domain-containing protein 0.0365 0.3748 0.6914
Brugia malayi Nuclear hormone receptor-like 1 0.0146 0.1426 0.263
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0205
Echinococcus granulosus serotonin receptor 0.0032 0.022 0.0252
Echinococcus multilocularis thyroid hormone receptor alpha 0.0276 0.2809 0.3219
Brugia malayi G-protein coupled receptor 0.0032 0.022 0.0406
Brugia malayi hypothetical protein 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Brugia malayi Ets-domain containing protein 0.0013 0.0011 0.002
Schistosoma mansoni inositol transporter 0.0046 0.0368 0.0422
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.022 0.0252
Mycobacterium tuberculosis Conserved protein 0.0149 0.1461 0.1461
Brugia malayi RNA, U transporter 1 0.0082 0.0749 0.1381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.022 0.0252
Mycobacterium leprae conserved hypothetical protein 0.0149 0.1461 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0371 0.0425
Schistosoma mansoni glutaminase 0.033 0.3381 0.3876
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0102 0.0117
Schistosoma mansoni hypothetical protein 0.0019 0.0079 0.009
Brugia malayi RE15519p 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.0146 0.1426 0.263
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0102 0.0699
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0146 0.1426 0.263
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.013 0.126 0.2324
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0325 0.2222
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.005 0.0058
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.022 0.0252
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0371 0.0426
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.022 0.0252
Onchocerca volvulus 0.0149 0.1461 0.2386
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0276 0.2809 0.5182
Loa Loa (eye worm) hypothetical protein 0.0146 0.1426 0.263
Loa Loa (eye worm) hypothetical protein 0.0522 0.5421 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1876 0.2151
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0122 0.0833
Brugia malayi transcription factor E74 isoform 0.0013 0.0011 0.002
Brugia malayi hypothetical protein 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Schistosoma mansoni biogenic amine receptor 0.0032 0.022 0.0252
Echinococcus multilocularis ets variant gene 4 0.0013 0.0011 0.0013
Brugia malayi Ets-domain containing protein 0.0087 0.0805 0.1485
Brugia malayi photoreceptor-specific nuclear receptor 0.0276 0.2809 0.5182
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0218 0.149
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0667 0.123
Echinococcus multilocularis orexin receptor type 2 0.0032 0.022 0.0252
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.022 0.0252
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0574 0.3929
Brugia malayi hypothetical protein 0.0032 0.022 0.0406
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0406
Brugia malayi sulfakinin receptor protein 0.0032 0.022 0.0406
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0139 0.0159
Schistosoma mansoni histamine h1 receptor 0.0032 0.022 0.0252
Loa Loa (eye worm) RecQ helicase 0.0049 0.0399 0.0735
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0046 0.0368 0.0422
Loa Loa (eye worm) hypothetical protein 0.0276 0.2809 0.5182
Schistosoma mansoni importin beta-1 0.0029 0.0183 0.021
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0032 0.0218 0.025

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 24.12 um PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP). Inhibition of the rate of hydrolysis of fluorogenic peptide substrate (H-Leu-NHMec). Secondary screen (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 45.79 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 53.5818 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction: HTRF assay against cherry picks. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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