Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0186 | 0.6382 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0073 | 0 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0186 | 0.6382 | 0.6382 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0186 | 0.6382 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0251 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0186 | 0.6382 | 0.6382 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.0222 | 0.0222 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0251 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0186 | 0.6382 | 0.6382 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0251 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0251 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0251 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0251 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0251 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0073 | 0 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0119 | 0.2602 | 0.2602 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0251 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0186 | 0.6382 | 0.6382 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0186 | 0.6382 | 0.6382 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0186 | 0.6382 | 0.6382 |
Brugia malayi | hypothetical protein | 0.0119 | 0.2602 | 0.2602 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0081 | 0.0426 | 0.0426 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0186 | 0.6382 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0251 | 1 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0077 | 0.0222 | 0.0222 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0251 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0.2602 | 0.4078 |
Schistosoma mansoni | glycogen phosphorylase | 0.0186 | 0.6382 | 0.6382 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0081 | 0.0426 | 0.0668 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0186 | 0.6382 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0186 | 0.6382 | 0.6382 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0186 | 0.6382 | 0.6382 |
Echinococcus granulosus | glycogen phosphorylase | 0.0186 | 0.6382 | 0.6382 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0186 | 0.6382 | 0.6382 |
Schistosoma mansoni | glycogen phosphorylase | 0.0081 | 0.0426 | 0.0426 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0081 | 0.0426 | 0.0426 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0251 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0119 | 0.2602 | 0.2602 |
Giardia lamblia | Glycogen phosphorylase | 0.0186 | 0.6382 | 1 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0081 | 0.0426 | 0.0668 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0251 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0186 | 0.6382 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0081 | 0.0426 | 0.0668 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0251 | 1 | 1 |
Onchocerca volvulus | 0.0251 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.