TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.621 | Formula: C26H40N4O3
H donors: 1 H acceptors: 2 LogP: 2.61 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CN(Cc1cccc(c1)OCCN1CCN(CC1)C(=O)CC1CCCC1)CC1CCC(=O)N1
InChi: 1S/C26H40N4O3/c1-28(20-23-9-10-25(31)27-23)19-22-7-4-8-24(17-22)33-16-15-29-11-13-30(14-12-29)26(32)18-21-5-2-3-6-21/h4,7-8,17,21,23H,2-3,5-6,9-16,18-20H2,1H3,(H,27,31)
InChiKey: JTJYSGBKKYFQRZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Wolbachia endosymbiont of Brugia malayi	deoxycytidine triphosphate deaminase	0.0116	0.2191	0.2509
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0348	0.1589
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0234
Entamoeba histolytica	90 kDa heat shock protein, putative	0.003	0.046	0.036
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0095	0.1753	0.2645
Schistosoma mansoni	hypothetical protein	0.017	0.3268	0.4943
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0039	0.0637	0.0594
Loa Loa (eye worm)	fatty acid synthase	0.0025	0.0342	0.0503
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0335	0.6602	0.6566
Onchocerca volvulus	Fatty acid synthase homolog	0.0045	0.0752	0.3036
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0165	0.0181
Trichomonas vaginalis	CAMK family protein kinase	0.0095	0.1753	0.1666
Trypanosoma cruzi	heat shock protein 90, putative	0.0039	0.0637	0.0538
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0046	0.0054
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0164	0.0234
Schistosoma mansoni	hypothetical protein	0.017	0.3268	0.4943
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0164	0.0248
Trypanosoma cruzi	heat shock protein 90, putative	0.0046	0.0771	0.0673
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0047	0.0798	0.1209
Trichomonas vaginalis	heat shock protein, putative	0.0033	0.0517	0.0417
Trypanosoma cruzi	thymidine kinase, putative	0.0504	1	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0534	0.0795
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0355	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0235	0.0342
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0026	0.0379	0.1719
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0235	0.0132
Toxoplasma gondii	type I fatty acid synthase, putative	0.0018	0.0203	0.0241
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0235	0.0356
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0009	0.0018	0.0083
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0165	0.0235
Leishmania major	hypothetical protein, conserved	0.0025	0.0355	0.0253
Giardia lamblia	Grp94/Hsp90	0.0043	0.0714	0.0672
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0165	0.0181
Plasmodium vivax	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0335	0.6602	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0114	0.001
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0095	0.1753	0.1666
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0114	0.001
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Plasmodium vivax	endoplasmin, putative	0.0046	0.0771	0.0942
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.2257	0.3409
Entamoeba histolytica	deoxycytidine triphosphate deaminase, putative	0.0116	0.2191	0.2109
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0771	0.0673
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0235	0.0132
Trypanosoma brucei	heat shock protein 84, putative	0.003	0.046	0.036
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, putative	0.0116	0.2191	0.2109
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0026	0.0379	0.1732
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0023	0.0315	0.1439
Mycobacterium ulcerans	thioesterase TesA	0.0021	0.0264	0.1207
Schistosoma mansoni	heat shock protein	0.0046	0.0771	0.1155
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Schistosoma mansoni	DNA helicase recq1	0.001	0.0046	0.0054
Trypanosoma cruzi	heat shock protein 85, putative	0.0046	0.0771	0.0673
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0043	0.0714	0.0616
Entamoeba histolytica	heat shock protein 90, putative	0.0046	0.0771	0.0673
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0271	0.0344
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0046	0.0054
Mycobacterium ulcerans	thioesterase	0.0021	0.0264	0.1207
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0235	0.0342
Trichomonas vaginalis	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0335	0.6602	0.6566
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0235	0.1073
Loa Loa (eye worm)	hypothetical protein	0.005	0.0852	0.1278
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Toxoplasma gondii	heat shock protein 75, putative	0.003	0.046	0.0633
Entamoeba histolytica	hypothetical protein	0.0335	0.6602	0.6566
Giardia lamblia	Kinase, PLK	0.0095	0.1753	0.1716
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.2257	0.3409
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0355	0.0253
Schistosoma mansoni	heat shock protein	0.003	0.046	0.0683
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0235	0.1073
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0039	0.0637	0.0952
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.0335	0.6602	0.6566
Trypanosoma brucei	heat shock protein 90, putative	0.0046	0.0771	0.0673
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0771	0.0673
Onchocerca volvulus		0.0043	0.0721	0.2819
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0315	0.0477
Echinococcus granulosus	dna polymerase eta	0.0019	0.0235	0.0342
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0021	0.0264	0.1207
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0165	0.0249
Toxoplasma gondii	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0335	0.6602	1
Mycobacterium ulcerans	fatty acid synthase Fas	0.0008	0.0003	0.0015
Treponema pallidum	deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)	0.0335	0.6602	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0348	0.1589
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0852	0.1291
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.033	0.0228
Trypanosoma cruzi	heat shock protein 85, putative	0.0046	0.0771	0.0673
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0348	0.1589
Trichomonas vaginalis	endoplasmin, putative	0.0033	0.0517	0.0417
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0016	0.0178	0.0812
Mycobacterium leprae	Polyketide synthase Pks13	0.0037	0.0597	0.2713
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0016	0.0172	0.0192
Trypanosoma cruzi	polo-like protein kinase, putative	0.0095	0.1753	0.1666
Leishmania major	heat shock protein, putative	0.003	0.046	0.036
Trypanosoma brucei	unspecified product	0.0019	0.0235	0.0132
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.001	0.0049	0.0222
Schistosoma mansoni	endoplasmin	0.0046	0.0771	0.1155
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0534	0.0808
Toxoplasma gondii	Hsp90 domain-containing protein	0.0174	0.3353	0.5045
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0235	0.0342
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0025	0.0348	0.1576
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0165	0.0235
Trypanosoma cruzi	heat shock protein 90, putative	0.0019	0.0233	0.013
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0026	0.0379	0.1719
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0165	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0534	0.0795
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Echinococcus granulosus	heat shock protein	0.0046	0.0771	0.1155
Schistosoma mansoni	hypothetical protein	0.0016	0.0164	0.0234
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0074	0.0097
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0074	0.0097
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Mycobacterium tuberculosis	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)	0.0116	0.2191	1
Trichomonas vaginalis	thymidine kinase, putative	0.0504	1	1
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0026	0.0379	0.1732
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0025	0.0348	0.1589
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Loa Loa (eye worm)	heat shock protein 75	0.003	0.046	0.0683
Schistosoma mansoni	hypothetical protein	0.0016	0.0164	0.0234
Trichomonas vaginalis	CAMK family protein kinase	0.0095	0.1753	0.1666
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0046	0.00000000013904
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0771	0.0673
Wolbachia endosymbiont of Brugia malayi	dUTPase	0.0335	0.6602	1
Brugia malayi	dUTP diphosphatase	0.0335	0.6602	1
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0046	0.0054
Leishmania major	DNA polymerase eta, putative	0.0019	0.0235	0.0132
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0046	0.0054
Trichomonas vaginalis	CAMK family protein kinase	0.0095	0.1753	0.1666
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Trypanosoma cruzi	thymidine kinase, putative	0.0504	1	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0046	0.0771	0.0673
Schistosoma mansoni	endoplasmin	0.0046	0.0771	0.1155
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0355	0.0471
Echinococcus multilocularis	heat shock protein 90	0.0046	0.0771	0.1155
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0383	0.0282
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.033	0.05
Trichomonas vaginalis	heat shock protein, putative	0.0043	0.0714	0.0616
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.002	0.025	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0042	0.069	0.1032
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0024	0.0333	0.1519
Toxoplasma gondii	heat shock protein 90, putative	0.0046	0.0771	0.1106
Leishmania major	thymidine kinase, putative	0.0504	1	1
Trichomonas vaginalis	heat shock protein, putative	0.0046	0.0771	0.0673
Schistosoma mansoni	heat shock protein	0.0046	0.0771	0.1155
Echinococcus multilocularis	dUTP pyrophosphatase	0.0335	0.6602	1
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0235	0.1073
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0026	0.0379	0.1732
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0335	0.6602	0.6566
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0355	0.0471
Plasmodium falciparum	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0335	0.6602	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.0637	0.0538
Echinococcus granulosus	bloom syndrome protein	0.0024	0.033	0.0486
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0355	0.0471
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.033	0.0228
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0165	0.0235
Entamoeba histolytica	hypothetical protein	0.0116	0.2191	0.2109
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0235	0.0132
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0165	0.0061
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0164	0.0234
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0771	0.0673
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.003	0.046	0.1009
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0095	0.1753	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.002	0.025	0.1127
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0852	0.1278
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0025	0.0348	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0127	0.0178
Schistosoma mansoni	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0335	0.6602	1
Brugia malayi	MH1 domain containing protein	0.0008	0.001	0.0015
Schistosoma mansoni	kinase	0.0048	0.0815	0.1222
Plasmodium falciparum	heat shock protein 90, putative	0.0027	0.0383	0.0515
Plasmodium vivax	heat shock protein, putative	0.0174	0.3353	0.4953
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.079	0.0693
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0037	0.0597	0.2724
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0355	0.0253
Trichomonas vaginalis	thymidine kinase, putative	0.0504	1	1
Loa Loa (eye worm)	acyl carrier protein	0.0011	0.0077	0.0102
Chlamydia trachomatis	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0335	0.6602	1
Echinococcus granulosus	heat shock protein 90	0.0039	0.0637	0.0952
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0235	0.0132
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Trichomonas vaginalis	CAMK family protein kinase	0.0095	0.1753	0.1666
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0021	0.0264	0.1193
Schistosoma mansoni	hypothetical protein	0.0016	0.0164	0.0234
Mycobacterium ulcerans	polyketide synthase	0.0025	0.0348	0.1589
Mycobacterium ulcerans	polyketide synthase Pks9	0.0016	0.0178	0.0812
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0235	0.0342
Brugia malayi	heat shock protein 90	0.0046	0.0771	0.1168
Trypanosoma cruzi	polo-like protein kinase, putative	0.0095	0.1753	0.1666
Mycobacterium ulcerans	polyketide synthase	0.0026	0.0379	0.1732
Toxoplasma gondii	heat shock protein HSP90	0.0046	0.0771	0.1106
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0043	0.0714	0.3259
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.002	0.0257	0.1171
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0335	0.6602	0.6566
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0037	0.0597	0.2724
Trichomonas vaginalis	CAMK family protein kinase	0.0095	0.1753	0.1666
Loa Loa (eye worm)	heat shock protein 90	0.0046	0.0771	0.1155
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0164	0.0234
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0771	0.0673
Brugia malayi	MH2 domain containing protein	0.012	0.2257	0.3418
Trypanosoma cruzi	Heat shock protein 83, putative	0.0046	0.0771	0.0673
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0016	0.0173	0.0014
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.033	0.0486
Mycobacterium ulcerans	deoxycytidine triphosphate deaminase	0.0116	0.2191	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0165	0.0061
Echinococcus multilocularis	heat shock protein	0.0046	0.0771	0.1155
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0043	0.0714	0.3249
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0235	0.0342
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0235	0.0342
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0165	0.0235
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0235	0.0132
Plasmodium falciparum	endoplasmin, putative	0.0033	0.0517	0.0719
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0008	0.0003	0.0015
Giardia lamblia	Thymidine kinase	0.0504	1	1
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0235	0.0342
Loa Loa (eye worm)	RecQ helicase	0.0024	0.033	0.0486
Echinococcus granulosus	endoplasmin	0.0043	0.0714	0.1068
Brugia malayi	MH2 domain containing protein	0.0008	0.001	0.0015
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0235	0.1073
Brugia malayi	serine/threonine-protein kinase plk-2	0.0095	0.1753	0.2656
Entamoeba histolytica	heat shock protein 90, putative	0.0046	0.0771	0.0673
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0024	0.0333	0.1519
Entamoeba histolytica	hypothetical protein	0.0219	0.4256	0.4195
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0114	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Trichomonas vaginalis	thymidine kinase, putative	0.0504	1	1
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0771	0.0673
Echinococcus multilocularis	geminin	0.017	0.3268	0.4943
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.0335	0.6602	0.6566
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0095	0.1753	0.2645
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0026	0.0379	0.1732
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0018	0.0207	0.0943
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0165	0.0061
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0235	0.0356
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0165	0.0235
Schistosoma mansoni	hypothetical protein	0.0011	0.0074	0.0097
Plasmodium vivax	heat shock protein 90, putative	0.003	0.046	0.0459
Echinococcus granulosus	heat shock protein 90	0.0046	0.0771	0.1155
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0235	0.0342
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0013	0.01	0.0082
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0235	0.0191
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0165	0.0249
Plasmodium vivax	heat shock protein 86, putative	0.0046	0.0771	0.0942
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0852	0.1291
Plasmodium falciparum	heat shock protein 90, putative	0.0174	0.3353	0.5045
Trichomonas vaginalis	CAMK family protein kinase	0.0095	0.1753	0.1666
Mycobacterium leprae	PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)	0.0116	0.2191	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Trypanosoma brucei	heat shock protein 90, putative	0.0046	0.0771	0.0673
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0771	0.0673
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0046	0.0069
Echinococcus multilocularis	endoplasmin	0.0043	0.0714	0.1068
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.079	0.0693
Entamoeba histolytica	hypothetical protein	0.0335	0.6602	0.6566
Toxoplasma gondii	type I fatty acid synthase, putative	0.0026	0.0379	0.0509
Brugia malayi	hypothetical protein	0.0025	0.0355	0.0537
Echinococcus granulosus	GPCR family 2	0.0016	0.0164	0.0234
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0026	0.0379	0.1732
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0165	0.0181
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0014	0.0131	0.0599
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0016	0.0178	0.0798
Trichomonas vaginalis	heat shock protein, putative	0.0043	0.0714	0.0616
Loa Loa (eye worm)	endoplasmin	0.0046	0.0771	0.1155
Trypanosoma cruzi	heat shock protein, putative	0.003	0.046	0.036
Echinococcus granulosus	geminin	0.017	0.3268	0.4943
Brugia malayi	hypothetical protein	0.0016	0.0174	0.0264
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0095	0.1753	0.1666
Echinococcus granulosus	dUTP pyrophosphatase	0.0335	0.6602	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0095	0.1753	0.2645
Brugia malayi	MH1 domain containing protein	0.0008	0.001	0.0015
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.002	0.025	0.1141
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0164	0.0234
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0235	0.0132
Brugia malayi	MH2 domain containing protein	0.0008	0.001	0.0015
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0228	0.0332
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0235	0.0342
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0355	0.0295
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0165	0.0061
Leishmania major	heat shock protein 83-1	0.0046	0.0771	0.0673
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0348	0.1589
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0235	0.0132
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0169	0.0189
Trichomonas vaginalis	heat shock protein, putative	0.0039	0.0637	0.0538
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0335	0.6602	0.6566
Loa Loa (eye worm)	hypothetical protein	0.001	0.0046	0.0054
Brugia malayi	Smad1	0.0008	0.001	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0121	0.2286	0.3453
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0165	0.0235
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0165	0.0751
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0025	0.0348	0.1589
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.003	0.046	0.0683
Plasmodium falciparum	heat shock protein 90	0.0046	0.0771	0.1106
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0046	0.0054
Mycobacterium ulcerans	heat shock protein 90	0.0043	0.0714	0.3259
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0164	0.0248
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.1753	0.2645
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0046	0.0069
Schistosoma mansoni	hypothetical protein	0.0016	0.0164	0.0234
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0165	0.0235
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0235	0.0342
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0046	0.0771	0.0729
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Trypanosoma brucei	thymidine kinase	0.0504	1	1
Loa Loa (eye worm)	dUTP diphosphatase	0.0335	0.6602	1
Trypanosoma brucei	unspecified product	0.0013	0.0114	0.001
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0771	0.0673
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0026	0.0379	0.1719
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.003	0.046	0.0683
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0235	0.0132
Trypanosoma brucei	polo-like protein kinase	0.0095	0.1753	0.1666
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0348	0.1589
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0235	0.0132
Trypanosoma brucei	Heat shock protein 83, putative	0.0046	0.0771	0.0673
Echinococcus multilocularis	heat shock protein 90	0.0039	0.0637	0.0952
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0164	0.0234
Mycobacterium ulcerans	polyketide synthase Pks13	0.0037	0.0597	0.2724
Mycobacterium ulcerans	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0116	0.2191	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0355	0.0523
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0025	0.0348	0.1576
Brugia malayi	Endoplasmin precursor	0.0046	0.0771	0.1168
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0164	0.0234
Schistosoma mansoni	DNA helicase recq5	0.001	0.0046	0.0054
Entamoeba histolytica	hypothetical protein	0.0219	0.4256	0.4195
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0165	0.0061
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0235	0.0132
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0023	0.0315	0.0463
Trichomonas vaginalis	CAMK family protein kinase	0.0095	0.1753	0.1666
Brugia malayi	Hsp90 protein	0.003	0.046	0.0697
Trypanosoma brucei	unspecified product	0.0013	0.0114	0.001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 808972