Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0051 | 0.7353 | 0.5661 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0309 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0309 | 0.0309 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.1582 | 1 |
Onchocerca volvulus | 0.0024 | 0.1582 | 0.5 | |
Loa Loa (eye worm) | glutamate receptor | 0.0041 | 0.5325 | 0.5325 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1582 | 0.1582 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.1582 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1582 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.1582 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.1582 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.1582 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.1582 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.1582 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0309 | 0.139 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0309 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0309 | 0.0309 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.1582 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7353 | 0.7353 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0051 | 0.7353 | 0.5661 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.1582 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0047 | 0.6528 | 0.6216 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0309 | 0.0309 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.1582 | 0.0825 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.1582 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0309 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0037 | 0.4499 | 0.4005 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.1582 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.1582 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1582 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0034 | 0.39 | 0.3351 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1582 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.1582 | 0.0825 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.1582 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0041 | 0.5325 | 0.4904 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.1582 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.1582 | 0.0825 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1582 | 0.1582 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.1582 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0309 | 0.0309 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0309 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.