Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNase H family protein | 0.0044 | 0.0396 | 0.0549 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0282 | 0.4542 | 0.4542 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0047 | 0.0461 | 0.0461 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0084 | 0.1096 | 0.1096 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0563 | 0.1862 |
Schistosoma mansoni | DNA polymerase gamma | 0.0195 | 0.3023 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma brucei | RNA helicase, putative | 0.0164 | 0.248 | 0.248 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0043 | 0.0388 | 0.0538 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.0023 | 0.0042 | 0.0042 |
Toxoplasma gondii | hypothetical protein | 0.0096 | 0.131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0909 | 0.1259 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0597 | 1 | 1 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0073 | 0.0909 | 0.0731 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0563 | 0.1862 |
Chlamydia trachomatis | DNA polymerase I | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0044 | 0.0396 | 0.0396 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0084 | 0.1096 | 0.1096 |
Plasmodium falciparum | DNA polymerase 1, putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | ribonuclease H1 | 0.0044 | 0.0396 | 0.1311 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.7051 | 0.9769 |
Entamoeba histolytica | DNA-directed DNA polymerase, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0597 | 1 | 1 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0043 | 0.0388 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0436 | 0.7218 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0597 | 1 | 1 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0044 | 0.0396 | 1 |
Toxoplasma gondii | ribonuclease HI protein | 0.0044 | 0.0396 | 0.3026 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0102 | 0.1414 | 0.1414 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0021 | 0 | 0.5 |
Brugia malayi | RNase H family protein | 0.0044 | 0.0396 | 0.0549 |
Schistosoma mansoni | phosphoglucomutase | 0.0044 | 0.0396 | 0.1311 |
Echinococcus granulosus | DNA polymerase subunit gamma | 0.0195 | 0.3023 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0314 | 0.5096 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Plasmodium falciparum | plastid replication-repair enzyme | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0084 | 0.1096 | 0.1096 |
Brugia malayi | DNA polymerase I family protein | 0.0195 | 0.3023 | 0.4188 |
Leishmania major | ribonuclease H1, putative | 0.0044 | 0.0396 | 0.0396 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0023 | 0.0042 | 0.1065 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0043 | 0.0388 | 0.2964 |
Echinococcus multilocularis | ribonuclease H1 | 0.0044 | 0.0396 | 0.1311 |
Brugia malayi | nuclear hormone receptor | 0.0436 | 0.7218 | 1 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0044 | 0.0396 | 1 |
Trypanosoma brucei | ribonuclease H1 | 0.0044 | 0.0396 | 0.0396 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0023 | 0.0042 | 0.1065 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0563 | 0.1862 |
Trypanosoma brucei | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.0023 | 0.0042 | 0.0042 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0047 | 0.0461 | 0.0461 |
Echinococcus multilocularis | hypothetical protein | 0.0195 | 0.3023 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0044 | 0.0396 | 0.1311 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0047 | 0.0461 | 0.0461 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Brugia malayi | RNase H family protein | 0.0044 | 0.0396 | 0.0549 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0084 | 0.1096 | 0.1096 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.0023 | 0.0042 | 0.0042 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma brucei | unspecified product | 0.0047 | 0.0461 | 0.0461 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0447 | 0.7404 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.248 | 0.8203 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0314 | 0.5096 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0044 | 0.0396 | 0.1311 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0282 | 0.4542 | 0.4542 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0044 | 0.0396 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.3023 | 0.4188 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma brucei | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0045 | 0.0421 | 1 |
Trypanosoma brucei | trans-sialidase | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0282 | 0.4542 | 0.4542 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0047 | 0.0461 | 0.0461 |
Trypanosoma brucei | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma brucei | trans-sialidase, putative | 0.0032 | 0.0188 | 0.0188 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0044 | 0.0396 | 0.0396 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.