Detailed information for compound 809129

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.493 | Formula: C22H22FN3OS
  • H donors: 0 H acceptors: 2 LogP: 3.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCN(CCN1Cc1ccccc1F)Cc1cnc(s1)c1ccccc1
  • InChi: 1S/C22H22FN3OS/c23-20-9-5-4-8-18(20)15-26-13-12-25(11-10-21(26)27)16-19-14-24-22(28-19)17-6-2-1-3-7-17/h1-9,14H,10-13,15-16H2
  • InChiKey: FCSHJGJCJMMQII-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0043 0.0021
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0059 0.0622 0.2946
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0225 0.1047
Schistosoma mansoni ran 0.0023 0.0104 0.0082
Trypanosoma brucei DNA topoisomerase ii 0.0052 0.0515 0.2433
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0299 0.0277
Loa Loa (eye worm) hypothetical protein 0.0127 0.159 0.1599
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0043 0.0021
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0048 0.0456 0.0715
Echinococcus multilocularis neuroligin 0.0045 0.0418 0.0397
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0137 0.1734 0.1716
Schistosoma mansoni nuclear receptor 0.0056 0.0573 0.0552
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0716 0.3343
Brugia malayi hypothetical protein 0.0018 0.0022 0.0023
Echinococcus granulosus GPCR family 2 0.0083 0.0962 0.0942
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0299 0.4142
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0285 0.0263
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0138 0.1746 0.8285
Brugia malayi latrophilin 2 splice variant baaae 0.018 0.2349 0.2391
Schistosoma mansoni hypothetical protein 0.0041 0.0353 0.0331
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0137 0.1734 0.1716
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0138 0.1746 0.8285
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0059 0.0622 0.2946
Echinococcus multilocularis expressed conserved protein 0.0093 0.1097 0.1077
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0138 0.1746 0.8285
Brugia malayi photoreceptor-specific nuclear receptor 0.0127 0.159 0.1618
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0299 0.1333
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0071 0.0784 0.0764
Trichomonas vaginalis ran, putative 0.0023 0.0104 0.0703
Brugia malayi Nuclear hormone receptor E75 0.0056 0.0573 0.0583
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0113 0.0091
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0137 0.1734 0.1765
Brugia malayi hypothetical protein 0.0018 0.0022 0.0023
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0104 0.0393
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0138 0.1746 0.8285
Loa Loa (eye worm) hypothetical protein 0.0052 0.0511 0.0499
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0138 0.1746 0.8285
Echinococcus granulosus dna polymerase kappa 0.0041 0.0358 0.0336
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0043 0.0044
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0225 0.1047
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0137 0.1734 0.8248
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0299 0.0277
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0962 0.098
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0127 0.159 0.1571
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.0022 0.0023
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Schistosoma mansoni lamin 0.0027 0.0155 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0127 0.159 0.1599
Echinococcus multilocularis expressed protein 0.0373 0.5132 0.5121
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0358 0.2885
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0113 0.0091
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0127 0.159 0.1618
Brugia malayi nuclear hormone receptor 0.0127 0.159 0.1618
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0162 0.2098 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Echinococcus multilocularis GPCR, family 2 0.0083 0.0962 0.0942
Echinococcus granulosus importin subunit beta 1 0.0032 0.0225 0.0203
Loa Loa (eye worm) protein-tyrosine phosphatase 0.07 0.9823 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Onchocerca volvulus 0.0056 0.0573 0.0906
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0138 0.1746 0.8285
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0043 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0047 0.0213
Echinococcus multilocularis protein dispatched 1 0.0105 0.127 0.1251
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0962 0.0942
Schistosoma mansoni ap endonuclease 0.0019 0.0047 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0358 0.1682
Echinococcus multilocularis FTZ F1 alpha 0.0127 0.159 0.1571
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0047 0.0213
Mycobacterium ulcerans carboxylesterase, LipT 0.0045 0.0418 0.1811
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0138 0.1746 0.8285
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Schistosoma mansoni lamin 0.0027 0.0155 0.0133
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0962 0.098
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0162 0.2098 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0127 0.159 0.1571
Trypanosoma cruzi DNA topoisomerase II, putative 0.0059 0.0622 0.2889
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0043 0.0021
Loa Loa (eye worm) hypothetical protein 0.0071 0.0784 0.0777
Echinococcus granulosus acetylcholinesterase 0.0268 0.362 0.3606
Loa Loa (eye worm) hypothetical protein 0.0045 0.0418 0.0404
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0138 0.1746 0.8285
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0358 0.1515
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0418 0.0397
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1587 0.1597
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0043 0.0021
Loa Loa (eye worm) hypothetical protein 0.0127 0.159 0.1599
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1583 0.1564
Leishmania major importin beta-1 subunit, putative 0.0026 0.0138 0.0558
Loa Loa (eye worm) hypothetical protein 0.0263 0.3544 0.3593
Brugia malayi hypothetical protein 0.0019 0.0043 0.0044
Schistosoma mansoni retinoic acid receptor RXR 0.0127 0.159 0.1571
Giardia lamblia DNA topoisomerase II 0.0063 0.0676 0.9784
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0358 0.1682
Loa Loa (eye worm) hypothetical protein 0.0268 0.362 0.3671
Schistosoma mansoni cell polarity protein 0.0024 0.0113 0.0091
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0128 0.12
Loa Loa (eye worm) TAR-binding protein 0.0126 0.1583 0.1592
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Loa Loa (eye worm) hypothetical protein 0.0071 0.0784 0.0777
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0066 0.0718 0.0697
Brugia malayi nuclear hormone receptor family member nhr-6 0.0056 0.0573 0.0583
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0043 0.0021
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0299 0.0277
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0127 0.159 0.1571
Schistosoma mansoni hypothetical protein 0.0083 0.0962 0.0942
Schistosoma mansoni hypothetical protein 0.0712 1 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0716 0.0729
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0043 0.0177
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0048 0.0456 0.0715
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0066 0.0718 0.0731
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0056 0.0573 0.0552
Schistosoma mansoni nuclear hormone receptor 0.0127 0.159 0.1571
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0056 0.0573 0.0552
Brugia malayi CHE-14 protein 0.0099 0.1184 0.1206
Brugia malayi nuclear receptor NHR-67 0.0056 0.0573 0.0583
Onchocerca volvulus 0.0045 0.0418 0.0652
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0716 0.5981
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0022 0.0023
Echinococcus multilocularis nuclear receptor nhr 48 0.0056 0.0573 0.0552
Brugia malayi Importin beta-1 subunit 0.0032 0.0225 0.0229
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0128 0.0507
Loa Loa (eye worm) carboxylesterase 0.0268 0.362 0.3671
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0127 0.159 0.1571
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0127 0.159 0.1571
Brugia malayi hypothetical protein 0.0018 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0188 0.0168
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0127 0.159 0.2581
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0263 0.1229
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0127 0.159 0.1599
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1804 0.1785
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.1184 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.07 0.9823 0.9823
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0138 0.1746 0.8285
Loa Loa (eye worm) hypothetical protein 0.0099 0.1184 0.1186
Echinococcus granulosus expressed protein 0.0373 0.5132 0.5121
Brugia malayi ecdysteroid receptor 0.044 0.6094 0.6204
Echinococcus granulosus intermediate filament protein 0.0027 0.0155 0.0133
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0138 0.1746 0.8285
Echinococcus multilocularis thyroid hormone receptor alpha 0.0127 0.159 0.1571
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0128 0.12
Brugia malayi Carboxylesterase family protein 0.0268 0.362 0.3685
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0113 0.0091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0127 0.159 0.1618
Echinococcus multilocularis tar DNA binding protein 0.0126 0.1583 0.1564
Schistosoma mansoni hypothetical protein 0.0712 1 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0048 0.0456 0.0715
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0113 0.0115
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0113 0.0115
Brugia malayi TAR-binding protein 0.0126 0.1583 0.1611
Loa Loa (eye worm) hypothetical protein 0.0024 0.0113 0.0093
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0137 0.1734 0.8262
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0317 0.0295
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0047 0.037
Schistosoma mansoni hypothetical protein 0.0041 0.0353 0.0331
Brugia malayi PXA domain containing protein 0.0019 0.0043 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1583 0.1564
Schistosoma mansoni nuclear hormone receptor 0.0056 0.0573 0.0552
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0138 0.1746 0.8285
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0138 0.1746 0.8285
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0138 0.1746 0.8285
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1587 0.1597
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0021
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0299 0.0277
Brugia malayi hypothetical protein 0.0071 0.0784 0.0799
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0047 0.0119
Echinococcus granulosus nuclear receptor nhr 48 0.0056 0.0573 0.0552
Echinococcus multilocularis protein patched 0.0099 0.1184 0.1165
Brugia malayi orphan nuclear receptor NR2E1 0.0056 0.0573 0.0583
Plasmodium falciparum importin beta, putative 0.0032 0.0225 0.265
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0155 0.0135
Schistosoma mansoni hypothetical protein 0.0083 0.0962 0.0942
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0018 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0021
Loa Loa (eye worm) hypothetical protein 0.0578 0.8069 0.821
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0299 0.1333
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0358 0.1682
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0045 0.0418 0.3408
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0138 0.1746 0.8285
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0043 0.0021
Brugia malayi RNA binding protein 0.0126 0.1583 0.1611
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.1804 0.1836
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0225 0.265
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0056 0.0573 0.0552
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0138 0.1746 0.8285
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0104 0.1223
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0022 0.008 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0127 0.159 0.1571
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0137 0.1734 0.8227
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0056 0.0573 0.0906
Entamoeba histolytica hypothetical protein 0.0036 0.0285 0.226
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0127 0.159 0.1618
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.0784 0.0799
Entamoeba histolytica hypothetical protein 0.0019 0.0043 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0127 0.159 0.1599
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0043 0.0021
Loa Loa (eye worm) hypothetical protein 0.0083 0.0962 0.0959
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0127 0.159 0.1571
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0138 0.1746 0.8285
Loa Loa (eye worm) hypothetical protein 0.0045 0.0418 0.0404
Echinococcus multilocularis snurportin 1 0.034 0.465 0.4637
Onchocerca volvulus 0.0045 0.0418 0.0652
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0043 0.0044
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0138 0.1746 0.8285
Schistosoma mansoni hypothetical protein 0.0041 0.0353 0.0331
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0162 0.2098 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0128 0.12
Loa Loa (eye worm) hypothetical protein 0.0137 0.1734 0.1747
Schistosoma mansoni hypothetical protein 0.0083 0.0962 0.0942
Echinococcus multilocularis geminin 0.0712 1 1
Chlamydia trachomatis DNA gyrase subunit B 0.0036 0.0283 1
Entamoeba histolytica hypothetical protein 0.0036 0.0285 0.226
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0317 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0043 0.0177
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0047 0.0025
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.007 0.0231
Echinococcus granulosus lamin 0.0027 0.0155 0.0133
Brugia malayi Carboxylesterase family protein 0.0045 0.0418 0.0426
Brugia malayi nuclear receptor NHR-88 0.0056 0.0573 0.0583
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0299 0.238
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0138 0.1746 0.8285
Echinococcus granulosus expressed conserved protein 0.0093 0.1097 0.1077
Giardia lamblia DINP protein human, muc B family 0.0021 0.007 0.0718
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0127 0.159 0.1571
Echinococcus multilocularis acetylcholinesterase 0.0268 0.362 0.3606
Loa Loa (eye worm) DR-78 0.0056 0.0573 0.0561
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0299 0.238
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.007 0.0309
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.0784 0.0764
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0299 0.0277
Plasmodium vivax DNA gyrase subunit B, putative 0.0022 0.008 0.0492
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0043 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0358 0.1682
Schistosoma mansoni acetylcholinesterase 0.0045 0.0418 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0043 0.0177
Brugia malayi hypothetical protein 0.0019 0.0043 0.0044
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0138 0.1746 0.8285
Entamoeba histolytica hypothetical protein 0.0019 0.0043 0.0177
Schistosoma mansoni hypothetical protein 0.0083 0.0962 0.0942
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0155 0.0158
Schistosoma mansoni hypothetical protein 0.0041 0.0353 0.0331
Toxoplasma gondii DNA topoisomerase 2, putative 0.0066 0.0718 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0127 0.159 0.1618
Loa Loa (eye worm) hypothetical protein 0.0127 0.159 0.1599
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0099 0.1184 0.1186
Schistosoma mansoni ran 0.0023 0.0104 0.0082
Mycobacterium tuberculosis Carboxylesterase LipT 0.0045 0.0418 0.1811
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0138 0.0558
Brugia malayi hypothetical protein 0.0056 0.0573 0.0583
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0104 0.0082
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0137 0.1734 0.8248
Mycobacterium ulcerans DNA gyrase subunit B 0.0022 0.008 0.0161
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0138 0.1746 0.8285
Onchocerca volvulus 0.0045 0.0418 0.0652
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.3131 0.3172
Echinococcus granulosus neuroligin 0.0045 0.0418 0.0397
Loa Loa (eye worm) hypothetical protein 0.0024 0.0113 0.0093
Loa Loa (eye worm) hypothetical protein 0.0045 0.0418 0.0404
Brugia malayi tailless protein 0.0056 0.0573 0.0583
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0358 0.1616
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0418 0.1811
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0127 0.159 0.1571
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0043 0.0021
Echinococcus granulosus pikachurin 0.0024 0.0113 0.0091
Trypanosoma brucei protein tyrosine phosphatase 1 0.0018 0.0022 0.008
Loa Loa (eye worm) hypothetical protein 0.0025 0.0128 0.0107
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0056 0.0573 0.0552
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1583 0.1564
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.2599 0.2583
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0043 0.0021
Brugia malayi nuclear receptor RXR 0.0071 0.0784 0.0799
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.007 0.0113
Loa Loa (eye worm) hypothetical protein 0.0045 0.0418 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0043 0.0177
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0047 0.0119
Leishmania major DNA topoisomerase ii 0.0059 0.0622 0.2889
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.069 0.5746
Brugia malayi hypothetical protein 0.0018 0.0022 0.0023
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0138 0.1746 0.8285
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0716 0.0695
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0299 0.1402
Schistosoma mansoni nuclear receptor 0.0056 0.0573 0.0552
Echinococcus granulosus para nitrobenzyl esterase 0.0045 0.0418 0.0397
Schistosoma mansoni hypothetical protein 0.0052 0.0511 0.049
Loa Loa (eye worm) TOPoisomerase family member 0.0066 0.0718 0.0709
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0138 0.1746 0.8285
Plasmodium vivax DNA topoisomerase II, putative 0.0066 0.0718 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0127 0.159 0.1618
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0285 0.0263
Brugia malayi PXA domain containing protein 0.0019 0.0043 0.0044
Echinococcus multilocularis ecdysone induced protein 78C 0.0127 0.159 0.1571
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0104 0.0106
Loa Loa (eye worm) RNA binding protein 0.0126 0.1583 0.1592
Echinococcus granulosus snurportin 1 0.034 0.465 0.4637
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.018 0.2349 0.2374
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0043 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0299 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0127 0.159 0.1618
Brugia malayi hypothetical protein 0.0018 0.0022 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0214 0.0996
Schistosoma mansoni importin beta-1 0.0032 0.0225 0.0203
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0045 0.0418 0.0397
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0962 0.0942
Onchocerca volvulus Bile acid receptor homolog 0.044 0.6094 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0043 0.0021
Schistosoma mansoni hypothetical protein 0.034 0.465 0.4637
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0022 0.008 1
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0022 0.0023
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0156 0.2014 0.1996
Loa Loa (eye worm) hypothetical protein 0.0027 0.0155 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Echinococcus multilocularis carboxylesterase 5A 0.0268 0.362 0.3606
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0358 0.1682
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0358 0.1616
Leishmania major DNA polymerase kappa, putative 0.0021 0.007 0.0231
Brugia malayi Protein-tyrosine phosphatase containing protein 0.07 0.9823 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0043 0.0021
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0104 0.0849
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0113 0.0093
Entamoeba histolytica DNA topoisomerase II, putative 0.0066 0.0718 0.5993
Trypanosoma brucei unspecified product 0.0034 0.0263 0.1229
Leishmania major GTP-binding protein, putative 0.0023 0.0104 0.0393
Loa Loa (eye worm) steroid hormone receptor 0.0127 0.159 0.1599
Brugia malayi Carboxylesterase family protein 0.0045 0.0418 0.0426
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0299 0.2384
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0263 0.3544 0.3608
Loa Loa (eye worm) hypothetical protein 0.0044 0.0405 0.039
Loa Loa (eye worm) hypothetical protein 0.0127 0.159 0.1599
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.2599 0.2583
Plasmodium falciparum DNA topoisomerase 2 0.0066 0.0718 1
Echinococcus granulosus tar DNA binding protein 0.0126 0.1583 0.1564
Echinococcus multilocularis musashi 0.0027 0.0155 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0128
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.069 0.5746
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0128 0.0507
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0358 0.2885
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0127 0.159 0.1618
Loa Loa (eye worm) hypothetical protein 0.0024 0.0113 0.0093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0127 0.159 0.1571
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.1583 0.1592
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0104 0.047
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0043 0.0021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0127 0.159 0.1571
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0358 0.1682
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0043 0.0044
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0043 0.0021
Mycobacterium ulcerans oxidoreductase 0.0123 0.1541 0.7285
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0358 0.1682
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0716 0.0708
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0127 0.159 0.1618
Echinococcus granulosus BC026374 protein S09 family 0.0045 0.0418 0.0397
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0043 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0358 0.1515
Leishmania major hypothetical protein, conserved 0.0025 0.0128 0.0507
Echinococcus multilocularis acetylcholinesterase 0.0268 0.362 0.3606
Entamoeba histolytica Ran family GTPase 0.0023 0.0104 0.0704
Brugia malayi hypothetical protein 0.0025 0.0128 0.013
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0047 0.0025
Echinococcus multilocularis slit 2 protein 0.0024 0.0113 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1804 0.1785
Brugia malayi small heat shock protein 0.0578 0.8069 0.8215
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0299 0.0277
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0138 0.1746 0.8285
Echinococcus multilocularis pikachurin 0.0024 0.0113 0.0091
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0299 0.238
Trichomonas vaginalis DNA topoisomerase II, putative 0.0066 0.0718 0.5983
Schistosoma mansoni ap endonuclease 0.0019 0.0047 0.0025
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0418 0.0397
Schistosoma mansoni gliotactin 0.0045 0.0418 0.0397
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0043 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.1804 0.1818
Loa Loa (eye worm) hypothetical protein 0.0045 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0127 0.159 0.1571
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0022 0.008 0.0161
Plasmodium falciparum DNA gyrase subunit B 0.0022 0.008 0.0492
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0138 0.1746 0.8285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0573 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0043 0.0177
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0104 0.0849
Brugia malayi nuclear receptor RXR 0.0056 0.0573 0.0583
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1583 0.1564
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0022 0.008 0.0492
Loa Loa (eye worm) hypothetical protein 0.0029 0.0188 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0214 0.0996
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0064 0.069 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1183 0.1184
Echinococcus granulosus lamin dm0 0.0027 0.0155 0.0133
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0104 0.0393
Schistosoma mansoni zinc finger protein 0.0056 0.0573 0.0552
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.034 0.465 0.4721
Loa Loa (eye worm) hypothetical protein 0.0044 0.0405 0.039
Brugia malayi Probable DNA topoisomerase II 0.0066 0.0718 0.0731
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0047 0.0198
Echinococcus multilocularis lamin 0.0027 0.0155 0.0133
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0113 0.0091
Onchocerca volvulus 0.0027 0.0155 0.0218
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0127 0.159 0.1571
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0127 0.159 0.1618
Echinococcus granulosus Nuclear hormone receptor HR96 0.0056 0.0573 0.0552
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0962 0.0942
Echinococcus granulosus sterol regulatory element binding protein 0.0099 0.1184 0.1165
Loa Loa (eye worm) hypothetical protein 0.0268 0.362 0.3671
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0358 0.1682
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0138 0.0997
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0043 0.0021
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0299 0.1333
Echinococcus multilocularis lamin dm0 0.0027 0.0155 0.0133
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0043 0.0021
Schistosoma mansoni coup transcription factor 0.0127 0.159 0.1571
Brugia malayi EGF-like domain containing protein 0.0024 0.0113 0.0115
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0043 0.0021
Trypanosoma cruzi DNA topoisomerase II, putative 0.0059 0.0622 0.2889
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0127 0.159 0.1618
Echinococcus granulosus thyroid hormone receptor alpha 0.0056 0.0573 0.0552
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0206
Onchocerca volvulus 0.0027 0.0155 0.0218
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0043 0.0021
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0052 0.0515 0.2372
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0137 0.1734 0.8248
Brugia malayi Nuclear hormone receptor-like 1 0.0127 0.159 0.1618
Brugia malayi RNA, U transporter 1 0.0091 0.1068 0.1087
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0127 0.159 0.1571
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.0784 0.0799
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0358 0.1682
Brugia malayi nuclear hormone receptor 0.0056 0.0573 0.0583
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0043 0.0021
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0056 0.0573 0.0552
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0047 0.0048
Echinococcus granulosus acetylcholinesterase 0.0268 0.362 0.3606
Echinococcus multilocularis sterol regulatory element binding protein 0.0099 0.1184 0.1165
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0358 0.1682
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0285 0.0263
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0071 0.0784 0.0777
Loa Loa (eye worm) hypothetical protein 0.0127 0.159 0.1599
Onchocerca volvulus 0.0045 0.0418 0.0652
Mycobacterium leprae putative cytochrome p450 0.0138 0.1746 0.5
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1583 0.1564
Brugia malayi polk-prov protein 0.0031 0.0214 0.0218
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0155 0.0135
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.1583 0.1611
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0127 0.159 0.1571
Echinococcus granulosus Protein patched homolog 1 0.0099 0.1184 0.1165
Schistosoma mansoni RAR-like nuclear receptor 0.0127 0.159 0.1571
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0043 0.0044
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0127 0.159 0.1571
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0056 0.0573 0.0583
Loa Loa (eye worm) acetylcholinesterase 1 0.0268 0.362 0.3671
Loa Loa (eye worm) carboxylesterase 0.0045 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Echinococcus multilocularis para nitrobenzyl esterase 0.0045 0.0418 0.0397
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0056 0.0573 0.0906
Schistosoma mansoni neuroligin 3 (S09 family) 0.0045 0.0418 0.0397
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0138 0.1746 0.8285
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0716 0.3343
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0127 0.159 0.1599
Brugia malayi Calcitonin receptor-like protein seb-1 0.0263 0.3544 0.3608
Schistosoma mansoni thyroid hormone receptor 0.0127 0.159 0.1571
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0263 0.3544 0.3593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0127 0.159 0.1599
Schistosoma mansoni hypothetical protein 0.0036 0.0285 0.0263
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.1541 0.7285
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0056 0.0573 0.0561
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0138 0.0997
Brugia malayi conserved hypotetical protein 0.0056 0.0573 0.0583
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0104 0.0082
Brugia malayi Carboxylesterase family protein 0.0045 0.0418 0.0426
Onchocerca volvulus 0.0127 0.159 0.2581
Brugia malayi MH2 domain containing protein 0.0127 0.1587 0.1616
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0043 0.0044
Brugia malayi hypothetical protein 0.0045 0.0418 0.0426
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.07 0.9823 0.9823
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0137 0.1734 0.1716
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0162 0.2098 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Loa Loa (eye worm) hypothetical protein 0.0071 0.0784 0.0777
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0066 0.0718 0.0731
Echinococcus multilocularis BC026374 protein (S09 family) 0.0045 0.0418 0.0397
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0071 0.0784 0.0764
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0162 0.2098 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0138 0.1746 0.8285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0127 0.159 0.1599
Entamoeba histolytica hypothetical protein 0.0036 0.0285 0.226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1804 0.1785
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0104 0.0083
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0128 0.0582
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0043 0.0021
Brugia malayi hypothetical protein 0.0036 0.0285 0.029
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0043 0.0021
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0418 0.1811
Entamoeba histolytica hypothetical protein 0.0036 0.0285 0.226
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0716 0.0695
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0127 0.159 0.1599
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0052 0.0515 0.2372
Loa Loa (eye worm) hypothetical protein 0.0127 0.159 0.1599
Brugia malayi Protein-tyrosine phosphatase 1 0.0018 0.0022 0.0023
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0358 0.0336
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0021
Schistosoma mansoni nuclear receptor nhr-48 0.0056 0.0573 0.0552
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0716 0.0695
Brugia malayi laminin alpha chain 0.0024 0.0113 0.0115
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0962 0.0959
Schistosoma mansoni steroid hormone receptor ad4bp 0.0127 0.159 0.1571
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1183 0.1163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0021
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0299 0.0304
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0043 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1804 0.1785
Brugia malayi hypothetical protein 0.0071 0.0784 0.0799
Brugia malayi Carboxylesterase family protein 0.0045 0.0418 0.0426
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0138 0.0997
Brugia malayi ecdysone receptor 0.0056 0.0573 0.0583
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0043 0.0021
Leishmania major mitochondrial DNA topoisomerase II 0.0052 0.0515 0.2372
Entamoeba histolytica hypothetical protein 0.0026 0.0138 0.0999
Brugia malayi follicle stimulating hormone receptor 0.0234 0.3131 0.3188
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0299 0.0277
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0127 0.159 0.1571
Loa Loa (eye worm) hypothetical protein 0.044 0.6094 0.6195
Brugia malayi steroid hormone receptor 0.0127 0.159 0.1618
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0043 0.0021
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0056 0.0573 0.0552
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0043 0.0021
Brugia malayi intermediate filament protein 0.0027 0.0155 0.0158
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0128 0.12
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0962 0.0942
Loa Loa (eye worm) carboxylesterase 0.0045 0.0418 0.0404
Onchocerca volvulus 0.0056 0.0573 0.0906
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.069 0.5746
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0127 0.159 0.1618
Echinococcus granulosus slit 2 protein 0.0024 0.0113 0.0091
Brugia malayi Carboxylesterase family protein 0.0268 0.362 0.3685
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0716 0.3396
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0358 0.1616
Loa Loa (eye worm) hypothetical protein 0.0045 0.0418 0.0404
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Plasmodium vivax importin-beta 2, putative 0.0032 0.0225 0.265
Echinococcus granulosus ecdysone induced protein 78C 0.0127 0.159 0.1571
Echinococcus granulosus FTZ F1 alpha 0.0127 0.159 0.1571
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0716 0.3343
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0358 0.1616
Loa Loa (eye worm) hypothetical protein 0.0045 0.0418 0.0404
Schistosoma mansoni nuclear hormone receptor 0.0056 0.0573 0.0552
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0043 0.0021
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0045 0.0418 0.0397
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0066 0.0718 0.0697
Brugia malayi Steroid receptor seven-up type 2 0.0127 0.159 0.1618
Brugia malayi hypothetical protein 0.0056 0.0573 0.0583
Schistosoma mansoni DNA topoisomerase II 0.0066 0.0718 0.0697
Schistosoma mansoni thyroid hormone receptor 0.0127 0.159 0.1571
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0127 0.159 0.1618
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0299 0.0277
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0043 0.0021
Loa Loa (eye worm) hypothetical protein 0.0071 0.0784 0.0777
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0162 0.2098 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0047 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0573 0.0552
Entamoeba histolytica hypothetical protein 0.0019 0.0043 0.0177
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0047 0.0213
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0043 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0127 0.159 0.1571
Loa Loa (eye worm) hypothetical protein 0.0056 0.0573 0.0561
Echinococcus granulosus carboxylesterase 5A 0.0268 0.362 0.3606
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0043 0.0021
Schistosoma mansoni patched 1 0.0099 0.1184 0.1165
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1183 0.1204
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0056 0.0573 0.0552
Brugia malayi nuclear receptor NHR-88 0.0127 0.159 0.1618
Schistosoma mansoni intermediate filament proteins 0.0027 0.0155 0.0133
Onchocerca volvulus 0.0045 0.0418 0.0652
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1804 0.1785
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0043 0.0021
Loa Loa (eye worm) hypothetical protein 0.0071 0.0784 0.0777
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0043 0.0177
Trichomonas vaginalis spcc417.12 protein, putative 0.0045 0.0418 0.3408
Onchocerca volvulus Protein ultraspiracle homolog 0.0127 0.159 0.2581
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0043 0.0021
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0418 0.0397
Loa Loa (eye worm) hypothetical protein 0.0127 0.159 0.1599
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0225 0.0203
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0268 0.362 0.3606
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1183 0.1163
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Brugia malayi Nuclear hormone receptor E75 0.0056 0.0573 0.0583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1804 0.1785
Schistosoma mansoni BC026374 protein (S09 family) 0.0045 0.0418 0.0397
Echinococcus granulosus Nuclear hormone receptor HR96 0.0056 0.0573 0.0552
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0043 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0043 0.0177
Loa Loa (eye worm) nuclear hormone receptor 0.0056 0.0573 0.0561
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0021
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0043 0.0021
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0043 0.0021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0127 0.159 0.1571
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0043 0.0021
Schistosoma mansoni slit 0.0024 0.0113 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1804 0.1785
Loa Loa (eye worm) nuclear receptor NHR-67 0.0056 0.0573 0.0561
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0071 0.0784 0.0764
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0358 0.1682
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0047 0.0119
Brugia malayi nuclear hormone receptor family member odr-7 0.0056 0.0573 0.0583
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0104 0.0849
Schistosoma mansoni hypothetical protein 0.018 0.2349 0.2332
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0022 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0127 0.159 0.1618
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1183 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.07 0.9823 0.9823

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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