Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0244 | 0.0491 | 0.3105 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0663 | 0.1394 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0663 | 0.1394 | 1 |
Brugia malayi | P38 map kinase family protein 2 | 0.0521 | 0.109 | 0.7676 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0663 | 0.1394 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0315 | 0.0645 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0663 | 0.1394 | 0.1351 |
Echinococcus multilocularis | thymidylate synthase | 0.0663 | 0.1394 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.004 | 0.005 | 0.0362 |
Schistosoma mansoni | glycogen phosphorylase | 0.0092 | 0.0163 | 0.1169 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0092 | 0.0163 | 0.0604 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0244 | 0.0491 | 0.3105 |
Brugia malayi | thymidylate synthase | 0.0663 | 0.1394 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0092 | 0.0163 | 0.0604 |
Schistosoma mansoni | glycogen phosphorylase | 0.0092 | 0.0163 | 0.1169 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0663 | 0.1394 | 1 |
Brugia malayi | Raf kinase | 0.0219 | 0.0436 | 0.2692 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0521 | 0.109 | 0.7676 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0092 | 0.0163 | 0.5 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0227 | 0.0454 | 0.2822 |
Echinococcus granulosus | glycogen phosphorylase | 0.0092 | 0.0163 | 0.0604 |
Mycobacterium ulcerans | thymidylate synthase | 0.0663 | 0.1394 | 0.1351 |
Echinococcus granulosus | thymidylate synthase | 0.0663 | 0.1394 | 1 |
Onchocerca volvulus | 0.0663 | 0.1394 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0663 | 0.1394 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0663 | 0.1394 | 1 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0227 | 0.0454 | 0.2822 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0092 | 0.0163 | 0.0604 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0092 | 0.0163 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0092 | 0.0163 | 0.0604 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.4652 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0092 | 0.0163 | 0.5 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0128 | 0.0242 | 0.1207 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0663 | 0.1394 | 1 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0244 | 0.0491 | 0.3105 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0521 | 0.109 | 0.7676 |
Brugia malayi | hypothetical protein | 0.0315 | 0.0645 | 0.4281 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0244 | 0.0491 | 0.3105 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0092 | 0.0163 | 0.0604 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0521 | 0.109 | 0.7676 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0092 | 0.0163 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0244 | 0.0491 | 0.3519 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.0084 | 0.0601 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0521 | 0.109 | 0.5936 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0521 | 0.109 | 0.7676 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0521 | 0.109 | 0.6721 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.0084 | 0.0601 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0315 | 0.0645 | 0.0597 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0521 | 0.109 | 0.5936 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0521 | 0.109 | 0.7676 |
Echinococcus granulosus | glycogen phosphorylase | 0.0092 | 0.0163 | 0.0604 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.4652 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0663 | 0.1394 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.0077 | 0.0027 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0521 | 0.109 | 0.7676 |
Schistosoma mansoni | hypothetical protein | 0.0232 | 0.0465 | 0.3338 |
Loa Loa (eye worm) | raf kinase | 0.0225 | 0.0451 | 0.2804 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0227 | 0.0454 | 0.3253 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0521 | 0.109 | 0.7676 |
Brugia malayi | carbohydrate phosphorylase | 0.0092 | 0.0163 | 0.0604 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.