Detailed information for compound 80940

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.439 | Formula: C22H26O5
  • H donors: 0 H acceptors: 0 LogP: 3.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1[C@@H]2COC[C@@H]2Cc2c1cc(OC)c(c2)OC
  • InChi: 1S/C22H26O5/c1-23-18-6-5-13(8-19(18)24-2)22-16-10-21(26-4)20(25-3)9-14(16)7-15-11-27-12-17(15)22/h5-6,8-10,15,17,22H,7,11-12H2,1-4H3/t15-,17-,22?/m0/s1
  • InChiKey: MNYFJOSGQNXLHS-TWMUNHRGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0031 0.0008
Toxoplasma gondii transporter, major facilitator family protein 0.0033 0.0232 0.6848
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0033 0.0232 0.0332
Brugia malayi Cathepsin L-like precursor 0.002 0.0099 0.0141
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0256 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0129 0.0129
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0013 0.0013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0035 0.0254 0.0254
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0031 0.0044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0035 0.0254 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0035 0.0254 0.0363
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0031 0.0044
Plasmodium vivax vivapain-2 0.002 0.0099 0.2207
Brugia malayi nuclear receptor NHR-67 0.0016 0.0062 0.0088
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0256 0.1863
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0339 0.2716
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0017 0.0068 0.0307
Brugia malayi Steroid receptor seven-up type 2 0.0035 0.0254 0.0363
Plasmodium vivax vivapain-2 0.002 0.0099 0.2207
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0035 0.0254 0.0363
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0129 0.0185
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0013 0.0019
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0339 0.113
Onchocerca volvulus 0.0043 0.0339 0.0467
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0099 0.0568
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0099 0.0141
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0129 0.0185
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0254 0.0363
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0044
Echinococcus granulosus geminin 0.0201 0.2003 0.2864
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0129 0.0185
Brugia malayi multidrug resistance protein 3 0.0013 0.0031 0.0044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0232 0.0332
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0062 0.0088
Brugia malayi hypothetical protein 0.0018 0.0082 0.0118
Brugia malayi Cathepsin L-like precursor 0.002 0.0099 0.0141
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0082 0.0118
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0043
Toxoplasma gondii protease inhibitor PI2 0.0022 0.0124 0.3648
Leishmania major cathepsin L-like protease 0.002 0.0099 0.056
Onchocerca volvulus Cathepsin F homolog 0.002 0.0099 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0226 0.0324
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Brugia malayi 6-phosphofructokinase 0.0129 0.1245 0.1781
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0062 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0099 0.0568
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0013 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0035 0.0254 0.0254
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0013 0.0019
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0232 0.0332
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0035 0.0254 0.0345
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0099 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Brugia malayi prostaglandin transporter 0.0033 0.0232 0.0332
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0069 0.0617 0.4946
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0031 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.1245 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0031 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0256 0.1863
Onchocerca volvulus 0.0035 0.0254 0.0345
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0062 0.0062
Schistosoma mansoni sodium-bile acid cotransporter related 0.039 0.3981 0.5694
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0062 0.0088
Echinococcus multilocularis cysteine protease 0.002 0.0099 0.0099
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0129 0.0185
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0033 0.0232 0.0332
Onchocerca volvulus 0.0677 0.6992 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0031 0.0031
Onchocerca volvulus 0.0032 0.0226 0.0306
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0035 0.0254 0.0363
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0129 0.0185
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0339 0.2543
Brugia malayi hypothetical protein 0.0016 0.0062 0.0088
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0013 0.0019
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0099 0.386
Onchocerca volvulus Bile acid receptor homolog 0.0035 0.0254 0.0345
Loa Loa (eye worm) agrin synaptic family protein 0.0022 0.0124 0.0177
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0256 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.0013 0.0019
Brugia malayi phosphofructokinase 0.0129 0.1245 0.1781
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0017 0.0068 0.0307
Echinococcus granulosus lamin dm0 0.0032 0.0226 0.0324
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0129 0.0185
Onchocerca volvulus 0.0033 0.0232 0.0314
Trypanosoma brucei multidrug resistance protein E 0.0017 0.0068 0.0296
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0099 0.0141
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0062 0.0069
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0066
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0029 0.0029
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.0013 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0339 0.0485
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0012 0.0013 0.0019
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0062 0.0088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0363
Brugia malayi hypothetical protein 0.0033 0.0232 0.0332
Loa Loa (eye worm) hypothetical protein 0.0023 0.0129 0.0185
Echinococcus multilocularis multidrug resistance associated protein 7 0.0017 0.0068 0.0068
Schistosoma mansoni nAChR subunit 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0363
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0062 0.0069
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0129 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0035 0.0254 0.0363
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0082 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0094
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0017 0.0068 0.0307
Loa Loa (eye worm) 6-phosphofructokinase 0.0129 0.1245 0.1781
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.0177
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0012 0.0013 0.0019
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0129 0.0817
Schistosoma mansoni nAChR subunit 0.0012 0.0013 0.0019
Brugia malayi hypothetical protein 0.0023 0.0129 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Brugia malayi Phospholipase A2 family protein 0.0108 0.1019 0.1457
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0099 0.0568
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0339 0.2543
Trypanosoma cruzi cruzipain precursor, putative 0.0076 0.0686 0.5501
Schistosoma mansoni coup transcription factor 0.0035 0.0254 0.0363
Schistosoma mansoni intermediate filament proteins 0.0032 0.0226 0.0324
Brugia malayi ecdysone receptor 0.0016 0.0062 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0129 0.0817
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0031 0.0031
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.0013 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0254 0.0363
Schistosoma mansoni follistatin 0.0022 0.0124 0.0177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0485
Loa Loa (eye worm) hypothetical protein 0.0015 0.0052 0.0075
Schistosoma mansoni nAChR subunit 0.0012 0.0013 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Leishmania major cathepsin L-like protease 0.002 0.0099 0.056
Toxoplasma gondii ABC1 family protein 0.0043 0.0339 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0339 0.2529
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0031 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0339 0.2716
Echinococcus granulosus sodium bile acid cotransporter 0.0677 0.6992 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0118
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0256 0.7314
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0339 0.113
Entamoeba histolytica hypothetical protein 0.0023 0.0129 0.0817
Brugia malayi Cation transporter family protein 0.0012 0.0013 0.0019
Brugia malayi Cathepsin L-like precursor 0.002 0.0099 0.0141
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0062 0.0062
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0232 0.0314
Onchocerca volvulus 0.0033 0.0232 0.0314
Echinococcus granulosus bloom syndrome protein 0.0025 0.0156 0.0223
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0099 0.0099
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0068 0.0315
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0129 0.1245 0.4453
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0485
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0129 0.0817
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0226 0.0324
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0082 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0254 0.0363
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0068 0.0315
Schistosoma mansoni lamin 0.0032 0.0226 0.0324
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0062 0.0088
Onchocerca volvulus 0.002 0.0099 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0129 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0082 0.0118
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0129 0.0129
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0031 0.0008
Brugia malayi secreted modular calcium-binding protein 1 0.0022 0.0124 0.0177
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0012 0.0013 0.0013
Schistosoma mansoni retinoic acid receptor RXR 0.0035 0.0254 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0256 0.7559
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.0013 0.0013
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0129 0.0185
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0124 0.0177
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0031 0.0008
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0256 0.7559
Leishmania major pentamidine resistance protein 1 0.0017 0.0068 0.0307
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0082 0.0118
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0035 0.0254 0.0363
Brugia malayi Cathepsin L-like precursor 0.002 0.0099 0.0141
Mycobacterium tuberculosis Conserved protein 0.0043 0.0339 0.113
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0012 0.0013 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0129 0.0185
Onchocerca volvulus 0.0032 0.0226 0.0306
Echinococcus multilocularis musashi 0.0032 0.0226 0.0226
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0129 0.0185
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0129 0.0817
Brugia malayi nuclear receptor RXR 0.0016 0.0062 0.0088
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0013 0.0019
Schistosoma mansoni organic anion transporter 0.0033 0.0232 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0035 0.0254 0.0363
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0485
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0031 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0339 0.2543
Onchocerca volvulus 0.002 0.0099 0.0123
Mycobacterium tuberculosis Conserved protein 0.0043 0.0339 0.113
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0256 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0339 0.113
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0124 0.3648
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0031 0.0008
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0129 0.0185
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Brugia malayi multidrug resistance related protein 1 0.0017 0.0068 0.0098
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0129 0.0185
Brugia malayi Cathepsin L-like precursor 0.002 0.0099 0.0141
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0232 0.0332
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0062 0.0088
Schistosoma mansoni RAR-like nuclear receptor 0.0035 0.0254 0.0363
Onchocerca volvulus 0.0013 0.003 0.0024
Brugia malayi PXA domain containing protein 0.0023 0.0129 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Schistosoma mansoni 6-phosphofructokinase 0.0129 0.1245 0.1781
Schistosoma mansoni nuclear receptor 0.0016 0.0062 0.0088
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Schistosoma mansoni smdr2 0.0013 0.0031 0.0044
Schistosoma mansoni multidrug resistance protein 0.0013 0.0031 0.0044
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0062 0.0062
Onchocerca volvulus 0.002 0.0099 0.0123
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0099 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Loa Loa (eye worm) hypothetical protein 0.0033 0.0232 0.0332
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0099 0.0141
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0013 0.0019
Brugia malayi nuclear receptor NHR-88 0.0016 0.0062 0.0088
Brugia malayi Cation transporter family protein 0.0012 0.0013 0.0019
Schistosoma mansoni hypothetical protein 0.0201 0.2003 0.2864
Leishmania major cathepsin L-like protease 0.0076 0.0686 0.539
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0363
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.01 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Echinococcus granulosus cathepsin l1 0.0013 0.003 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0254 0.0363
Brugia malayi hypothetical protein 0.0023 0.0129 0.0185
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0129 0.0185
Schistosoma mansoni nAChR subunit 0.0012 0.0013 0.0019
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.0013 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0339 1
Schistosoma mansoni multidrug resistance protein 0.0017 0.0068 0.0098
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0017 0.0068 0.0307
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0129 0.0185
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.1245 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.007 0.0101
Loa Loa (eye worm) hypothetical protein 0.0023 0.0129 0.0185
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0035 0.0254 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0035 0.0254 0.0363
Toxoplasma gondii cathepsin CPL 0.002 0.0099 0.2918
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0099 0.386
Echinococcus multilocularis lamin 0.0032 0.0226 0.0226
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0511 0.5251 0.751
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0129 0.0185
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0062 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0035 0.0254 0.0363
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0035 0.0254 0.0254
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0035 0.0254 0.0363
Brugia malayi nuclear hormone receptor 0.0035 0.0254 0.0363
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0256 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0485
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0062 0.0088
Leishmania major p-glycoprotein e 0.0017 0.0068 0.0307
Leishmania major cysteine peptidase A (CPA) 0.002 0.0099 0.056
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0129 0.0185
Schistosoma mansoni multidrug resistance protein 0.0017 0.0068 0.0098
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0129 0.0185
Brugia malayi ABC transporter transmembrane region family protein 0.0017 0.0068 0.0098
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.0013 0.0019
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0156 0.0223
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0013 0.0013
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0129 0.1245 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0129 0.0129
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0339 0.0485
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0339 0.113
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0339 0.113
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0013 0.0013
Echinococcus granulosus multidrug resistance associated protein 1 0.0017 0.0068 0.0098
Brugia malayi hypothetical protein 0.0033 0.0232 0.0332
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0256 0.7314
Trypanosoma cruzi MFS transporter, putative 0.0033 0.0232 0.1857
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0686 0.5501
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0339 0.0485
Schistosoma mansoni sodium-bile acid cotransporter related 0.0677 0.6992 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0363
Echinococcus granulosus sodium bile acid cotransporter 0.0677 0.6992 1
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0013 0.0019
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.0013 0.0019
Loa Loa (eye worm) fibroinase 0.002 0.0099 0.0141
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0035 0.0254 0.0363
Brugia malayi tailless protein 0.0016 0.0062 0.0088
Brugia malayi cathepsin L-like precursor 0.0013 0.003 0.0043
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.1245 1
Brugia malayi Cathepsin L-like precursor 0.0013 0.003 0.0043
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0013 0.0019
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0031 0.0008
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0099 0.0786
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0031 0.1207
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0339 0.0485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0099 0.0099
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0031 0.0031
Onchocerca volvulus 0.002 0.0099 0.0123
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0256 0.1863
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0256 0.7559
Brugia malayi ecdysteroid receptor 0.0035 0.0254 0.0363
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0129 0.0185
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0031 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0256 0.1863
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0029 0.0041
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.003 0.0043
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0017 0.0068 0.0098
Echinococcus multilocularis FTZ F1 alpha 0.0035 0.0254 0.0254
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0062 0.0088
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0013 0.0019
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0068 0.0315
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0129 0.0185
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0129 0.0129
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0339 0.113
Entamoeba histolytica phosphofructokinase, putative 0.0129 0.1245 1
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0129 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0254 0.0363
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0017 0.0068 0.0296
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0031 0.0008
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0339 0.113
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0129 0.0185
Onchocerca volvulus 0.0016 0.0062 0.0069
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0031 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0099 0.0568
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0013 0.0019
Echinococcus multilocularis expressed protein 0.0022 0.0124 0.0124
Brugia malayi hypothetical protein 0.0018 0.0082 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0099 0.0568
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0031 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0232 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Onchocerca volvulus Phospholipase A2 homolog 0.0511 0.5251 0.7505
Onchocerca volvulus 0.0033 0.0232 0.0314
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0062 0.0088
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0031 0.0008
Trichomonas vaginalis esterase, putative 0.0043 0.0339 0.2543
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0129 0.0185
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.000000000050014 0.0000000014751
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0017 0.0068 0.0539
Schistosoma mansoni nAChR subunit 0.0012 0.0013 0.0019
Loa Loa (eye worm) multidrug resistance-associated protein 0.0011 0.0003 0.0005
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0033 0.0232 0.0332
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0273 0.2758 1
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0232 0.0314
Onchocerca volvulus Cathepsin L homolog 0.002 0.0099 0.0123
Echinococcus granulosus multidrug resistance associated protein 4 0.0011 0.0001 0.0002
Entamoeba histolytica ABC transporter, putative 0.0017 0.0068 0.0315
Echinococcus granulosus multidrug resistance associated protein 7 0.0017 0.0068 0.0098
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Onchocerca volvulus 0.0043 0.0339 0.0467
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0013 0.0019
Echinococcus multilocularis 6 phosphofructokinase 0.0129 0.1245 0.1245
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0129 0.0817
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0124 0.3648
Loa Loa (eye worm) 6-phosphofructokinase 0.0129 0.1245 0.1781
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0129 0.0129
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0124 0.3648
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0013 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0035 0.0254 0.0363
Echinococcus multilocularis lamin dm0 0.0032 0.0226 0.0226
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0013 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Giardia lamblia ABC transporter, putative 0.0017 0.0068 0.2661
Loa Loa (eye worm) hypothetical protein 0.0033 0.0232 0.0332
Echinococcus granulosus lamin 0.0032 0.0226 0.0324
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0099 0.0141
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0124 0.0177
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0232 0.0332
Loa Loa (eye worm) LGC-31 protein 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0129 0.0185
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0013 0.0019
Brugia malayi beta-lactamase family protein 0.0043 0.0339 0.0485
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.0013 0.0019
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0068 0.0315
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0033 0.0232 0.0232
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0031 0.0031
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0062 0.0088
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0124 0.3648
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0124 0.0177
Schistosoma mansoni multidrug resistance protein 0.0017 0.0068 0.0098
Brugia malayi intermediate filament protein 0.0032 0.0226 0.0324
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0035 0.0254 0.0363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0031 0.0008
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.0013 0.0019
Loa Loa (eye worm) beta-lactamase 0.0043 0.0339 0.0485
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0012 0.0013 0.0019
Echinococcus multilocularis sodium bile acid cotransporter 0.0677 0.6992 0.6992
Onchocerca volvulus 0.002 0.0099 0.0123
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0031 0.0044
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0031 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Brugia malayi 6-phosphofructokinase 0.0129 0.1248 0.1784
Echinococcus multilocularis geminin 0.0201 0.2003 0.2003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0129 0.0185
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0254 0.0363
Trichomonas vaginalis abcb9, putative 0.0013 0.0031 0.0008
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0031 0.0008
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0031 0.0008
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0256 0.1863
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0043
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0031 0.0008
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0062 0.0088
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0031 0.0008
Echinococcus multilocularis sodium bile acid cotransporter 0.0677 0.6992 0.6992
Entamoeba histolytica multidrug resistance protein, putative 0.0017 0.0068 0.0315
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0254 0.0254
Entamoeba histolytica hypothetical protein 0.0017 0.0068 0.0315
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0339 0.2543
Leishmania major cathepsin L-like protease 0.002 0.0099 0.056
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0031 0.0008
Schistosoma mansoni hypothetical protein 0.0201 0.2003 0.2864
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0012 0.0013 0.0019
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0031 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0099 0.0568
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0686 0.5501
Brugia malayi SPARC precursor 0.0022 0.0124 0.0177
Leishmania major cathepsin L-like protease 0.0076 0.0686 0.539
Entamoeba histolytica hypothetical protein 0.0023 0.0129 0.0817
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0013 0.0019
Brugia malayi hypothetical protein 0.0016 0.0062 0.0088
Loa Loa (eye worm) phosphofructokinase 0.0129 0.1245 0.1781
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0485
Brugia malayi photoreceptor-specific nuclear receptor 0.0035 0.0254 0.0363
Loa Loa (eye worm) RecQ helicase 0.0025 0.0156 0.0223
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0062 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0099 0.0568
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0099 0.0141
Onchocerca volvulus 0.0043 0.0339 0.0467
Onchocerca volvulus Phospholipase A2 homolog 0.0108 0.1019 0.1441
Trichomonas vaginalis taga, putative 0.0013 0.0031 0.0008
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0129 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.0177
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0062 0.0088
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0068 0.2661
Echinococcus multilocularis nAChR subunit 0.0012 0.0013 0.0013
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0033 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0363
Brugia malayi conserved hypotetical protein 0.0016 0.0062 0.0088
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0256 0.1863
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0035 0.0254 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0035 0.0254 0.0363
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0129 0.0129
Onchocerca volvulus 0.0033 0.0232 0.0314
Loa Loa (eye worm) hypothetical protein 0.0677 0.6992 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0031 0.0008
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0118
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.003 0.0043
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0339 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0254 0.0363
Onchocerca volvulus 0.002 0.0099 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0035 0.0254 0.0363
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0254 0.0363
Echinococcus multilocularis expressed protein 0.0444 0.4544 0.4544
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0031 0.0008
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0068 0.2661
Echinococcus granulosus FTZ F1 alpha 0.0035 0.0254 0.0363
Brugia malayi nuclear receptor RXR 0.0018 0.0082 0.0118
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0129 0.0129
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0062 0.0088
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0062 0.0088
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0141
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0082 0.0082
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0129 0.0185
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0031 0.0044
Schistosoma mansoni multidrug resistance protein 0.0017 0.0068 0.0098
Brugia malayi Sodium Bile acid symporter family protein 0.0677 0.6992 1
Loa Loa (eye worm) DR-78 0.0016 0.0062 0.0088
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0031 0.0031
Brugia malayi ABC transporter family protein 0.0013 0.0031 0.0044
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0339 0.0485
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.0177
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0012 0.0013 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0099 0.0568
Entamoeba histolytica hypothetical protein 0.0023 0.0129 0.0817
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0052 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0254 0.0254
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0031 0.0044
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0031 0.0008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0013 0.0019
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0129 0.0185
Schistosoma mansoni zinc finger protein 0.0016 0.0062 0.0088
Schistosoma mansoni agrin 0.0022 0.0124 0.0177
Echinococcus granulosus 6 phosphofructokinase 0.0129 0.1245 0.1781
Echinococcus granulosus ecdysone induced protein 78C 0.0035 0.0254 0.0363
Echinococcus granulosus sodium bile acid cotransporter 0.0677 0.6992 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0098
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0043
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0129 0.0185
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Echinococcus granulosus expressed protein 0.0444 0.4544 0.6499
Schistosoma mansoni multidrug resistance protein 0.0013 0.0031 0.0044
Mycobacterium ulcerans 6-phosphofructokinase 0.0129 0.1245 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0339 0.113
Echinococcus multilocularis follistatin 0.0022 0.0124 0.0124
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0062 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Schistosoma mansoni nAChR subunit 0.0012 0.0013 0.0019
Echinococcus multilocularis multidrug resistance associated protein 1 0.0017 0.0068 0.0068
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0068 0.2004
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.1245 1
Trypanosoma brucei p-glycoprotein 0.0017 0.0068 0.0296
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0124 0.0177
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0062 0.0088
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0052 0.0075
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0686 0.5501
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.0013 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0254 0.0363
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0066 0.257
Onchocerca volvulus Protein ultraspiracle homolog 0.0035 0.0254 0.0345
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0339 0.2543
Echinococcus granulosus intermediate filament protein 0.0032 0.0226 0.0324
Leishmania major cathepsin L-like protease 0.0076 0.0686 0.539
Onchocerca volvulus 0.0016 0.0062 0.0069
Leishmania major hypothetical protein, conserved 0.0043 0.0339 0.2537
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0035 0.0254 0.0363
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0129 0.1245 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0031 0.0912
Leishmania major cathepsin L-like protease 0.002 0.0099 0.056
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0156 0.1039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0118
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0032 0.0251
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0031 0.0044
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0129 0.0185
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0031 0.0912
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0082 0.0118
Echinococcus granulosus agrin 0.0022 0.0124 0.0177
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0013 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0254 0.0363
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0129 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Echinococcus granulosus cathepsin l1 0.002 0.0099 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0099 0.0568
Brugia malayi PXA domain containing protein 0.0023 0.0129 0.0185
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Schistosoma mansoni steroid hormone receptor ad4bp 0.0035 0.0254 0.0363
Schistosoma mansoni nuclear receptor 0.0016 0.0062 0.0088
Echinococcus multilocularis agrin 0.0022 0.0124 0.0124
Schistosoma mansoni sodium-bile acid cotransporter 0.0287 0.2901 0.4149
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0129 0.0185
Schistosoma mansoni 6-phosphofructokinase 0.0129 0.1245 0.1781
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0156 0.0156
Brugia malayi beta-lactamase family protein 0.0043 0.0339 0.0485
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0129 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0226 0.0324
Leishmania major cathepsin L-like protease 0.002 0.0099 0.056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0062 0.0062
Echinococcus granulosus follistatin 0.0022 0.0124 0.0177
Echinococcus multilocularis ecdysone induced protein 78C 0.0035 0.0254 0.0254
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0013 0.0013
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0129 0.0129
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0254 0.0363
Trichomonas vaginalis abcb9, putative 0.0013 0.0031 0.0008
Brugia malayi nuclear receptor NHR-88 0.0035 0.0254 0.0363
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0146
Schistosoma mansoni multidrug resistance protein 0.0013 0.0031 0.0044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0013 0.0019
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0232 0.0332
Echinococcus multilocularis cysteine protease 0.002 0.0099 0.0099
Brugia malayi Cation transporter family protein 0.0012 0.0013 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0035 0.0254 0.0363
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0156 0.1039
Entamoeba histolytica cysteine protease, putative 0.002 0.0099 0.0568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0035 0.0254 0.0363
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0099 0.386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0686 0.5385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0099 0.0568
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0035 0.0254 0.0363
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0035 0.0254 0.0363
Brugia malayi Cathepsin L-like precursor 0.002 0.0099 0.0141
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0031 0.0008
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0129 0.0129
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0031 0.0008
Leishmania major ATP-dependent phosphofructokinase 0.0129 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0124 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0256 1
Onchocerca volvulus 0.0013 0.0031 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0062 0.0088
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0232 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0035 0.0254 0.0363
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0031 0.0008
Loa Loa (eye worm) cysteine protease 0.002 0.0099 0.0141
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0485
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0226 0.0324
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0031 0.0008
Loa Loa (eye worm) steroid hormone receptor 0.0035 0.0254 0.0363
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0363
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0099 0.0568
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0017 0.0068 0.0296
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0129 0.0185
Loa Loa (eye worm) hypothetical protein 0.0031 0.022 0.0315
Echinococcus granulosus Solute carrier organic anion transporter family 0.0033 0.0232 0.0332
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0031 0.0044
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0031 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0019
Trichomonas vaginalis abcb9, putative 0.0013 0.0031 0.0008
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0013 0.0019
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0031 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0254 0.0363
Loa Loa (eye worm) hypothetical protein 0.0023 0.0129 0.0185
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0066
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0035 0.0254 0.0363
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0062 0.0062
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0031 0.0044
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0012 0.0013 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0129 0.0817
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0032 0.002
Echinococcus multilocularis multidrug resistance associated protein 4 0.0011 0.0001 0.0001
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0129 0.0185
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0118
Trypanosoma cruzi multidrug resistance protein E, putative 0.0017 0.0068 0.0539
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0256 0.1863
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0031 0.0008
Echinococcus multilocularis sodium bile acid cotransporter 0.0677 0.6992 0.6992
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.0068 0.2012
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0129 0.0817
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0099 0.0141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0254 0.0363
Onchocerca volvulus 0.0022 0.0124 0.0158
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0031 0.0031
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0031 0.0008
Schistosoma mansoni lamin 0.0032 0.0226 0.0324
Loa Loa (eye worm) hypothetical protein 0.0108 0.1019 0.1457
Onchocerca volvulus 0.0033 0.0232 0.0314
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0129 0.0185
Onchocerca volvulus 0.002 0.0099 0.0123
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0031 0.0008
Brugia malayi Cathepsin L-like precursor 0.0013 0.003 0.0043
Trypanosoma cruzi major cysteine proteinase, putative 0.006 0.0515 0.4133
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0032 0.002
Onchocerca volvulus Cathepsin L homolog 0.002 0.0099 0.0123
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.007 0.0101
Brugia malayi nuclear hormone receptor 0.0016 0.0062 0.0088
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0044
Loa Loa (eye worm) ctsf protein 0.002 0.0099 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0099 0.0568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0099 0.0568
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0129 0.0185
Leishmania major ABC-thiol transporter 0.0017 0.0068 0.0307
Brugia malayi steroid hormone receptor 0.0035 0.0254 0.0363
Entamoeba histolytica phosphofructokinase, putative 0.0129 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0118
Schistosoma mansoni organic anion transporter 0.0033 0.0232 0.0332
Brugia malayi beta-lactamase 0.0043 0.0339 0.0485
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0062 0.0088
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0013 0.0019
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0363
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0256 0.1863
Echinococcus multilocularis thyroid hormone receptor alpha 0.0035 0.0254 0.0254
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0129 0.0185
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0032 0.0011
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0017 0.0068 0.0539
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0129 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0099 0.0568
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.007 0.127
Loa Loa (eye worm) hypothetical protein 0.0033 0.0232 0.0332
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0035 0.0254 0.0254
Giardia lamblia MRP-like ABC transporter 0.0017 0.0068 0.2661
Echinococcus granulosus nAChR subunit 0.0012 0.0013 0.0019
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0124 0.4834
Schistosoma mansoni nAChR subunit 0.0012 0.0013 0.0019
Entamoeba histolytica phosphofructokinase, putative 0.0129 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0088
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.0013 0.0019
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0062 0.0062

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 14741 ng ml-1 Cytotoxicity was assessed using vincristine-resistant human leukemic cell line HL60/Vinc ChEMBL. 11170627
IC50 (functional) = 21862 ng ml-1 Cytotoxicity was assessed using human leukemic cell line CCRF-CEM ChEMBL. 11170627
IC50 (functional) = 23336 ng ml-1 Cytotoxicity was assessed using adriamycin-resistant human leukemic cell line HL60/ADR ChEMBL. 11170627
IC50 (functional) = 26054 ng ml-1 Cytotoxicity was assessed using adriamycin-resistant human leukemic cell line HL60/ADR ChEMBL. 11170627
IC50 (functional) = 36083 ng ml-1 Cytotoxicity was assessed using vincristine-resistant human leukemic cell line HL60/Vinc ChEMBL. 11170627
IC50 (functional) = 36251 ng ml-1 Cytotoxicity was assessed using drug-sensitive human leukemic cell line HL60/S ChEMBL. 11170627
IC50 (functional) = 38450 ng ml-1 Cytotoxicity was assessed using human leukemic cell line CCRF-CEM ChEMBL. 11170627
IC50 (functional) = 117178 ng ml-1 Cytotoxicity was assessed using drug-sensitive human leukemic cell line HL60/S ChEMBL. 11170627
Relative potency (functional) = 0.01 Relative potency compared to cytotoxicity against HL60/S cell line of etoposide ChEMBL. 11170627
Relative potency (functional) = 0.03 Relative potency compared to cytotoxicity against CCRF-CEM cell line of etoposide ChEMBL. 11170627
Relative potency (functional) = 0.05 Relative potency compared to cytotoxicity against CCRF-CEM cell line of etoposide ChEMBL. 11170627
Relative potency (functional) = 0.05 Relative potency compared to cytotoxicity against HL60/S cell line of etoposide ChEMBL. 11170627
RF (functional) = 0.2 Resistance factor was determined using the ratio of (IC50) of drug resistance cells/drug sensitive cells in HL60/ADR cell line ChEMBL. 11170627
RF (functional) = 0.3 Resistance factor was determined using the ratio of (IC50) of drug resistance cells/drug sensitive cells in HL60/Vinc cell line ChEMBL. 11170627
RF (functional) = 0.4 Resistance factor was determined using the ratio of (IC50) of drug resistance cells/drug sensitive cells in HL60/Vinc cell line ChEMBL. 11170627
RF (functional) = 0.7 Resistance factor was determined using the ratio of (IC50) of drug resistance cells/drug sensitive cells in HL60/ADR cell line ChEMBL. 11170627

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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