Detailed information for compound 80971

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 167.1 | Formula: C4H10NO4P
  • H donors: 3 H acceptors: 4 LogP: -4.64 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H](C(=O)CP(=O)(O)O)N
  • InChi: 1S/C4H10NO4P/c1-3(5)4(6)2-10(7,8)9/h3H,2,5H2,1H3,(H2,7,8,9)/t3-/m0/s1
  • InChiKey: YCWGDQFWWLSCRS-VKHMYHEASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0077 0.1013 0.2814
Onchocerca volvulus 0.006 0.077 0.2043
Loa Loa (eye worm) hypothetical protein 0.0041 0.0474 0.0911
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0473 0.0471
Onchocerca volvulus 0.006 0.077 0.2043
Loa Loa (eye worm) hypothetical protein 0.004 0.0473 0.0908
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1481
Onchocerca volvulus 0.0036 0.041 0.0901
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0358 0.5189 0.5127
Echinococcus multilocularis ecdysone induced protein 78C 0.0077 0.1013 0.1011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0077 0.1013 0.1011
Echinococcus multilocularis microtubule associated protein 2 0.0682 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0052 0.0097
Echinococcus multilocularis tumor protein p63 0.035 0.5067 0.5066
Echinococcus multilocularis carboxylesterase 5A 0.0358 0.5189 0.5188
Brugia malayi hypothetical protein 0.0041 0.0474 0.0914
Loa Loa (eye worm) hypothetical protein 0.0041 0.0474 0.0911
Loa Loa (eye worm) hypothetical protein 0.004 0.0473 0.0908
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.0474 0.0473
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.006 0.077 0.7784
Loa Loa (eye worm) hypothetical protein 0.0017 0.0126 0.0239
Loa Loa (eye worm) hypothetical protein 0.0077 0.1013 0.1949
Echinococcus granulosus ecdysone induced protein 78C 0.0077 0.1013 0.1011
Brugia malayi laminin alpha chain 0.0027 0.0277 0.0533
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0953 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0017 0.0126 0.0124
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0077 0.1013 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0077 0.1013 0.1952
Toxoplasma gondii exonuclease III APE 0.002 0.0169 0.0797
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0036 0.041 0.0901
Echinococcus multilocularis acetylcholinesterase 0.0358 0.5189 0.5188
Echinococcus multilocularis geminin 0.0379 0.5498 0.5498
Schistosoma mansoni memapsin-2 (A01 family) 0.0426 0.6203 0.6155
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0073 0.0953 0.0838
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0474 0.0353
Brugia malayi steroid hormone receptor 0.0077 0.1013 0.1952
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0073 0.0953 0.0838
Echinococcus multilocularis neuroligin 0.006 0.077 0.0768
Onchocerca volvulus 0.0077 0.1013 0.2814
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0036 0.041 0.0787
Schistosoma mansoni nuclear hormone receptor 0.0036 0.041 0.0288
Brugia malayi nuclear receptor RXR 0.0041 0.0474 0.0914
Brugia malayi Carboxylesterase family protein 0.006 0.077 0.1483
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0077 0.1013 0.1952
Brugia malayi ecdysteroid receptor 0.0229 0.3278 0.6318
Brugia malayi Cytochrome P450 family protein 0.0012 0.0052 0.01
Brugia malayi conserved hypotetical protein 0.0036 0.041 0.079
Brugia malayi Nuclear hormone receptor E75 0.0036 0.041 0.079
Echinococcus multilocularis protein dispatched 1 0.0049 0.0596 0.0594
Echinococcus multilocularis BC026374 protein (S09 family) 0.006 0.077 0.0768
Echinococcus granulosus neurogenic locus notch protein 0.0027 0.0277 0.0275
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.041 0.0408
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1351 1
Schistosoma mansoni coup transcription factor 0.0077 0.1013 0.0898
Schistosoma mansoni rab6-interacting 0.004 0.0473 0.0352
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.053
Schistosoma mansoni lipoxygenase 0.004 0.0473 0.0352
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0169 0.13
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0169 0.125
Loa Loa (eye worm) hypothetical protein 0.0041 0.0474 0.0911
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0765 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0077 0.1013 0.1952
Schistosoma mansoni acetylcholinesterase 0.006 0.077 0.0652
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.5875 0.5874
Loa Loa (eye worm) hypothetical protein 0.0358 0.5189 1
Brugia malayi hypothetical protein 0.0017 0.0126 0.0242
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0474 0.0914
Brugia malayi CHE-14 protein 0.0043 0.0506 0.0976
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0077 0.1013 0.0898
Loa Loa (eye worm) doublecortin family protein 0.004 0.0473 0.0908
Brugia malayi nuclear hormone receptor family member nhr-6 0.0036 0.041 0.079
Brugia malayi Doublecortin family protein 0.004 0.0473 0.0911
Loa Loa (eye worm) abnormal epIthelia family member 0.0027 0.0277 0.053
Echinococcus granulosus geminin 0.0379 0.5498 0.5498
Schistosoma mansoni gliotactin 0.006 0.077 0.0652
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0953 1
Schistosoma mansoni patched 1 0.0043 0.0506 0.0386
Echinococcus multilocularis FTZ F1 alpha 0.0077 0.1013 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0077 0.1013 0.1952
Brugia malayi nuclear receptor NHR-88 0.0077 0.1013 0.1952
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0169 0.0326
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Brugia malayi Carboxylesterase family protein 0.006 0.077 0.1483
Echinococcus granulosus slit 2 protein 0.0027 0.0277 0.0275
Schistosoma mansoni neuroligin 3 (S09 family) 0.006 0.077 0.0652
Loa Loa (eye worm) hypothetical protein 0.0077 0.1013 0.1949
Echinococcus granulosus tumor protein p63 0.035 0.5067 0.5066
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Brugia malayi nuclear hormone receptor 0.0036 0.041 0.079
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0073 0.0953 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0113 0.1555 0.1554
Echinococcus granulosus FTZ F1 alpha 0.0077 0.1013 0.1011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.3467 0.6681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0077 0.1013 0.1949
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0953 1
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1481
Echinococcus granulosus nuclear receptor nhr 48 0.0036 0.041 0.0408
Mycobacterium tuberculosis Carboxylesterase LipT 0.006 0.077 1
Brugia malayi hypothetical protein 0.006 0.077 0.1483
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0953 0.0952
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0474 0.0914
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0077 0.1013 0.1011
Echinococcus granulosus neuroligin 0.006 0.077 0.0768
Echinococcus multilocularis acetylcholinesterase 0.0358 0.5189 0.5188
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0077 0.1013 0.1952
Onchocerca volvulus 0.004 0.0473 0.1101
Echinococcus multilocularis RUN 0.004 0.0473 0.0471
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.1013 0.1011
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1351 0.2604
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1481
Echinococcus multilocularis nuclear receptor nhr 48 0.0036 0.041 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0506 0.4601
Brugia malayi nuclear hormone receptor 0.0077 0.1013 0.1952
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0169 0.5
Echinococcus multilocularis ubiquitin specific protease 41 0.0073 0.0953 0.0952
Brugia malayi Steroid receptor seven-up type 2 0.0077 0.1013 0.1952
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0077 0.1013 0.1011
Schistosoma mansoni polycystin 1-related 0.004 0.0473 0.0352
Brugia malayi hypothetical protein 0.0017 0.0126 0.0242
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0473 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0036 0.041 0.0408
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.041 0.0408
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0126 0.0242
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Schistosoma mansoni hypothetical protein 0.0041 0.0483 0.0362
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.006 0.077 1
Loa Loa (eye worm) nuclear hormone receptor 0.0036 0.041 0.0787
Echinococcus multilocularis cpg binding protein 0.003 0.0317 0.0315
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0169 0.0525
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0077 0.1013 0.1011
Echinococcus granulosus carboxylesterase 5A 0.0358 0.5189 0.5188
Loa Loa (eye worm) hypothetical protein 0.0077 0.1013 0.1949
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0953 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0169 0.13
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0953 0.0952
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1351 0.135
Schistosoma mansoni RAR-like nuclear receptor 0.0077 0.1013 0.0898
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0113 0.1555 0.1554
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.006 0.077 0.0652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0077 0.1013 0.1949
Schistosoma mansoni hypothetical protein 0.0041 0.0483 0.0362
Echinococcus granulosus expressed conserved protein 0.0094 0.1261 0.126
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0077 0.1013 0.0898
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0052 0.0097
Echinococcus multilocularis pikachurin 0.0027 0.0277 0.0275
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0169 0.1632
Brugia malayi Carboxylesterase family protein 0.006 0.077 0.1483
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0377 0.5474 0.5417
Schistosoma mansoni hypothetical protein 0.0041 0.0483 0.0362
Echinococcus granulosus family S9 non peptidase ue S09 family 0.006 0.077 0.0768
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1986 0.1985
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0073 0.0953 0.6633
Loa Loa (eye worm) hypothetical protein 0.0073 0.0953 0.1834
Brugia malayi CXXC zinc finger family protein 0.0028 0.0293 0.0564
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1719 0.1718
Schistosoma mansoni slit 0.0027 0.0277 0.0153
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1481
Brugia malayi hypothetical protein 0.004 0.0473 0.0911
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0506 0.0505
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0506 0.0505
Echinococcus multilocularis para nitrobenzyl esterase 0.006 0.077 0.0768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0077 0.1013 0.1949
Schistosoma mansoni hypothetical protein 0.0404 0.5875 0.5822
Onchocerca volvulus 0.0051 0.0632 0.1606
Brugia malayi ecdysone receptor 0.0036 0.041 0.079
Mycobacterium ulcerans carboxylesterase, LipT 0.006 0.077 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.5189 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0077 0.1013 0.1952
Schistosoma mansoni ap endonuclease 0.002 0.0169 0.0044
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0036 0.041 0.0408
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0077 0.1013 0.0898
Onchocerca volvulus 0.006 0.077 0.2043
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.0474 0.0473
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.1013 0.1011
Loa Loa (eye worm) nuclear receptor NHR-67 0.0036 0.041 0.0787
Onchocerca volvulus Bile acid receptor homolog 0.0229 0.3278 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0169 0.125
Echinococcus granulosus cpg binding protein 0.003 0.0317 0.0315
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0506 0.0973
Loa Loa (eye worm) carboxylesterase 0.006 0.077 0.1481
Schistosoma mansoni lipoxygenase 0.0113 0.1555 0.1448
Brugia malayi photoreceptor-specific nuclear receptor 0.0077 0.1013 0.1952
Schistosoma mansoni cell polarity protein 0.0027 0.0277 0.0153
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.0474 0.0911
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0169 0.0322
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0017 0.0126 0.0239
Schistosoma mansoni hypothetical protein 0.004 0.0473 0.0352
Brugia malayi Carboxylesterase family protein 0.006 0.077 0.1483
Schistosoma mansoni nuclear hormone receptor 0.0077 0.1013 0.0898
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0473 0.0471
Loa Loa (eye worm) hypothetical protein 0.0017 0.0126 0.0239
Schistosoma mansoni ap endonuclease 0.002 0.0169 0.0044
Echinococcus granulosus acetylcholinesterase 0.0358 0.5189 0.5188
Brugia malayi hypothetical protein 0.0041 0.0474 0.0914
Echinococcus multilocularis slit 2 protein 0.0027 0.0277 0.0275
Loa Loa (eye worm) hypothetical protein 0.0041 0.0474 0.0911
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0953 0.0952
Brugia malayi tailless protein 0.0036 0.041 0.079
Trichomonas vaginalis spcc417.12 protein, putative 0.006 0.077 0.7784
Onchocerca volvulus 0.0028 0.0293 0.0531
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.0474 0.0353
Schistosoma mansoni rab6-interacting 0.004 0.0473 0.0352
Loa Loa (eye worm) hypothetical protein 0.0077 0.1013 0.1949
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1481
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1719 0.1718
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Brugia malayi Pepsin A precursor 0.0017 0.0126 0.0242
Schistosoma mansoni steroid hormone receptor ad4bp 0.0077 0.1013 0.0898
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.053
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0473 0.0471
Schistosoma mansoni cpg binding protein 0.0028 0.0293 0.0169
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0169 0.0167
Echinococcus granulosus para nitrobenzyl esterase 0.006 0.077 0.0768
Schistosoma mansoni microtubule-associated protein tau 0.0682 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.041 0.0408
Brugia malayi orphan nuclear receptor NR2E1 0.0036 0.041 0.079
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.053
Brugia malayi nuclear receptor NHR-67 0.0036 0.041 0.079
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0953 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0473 0.0471
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0169 0.0167
Schistosoma mansoni cpg binding protein 0.003 0.0317 0.0194
Loa Loa (eye worm) hypothetical protein 0.0051 0.0632 0.1215
Loa Loa (eye worm) hypothetical protein 0.0077 0.1013 0.1949
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1481
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.006 0.077 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0077 0.1013 0.1011
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1986 0.1985
Schistosoma mansoni cpg binding protein 0.003 0.0317 0.0194
Brugia malayi laminin-like protein K08C7.3 precursor 0.0027 0.0277 0.0533
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0073 0.0953 0.1837
Echinococcus granulosus ubiquitin specific protease 41 0.0073 0.0953 0.0952
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0473 0.0471
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0077 0.1013 0.1011
Loa Loa (eye worm) acetylcholinesterase 1 0.0358 0.5189 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.0126 0.0239
Brugia malayi nuclear receptor RXR 0.0036 0.041 0.079
Schistosoma mansoni loxhd1 0.004 0.0473 0.0352
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0027 0.0277 0.0533
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0017 0.0126 0.0124
Schistosoma mansoni nuclear hormone receptor 0.0036 0.041 0.0288
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0293 0.0561
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.041 0.0408
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0036 0.041 0.079
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0169 0.5
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1351 0.135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0077 0.1013 0.1949
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0077 0.1013 0.1949
Onchocerca volvulus Protein ultraspiracle homolog 0.0077 0.1013 0.2814
Schistosoma mansoni thyroid hormone receptor 0.0201 0.286 0.277
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0077 0.1013 0.1011
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0052 0.0097
Onchocerca volvulus 0.0036 0.041 0.0901
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0077 0.1013 0.0898
Loa Loa (eye worm) hypothetical protein 0.0041 0.0474 0.0911
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0073 0.0953 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0126 0.0239
Brugia malayi Carboxylesterase family protein 0.0358 0.5189 1
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0632 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0077 0.1013 0.1952
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0077 0.1013 0.1952
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0077 0.1013 0.1949
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Schistosoma mansoni hypothetical protein 0.0379 0.5498 0.5441
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.1013 0.1952
Brugia malayi hypothetical protein 0.004 0.0473 0.0911
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0169 0.0525
Loa Loa (eye worm) hypothetical protein 0.0229 0.3278 0.6317
Echinococcus multilocularis thyroid hormone receptor alpha 0.0201 0.286 0.2859
Loa Loa (eye worm) carboxylesterase 0.0358 0.5189 1
Echinococcus multilocularis neurogenic locus notch protein 0.0027 0.0277 0.0275
Brugia malayi hypothetical protein 0.0036 0.041 0.079
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.067 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.1013 0.0898
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0036 0.041 0.0408
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.006 0.077 0.0652
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0169 0.13
Loa Loa (eye worm) hypothetical protein 0.0077 0.1013 0.1949
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.041 0.0408
Schistosoma mansoni hypothetical protein 0.0041 0.0483 0.0362
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0953 1
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0027 0.0277 0.0153
Schistosoma mansoni hypothetical protein 0.0124 0.1719 0.1614
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1374 0.1264
Schistosoma mansoni nuclear receptor 0.0036 0.041 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0077 0.1013 0.1952
Echinococcus granulosus BC026374 protein S09 family 0.006 0.077 0.0768
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0126 0.0242
Loa Loa (eye worm) carboxylesterase 0.006 0.077 0.1481
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0036 0.041 0.0408
Brugia malayi nuclear receptor NHR-88 0.0036 0.041 0.079
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0036 0.041 0.0901
Loa Loa (eye worm) DR-78 0.0036 0.041 0.0787
Brugia malayi nuclear hormone receptor family member odr-7 0.0036 0.041 0.079
Onchocerca volvulus 0.006 0.077 0.2043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.041 0.0408
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0473 1
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.0126 0.0239
Echinococcus granulosus dnaJ subfamily B 0.0404 0.5875 0.5874
Brugia malayi Carboxylesterase family protein 0.0358 0.5189 1
Brugia malayi Nuclear hormone receptor E75 0.0036 0.041 0.079
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0473 0.0471
Schistosoma mansoni laminin gamma-3 chain 0.0027 0.0277 0.0153
Onchocerca volvulus 0.006 0.077 0.2043
Echinococcus multilocularis expressed conserved protein 0.0094 0.1261 0.126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0077 0.1013 0.1952
Schistosoma mansoni zinc finger protein 0.0036 0.041 0.0288
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0077 0.1013 0.1011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0077 0.1013 0.1952
Loa Loa (eye worm) hypothetical protein 0.0052 0.0649 0.1248
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Loa Loa (eye worm) hypothetical protein 0.0043 0.0506 0.0973
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0036 0.041 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.1013 0.1011
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.006 0.077 0.0768
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.1013 0.1011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0077 0.1013 0.1949
Brugia malayi follicle stimulating hormone receptor 0.0242 0.3467 0.6682
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0077 0.1013 0.1952
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.0787
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0953 0.0952
Onchocerca volvulus 0.004 0.0473 0.1101
Brugia malayi hypothetical protein 0.0036 0.041 0.079
Schistosoma mansoni nuclear receptor 0.0036 0.041 0.0288
Loa Loa (eye worm) hypothetical protein 0.01 0.1351 0.2601
Echinococcus granulosus pikachurin 0.0027 0.0277 0.0275
Loa Loa (eye worm) steroid hormone receptor 0.0077 0.1013 0.1949
Echinococcus granulosus RUN 0.004 0.0473 0.0471
Schistosoma mansoni nuclear receptor nhr-48 0.0036 0.041 0.0288
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1481
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0077 0.1013 0.1952
Echinococcus granulosus acetylcholinesterase 0.0358 0.5189 0.5188
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0126 0.0242
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.006 0.077 0.0652
Schistosoma mansoni thyroid hormone receptor 0.0201 0.286 0.277
Schistosoma mansoni retinoic acid receptor RXR 0.0077 0.1013 0.0898
Echinococcus multilocularis protein patched 0.0043 0.0506 0.0505
Loa Loa (eye worm) hypothetical protein 0.0077 0.1013 0.1949
Brugia malayi Cytochrome P450 family protein 0.0012 0.0052 0.01
Brugia malayi EGF-like domain containing protein 0.0027 0.0277 0.0533
Schistosoma mansoni BC026374 protein (S09 family) 0.006 0.077 0.0652
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0169 0.13
Schistosoma mansoni hypothetical protein 0.0379 0.5498 0.5441
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0506 0.0505
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0077 0.1013 0.0898

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 14 % Percent inhibition of D-Alanine-D-Alanine Ligase at 10e-3 M of the compound ChEMBL. 2502630

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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