Detailed information for compound 810017

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 486.562 | Formula: C28H30N4O4
  • H donors: 2 H acceptors: 3 LogP: 2.81 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1ccc(o1)C(=O)NCc1c(C)ncc2c1CCN(C2)C(=O)c1ccc2c(c1)c(C)c([nH]2)C
  • InChi: 1S/C28H30N4O4/c1-16-17(2)31-25-7-5-19(11-23(16)25)28(34)32-10-9-22-20(14-32)12-29-18(3)24(22)13-30-27(33)26-8-6-21(36-26)15-35-4/h5-8,11-12,31H,9-10,13-15H2,1-4H3,(H,30,33)
  • InChiKey: PGZSAYMLLJGCOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA polymerase eta, putative 0.0015 0.0027 0.0039
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0017 0.0031
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0023 0.0068 0.0051
Entamoeba histolytica hypothetical protein 0.0335 0.1631 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0245 0.1182 0.1167
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0025 0.008 0.0099
Mycobacterium tuberculosis Probable thymidylate synthase ThyX (ts) (TSase) 0.1031 0.5119 0.9536
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1122 0.5577 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0027 0.001
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.108 0.5367 1
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0027 0.005
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0245 0.1182 0.1167
Giardia lamblia Deoxynucleoside kinase 0.1883 0.9394 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0245 0.1182 0.2119
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0335 0.1631 1
Schistosoma mansoni thymidine kinase 0.2004 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0013 0.0017 0.0032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0017 0.0031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0027 0.005
Leishmania major cathepsin L-like protease 0.0013 0.0017 0.0032
Brugia malayi Cathepsin L-like precursor 0.0013 0.0017 0.0031
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0028 0.0095 0.0482
Loa Loa (eye worm) hypothetical protein 0.0408 0.2 0.3586
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0245 0.1182 0.1167
Leishmania major thymidine kinase, putative 0.0192 0.0915 0.1705
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2529 1
Leishmania major DNA polymerase kappa, putative 0.0015 0.0027 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Echinococcus multilocularis dna polymerase eta 0.0015 0.0027 0.001
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0146 0.0272
Loa Loa (eye worm) deoxynucleoside kinase 0.0335 0.1631 0.2924
Plasmodium vivax amine transporter, putative 0.0245 0.1182 0.2177
Leishmania major cathepsin L-like protease 0.0013 0.0017 0.0032
Loa Loa (eye worm) thymidylate synthase 0.108 0.5367 0.9624
Schistosoma mansoni sodium-dependent amino acid transporter 0.0245 0.1182 0.1167
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0063 0.0046
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0245 0.1182 0.2119
Leishmania major cathepsin L-like protease 0.0013 0.0017 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1631 0.6425
Loa Loa (eye worm) hypothetical protein 0.0245 0.1182 0.2119
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0068 0.0051
Leishmania major cathepsin L-like protease 0.0049 0.0199 0.037
Treponema pallidum sodium- and chloride- dependent transporter 0.0408 0.2 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0245 0.1182 0.2119
Brugia malayi Cathepsin L-like precursor 0.0013 0.0017 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.005
Brugia malayi Cathepsin L-like precursor 0.0013 0.0017 0.0031
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1122 0.5577 1
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1631 0.6425
Schistosoma mansoni hypothetical protein 0.004 0.0152 0.0135
Schistosoma mansoni sodium/chloride dependent transporter 0.1122 0.5577 0.5569
Trypanosoma brucei unspecified product 0.0019 0.0049 0.0091
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0049 0.0091
Entamoeba histolytica hypothetical protein 0.0335 0.1631 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.108 0.5367 1
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.108 0.5367 0.5359
Onchocerca volvulus 0.0023 0.0068 0.0094
Entamoeba histolytica hypothetical protein 0.0335 0.1631 1
Schistosoma mansoni inositol monophosphatase 0.0028 0.0095 0.0078
Plasmodium falciparum transporter, putative 0.0245 0.1182 0.2177
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0027 0.005
Entamoeba histolytica hypothetical protein 0.0335 0.1631 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0027 0.005
Schistosoma mansoni sodium/chloride dependent transporter 0.0408 0.2 0.1986
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0027 0.001
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0095 0.0177
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0335 0.1631 0.1616
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.005
Trypanosoma brucei ingi protein (ORF1) 0.0019 0.0049 0.0091
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0199 0.037
Loa Loa (eye worm) hypothetical protein 0.0408 0.2 0.3586
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0245 0.1182 0.1167
Trypanosoma brucei ribonuclease H1 0.0018 0.0041 0.0077
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.108 0.5367 1
Brugia malayi RNase H family protein 0.0018 0.0041 0.0074
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0335 0.1631 0.1616
Echinococcus granulosus dna polymerase kappa 0.0015 0.0027 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0245 0.1182 0.1167
Brugia malayi thymidylate synthase 0.108 0.5367 0.9624
Loa Loa (eye worm) hypothetical protein 0.0245 0.1182 0.2119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0068 0.0051
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0028 0.0095 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.005
Loa Loa (eye worm) ctsf protein 0.0013 0.0017 0.0031
Trypanosoma brucei unspecified product 0.0015 0.0027 0.005
Trichomonas vaginalis thymidine kinase, putative 0.0192 0.0915 0.3575
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.2004 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0004 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0027 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1631 0.6425
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0514 0.2529 0.4711
Leishmania major ribonuclease H1, putative 0.0018 0.0041 0.0077
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0027 0.005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0245 0.1182 0.1167
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0028 0.0095 1
Toxoplasma gondii ribonuclease HI protein 0.0018 0.0041 0.0045
Schistosoma mansoni phosphoglucomutase 0.0018 0.0041 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0182 0.0866 0.338
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0027 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.108 0.5367 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0027 0.0061
Loa Loa (eye worm) fibroinase 0.0013 0.0017 0.0031
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0015 0.0027 0.0039
Echinococcus granulosus serotonin transporter 0.0408 0.2 0.1986
Echinococcus multilocularis sodium and chloride dependent glycine 0.1122 0.5577 0.5569
Onchocerca volvulus 0.0245 0.1182 0.2177
Echinococcus multilocularis dna polymerase kappa 0.0015 0.0027 0.001
Trypanosoma cruzi thymidine kinase, putative 0.0192 0.0915 0.1705
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0095 0.0177
Entamoeba histolytica hypothetical protein 0.0335 0.1631 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Giardia lamblia Hypothetical protein 0.0335 0.1631 0.1712
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) 0.1031 0.5119 0.9531
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0121
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0027 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.108 0.5367 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0023 0.0068 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1631 0.6425
Echinococcus multilocularis ribonuclease H1 0.0018 0.0041 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0004 0.0007
Brugia malayi Deoxynucleoside kinase family protein 0.0335 0.1631 0.2924
Toxoplasma gondii hypothetical protein 0.0245 0.1182 0.2177
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0335 0.1631 0.1616
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0245 0.1182 0.1167
Mycobacterium ulcerans FAD-dependent thymidylate synthase 0.1031 0.5119 0.9538
Loa Loa (eye worm) solute carrier family 6 member 4 0.0408 0.2 0.3586
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0335 0.1631 0.1712
Brugia malayi Cathepsin L-like precursor 0.0013 0.0017 0.0031
Trypanosoma brucei unspecified product 0.001 0.0004 0.0007
Echinococcus multilocularis thymidylate synthase 0.108 0.5367 0.5359
Loa Loa (eye worm) hypothetical protein 0.0245 0.1182 0.2119
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0245 0.1182 0.2177
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0199 0.037
Brugia malayi RNase H family protein 0.0018 0.0041 0.0074
Leishmania major cathepsin L-like protease 0.0013 0.0017 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0199 0.037
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0095 0.0177
Brugia malayi hypothetical protein 0.0245 0.1182 0.2119
Mycobacterium ulcerans thymidylate synthase 0.108 0.5367 1
Giardia lamblia Thymidine kinase 0.0192 0.0915 0.0948
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0335 0.1631 1
Brugia malayi Inositol-1 0.0028 0.0095 0.017
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0408 0.2 0.3586
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.016 0.0755 0.1354
Onchocerca volvulus 0.0408 0.2 0.3706
Onchocerca volvulus 0.108 0.5367 1
Loa Loa (eye worm) cysteine protease 0.0013 0.0017 0.0031
Leishmania major cathepsin L-like protease 0.0013 0.0017 0.0032
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0015 0.0027 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.005
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0245 0.1182 0.1167
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0245 0.1182 0.2177
Toxoplasma gondii hypothetical protein 0.0245 0.1182 0.2177
Schistosoma mansoni hypothetical protein 0.0066 0.0285 0.0268
Loa Loa (eye worm) norepinephrine transporter 0.0408 0.2 0.3586
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0027 0.001
Echinococcus granulosus inositol monophosphatase 1 0.0028 0.0095 0.0078
Echinococcus granulosus histone lysine methyltransferase setb 0.0023 0.0068 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.005
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0245 0.1182 0.1167
Loa Loa (eye worm) hypothetical protein 0.0408 0.2 0.3586
Entamoeba histolytica thymidine kinase, putative 0.0192 0.0915 0.5564
Echinococcus multilocularis serotonin transporter 0.0408 0.2 0.1986
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0245 0.1182 0.1167
Trichomonas vaginalis thymidine kinase, putative 0.0192 0.0915 0.3575
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0245 0.1182 0.1167
Leishmania major dihydrofolate reductase-thymidylate synthase 0.108 0.5367 1
Entamoeba histolytica hypothetical protein 0.0335 0.1631 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Schistosoma mansoni phosphoglucomutase 0.0018 0.0041 0.0024
Brugia malayi Cathepsin L-like precursor 0.0013 0.0017 0.0031
Echinococcus granulosus dna polymerase eta 0.0015 0.0027 0.001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.0095 0.031
Entamoeba histolytica hypothetical protein 0.0335 0.1631 1
Echinococcus multilocularis thymidine kinase 0.2004 1 1
Trypanosoma cruzi ribonuclease H1, putative 0.0018 0.0041 0.0077
Echinococcus multilocularis inositol monophosphatase 1 0.0028 0.0095 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0068 0.0051
Brugia malayi hypothetical protein 0.0514 0.2529 0.4534
Trypanosoma brucei thymidine kinase 0.0192 0.0915 0.1705
Trypanosoma cruzi ribonuclease H1, putative 0.0018 0.0041 0.0077
Leishmania major cathepsin L-like protease 0.0049 0.0199 0.037
Loa Loa (eye worm) hypothetical protein 0.1122 0.5577 1
Mycobacterium tuberculosis Hypothetical protein 0.0514 0.2529 0.4684
Trypanosoma brucei RNA helicase, putative 0.0066 0.0285 0.053
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0335 0.1631 1
Leishmania major cathepsin L-like protease 0.0049 0.0199 0.037
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0408 0.2 0.1986
Schistosoma mansoni inositol monophosphatase 0.0028 0.0095 0.0078
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0335 0.1631 1
Schistosoma mansoni phosphoglucomutase 0.0018 0.0041 0.0024
Trypanosoma cruzi cruzipain precursor, putative 0.0049 0.0199 0.037
Echinococcus granulosus ribonuclease H1 0.0018 0.0041 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.005
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0027 0.005
Giardia lamblia Ribonuclease H 0.0018 0.0041 0.0015
Echinococcus granulosus sodium and chloride dependent glycine 0.1122 0.5577 0.5569
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.108 0.5367 1
Plasmodium falciparum amino acid transporter, putative 0.0245 0.1182 0.2177
Plasmodium vivax hypothetical protein, conserved 0.0245 0.1182 0.2177
Echinococcus granulosus thymidine kinase 0.2004 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0023 0.0068 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0004 0.0007
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.108 0.5367 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0027 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0027 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0199 0.037
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0245 0.1182 0.1167
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0245 0.1182 0.2119
Plasmodium vivax SET domain protein, putative 0.0023 0.0068 0.0094
Onchocerca volvulus 0.0182 0.0866 0.1586
Trypanosoma cruzi thymidine kinase, putative 0.0192 0.0915 0.1705
Echinococcus multilocularis transfer RNA-Ile 0.2004 1 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0245 0.1182 0.1167
Brugia malayi RNase H family protein 0.0018 0.0041 0.0074
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0245 0.1182 0.1167
Leishmania major cysteine peptidase A (CPA) 0.0013 0.0017 0.0032
Schistosoma mansoni sodium/chloride dependent transporter 0.1122 0.5577 0.5569
Loa Loa (eye worm) hypothetical protein 0.1122 0.5577 1
Brugia malayi Pre-SET motif family protein 0.016 0.0755 0.1354
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1631 0.6425
Entamoeba histolytica hypothetical protein 0.0335 0.1631 1
Onchocerca volvulus 0.0245 0.1182 0.2177
Brugia malayi Pre-SET motif family protein 0.0023 0.0068 0.0121
Echinococcus multilocularis thymidine kinase 0.2004 1 1
Trichomonas vaginalis ribonuclease H1, putative 0.0018 0.0041 0.0095
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0095 0.0177
Loa Loa (eye worm) hypothetical protein 0.0245 0.1182 0.2119
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0245 0.1182 0.1167
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0027 0.0048
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0027 0.0048
Trypanosoma brucei unspecified product 0.001 0.0004 0.0007
Loa Loa (eye worm) serotonin transporter b 0.0408 0.2 0.3586
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0068 0.0051
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0028 0.0095 0.0177
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0027 0.005
Echinococcus granulosus thymidylate synthase 0.108 0.5367 0.5359
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.0095 0.031
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0245 0.1182 0.5
Brugia malayi Cathepsin L-like precursor 0.0013 0.0017 0.0031
Onchocerca volvulus Ribonuclease H1 homolog 0.0018 0.0041 0.0045
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0045 0.0177 0.033
Loa Loa (eye worm) inositol-1 0.0028 0.0095 0.017
Entamoeba histolytica hypothetical protein 0.0335 0.1631 1
Schistosoma mansoni DNA polymerase eta 0.0015 0.0027 0.001
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0245 0.1182 0.2177
Onchocerca volvulus 0.0245 0.1182 0.2177
Loa Loa (eye worm) hypothetical protein 0.0245 0.1182 0.2119
Trichomonas vaginalis inositol monophosphatase, putative 0.0028 0.0095 0.031
Trichomonas vaginalis thymidine kinase, putative 0.0192 0.0915 0.3575
Trypanosoma brucei ingi protein (ORF1) 0.0019 0.0049 0.0091
Leishmania major DNA polymerase eta, putative 0.0015 0.0027 0.005
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0013 0.0017 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.005
Echinococcus multilocularis sodium and chloride dependent glycine 0.1122 0.5577 0.5569
Echinococcus granulosus sodium and chloride dependent glycine 0.1122 0.5577 0.5569
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0019 0.0049 0.0091
Giardia lamblia Hypothetical protein 0.0335 0.1631 0.1712
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0027 0.005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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