TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 468.612 | Formula: C25H32N4O3S
H donors: 1 H acceptors: 3 LogP: 2.03 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CSc1ccccc1)NCc1c(C)ncc2c1CCN(C2)C(=O)C(N1CCOCC1)C
InChi: 1S/C25H32N4O3S/c1-18-23(15-27-24(30)17-33-21-6-4-3-5-7-21)22-8-9-29(16-20(22)14-26-18)25(31)19(2)28-10-12-32-13-11-28/h3-7,14,19H,8-13,15-17H2,1-2H3,(H,27,30)
InChiKey: CZHXKHFHYOUDBE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Smad4	0.0008	0.0006	0.0006
Brugia malayi	Melatonin receptor type 1A	0.0007	0.0003	0.0003
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0007	0.0003	0.0003
Echinococcus granulosus	orexin receptor type 2	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0067	0.022	0.022
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0108	0.0108
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0007	0.0003	0.0003
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0006	0.0006
Echinococcus granulosus	neuropeptide receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0009	0.0009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Brugia malayi	Dopamine receptor protein 2	0.0007	0.0003	0.0003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0003	0.0003
Echinococcus multilocularis	neuropeptide Y receptor	0.0007	0.0003	0.0003
Brugia malayi	larval opioid receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0192	0.0192
Echinococcus multilocularis	sex peptide receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	smad	0.0008	0.0006	0.0006
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	neuropeptide receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0031	0.009	0.009
Brugia malayi	neuropeptide F receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0002	0.0002
Onchocerca volvulus		0.0007	0.0003	0.0003
Brugia malayi	Smad1	0.0008	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0007	0.0003	0.0003
Echinococcus granulosus	allatostatin A receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	biogenic amine 5HT receptor	0.0007	0.0003	0.0003
Brugia malayi	Dopamine receptor protein 1	0.0007	0.0003	0.0003
Onchocerca volvulus		0.0028	0.0078	0.0078
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0009	0.0009
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0009	0.0009
Echinococcus multilocularis	G protein coupled receptor 139	0.0007	0.0003	0.0003
Brugia malayi	putative neuropeptide receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0009
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.009	0.009
Echinococcus granulosus	biogenic amine 5HT receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus multilocularis	dro:myosuppressin receptor	0.0007	0.0003	0.0003
Brugia malayi	G-protein coupled receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0078	0.0078
Entamoeba histolytica	hypothetical protein	0.0036	0.0108	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.1313	0.4745	0.4745
Schistosoma mansoni	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.009	0.009
Schistosoma mansoni	biogenic amine receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0006	0.0006
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.1313	0.4745	0.4745
Onchocerca volvulus		0.276	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Entamoeba histolytica	hypothetical protein	0.0036	0.0108	1
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.276	1	1
Onchocerca volvulus		0.0007	0.0003	0.0003
Onchocerca volvulus		0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	serotonin receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Onchocerca volvulus		0.0007	0.0003	0.0003
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0007	0.0003	0.0003
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.0333	0.0333
Schistosoma mansoni	neuropeptide receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0003	0.0003
Schistosoma mansoni	myosin xvIII	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	putative neuropeptide receptor NPR1	0.0007	0.0003	0.0003
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0009	0.0009
Schistosoma mansoni	amine GPCR	0.0007	0.0003	0.0003
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	allatostatin A receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0031	0.009	0.009
Echinococcus multilocularis	geminin	0.0168	0.0587	0.0587
Onchocerca volvulus		0.0007	0.0003	0.0003
Echinococcus multilocularis	g protein coupled receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0009	0.0009
Echinococcus granulosus	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0031	0.009	0.009
Echinococcus multilocularis	GPCR, family 2	0.0031	0.009	0.009
Echinococcus multilocularis	neuropeptide receptor A26	0.0007	0.0003	0.0003
Brugia malayi	MH1 domain containing protein	0.0008	0.0006	0.0006
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0018	0.0018
Brugia malayi	follicle stimulating hormone receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0006	0.0006
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	biogenic amine receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0009	0.0009
Echinococcus granulosus	dro:myosuppressin receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	Smad4	0.0008	0.0006	0.0006
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0007	0.0003	0.0003
Echinococcus granulosus	7tm_1 domain containing protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	DIX domain containing protein	0.0009	0.0009	0.0009
Echinococcus multilocularis	fmrfamide receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Brugia malayi	AKH receptor	0.0007	0.0003	0.0003
Brugia malayi	neuropeptide F receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Onchocerca volvulus		0.0007	0.0003	0.0003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0003	0.0003
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0008	0.0008
Loa Loa (eye worm)	thymidylate synthase	0.276	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	tm gpcr rhodopsin	0.0007	0.0003	0.0003
Onchocerca volvulus		0.0007	0.0003	0.0003
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0007	0.0003	0.0003
Schistosoma mansoni	amine GPCR	0.0007	0.0003	0.0003
Schistosoma mansoni	neuropeptide receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	thymidylate synthase	0.276	1	1
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0108	0.0108
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0025	0.0068	0.0068
Schistosoma mansoni	cpg binding protein	0.0029	0.0084	0.0084
Schistosoma mansoni	hypothetical protein	0.0036	0.0108	0.0108
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	g-protein coupled receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	sex peptide receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0067	0.022	0.022
Schistosoma mansoni	cpg binding protein	0.0028	0.0078	0.0078
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0007	0.0003	0.0003
Brugia malayi	ORL1-like opioid receptor	0.0007	0.0003	0.0003
Brugia malayi	G-protein coupled receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0627	0.0627
Brugia malayi	F/Y-rich N-terminus family protein	0.0008	0.0008	0.0008
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0009	0.0009	0.0009
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.276	1	1
Onchocerca volvulus		0.0007	0.0003	0.0003
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0006	0.0006
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0007	0.0003	0.0003
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0002	0.0002
Echinococcus multilocularis	g protein coupled receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	fmrfamide receptor	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	neuropeptide Y receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	tm gpcr rhodopsin	0.0007	0.0003	0.0003
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0007	0.0003	0.0003
Echinococcus multilocularis	neuropeptide s receptor	0.0007	0.0003	0.0003
Brugia malayi	N-terminal motif family protein	0.0179	0.0627	0.0627
Echinococcus granulosus	neuropeptide receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0007	0.0003	0.0003
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0.0003	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.1313	0.4745	1
Brugia malayi	Serotonin receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0011	0.0018	0.0018
Entamoeba histolytica	hypothetical protein	0.0036	0.0108	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	cpg binding protein	0.0029	0.0084	0.0084
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Onchocerca volvulus		0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Mycobacterium ulcerans	thymidylate synthase	0.276	1	1
Onchocerca volvulus		0.0007	0.0003	0.0003
Schistosoma mansoni	dep domain containing protein	0.0009	0.0009	0.0009
Echinococcus granulosus	neuropeptides capa receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	opsin-like receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	neuropeptides capa receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	g protein coupled receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0006	0.0006
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0007	0.0003	0.0003
Onchocerca volvulus		0.0007	0.0003	0.0003
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.276	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0396	0.1416	0.1416
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	GnHR receptor homolog	0.0007	0.0003	0.0003
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0009	0.0009
Echinococcus multilocularis	neuropeptides capa receptor	0.0007	0.0003	0.0003
Brugia malayi	RE15519p	0.0007	0.0003	0.0003
Echinococcus multilocularis	smad	0.0008	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	neuropeptide f receptor 76f	0.0007	0.0003	0.0003
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	serotonin receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	amine GPCR	0.0007	0.0003	0.0003
Echinococcus granulosus	neuropeptide Y receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0006	0.0006
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0008	0.0008
Schistosoma mansoni	Smad4	0.0008	0.0006	0.0006
Brugia malayi	MH2 domain containing protein	0.0116	0.0397	0.0397
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	dnaJ subfamily B	0.0396	0.1416	0.1416
Onchocerca volvulus		0.0007	0.0003	0.0003
Loa Loa (eye worm)	Smad1	0.0008	0.0006	0.0006
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0007	0.0003	0.0003
Schistosoma mansoni	amine GPCR	0.0007	0.0003	0.0003
Schistosoma mansoni	cpg binding protein	0.0029	0.0084	0.0084
Echinococcus granulosus	fmrfamide receptor	0.0007	0.0003	0.0003
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0068	0.0059
Schistosoma mansoni	dishevelled	0.0009	0.0009	0.0009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0003	0.0003
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0007	0.0003	0.0003
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0007	0.0003	0.0003
Brugia malayi	MH2 domain containing protein	0.0008	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0333	0.0333
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0007	0.0003	0.0003
Brugia malayi	G protein-coupled receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0003	0.0003
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0168	0.0587	0.0587
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0003	0.0003
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0007	0.0003	0.0003
Echinococcus granulosus	tm gpcr rhodopsin	0.0007	0.0003	0.0003
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0009	0.0009
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0078	0.0078
Echinococcus multilocularis	neuropeptide Y receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	G-protein coupled receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	histamine h1 receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0007	0.0003	0.0003
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0006	0.0006
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0002	0.0002
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.276	1	1
Onchocerca volvulus		0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	7TM GPCR rhodopsin	0.0007	0.0003	0.0003
Echinococcus multilocularis	orexin receptor type 2	0.0007	0.0003	0.0003
Brugia malayi	MH2 domain containing protein	0.0008	0.0006	0.0006
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0007	0.0003	0.0003
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.009	0.009
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0009	0.0009
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	sulfakinin receptor protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0397	0.0397
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0006	0.0006
Schistosoma mansoni	smad	0.0008	0.0006	0.0006
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.022	0.022
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0006	0.0006
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.0333	0.0333
Loa Loa (eye worm)	neuropeptide F receptor	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0009	0.0009	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Echinococcus granulosus	somatostatin receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0018	0.0018
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0007	0.0003	0.0003
Loa Loa (eye worm)	melatonin receptor type 1A	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	G-protein coupled receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0003	0.0003
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0009	0.0009
Onchocerca volvulus		0.0009	0.0009	0.0009
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0009	0.0009
Schistosoma mansoni	neuropeptide receptor	0.0007	0.0003	0.0003
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0007	0.0003	0.0003
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.276	1	1
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Onchocerca volvulus		0.0007	0.0003	0.0003
Brugia malayi	Dopamine receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0068	0.0068
Echinococcus granulosus	thymidylate synthase	0.276	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Onchocerca volvulus		0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	GPCR family 2	0.0031	0.009	0.009
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus multilocularis	somatostatin receptor	0.0007	0.0003	0.0003
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0179	0.0627	0.0627
Echinococcus granulosus	neuropeptide s receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Onchocerca volvulus		0.0007	0.0003	0.0003
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0068	0.0068
Schistosoma mansoni	hypothetical protein	0.0168	0.0587	0.0587
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.276	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	neuropeptides capa receptor	0.0007	0.0003	0.0003
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0009
Onchocerca volvulus		0.0007	0.0003	0.0003
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0007	0.0003	0.0003
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0169	0.016
Schistosoma mansoni	opsin-like receptor	0.0007	0.0003	0.0003
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0007	0.0003	0.0003
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0009	0.0009
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.0333	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0007	0.0003	0.0003
Loa Loa (eye worm)	TYRA-2 protein	0.0007	0.0003	0.0003
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0002	0.0002
Echinococcus granulosus	neuropeptide receptor A26	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0031	0.009	0.009
Echinococcus multilocularis	neuropeptide receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	g protein coupled receptor	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0016	0.0036	0.0036
Schistosoma mansoni	growth hormone secretagogue receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0007	0.0003	0.0003
Echinococcus granulosus	g protein coupled receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0006	0.0006
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0397	0.0397
Brugia malayi	Serotonin receptor	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.009	0.009
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0007	0.0003	0.0003
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.276	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0009	0.0009
Schistosoma mansoni	amine GPCR	0.0007	0.0003	0.0003
Schistosoma mansoni	neuropeptide F-like receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0009	0.0009
Schistosoma mansoni	dishevelled	0.0009	0.0009	0.0009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0003	0.0003
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0007	0.0003	0.0003
Entamoeba histolytica	hypothetical protein	0.0036	0.0108	1
Echinococcus multilocularis	cpg binding protein	0.0029	0.0084	0.0084
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0031	0.009	0.009
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0007	0.0003	0.0003
Echinococcus multilocularis	g-protein coupled receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0068	0.0068
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.276	1	1
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0009	0.0009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.009	0.009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Echinococcus granulosus	G protein coupled receptor 139	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	opsin-like receptor	0.0007	0.0003	0.0003
Brugia malayi	MH1 domain containing protein	0.0008	0.0006	0.0006
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0108	0.0108
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0007	0.0003	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	biogenic amine receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	geminin	0.0168	0.0587	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0008	0.0008
Schistosoma mansoni	neuropeptide receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0007	0.0003	0.0003
Loa Loa (eye worm)	neuropeptide F receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	g protein coupled receptor	0.0007	0.0003	0.0003
Schistosoma mansoni	adenoreceptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.0003	0.0003
Mycobacterium tuberculosis	Hypothetical protein	0.1313	0.4745	0.1006
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	neuropeptide FF receptor 2	0.0007	0.0003	0.0003
Echinococcus multilocularis	serotonin receptor	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0036	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	G protein-coupled receptor F59B2.13	0.0007	0.0003	0.0003
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.009	0.009
Echinococcus multilocularis	dnaJ subfamily B	0.0396	0.1416	0.1416
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.276	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0007	0.0003	0.0003

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 810111