Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.064 | 0.0167 |
Giardia lamblia | DINP protein human, muc B family | 0.0059 | 0.46 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0078 | 0.7615 | 0.7615 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0041 | 0.1928 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.7041 | 0.9456 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.064 | 0.086 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0078 | 0.7615 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0052 | 0.3606 | 0.3606 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.1122 | 0.0847 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.2097 | 0.2221 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0925 | 0.1242 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Echinococcus multilocularis | expressed protein | 0.0033 | 0.064 | 0.064 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0925 | 0.0925 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Trichomonas vaginalis | rotamase, putative | 0.0033 | 0.064 | 0.0167 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.468 | 0.6285 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0052 | 0.3606 | 0.4842 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.46 | 0.575 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0925 | 0.0925 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0077 | 0.7446 | 0.9762 |
Schistosoma mansoni | DNA polymerase eta | 0.0077 | 0.7446 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0078 | 0.7615 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0925 | 0.1242 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.2097 | 0.2221 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0052 | 0.3606 | 0.3606 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0059 | 0.46 | 1 |
Brugia malayi | polk-prov protein | 0.0042 | 0.2097 | 0.2097 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0052 | 0.3606 | 0.4842 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.1122 | 0.0847 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.2117 | 0.2249 |
Onchocerca volvulus | Alhambra homolog | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0925 | 0.0925 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0078 | 0.7615 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0077 | 0.7446 | 0.7446 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0032 | 0.0522 | 0.2705 |
Echinococcus multilocularis | dna polymerase kappa | 0.0078 | 0.7615 | 0.7615 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0077 | 0.7446 | 0.7446 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0052 | 0.3606 | 0.4842 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0072 | 0.662 | 0.8598 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.1721 | 0.1721 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0052 | 0.3606 | 0.3606 |
Leishmania major | DNA polymerase eta, putative | 0.0077 | 0.7446 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0041 | 0.1928 | 0.1983 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0078 | 0.7615 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.2117 | 0.2249 |
Leishmania major | DNA polymerase eta, putative | 0.0041 | 0.1928 | 0.2031 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0059 | 0.46 | 0.589 |
Echinococcus granulosus | expressed protein | 0.0033 | 0.064 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.314 | 0.4217 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0077 | 0.7446 | 0.9762 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0033 | 0.064 | 0.064 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0925 | 0.1242 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0078 | 0.7615 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0059 | 0.46 | 0.589 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.7446 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.1721 | 0.1721 |
Schistosoma mansoni | rotamase | 0.0033 | 0.064 | 0.086 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0052 | 0.3606 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.2117 | 0.2249 |
Echinococcus multilocularis | dna polymerase eta | 0.0077 | 0.7446 | 0.7446 |
Trypanosoma brucei | unspecified product | 0.0072 | 0.662 | 0.8598 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0078 | 0.7615 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0078 | 0.7615 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2097 | 0.2816 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | 0 uM | Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus(HSV) -1 (thymidine kinase deficient) in vero cells; Not tested | ChEMBL. | 2842506 |
MIC (functional) | 0 uM | Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus(HSV) -1 (thymidine kinase deficient) in HEp-2 cells; Not tested | ChEMBL. | 2842506 |
MIC (functional) | 0 uM | Minimum inhibitory concentration causing 25% inhibition cytopathic effect induced by Herpes simplex virus(HSV) -2 (thymidine kinase deficient) in vero cells; Not tested | ChEMBL. | 2842506 |
MIC (functional) | 0 uM | Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus(HSV) -2 (thymidine kinase deficient) in HEp-2 cells; Not tested | ChEMBL. | 2842506 |
MIC (functional) | > 264 uM | Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus-1 (Brand) in vero cells | ChEMBL. | 2842506 |
MIC (functional) | > 264 uM | Minimum inhibitory concentration causing 25% inhibition cytopathic effect induced by Herpes simplex virus-1 (Brand) in HEp-2 cells | ChEMBL. | 2842506 |
MIC (functional) | > 264 uM | Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by herpes simplex virus (HSV)-1 (K979) in vero cells. | ChEMBL. | 2842506 |
MIC (functional) | > 264 uM | Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus-1 (K979) in HEp-2 cells | ChEMBL. | 2842506 |
MTC (functional) | >= 872 uM | Minimum cytotoxic concentration causing toxic effects on uninfected cells in rabbit | ChEMBL. | 2842506 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.