Detailed information for compound 810394

Basic information

Technical information
  • TDR Targets ID: 810394
  • Name: N-(4-bromophenyl)-9H-xanthene-9-carboxamide
  • MW: 380.235 | Formula: C20H14BrNO2
  • H donors: 1 H acceptors: 1 LogP: 4.69 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1c2ccccc2Oc2c1cccc2)Nc1ccc(cc1)Br
  • InChi: 1S/C20H14BrNO2/c21-13-9-11-14(12-10-13)22-20(23)19-15-5-1-3-7-17(15)24-18-8-4-2-6-16(18)19/h1-12,19H,(H,22,23)
  • InChiKey: MVYDNTUMRJCDPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_800823
  • ZINC01189031
  • CBMicro_017096
  • STK041276
  • BIM-0017110.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AUR protein kinase 0.0255 1 1
Trichomonas vaginalis AGC family protein kinase 0.0255 1 1
Schistosoma mansoni tyrosine kinase 0.0016 0.0204 0.0121
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.0204 0.0121
Loa Loa (eye worm) TK/ABL protein kinase 0.0214 0.8327 0.8313
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0204 0.791 0.7893
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.1391 0.1318
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.0204 0.0121
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1391 0.1318
Echinococcus granulosus tyrosine protein kinase ABL1 0.0214 0.8327 0.8313
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0204 0.791 0.7893
Onchocerca volvulus 0.0011 0 0.5
Echinococcus granulosus aurora kinase A 0.0255 1 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0255 1 1
Echinococcus multilocularis aurora kinase A 0.0255 1 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0255 1 1
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.0204 0.0121
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.1391 0.1318
Brugia malayi MAP kinase sur-1 0.023 0.8998 0.899
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.1391 0.1318
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0255 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1391 0.1318
Schistosoma mansoni tyrosine kinase 0.0016 0.0204 0.0121
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0255 1 0.5
Trypanosoma brucei aurora B kinase 0.0255 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.005 0.1582 0.1511
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.0204 0.0121
Schistosoma mansoni tyrosine kinase 0.0207 0.8051 0.8035
Entamoeba histolytica protein kinase , putative 0.0255 1 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0846 0.084
Schistosoma mansoni protein kinase 0.0255 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0255 1 1
Schistosoma mansoni tyrosine kinase 0.0045 0.1391 0.1318
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.1391 0.1318
Plasmodium falciparum serine/threonine protein kinase, putative 0.0255 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0032 0.0846 0.0769
Loa Loa (eye worm) SRC-1 0.0045 0.1391 0.1318
Loa Loa (eye worm) TK protein kinase 0.0039 0.1122 0.1047
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0255 1 1
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0204 0.791 0.7893
Trichomonas vaginalis AGC family protein kinase 0.0255 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.023 0.8998 0.899
Brugia malayi serine/threonine kinase 12 0.0255 1 1
Brugia malayi serine/threonine-protein kinase 6 0.0255 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.023 0.8998 0.899
Echinococcus multilocularis mitogen activated protein kinase 0.023 0.8998 0.899
Giardia lamblia Aurora kinase 0.0255 1 1
Brugia malayi SRC-1 0.0045 0.1391 0.1318
Schistosoma mansoni tyrosine kinase 0.0045 0.1391 0.1318
Brugia malayi Tyrosine-protein kinase abl-1 0.0126 0.4722 0.4678
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1391 0.1318
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1391 0.1318
Entamoeba histolytica protein kinase, putative 0.0255 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0094 0.3413 0.3357
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.1391 0.1318
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1391 0.1318
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.791 0.7893
Trichomonas vaginalis AGC family protein kinase 0.0255 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0039 0.1122 0.1047
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.1391 0.1318
Entamoeba histolytica protein kinase, putative 0.0255 1 1
Trichomonas vaginalis AGC family protein kinase 0.0255 1 1
Brugia malayi protein-tyrosine kinase 0.0039 0.1122 0.1047
Echinococcus granulosus tyrosine kinase 0.0039 0.1122 0.1047
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0255 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0039 0.1122 0.1047
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0214 0.8327 0.8313
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.1122 0.1047
Echinococcus multilocularis tyrosine protein kinase Srms 0.0039 0.1122 0.1047
Echinococcus multilocularis mitogen activated protein kinase 3 0.023 0.8998 0.899
Trypanosoma cruzi aurora B kinase, putative 0.0255 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.1001 0.0925
Loa Loa (eye worm) hypothetical protein 0.0081 0.2868 0.2808
Echinococcus granulosus mitogen activated protein kinase 0.023 0.8998 0.899
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.1391 0.1318
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0039 0.1122 0.1047
Schistosoma mansoni serine/threonine protein kinase 0.023 0.8998 0.899
Loa Loa (eye worm) AUR protein kinase 0.0255 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0094 0.3413 0.3357
Entamoeba histolytica protein kinase domain containing protein 0.0204 0.791 0.7909
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0846 0.0769
Entamoeba histolytica protein kinase domain containing protein 0.0255 1 1
Echinococcus granulosus c src tyrosine kinase 0.0016 0.0204 0.0121
Toxoplasma gondii aurora kinase 0.0255 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.1001 0.0925
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1391 0.1318
Loa Loa (eye worm) AUR protein kinase 0.0255 1 1
Leishmania major protein kinase, putative 0.0255 1 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0846 0.0769
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.1391 0.1318
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.1391 0.1318
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0204 0.791 0.7893
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.1391 0.1318

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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