Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0106 | 0.1611 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0213 | 0.4744 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0212 | 0.4707 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0212 | 0.4707 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0212 | 0.4707 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0212 | 0.4707 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0213 | 0.4744 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0212 | 0.4707 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0212 | 0.4707 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0213 | 0.4744 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0212 | 0.4707 | 1 |
Brugia malayi | thymidylate synthase | 0.0106 | 0.1611 | 0.3423 |
Brugia malayi | Dihydrofolate reductase | 0.0212 | 0.4707 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0212 | 0.4707 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0106 | 0.1611 | 0.3423 |
Trypanosoma brucei | pteridine reductase 1 | 0.0389 | 0.985 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0212 | 0.4707 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0213 | 0.4744 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.