Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 1 | 1 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.1801 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0541 | 0.0541 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.8481 | 0.8394 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0541 | 0.0638 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0541 | 0.2559 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0541 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0541 | 0.3004 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0541 | 0.0541 |
Echinococcus multilocularis | lamin | 0.0027 | 0.1048 | 0.1048 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0541 | 0.0638 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0541 | 0.2559 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.1801 | 0.2123 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0037 | 0.1801 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.1801 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0541 | 0.2559 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0541 | 0.0541 |
Schistosoma mansoni | lamin | 0.0027 | 0.1048 | 0.0537 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0541 | 0.0541 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0541 | 0.2559 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0541 | 0.0541 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0541 | 0.3004 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.1801 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0541 | 0.3004 |
Onchocerca volvulus | 0.0027 | 0.1048 | 1 | |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.1048 | 0.1236 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.1048 | 0.1048 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.1801 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0541 | 0.0541 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.1801 | 0.1801 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0541 | 0.0638 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0541 | 0.0638 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0037 | 0.1801 | 0.1801 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.1048 | 0.0537 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.1801 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0541 | 0.3004 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0541 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1011 | 0.5616 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0541 | 0.3004 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0541 | 0.2559 |
Echinococcus granulosus | lamin | 0.0027 | 0.1048 | 0.1236 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0541 | 0.2559 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0037 | 0.1801 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.1048 | 0.5822 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0037 | 0.1801 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0541 | 0.2559 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0541 | 0.2559 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0127 | 0.8481 | 0.8481 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1801 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0541 | 0.2559 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0541 | 0.0541 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0541 | 0.3004 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0037 | 0.1801 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1048 | 0.5822 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0541 | 0.2559 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0541 | 0.2559 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.1048 | 0.5822 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0541 | 0.2559 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0541 | 0.2559 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0541 | 0.3004 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0541 | 0.3004 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0541 | 0.2559 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0541 | 0.2559 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0037 | 0.1801 | 0.2123 |
Onchocerca volvulus | 0.0027 | 0.1048 | 1 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0108 | 0.0598 |
Echinococcus multilocularis | musashi | 0.0027 | 0.1048 | 0.1048 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.1801 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0541 | 0.3004 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0541 | 0.2559 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0541 | 0.2559 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0541 | 0.0541 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.1801 | 0.2123 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0541 | 0.2559 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0541 | 0.3004 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.1048 | 0.1236 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0541 | 0.0638 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0127 | 0.8481 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.1048 | 0.5557 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0541 | 0.3004 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0541 | 0.0638 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0541 | 0.2559 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0541 | 0.3004 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0541 | 0.3004 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0541 | 0.0638 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0541 | 0.3004 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0037 | 0.1801 | 0.1332 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.1801 | 0.1801 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0541 | 0.2559 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0541 | 0.3004 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.1048 | 0.5557 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0541 | 0.3004 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0037 | 0.1801 | 0.1332 |
Schistosoma mansoni | lamin | 0.0027 | 0.1048 | 0.0537 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.