Detailed information for compound 81157

Basic information

Technical information
  • TDR Targets ID: 81157
  • Name: [(3-ethylanilino)-phosphonomethyl]phosphonic acid
  • MW: 295.166 | Formula: C9H15NO6P2
  • H donors: 5 H acceptors: 6 LogP: -0.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc(c1)NC(P(=O)(O)O)P(=O)(O)O
  • InChi: 1S/C9H15NO6P2/c1-2-7-4-3-5-8(6-7)10-9(17(11,12)13)18(14,15)16/h3-6,9-10H,2H2,1H3,(H2,11,12,13)(H2,14,15,16)
  • InChiKey: FGDXXBXMQRKSFT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(3-ethylanilino)-phosphono-methyl]phosphonic acid
  • [[(3-ethylphenyl)amino]-phosphono-methyl]phosphonic acid
  • [[(3-ethylphenyl)amino]-phosphonomethyl]phosphonic acid
  • Phosphonic acid, [[(3-ethylphenyl)amino]methylene]bis-
  • NSC725575
  • [(3-ethylphenyl)aminomethylene]-1,1-bisphosphonate
  • AIDS-257682
  • AIDS257682

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 Starlite/ChEMBL References
Trypanosoma brucei gambiense vacuolar-type proton translocating pyrophosphatase 1, putative References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 Get druggable targets OG5_128905 All targets in OG5_128905
Leishmania mexicana vacuolar-type proton translocating pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium knowlesi vacuolar-type H+-translocating inorganic pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma brucei gambiense vacuolar-type proton translocating pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium knowlesi V-type H(+)-translocating pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma brucei gambiense vacuolar-type proton translocating pyrophosphatase 1 Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium berghei V-type H(+)-translocating pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Leishmania donovani Pyrophosphate-energized vacuolar membrane proton pump 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Neospora caninum hypothetical protein Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma congolense vacuolar-type proton translocating pyrophosphatase 1 Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium berghei inorganic pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium yoelii V-type H(+)-translocating pyrophosphatase Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium yoelii vacuolar-type H+ pumping pyrophosphatase-related Get druggable targets OG5_128905 All targets in OG5_128905
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 Get druggable targets OG5_128905 All targets in OG5_128905
Leishmania braziliensis vacuolar-type proton translocating pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Leishmania infantum vacuolar-type proton translocating pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative Get druggable targets OG5_128905 All targets in OG5_128905
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0239 0.2908 0.2908
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0064 0.022
Schistosoma mansoni nuclear hormone receptor 0.003 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi nuclear receptor NHR-88 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0167
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0654
Echinococcus granulosus FTZ F1 alpha 0.003 0.0287 0.0287
Onchocerca volvulus Neuropeptide F receptor homolog 0.0239 0.2908 1
Schistosoma mansoni neuropeptide receptor 0.0239 0.2908 0.2908
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0287 0.0287
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0405 0.4988 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0239 0.2908 0.2908
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0405 0.4988 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0239 0.2908 0.2908
Echinococcus multilocularis dro:myosuppressin receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0239 0.2908 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni rab6-interacting 0.0021 0.0168 0.0168
Onchocerca volvulus 0.0033 0.0328 0.0853
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Onchocerca volvulus 0.0033 0.0328 0.0853
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0287 0.0287
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0287 0.0986
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0452 0.0672
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0405 0.4988 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0239 0.2908 1
Plasmodium vivax vivapain-1 0.0017 0.0126 0.0156
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0088 0.0088
Echinococcus multilocularis neuropeptide FF receptor 2 0.0239 0.2908 0.2908
Echinococcus multilocularis ankyrin repeat protein 0.0166 0.1991 0.1991
Schistosoma mansoni amine GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni opsin-like receptor 0.0239 0.2908 0.2908
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis g protein coupled receptor 0.0239 0.2908 0.2908
Schistosoma mansoni nuclear receptor 0.0014 0.0088 0.0088
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0287 0.0287
Onchocerca volvulus 0.0239 0.2908 1
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0328 0.0567
Leishmania major cathepsin L-like protease 0.0033 0.0328 0.0537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0239 0.2908 0.2908
Schistosoma mansoni neuropeptide F-like receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) neuropeptide F receptor 0.0239 0.2908 1
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0287 0.0986
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0287 0.0986
Brugia malayi neuropeptide F receptor 0.0239 0.2908 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0328 0.0328
Plasmodium vivax vivapain-3 0.0017 0.0126 0.0156
Echinococcus multilocularis neuropeptides capa receptor 0.0239 0.2908 0.2908
Echinococcus granulosus alpha 1A adrenergic receptor 0.0239 0.2908 0.2908
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus cpg binding protein 0.006 0.0659 0.0659
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0239 0.2908 0.2908
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1503 0.2946
Onchocerca volvulus 0.0239 0.2908 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Brugia malayi G protein-coupled receptor F59B2.13 0.0239 0.2908 1
Echinococcus granulosus cathepsin L 0.0017 0.0126 0.0126
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0452 1
Brugia malayi Serotonin receptor 0.0239 0.2908 1
Echinococcus multilocularis g-protein coupled receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis dnaJ subfamily B 0.0805 1 1
Onchocerca volvulus 0.0033 0.0328 0.0853
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0088 0.0088
Onchocerca volvulus 0.0057 0.0619 0.1882
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis G-protein coupled receptor, putative 0.0239 0.2908 0.2908
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0088 0.0088
Echinococcus multilocularis neuropeptides capa receptor 0.0239 0.2908 0.2908
Echinococcus granulosus neuropeptide FF receptor 2 0.0239 0.2908 0.2908
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0287 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0287 0.0986
Leishmania major cathepsin L-like protease 0.0127 0.1503 0.2924
Brugia malayi Cytochrome P450 family protein 0.0012 0.0064 0.022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Brugia malayi putative neuropeptide receptor NPR1 0.0239 0.2908 1
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0408 0.0408
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0328 0.1129
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0287 0.0287
Echinococcus granulosus neuropeptides capa receptor 0.0239 0.2908 0.2908
Echinococcus granulosus orexin receptor type 2 0.0239 0.2908 0.2908
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0287 0.0986
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0064 0.0031
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0088 0.0088
Onchocerca volvulus 0.0239 0.2908 1
Schistosoma mansoni neuropeptide F-like receptor 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus granulosus tm gpcr rhodopsin 0.0239 0.2908 0.2908
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0287 0.0287
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.1921 0.1921
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0166 0.1991 0.1991
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0405 0.4988 1
Schistosoma mansoni hypothetical protein 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1503 0.2946
Schistosoma mansoni amine GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0408 0.8655
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0109 0.0376
Onchocerca volvulus 0.0239 0.2908 1
Brugia malayi nuclear receptor NHR-88 0.0014 0.0088 0.0302
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0328 0.0853
Schistosoma mansoni growth hormone secretagogue receptor 0.0239 0.2908 0.2908
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0126 0.0126
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0239 0.2908 0.2908
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0168 0.0168
Schistosoma mansoni neuropeptide receptor 0.0239 0.2908 0.2908
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0408 0.1404
Echinococcus granulosus allatostatin A receptor 0.0239 0.2908 0.2908
Brugia malayi sulfakinin receptor protein 0.0239 0.2908 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0088 0.0088
Schistosoma mansoni alpha-1 adrenergic receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0239 0.2908 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0287 0.0287
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0452 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Brugia malayi nuclear hormone receptor 0.0014 0.0088 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0502 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0168 0.0243
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0287 0.0986
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0088 0.0088
Brugia malayi hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni myosin xvIII 0.0239 0.2908 0.2908
Schistosoma mansoni histamine h1 receptor 0.0239 0.2908 0.2908
Echinococcus granulosus neuropeptide receptor 0.0239 0.2908 0.2908
Schistosoma mansoni hypothetical protein 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0328 0.0328
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0328 0.598
Brugia malayi hypothetical protein 0.0239 0.2908 1
Brugia malayi AKH receptor 0.0239 0.2908 1
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0088 0.0302
Schistosoma mansoni cpg binding protein 0.006 0.0659 0.0659
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0239 0.2908 0.2908
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0088 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0654
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Onchocerca volvulus 0.0022 0.019 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Onchocerca volvulus 0.0239 0.2908 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0126 0.0126
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0328 0.0537
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0239 0.2908 0.2908
Schistosoma mansoni thyroid hormone receptor 0.0154 0.1846 0.1846
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0502 0.0372
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0239 0.2908 0.2908
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.019 0.019
Schistosoma mansoni biogenic amine receptor 0.0239 0.2908 0.2908
Schistosoma mansoni biogenic amine receptor 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0126 0.1274
Brugia malayi nuclear receptor RXR 0.0016 0.0109 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni loxhd1 0.0021 0.0168 0.0168
Brugia malayi Melatonin receptor type 1A 0.0239 0.2908 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0502 0.0917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.1413 0.1413
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni neuropeptide f receptor 76f 0.0239 0.2908 0.2908
Schistosoma mansoni cathepsin s 0.0011 0.0049 0.0049
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0328 0.0417
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0064 0.0031
Onchocerca volvulus 0.0033 0.0328 0.0853
Brugia malayi hypothetical protein 0.0016 0.0109 0.0376
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0064 0.022
Echinococcus granulosus hypothetical protein 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi Cathepsin L-like precursor 0.0022 0.019 0.0654
Echinococcus granulosus g protein coupled receptor 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0088 0.0088
Onchocerca volvulus 0.0239 0.2908 1
Schistosoma mansoni amine GPCR 0.0239 0.2908 0.2908
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0088 0.0302
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0127 0.0436
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0239 0.2908 0.2908
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0405 0.4988 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0408 0.0408
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0287 0.0705
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0287 0.0986
Brugia malayi Cytochrome P450 family protein 0.0012 0.0064 0.022
Onchocerca volvulus 0.0239 0.2908 1
Echinococcus granulosus RUN 0.0021 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0239 0.2908 0.2908
Echinococcus multilocularis neuropeptide Y receptor 0.0239 0.2908 0.2908
Brugia malayi hypothetical protein 0.0239 0.2908 1
Leishmania major cathepsin L-like protease 0.0033 0.0328 0.0537
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0376
Schistosoma mansoni opsin-like receptor 0.0239 0.2908 0.2908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0126 0.0126
Schistosoma mansoni neuropeptide receptor 0.0239 0.2908 0.2908
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0021 0.0168 0.0579
Schistosoma mansoni hypothetical protein 0.0239 0.2908 0.2908
Echinococcus granulosus fmrfamide receptor 0.0239 0.2908 0.2908
Onchocerca volvulus 0.0021 0.0168 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus granulosus cysteine protease 0.0017 0.0126 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0408 0.7836
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0328 0.0328
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.1302 0.2089
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.019 0.0654
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi CXXC zinc finger family protein 0.0057 0.0619 0.2128
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0287 0.0986
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0088 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.019 0.2771
Loa Loa (eye worm) melatonin receptor type 1A 0.0239 0.2908 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0328 0.0328
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0088 0.0088
Loa Loa (eye worm) cysteine protease 0.0033 0.0328 0.1129
Echinococcus granulosus tm gpcr rhodopsin 0.0239 0.2908 0.2908
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0328 0.1129
Brugia malayi steroid hormone receptor 0.003 0.0287 0.0986
Schistosoma mansoni rab6-interacting 0.0021 0.0168 0.0168
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0126 0.0156
Leishmania major cathepsin L-like protease 0.0033 0.0328 0.0537
Loa Loa (eye worm) DR-78 0.0014 0.0088 0.0302
Schistosoma mansoni coup transcription factor 0.003 0.0287 0.0287
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0287 0.0287
Schistosoma mansoni hypothetical protein 0.0805 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0239 0.2908 0.2908
Echinococcus multilocularis neuropeptide receptor 0.0239 0.2908 0.2908
Onchocerca volvulus 0.003 0.0287 0.0705
Echinococcus granulosus g protein coupled receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0239 0.2908 0.2908
Schistosoma mansoni polycystin 1-related 0.0021 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni opsin-like receptor 0.0239 0.2908 0.2908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Plasmodium vivax unspecified product 0.0017 0.0126 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0109 0.0109
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0328 0.0853
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0168 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Brugia malayi Dopamine receptor 0.0239 0.2908 1
Schistosoma mansoni lipoxygenase 0.0021 0.0168 0.0168
Echinococcus granulosus cathepsin l1 0.0033 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.1365 0.2666
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0049 0.0167
Loa Loa (eye worm) neuropeptide F receptor 0.0239 0.2908 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0287 0.0287
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0287 0.0986
Leishmania major cathepsin L-like protease 0.0127 0.1503 0.2924
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0239 0.2908 0.2908
Trypanosoma brucei RNA helicase, putative 0.0153 0.1825 0.3577
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0376
Schistosoma mansoni adenoreceptor 0.0239 0.2908 0.2908
Echinococcus multilocularis cysteine protease 0.0033 0.0328 0.0328
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0328 0.0853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0126 0.0126
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0405 0.4988 1
Schistosoma mansoni hypothetical protein 0.0021 0.0168 0.0168
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Schistosoma mansoni biogenic amine (5HT) receptor 0.0239 0.2908 0.2908
Brugia malayi Doublecortin family protein 0.0021 0.0168 0.0579
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0287 0.0287
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0049 0.0167
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) G-protein coupled receptor 0.0239 0.2908 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Brugia malayi G-protein coupled receptor 0.0239 0.2908 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0109 0.0376
Echinococcus granulosus 7tm_1 domain containing protein 0.0239 0.2908 0.2908
Brugia malayi hypothetical protein 0.0014 0.0088 0.0302
Brugia malayi G-protein coupled receptor 0.0239 0.2908 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0287 0.0287
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.1846 0.1846
Echinococcus granulosus g protein coupled receptor 0.0239 0.2908 0.2908
Echinococcus granulosus serotonin receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0239 0.2908 0.2908
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0287 0.0986
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0287 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Echinococcus multilocularis neuropeptide receptor A26 0.0239 0.2908 0.2908
Schistosoma mansoni amine GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0328 0.6206
Onchocerca volvulus 0.0033 0.0328 0.0853
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0239 0.2908 0.2908
Echinococcus granulosus somatostatin receptor 0.0239 0.2908 0.2908
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0088 0.0088
Brugia malayi nuclear receptor RXR 0.0014 0.0088 0.0302
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0088 0.0088
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0633 0.0633
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0633 0.0633
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0328 0.0328
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0239 0.2908 1
Onchocerca volvulus 0.0239 0.2908 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0239 0.2908 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0239 0.2908 0.2908
Loa Loa (eye worm) TYRA-2 protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis cysteine protease 0.0033 0.0328 0.0328
Echinococcus multilocularis neuropeptide s receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis g protein coupled receptor 0.0239 0.2908 0.2908
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0239 0.2908 0.2908
Brugia malayi neuropeptide F receptor 0.0239 0.2908 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0408 0.0408
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.1921 0.1921
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0408 0.07
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.1921 0.6606
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0408 0.0408
Echinococcus granulosus dro:myosuppressin receptor 0.0239 0.2908 0.2908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis g protein coupled receptor 0.0239 0.2908 0.2908
Brugia malayi nuclear receptor NHR-67 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Brugia malayi hypothetical protein 0.0239 0.2908 1
Brugia malayi nuclear hormone receptor 0.003 0.0287 0.0986
Brugia malayi hypothetical protein 0.0021 0.0168 0.0579
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni hypothetical protein 0.0124 0.1469 0.1469
Brugia malayi cathepsin L-like precursor 0.0022 0.019 0.0654
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0126 0.0432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Schistosoma mansoni amine GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0654
Schistosoma mansoni cpg binding protein 0.006 0.0659 0.0659
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0287 0.0986
Echinococcus multilocularis serotonin receptor 0.0239 0.2908 0.2908
Echinococcus granulosus peptide allatostatin:somatostatin 0.0239 0.2908 0.2908
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0287 0.0287
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0239 0.2908 0.2908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0287 0.0986
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0376
Brugia malayi hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) fibroinase 0.0033 0.0328 0.1129
Echinococcus granulosus neuropeptide receptor A26 0.0239 0.2908 0.2908
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0086 0.0086
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0126 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.019 0.2771
Echinococcus multilocularis sex peptide receptor 0.0239 0.2908 0.2908
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0109 0.0109
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0088 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0287 0.0986
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0287 0.0287
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0088 0.0302
Echinococcus granulosus neuropeptides capa receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis allatostatin A receptor 0.0239 0.2908 0.2908
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0239 0.2908 1
Schistosoma mansoni hypothetical protein 0.0153 0.1825 0.1825
Echinococcus multilocularis orexin receptor type 2 0.0239 0.2908 0.2908
Brugia malayi larval opioid receptor 0.0239 0.2908 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0328 0.0328
Brugia malayi tailless protein 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0088 0.0088
Brugia malayi hypothetical protein 0.0016 0.0109 0.0376
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) histone methyltransferase 0.0017 0.013 0.0445
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0168 0.0088
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0239 0.2908 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0287 0.0287
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0168 0.0168
Echinococcus granulosus neuropeptide Y receptor 0.0239 0.2908 0.2908
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0287 0.0287
Onchocerca volvulus 0.0033 0.0328 0.0853
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0126 0.0156
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0408 0.7836
Brugia malayi follicle stimulating hormone receptor 0.0239 0.2908 1
Leishmania major cathepsin L-like protease 0.0033 0.0328 0.0537
Brugia malayi ecdysteroid receptor 0.003 0.0287 0.0986
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0239 0.2908 0.2908
Onchocerca volvulus 0.0033 0.0328 0.0853
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0405 0.4988 1
Brugia malayi hypothetical protein 0.0021 0.0168 0.0579
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0168 0.0579
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis transient receptor potential cation channel 0.0166 0.1994 0.1994
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0328 0.598
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0033 0.0328 0.1129
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0408 0.0408
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0086 0.0086
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0328 0.0417
Echinococcus granulosus biogenic amine 5HT receptor 0.0239 0.2908 0.2908
Leishmania major cathepsin L-like protease 0.0127 0.1503 0.2924
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi hypothetical protein 0.0014 0.0088 0.0302
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0168 0.0168
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0168 0.0168
Schistosoma mansoni zinc finger protein 0.0014 0.0088 0.0088
Brugia malayi conserved hypotetical protein 0.0014 0.0088 0.0302
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0405 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0168 0.0579
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Onchocerca volvulus 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0239 0.2908 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0328 0.0328
Echinococcus granulosus G protein coupled receptor 139 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0408 0.0729
Echinococcus granulosus sex peptide receptor 0.0239 0.2908 0.2908
Echinococcus granulosus cathepsin l1 0.0022 0.019 0.019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0287 0.0986
Brugia malayi RE15519p 0.0239 0.2908 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Onchocerca volvulus 0.0239 0.2908 1
Brugia malayi Cathepsin L-like precursor 0.0022 0.019 0.0654
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0328 0.0417
Schistosoma mansoni neuropeptide receptor 0.0239 0.2908 0.2908
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0287 0.0986
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0287 0.0287
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Echinococcus multilocularis neuropeptide Y receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis somatostatin receptor 0.0239 0.2908 0.2908
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0088 0.0088
Echinococcus granulosus neuropeptide receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.2908 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0239 0.2908 0.2908
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0287 0.0705
Echinococcus granulosus neuropeptide s receptor 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0126 0.0156
Echinococcus multilocularis neuropeptide receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0109 0.0109
Echinococcus multilocularis cathepsin L 0.0017 0.0126 0.0126
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0376
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0088 0.0088
Schistosoma mansoni thyroid hormone receptor 0.0154 0.1846 0.1846
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.013 0.013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.013 0.013
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0088 0.0302
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.1865 0.1865
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Leishmania major cathepsin L-like protease 0.0033 0.0328 0.0537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Brugia malayi Cathepsin L-like precursor 0.0011 0.0049 0.0167
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0405 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis RUN 0.0021 0.0168 0.0168
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1469 0.1469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0126 0.0126
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0328 0.1129
Brugia malayi ORL1-like opioid receptor 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0239 0.2908 0.2908
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0088 0.0088
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0287 0.0287
Echinococcus multilocularis G protein coupled receptor 139 0.0239 0.2908 0.2908
Schistosoma mansoni cpg binding protein 0.0057 0.0619 0.0619
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0088 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Plasmodium vivax vivapain-2 0.0033 0.0328 0.0567
Brugia malayi G protein-coupled receptor 0.0239 0.2908 1
Onchocerca volvulus 0.0239 0.2908 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0239 0.2908 0.2908
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Echinococcus multilocularis cpg binding protein 0.006 0.0659 0.0659
Echinococcus granulosus g-protein coupled receptor 0.0239 0.2908 0.2908
Brugia malayi hypothetical protein 0.0239 0.2908 1
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1503 0.2946
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0064 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0408 0.7836
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus multilocularis serotonin receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0239 0.2908 0.2908
Brugia malayi Dopamine receptor protein 1 0.0239 0.2908 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0619 0.2128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0086 0.0086
Brugia malayi ecdysone receptor 0.0014 0.0088 0.0302
Echinococcus granulosus ankyrin repeat protein 0.0166 0.1991 0.1991
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0126 0.0432
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus multilocularis fmrfamide receptor 0.0239 0.2908 0.2908
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0126 0.0126
Echinococcus multilocularis fmrfamide receptor 0.0239 0.2908 0.2908
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0287 0.0287
Onchocerca volvulus 0.0239 0.2908 1
Brugia malayi hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1469 0.1469
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0287 0.0986
Loa Loa (eye worm) ctsf protein 0.0033 0.0328 0.1129
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni nuclear receptor 0.0014 0.0088 0.0088
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0287 0.0287
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0287 0.0287
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0088 0.0088
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.1503 0.2946
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0376
Echinococcus granulosus 7TM GPCR rhodopsin 0.0239 0.2908 0.2908
Echinococcus granulosus neuropeptide Y receptor 0.0239 0.2908 0.2908
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0239 0.2908 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0328 0.6206
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0287 0.0986
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0502 0.0502
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0086 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0408 0.0408
Plasmodium vivax vivapain-2 0.0033 0.0328 0.0567
Brugia malayi Dopamine receptor protein 2 0.0239 0.2908 1
Echinococcus granulosus tm gpcr rhodopsin 0.0239 0.2908 0.2908
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.019 0.1975
Brugia malayi putative neuropeptide receptor 0.0239 0.2908 1
Onchocerca volvulus 0.0239 0.2908 1
Echinococcus granulosus transient receptor potential cation channel 0.0166 0.1991 0.1991
Loa Loa (eye worm) hypothetical protein 0.004 0.0408 0.1404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0049 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0405 0.4988 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0126 0.1274
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0408 0.07
Onchocerca volvulus 0.0239 0.2908 1
Onchocerca volvulus 0.0239 0.2908 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0408 0.0729
Onchocerca volvulus 0.0021 0.0168 0.0285
Schistosoma mansoni lipoxygenase 0.0058 0.0633 0.0633
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0287 0.0287
Loa Loa (eye worm) G-protein coupled receptor 0.0239 0.2908 1
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.1162 0.2255
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0328 0.6206
Onchocerca volvulus 0.0239 0.2908 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0239 0.2908 0.2908
Schistosoma mansoni biogenic amine receptor 0.0239 0.2908 0.2908
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Brugia malayi GnHR receptor homolog 0.0239 0.2908 1
Brugia malayi Serotonin receptor 0.0239 0.2908 1
Loa Loa (eye worm) acetyltransferase 0.016 0.1921 0.6606
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0287 0.0705
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0126 0.0156
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0287 0.0986
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0109 0.0376
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0064 0.022
Onchocerca volvulus 0.0239 0.2908 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0502 0.0372
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0239 0.2908 0.2908
Brugia malayi hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0086 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 1016 uM Dose of the compound to inhibit the growth of human KB carcinoma cell line ChEMBL. 16162013
ED50 (functional) = 1016 uM Dose of the compound to inhibit the growth of human KB carcinoma cell line ChEMBL. 16162013
IC50 (binding) = 2.4 uM Inhibition of recombinant trypanosoma brucei soluble vacuolar pyrophosphatase expressed in escherichia coli ChEMBL. 16162013
IC50 (binding) = 2.4 uM Inhibition of recombinant trypanosoma brucei soluble vacuolar pyrophosphatase expressed in escherichia coli ChEMBL. 16162013
IC50 (functional) > 200 uM In vitro growth inhibition against Entamoeba histolytica ChEMBL. 14695831
IC50 (functional) > 200 uM In vitro growth inhibition against Plasmodium falciparum ChEMBL. 14695831
IC50 (functional) > 200 uM In vitro growth inhibition against Entamoeba histolytica ChEMBL. 14695831
IC50 (functional) > 200 uM In vitro growth inhibition against Plasmodium falciparum ChEMBL. 14695831
IC50 (functional) = 200 uM Antimicrobial activity against Plasmodium falciparum ChEMBL. 20185316
IC50 (functional) = 200 uM Antimicrobial activity against Entamoeba histolytica ChEMBL. 20185316
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
LD50 (ADMET) > 1016 uM Toxicity evaluated against human nasopharyngeal carcinoma KB cell line ChEMBL. 14695831
LD50 (ADMET) > 1016 uM Toxicity evaluated against human nasopharyngeal carcinoma KB cell line ChEMBL. 14695831
TI (functional) = 423 Ratio of ED50 against KB cell line to that of IC50 of TbVSP1 ChEMBL. 16162013
TI (functional) = 423 Ratio of ED50 against KB cell line to that of IC50 of TbVSP1 ChEMBL. 16162013

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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