Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0017 | 0.0023 | 0.0008 |
Brugia malayi | protein C17H12.11 | 0.0997 | 0.3813 | 0.3807 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0066 | 0.0212 | 0.0198 |
Schistosoma mansoni | tyrosine kinase | 0.0017 | 0.0023 | 0.0008 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0023 | 0.5 |
Onchocerca volvulus | 0.0023 | 0.0046 | 1 | |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0016 | 0.0019 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0023 | 0.0009 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0046 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0076 | 0.0249 | 0.0235 |
Mycobacterium ulcerans | haloalkane dehalogenase | 0.079 | 0.3012 | 1 |
Schistosoma mansoni | tgf-beta family | 0.0016 | 0.0019 | 0.0005 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0076 | 0.0249 | 0.0235 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0046 | 0.5 |
Echinococcus multilocularis | activin receptor type | 0.1175 | 0.4501 | 0.4493 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0076 | 0.0249 | 0.0235 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.1001 | 0.3828 | 0.3821 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0076 | 0.0249 | 0.0235 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0061 | 0.0191 | 0.0177 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0076 | 0.0249 | 0.0235 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0023 | 0.5 |
Echinococcus granulosus | activin receptor type | 0.1175 | 0.4501 | 0.4493 |
Loa Loa (eye worm) | bone morphogenic protein 6 | 0.0063 | 0.0201 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0023 | 0.0009 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0046 | 0.5 |
Echinococcus granulosus | anti dorsalizing morphogenetic protein 1a | 0.0063 | 0.0201 | 0.0186 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0061 | 0.0191 | 0.0177 |
Brugia malayi | hypothetical protein | 0.0997 | 0.3813 | 0.3807 |
Schistosoma mansoni | protein kinase | 0.2596 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0046 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0997 | 0.3813 | 0.3807 |
Mycobacterium tuberculosis | Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) | 0.079 | 0.3012 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0076 | 0.0249 | 0.0235 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0023 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0068 | 0.0221 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0019 | 0.0005 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0046 | 0.0075 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0046 | 0.2359 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0046 | 0.0031 |
Schistosoma mansoni | protein kinase | 0.1171 | 0.4486 | 0.4478 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.2596 | 1 | 1 |
Brugia malayi | SRC-1 | 0.0076 | 0.0249 | 0.0235 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0046 | 0.0075 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0046 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0023 | 0.0009 |
Echinococcus multilocularis | tgf beta family | 0.0016 | 0.0019 | 0.0005 |
Entamoeba histolytica | protein kinase, putative | 0.0061 | 0.0191 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0076 | 0.0249 | 0.0235 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0046 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0076 | 0.0249 | 0.0235 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0076 | 0.0249 | 0.0235 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0079 | 0.0264 | 0.0249 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.2595 | 0.9994 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0076 | 0.0249 | 0.0235 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0068 | 0.0221 | 0.0206 |
Brugia malayi | Protein kinase domain containing protein | 0.1001 | 0.3828 | 0.3821 |
Loa Loa (eye worm) | LjBmp2/4b | 0.0016 | 0.0019 | 0.0005 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0076 | 0.0249 | 0.0235 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0068 | 0.0221 | 0.0206 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0046 | 0.2359 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0063 | 0.0201 | 0.0186 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0046 | 0.0075 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0046 | 0.0087 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0017 | 0.0023 | 0.0008 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0016 | 0.0019 | 0.0005 |
Echinococcus multilocularis | anti dorsalizing morphogenetic protein 1a | 0.0063 | 0.0201 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0023 | 0.0009 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.1173 | 0.4493 | 0.4485 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0019 | 0.0005 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0076 | 0.0249 | 0.0235 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0046 | 0.0075 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0046 | 0.0075 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0046 | 0.0075 |
Onchocerca volvulus | 0.0016 | 0.0019 | 0.4215 | |
Echinococcus granulosus | c src tyrosine kinase | 0.0017 | 0.0023 | 0.0008 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0068 | 0.0221 | 0.0206 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0046 | 0.0075 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0076 | 0.0249 | 0.0235 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0017 | 0.0023 | 0.0008 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0017 | 0.0023 | 0.0008 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0046 | 0.0031 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0046 | 0.0075 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0068 | 0.0221 | 0.0206 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0046 | 0.2359 |
Schistosoma mansoni | tyrosine kinase | 0.0017 | 0.0023 | 0.0008 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.1001 | 0.3828 | 0.3821 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.2595 | 0.9994 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.0068 | 0.0221 | 0.0206 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0076 | 0.0249 | 0.0235 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0023 | 0.0012 |
Schistosoma mansoni | tgf-beta family | 0.0016 | 0.0019 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0023 | 0.0009 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0076 | 0.0249 | 0.0235 |
Echinococcus granulosus | tgf beta family | 0.0016 | 0.0019 | 0.0005 |
Loa Loa (eye worm) | TK protein kinase | 0.0068 | 0.0221 | 0.0206 |
Echinococcus multilocularis | bone morphogenetic protein 2 | 0.0016 | 0.0019 | 0.0005 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0066 | 0.0212 | 0.0198 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0046 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0076 | 0.0249 | 0.0235 |
Loa Loa (eye worm) | TK protein kinase | 0.0061 | 0.0191 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0046 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0076 | 0.0249 | 0.0235 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.2596 | 1 | 1 |
Loa Loa (eye worm) | growth/differentiation factor 10 | 0.0016 | 0.0019 | 0.0005 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0017 | 0.0023 | 0.0008 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0046 | 0.0087 |
Onchocerca volvulus | 0.0016 | 0.0019 | 0.4215 | |
Schistosoma mansoni | tyrosine kinase | 0.0076 | 0.0249 | 0.0235 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0019 | 0.0005 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0076 | 0.0249 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0019 | 0.0005 |
Echinococcus granulosus | tyrosine kinase | 0.0068 | 0.0221 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0046 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0017 | 0.0023 | 0.0008 |
Echinococcus granulosus | bone morphogenetic protein 2 | 0.0016 | 0.0019 | 0.0005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.