Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.1472 | 1 | 1 |
Onchocerca volvulus | 0.0249 | 0.1625 | 1 | |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.0225 | 0.3059 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0249 | 0.1625 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1625 | 0.1625 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0249 | 0.1625 | 1 |
Onchocerca volvulus | 0.0249 | 0.1625 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0035 | 0.0035 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0177 | 0.0177 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0238 | 0.1549 | 0.9475 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0177 | 0.1745 |
Schistosoma mansoni | hypothetical protein | 0.0373 | 0.2479 | 0.2479 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1472 | 1 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.02 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.0225 | 0.033 |
Echinococcus granulosus | geminin | 0.0373 | 0.2479 | 0.2479 |
Loa Loa (eye worm) | hypothetical protein | 0.1472 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0249 | 0.1625 | 0.1625 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.0477 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0164 | 0.0164 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1472 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0477 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0249 | 0.1625 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0249 | 0.1625 | 0.1625 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0249 | 0.1625 | 0.1625 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.0225 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.2176 | 0.2176 |
Onchocerca volvulus | 0.0249 | 0.1625 | 1 | |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0477 | 0.2073 |
Echinococcus multilocularis | neuroligin | 0.0249 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | acetyltransferase | 0.015 | 0.0951 | 0.0951 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.015 | 0.0951 | 0.0951 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.0477 | 0.0477 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.0773 | 0.0773 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.0388 | 0.1453 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0035 | 0.0035 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0249 | 0.1625 | 0.1625 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0177 | 0.1745 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0035 | 0.0035 |
Echinococcus multilocularis | geminin | 0.0373 | 0.2479 | 0.2479 |
Brugia malayi | Carboxylesterase family protein | 0.0249 | 0.1625 | 0.1625 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0388 | 0.0388 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.0773 | 0.0773 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0053 | 0.0286 | 0.0286 |
Echinococcus multilocularis | muscleblind protein | 0.0329 | 0.2176 | 0.2176 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0053 | 0.0286 | 0.4744 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0177 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.1472 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1472 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1472 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1472 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0477 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0477 | 0.2073 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0035 | 0.0035 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.0388 | 0.0388 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0477 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0146 | 0.0922 | 0.0922 |
Echinococcus granulosus | acetylcholinesterase | 0.1472 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0177 | 0.0177 |
Schistosoma mansoni | gliotactin | 0.0249 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.2176 | 0.2176 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1625 | 0.1625 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.02 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0329 | 0.2176 | 0.2176 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0249 | 0.1625 | 0.1625 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.02 | 0.2366 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0035 | 0.0035 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.015 | 0.0951 | 0.0951 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0249 | 0.1625 | 0.1625 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0276 | 0.1812 | 0.1812 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0035 | 0.0035 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0177 | 0.1745 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0477 | 0.5 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0053 | 0.0286 | 0.0286 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0035 | 0.0035 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0477 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0249 | 0.1625 | 0.1625 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0053 | 0.0286 | 0.0753 |
Echinococcus multilocularis | acetylcholinesterase | 0.1472 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.0388 | 0.7529 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0308 | 0.0308 |
Onchocerca volvulus | 0.0037 | 0.0177 | 0.109 | |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1625 | 0.1625 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0249 | 0.1625 | 0.1625 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.0477 | 0.0477 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0177 | 0.0177 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0081 | 0.0477 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0276 | 0.1812 | 0.1812 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0388 | 0.1453 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0249 | 0.1625 | 0.1625 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0249 | 0.1625 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0308 | 0.0308 |
Brugia malayi | hypothetical protein | 0.0249 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | carboxylesterase | 0.0249 | 0.1625 | 0.1625 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0249 | 0.1625 | 1 |
Brugia malayi | hypothetical protein | 0.0276 | 0.1812 | 0.1812 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.0225 | 0.0225 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.0388 | 0.0388 |
Schistosoma mansoni | hypothetical protein | 0.0373 | 0.2479 | 0.2479 |
Onchocerca volvulus | 0.0037 | 0.0177 | 0.109 | |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0081 | 0.0477 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0177 | 0.0177 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0035 | 0.0035 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.0225 | 0.3059 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0177 | 0.0177 |
Onchocerca volvulus | 0.0249 | 0.1625 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0249 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0177 | 0.0177 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0249 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0177 | 0.0177 |
Echinococcus granulosus | neuroligin | 0.0249 | 0.1625 | 0.1625 |
Onchocerca volvulus | 0.0037 | 0.0177 | 0.109 | |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0035 | 0.0035 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0177 | 0.1745 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.1812 | 0.1812 |
Schistosoma mansoni | acetylcholinesterase | 0.0249 | 0.1625 | 0.1625 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0164 | 0.0164 |
Echinococcus granulosus | carboxylesterase 5A | 0.1472 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0035 | 0.0035 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.0225 | 0.3059 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0177 | 0.5 |
Onchocerca volvulus | 0.0249 | 0.1625 | 1 | |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0053 | 0.0286 | 0.0753 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0276 | 0.0276 |
Brugia malayi | Probable ClpP-like protease | 0.0081 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | carboxylesterase | 0.0249 | 0.1625 | 0.1625 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.0477 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0388 | 0.1453 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0249 | 0.1625 | 0.1625 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0177 | 0.0177 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0249 | 0.1625 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0249 | 0.1625 | 0.1625 |
Echinococcus granulosus | muscleblind protein | 0.0329 | 0.2176 | 0.2176 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.015 | 0.0951 | 0.0951 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0035 | 0.0035 |
Brugia malayi | Muscleblind-like protein | 0.0329 | 0.2176 | 0.2176 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0177 | 0.0177 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0477 | 0.0477 |
Echinococcus granulosus | acetylcholinesterase | 0.1472 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0249 | 0.1625 | 0.1625 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0177 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0177 | 0.0177 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0035 | 0.0035 |
Onchocerca volvulus | 0.0056 | 0.0308 | 0.1894 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0388 | 0.1453 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0308 | 0.0308 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0276 | 0.0276 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0081 | 0.0477 | 0.0477 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0388 | 0.0388 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0276 | 0.0276 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.0388 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.