Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0267 | 0.0925 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0267 | 0.0925 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0144 | 0.2887 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0144 | 0.2887 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0267 | 0.0925 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0144 | 0.2887 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0267 | 0.0925 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0267 | 0.0925 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0266 | 0.6003 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0144 | 0.2887 | 1 |
Onchocerca volvulus | 0.0042 | 0.0267 | 1 | |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0144 | 0.2887 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0267 | 0.0925 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0267 | 0.0925 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0267 | 0.0925 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0089 | 0.1482 | 0.5136 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0555 | 0.1923 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0267 | 0.0925 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0266 | 0.0923 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0089 | 0.1482 | 0.5136 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0144 | 0.2887 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0555 | 0.1923 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0555 | 0.1923 |
Onchocerca volvulus | 0.0042 | 0.0267 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0267 | 0.0925 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0144 | 0.2887 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0144 | 0.2887 | 0.2691 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0144 | 0.2887 | 0.4567 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0555 | 0.1923 |
Onchocerca volvulus | 0.0042 | 0.0267 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0555 | 0.1923 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0144 | 0.2887 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0267 | 0.0925 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0144 | 0.2887 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0555 | 0.1923 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0267 | 0.0925 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0144 | 0.2887 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0266 | 0.0923 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0045 | 0.0359 | 0.0351 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0266 | 0.0923 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0144 | 0.2887 | 0.2691 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0144 | 0.2887 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0267 | 0.0925 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0267 | 0.0925 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0144 | 0.2887 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0144 | 0.2887 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0144 | 0.2887 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0266 | 0.0923 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0266 | 0.0923 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0555 | 0.1923 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0555 | 0.1923 |
Brugia malayi | Adenosylhomocysteinase | 0.0144 | 0.2887 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0089 | 0.1482 | 0.5136 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0144 | 0.2887 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0267 | 0.0925 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0555 | 0.1923 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0267 | 0.0925 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0089 | 0.1482 | 0.5136 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.