Detailed information for compound 811843

Basic information

Technical information
  • TDR Targets ID: 811843
  • Name: N-(2,4-dioxo-1H-pyrimidin-5-yl)-3,5-dimethoxy benzamide
  • MW: 291.259 | Formula: C13H13N3O5
  • H donors: 3 H acceptors: 5 LogP: 0.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)cc(c1)C(=O)Nc1cnc(nc1O)O
  • InChi: 1S/C13H13N3O5/c1-20-8-3-7(4-9(5-8)21-2)11(17)15-10-6-14-13(19)16-12(10)18/h3-6H,1-2H3,(H,15,17)(H2,14,16,18,19)
  • InChiKey: DZARVNWUFNKKJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,4-dioxo-1H-pyrimidin-5-yl)-3,5-dimethoxy-benzamide
  • N-(2,4-diketo-1H-pyrimidin-5-yl)-3,5-dimethoxy-benzamide
  • ZINC00063979
  • Oprea1_678314
  • CBMicro_021656
  • BIM-0021591.P001
  • Oprea1_571127
  • A1530/0066522

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0061 0.1296 0.9416
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0015 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1296 0.9416
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.122 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0074 0.0075
Echinococcus granulosus FTZ F1 alpha 0.002 0.0074 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0074 0.0075
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0015 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0074 0.0059
Onchocerca volvulus 0.0051 0.0988 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0074 0.0188
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.122 0.3105
Loa Loa (eye worm) hypothetical protein 0.0064 0.1375 1
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0028 0.0102
Echinococcus granulosus tumor protein p63 0.0347 0.9823 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0074 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1296 0.3297
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0074 0.0188
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0074 0.0436
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0436
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.122 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0074 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0074 0.0075
Echinococcus granulosus fetal alzheimer antigen falz 0.002 0.008 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0436
Brugia malayi nuclear receptor NHR-88 0.002 0.0074 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0074 0.0436
Schistosoma mansoni ap endonuclease 0.0018 0.0015 0.0037
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0015 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0015 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0074 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0074 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.122 1
Brugia malayi Bromodomain containing protein 0.0068 0.149 0.1478
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.393 0.4001
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.122 0.3105
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.122 0.1242
Entamoeba histolytica hypothetical protein 0.0104 0.2578 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0015 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0015 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0074 0.0075
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0015 0.5
Echinococcus granulosus tar DNA binding protein 0.0061 0.1296 0.1319
Echinococcus multilocularis fetal alzheimer antigen, falz 0.002 0.008 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0074 0.0059
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0074 0.0075
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0015 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0074 0.0059
Schistosoma mansoni hypothetical protein 0.0104 0.2578 0.656
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.122 0.1242
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0436
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0015 0.5
Schistosoma mansoni thyroid hormone receptor 0.015 0.393 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0436
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0074 0.0075
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0074 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0074 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1296 0.3297
Entamoeba histolytica hypothetical protein 0.0104 0.2578 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0074 0.0188
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0074 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1296 0.3297
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1296 0.3297
Loa Loa (eye worm) hypothetical protein 0.0035 0.0505 0.3607
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0032 0.044 0.0448
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.333 0.339
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0074 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0074 0.0059
Entamoeba histolytica hypothetical protein 0.0104 0.2578 1
Schistosoma mansoni coup transcription factor 0.002 0.0074 0.0188
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0074 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0074 0.0188
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1296 0.9416
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0074 0.0075
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0074 0.0188
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0015 0.0015
Schistosoma mansoni nuclear hormone receptor 0.002 0.0074 0.0188
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0074 0.0075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0074 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0074 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0074 0.0059
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.122 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0074 0.0075
Brugia malayi ecdysteroid receptor 0.002 0.0074 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.122 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0015 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0074 0.0059
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0032 0.044 0.0448
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.002 0.008 0.0203
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0074 0.0075
Schistosoma mansoni bromodomain containing protein 0.0057 0.1175 0.299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0074 0.0436
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0074 0.0059
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0054 0.1079 0.1098
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0074 0.0436
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0074 0.0188
Brugia malayi nuclear hormone receptor 0.002 0.0074 0.0059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0074 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0074 0.0436
Entamoeba histolytica hypothetical protein 0.0104 0.2578 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0054 0.1079 0.1098
Schistosoma mansoni thyroid hormone receptor 0.015 0.393 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0569 0.4074
Schistosoma mansoni hypothetical protein 0.0019 0.0028 0.0072
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1296 0.1283
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0074 0.0059
Schistosoma mansoni hypothetical protein 0.0129 0.333 0.8473
Brugia malayi RNA binding protein 0.0061 0.1296 0.1283
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1296 0.1319
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0988 0.2515
Brugia malayi steroid hormone receptor 0.002 0.0074 0.0059
Brugia malayi Bromodomain containing protein 0.0035 0.0503 0.049
Schistosoma mansoni transcription factor LCR-F1 0.0104 0.2578 0.656
Schistosoma mansoni ap endonuclease 0.0018 0.0015 0.0037
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0074 0.0188
Brugia malayi TAR-binding protein 0.0061 0.1296 0.1283
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0074 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0074 0.0059
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0074 0.0075
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0104 0.2578 0.2624
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0436
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.122 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0436
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1296 0.3297
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.333 0.339
Brugia malayi PHD-finger family protein 0.0022 0.0143 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0436
Loa Loa (eye worm) hypothetical protein 0.0038 0.062 0.4452
Echinococcus multilocularis tumor protein p63 0.0347 0.9823 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0074 0.0436
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0015 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0104 0.2578 0.2624
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0074 0.0188
Loa Loa (eye worm) hypothetical protein 0.0051 0.0988 0.7157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0074 0.0436
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0074 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0436
Brugia malayi hypothetical protein 0.0104 0.2578 0.2567

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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