Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0415 | 0.6742 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0028 | 0.0066 | 0.0157 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0033 | 0.015 | 0.0223 |
Leishmania major | oxidoreductase-like protein | 0.0028 | 0.0066 | 1 |
Leishmania major | pteridine reductase 1 | 0.0028 | 0.0066 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.015 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0028 | 0.0066 | 0.0117 |
Brugia malayi | Importin beta-1 subunit | 0.0033 | 0.015 | 0.0433 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0028 | 0.0066 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0415 | 0.6742 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0269 | 0.4229 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0028 | 0.0066 | 0.0192 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0043 | 0.0063 |
Trichomonas vaginalis | importin beta-1, putative | 0.0027 | 0.0043 | 0.0063 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0269 | 0.4229 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.3464 | 0.6129 |
Schistosoma mansoni | hypothetical protein | 0.0352 | 0.5652 | 1 |
Brugia malayi | hypothetical protein | 0.0225 | 0.3464 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0415 | 0.6742 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0352 | 0.5652 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0033 | 0.015 | 0.0223 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0028 | 0.0066 | 0.0098 |
Brugia malayi | hypothetical protein | 0.0081 | 0.0983 | 0.2836 |
Plasmodium falciparum | importin beta, putative | 0.0033 | 0.015 | 0.0223 |
Leishmania major | importin beta-1 subunit, putative | 0.0027 | 0.0043 | 0.6414 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0028 | 0.0066 | 0.4423 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0269 | 0.4229 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0028 | 0.0066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0983 | 0.1738 |
Trypanosoma brucei | pteridine reductase 1 | 0.0028 | 0.0066 | 0.4423 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0131 | 0.1852 | 0.2674 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0028 | 0.0066 | 0.0117 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0269 | 0.4229 | 0.6272 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0028 | 0.0066 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0028 | 0.0066 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0269 | 0.4229 | 0.6272 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0028 | 0.0066 | 0.0098 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0028 | 0.0066 | 0.0066 |
Echinococcus granulosus | importin subunit beta 1 | 0.0033 | 0.015 | 0.0266 |
Onchocerca volvulus | 0.0225 | 0.3464 | 1 | |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0028 | 0.0066 | 0.0117 |
Schistosoma mansoni | importin beta-1 | 0.0033 | 0.015 | 0.0266 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0027 | 0.0043 | 0.6414 |
Echinococcus multilocularis | snurportin 1 | 0.0352 | 0.5652 | 0.5652 |
Schistosoma mansoni | eyes absent homolog | 0.0081 | 0.0983 | 0.1738 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0131 | 0.1852 | 0.2674 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0028 | 0.0066 | 0.0117 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0269 | 0.4229 | 0.6272 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0028 | 0.0066 | 0.0098 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0269 | 0.4229 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0033 | 0.015 | 0.015 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0415 | 0.6742 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0415 | 0.6742 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0415 | 0.6742 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0415 | 0.6742 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0415 | 0.6742 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0028 | 0.0066 | 0.0117 |
Brugia malayi | RNA, U transporter 1 | 0.0094 | 0.1199 | 0.346 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0043 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0066 | 0.0117 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0028 | 0.0066 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0028 | 0.0066 | 0.4423 |
Echinococcus granulosus | snurportin 1 | 0.0352 | 0.5652 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0028 | 0.0066 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0269 | 0.4229 | 0.6272 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0269 | 0.4229 | 0.6272 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0028 | 0.0066 | 0.0098 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0269 | 0.4229 | 0.6272 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0028 | 0.0066 | 0.0098 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0028 | 0.0066 | 0.0117 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0415 | 0.6742 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0043 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0983 | 0.1738 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.015 | 0.0266 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0269 | 0.4229 | 0.6272 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.015 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0028 | 0.0066 | 0.0192 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0269 | 0.4229 | 0.6272 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0131 | 0.1852 | 0.2674 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.