Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0295 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0774 | 0.9657 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0774 | 0.9657 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0774 | 0.9657 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0774 | 0.9657 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0774 | 0.9657 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0774 | 0.9657 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0774 | 0.9657 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0774 | 0.9657 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0774 | 0.9657 | 0.5 |
Onchocerca volvulus | 0.0295 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.