Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0535 | 0.0535 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.7723 | 1 |
Echinococcus multilocularis | lamin | 0.0031 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.7723 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.7723 | 1 |
Onchocerca volvulus | 0.0031 | 1 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0031 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0535 | 0.0535 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0.0535 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 1 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0031 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.9606 | 0.9606 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0896 | 0.0896 |
Brugia malayi | hypothetical protein | 0.0028 | 0.7723 | 0.7723 |
Schistosoma mansoni | lamin | 0.0031 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.7723 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.7723 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.7723 | 0.7723 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0535 | 0.0535 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.7723 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.7723 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.7723 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.