TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 307.428 | Formula: C18H29NO3
H donors: 1 H acceptors: 1 LogP: 3.26 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCN(C1CCc2c(C1)cc(c(c2)OC)OC)CC(O)C
InChi: 1S/C18H29NO3/c1-5-8-19(12-13(2)20)16-7-6-14-10-17(21-3)18(22-4)11-15(14)9-16/h10-11,13,16,20H,5-9,12H2,1-4H3
InChiKey: HRJACMZUAXVAOH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	pyruvate kinase	0.0071	0.0492	0.0512
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0041	0.0042
Schistosoma mansoni	aldehyde dehydrogenase	0.0134	0.1214	0.1252
Brugia malayi	TAR-binding protein	0.0262	0.2686	0.2785
Schistosoma mansoni	topbp1	0.0034	0.0062	0.0052
Toxoplasma gondii	pyruvate kinase PyKII	0.0037	0.0094	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0475	0.5133	0.7088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.0816	0.0837
Schistosoma mansoni	DNA ligase IV	0.0034	0.0062	0.0052
Loa Loa (eye worm)	pyruvate kinase-PB	0.005	0.0244	0.0326
Entamoeba histolytica	pyruvate kinase, putative	0.005	0.0244	0.0191
Trichomonas vaginalis	glucosylceramidase, putative	0.0365	0.3874	0.6704
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0041	0.0029
Echinococcus multilocularis	tankyrase	0.0064	0.041	0.0414
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0015	0.0003
Brugia malayi	intermediate filament protein	0.003	0.0015	0.0003
Schistosoma mansoni	intermediate filament proteins	0.003	0.0015	0.0003
Onchocerca volvulus		0.0234	0.2365	0.6449
Plasmodium vivax	pyruvate kinase, putative	0.0071	0.0492	0.8677
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0071	0.0492	0.8546
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0341	0.359	0.4953
Trichomonas vaginalis	glucosylceramidase, putative	0.0528	0.5749	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0065	0.0422	0.1715
Echinococcus multilocularis	pyruvate kinase	0.0037	0.0094	0.0085
Trichomonas vaginalis	glucosylceramidase, putative	0.0528	0.5749	1
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0864	0.9611	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0084	0.0087
Schistosoma mansoni	topbp1	0.0034	0.0062	0.0052
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.2686	0.2785
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0099	0.0816	0.0849
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0041	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0467	0.0634
Schistosoma mansoni	hypothetical protein	0.0187	0.182	0.1883
Onchocerca volvulus	Glucosylceramidase homolog	0.0347	0.366	1
Loa Loa (eye worm)	tnks protein	0.0064	0.041	0.0556
Trichomonas vaginalis	glucosylceramidase, putative	0.0528	0.5749	1
Trypanosoma cruzi	DNA repair protein, putative	0.0113	0.0971	0.1792
Echinococcus granulosus	geminin	0.0187	0.182	0.1893
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0062	0.0074
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0099	0.0816	0.0837
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0041	0.0044
Leishmania major	pyruvate kinase	0.0071	0.0492	0.0886
Giardia lamblia	Pyruvate kinase	0.0071	0.0492	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0084	0.0022
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0219	0.2195	0.3025
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0062	0.0074
Echinococcus granulosus	pyruvate kinase	0.0037	0.0094	0.0097
Toxoplasma gondii	pyruvate kinase PyK1	0.0071	0.0492	0.048
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0565	1
Echinococcus granulosus	lamin	0.003	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0062	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.041	0.0612
Trichomonas vaginalis	glucosylceramidase, putative	0.0347	0.366	0.6326
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0467	0.0474
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.0565	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0062	0.0074
Trichomonas vaginalis	glucosylceramidase, putative	0.0347	0.366	0.6326
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0062	0.0074
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.2686	0.2785
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.0565	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.0565	1
Brugia malayi	DKFZp564C0469 protein	0.0034	0.0062	0.0052
Brugia malayi	WGR domain containing protein	0.0864	0.9611	1
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.2365	0.4049
Schistosoma mansoni	hypothetical protein	0.0036	0.0084	0.0074
Leishmania major	DNA repair protein, putative	0.0113	0.0971	0.6927
Schistosoma mansoni	chromosome transmission fidelity factor	0.0034	0.0062	0.0052
Trichomonas vaginalis	glucosylceramidase, putative	0.0528	0.5749	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0134	0.1214	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.2038	0.2807
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.2686	0.2785
Echinococcus granulosus	pyruvate kinase	0.0071	0.0492	0.0512
Giardia lamblia	Pyruvate kinase	0.0037	0.0094	0.0729
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0053	0.0284	0.038
Echinococcus granulosus	nibrin	0.0034	0.0062	0.0065
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0012	0.0013
Loa Loa (eye worm)	pyruvate kinase	0.0071	0.0492	0.0669
Loa Loa (eye worm)	hypothetical protein	0.003	0.0015	0.0009
Entamoeba histolytica	hypothetical protein	0.0036	0.0084	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0062	0.0074
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0475	0.5133	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0347	0.366	0.6326
Echinococcus multilocularis	geminin	0.0187	0.182	0.1883
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0565	0.4367
Echinococcus multilocularis	neuropeptide s receptor	0.0478	0.5168	0.5372
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0099	0.0816	0.0837
Trichomonas vaginalis	pyruvate kinase, putative	0.0071	0.0492	0.0756
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0528	0.5749	0.5976
Plasmodium falciparum	pyruvate kinase 2	0.0037	0.0094	0.0623
Echinococcus granulosus	intermediate filament protein	0.003	0.0015	0.0015
Echinococcus multilocularis	tar DNA binding protein	0.0262	0.2686	0.2785
Loa Loa (eye worm)	hypothetical protein	0.0658	0.7238	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0134	0.1214	0.1252
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.0834	0.1142
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0268	0.276	0.2872
Brugia malayi	Pre-SET motif family protein	0.0206	0.2038	0.211
Echinococcus multilocularis	nibrin	0.0034	0.0062	0.0052
Schistosoma mansoni	hypothetical protein	0.0032	0.0041	0.0029
Echinococcus granulosus	replication factor c subunit 1	0.0034	0.0062	0.0065
Brugia malayi	Tnks protein	0.0064	0.041	0.0414
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0258	0.0256
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0071	0.0492	0.05
Echinococcus multilocularis	microtubule associated protein 2	0.076	0.8414	0.8753
Trypanosoma brucei	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0113	0.0971	0.1792
Mycobacterium ulcerans	pyruvate kinase	0.0071	0.0492	0.3732
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0492	0.0669
Echinococcus granulosus	pyruvate kinase	0.0037	0.0094	0.0097
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0565	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0041	0.0029
Onchocerca volvulus	DNA ligase 3 homolog	0.0113	0.0971	0.2628
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.0565	0.0576
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.0816	0.0837
Brugia malayi	hypothetical protein	0.0036	0.0084	0.0074
Schistosoma mansoni	pyruvate kinase	0.0071	0.0492	0.05
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.0816	0.0837
Onchocerca volvulus		0.0034	0.0062	0.0137
Brugia malayi	RNA binding protein	0.0262	0.2686	0.2785
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.041	0.0612
Loa Loa (eye worm)	RNA binding protein	0.0262	0.2686	0.3703
Plasmodium falciparum	pyruvate kinase	0.0071	0.0492	0.8546
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0134	0.1214	1
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0528	0.5749	0.794
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0258	0.3891
Loa Loa (eye worm)	hypothetical protein	0.005	0.0244	0.0326
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0071	0.0492	0.2449
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0804	0.8924	0.9284
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0134	0.1214	1
Toxoplasma gondii	ATPase, AAA family protein	0.0034	0.0062	0.005
Plasmodium vivax	pyruvate kinase 2, putative	0.0037	0.0094	0.1468
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0262	0.2686	0.3703
Brugia malayi	hypothetical protein	0.0034	0.0062	0.0052
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0065	0.0422	0.0427
Echinococcus granulosus	poly adp ribose polymerase 2	0.0475	0.5133	0.5341
Entamoeba histolytica	hypothetical protein	0.0134	0.1217	0.1209
Echinococcus multilocularis	pyruvate kinase	0.0037	0.0094	0.0085
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0065	0.0422	0.0427
Trichomonas vaginalis	glucosylceramidase, putative	0.0528	0.5749	1
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0475	0.5133	0.5335
Echinococcus multilocularis	lamin	0.003	0.0015	0.0003
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0065	0.0422	0.3123
Echinococcus multilocularis	pyruvate kinase	0.0071	0.0492	0.05
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0565	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0971	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0834	0.1142
Trypanosoma brucei	pyruvate kinase 1, putative	0.0071	0.0492	0.0848
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0134	0.1214	1
Echinococcus multilocularis	musashi	0.003	0.0015	0.0003
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0134	0.1217	0.1266
Schistosoma mansoni	vesicular acetylcholine transporter	0.0219	0.2195	0.2274
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0475	0.5133	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.0565	0.0576
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0071	0.0492	0.0848
Trypanosoma brucei	pyruvate kinase 1	0.0071	0.0492	0.0848
Trichomonas vaginalis	glucosylceramidase, putative	0.0365	0.3874	0.6704
Trichomonas vaginalis	glucosylceramidase, putative	0.0347	0.366	0.6326
Trichomonas vaginalis	replication factor C large subunit, putative	0.0034	0.0062	0.00000055767
Brugia malayi	topoisomerase	0.0034	0.0062	0.0052
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0565	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0134	0.1214	0.1263
Trypanosoma brucei	DNA repair protein, putative	0.0113	0.0971	0.1792
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.041	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.041	0.0612
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0198	0.1954	0.2022
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0071	0.0492	0.0848
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0864	0.9611	1
Entamoeba histolytica	zinc finger protein, putative	0.0064	0.041	0.0364
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0258	0.0268
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0065	0.0422	0.0427
Entamoeba histolytica	hypothetical protein	0.0064	0.041	0.0364
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.041	0.0612
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0565	1
Entamoeba histolytica	hypothetical protein	0.0064	0.041	0.0364
Trichomonas vaginalis	glucosylceramidase, putative	0.0347	0.366	0.6326
Echinococcus granulosus	lamin dm0	0.003	0.0015	0.0015
Plasmodium vivax	replication factor C subunit 1, putative	0.0034	0.0062	0.0901
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.041	0.0612
Echinococcus multilocularis	lamin dm0	0.003	0.0015	0.0003
Brugia malayi	WGR domain containing protein	0.0475	0.5133	0.5335
Entamoeba histolytica	hypothetical protein	0.0064	0.041	0.0364
Trichomonas vaginalis	pyruvate kinase, putative	0.0071	0.0492	0.0756
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0219	0.2195	0.5985
Schistosoma mansoni	hypothetical protein	0.0187	0.182	0.1883
Brugia malayi	Probable ClpP-like protease	0.0078	0.0565	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0041	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.041	0.0612
Echinococcus multilocularis	replication factor c subunit 1	0.0034	0.0062	0.0052
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0034	0.0062	0.00000033212
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0565	0.077
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0565	0.0554
Schistosoma mansoni	pyruvate kinase	0.0071	0.0492	0.05
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0411	0.4396	0.4567
Echinococcus multilocularis	neuropeptide receptor A26	0.0478	0.5168	0.5372
Echinococcus multilocularis	pyruvate kinase	0.0037	0.0094	0.0085
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0565	0.0554
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0864	0.9611	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0041	0.0029
Schistosoma mansoni	pyruvate kinase	0.0037	0.0094	0.0085
Echinococcus granulosus	GPCR family 2	0.0032	0.0041	0.0042
Echinococcus granulosus	neuropeptide receptor A26	0.0478	0.5168	0.5378
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0041	0.0029
Echinococcus multilocularis	pyruvate kinase	0.0056	0.032	0.032
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0099	0.0816	0.0837
Echinococcus multilocularis	pyruvate kinase	0.0071	0.0492	0.05
Onchocerca volvulus	Pyruvate kinase homolog	0.0071	0.0492	0.1315
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0041	0.0029
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0084	0.0074
Onchocerca volvulus	Pyruvate kinase homolog	0.0071	0.0492	0.1315
Brugia malayi	RNA recognition motif domain containing protein	0.0262	0.2686	0.2785
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0065	0.0422	0.3123
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0015	0.0009
Loa Loa (eye worm)	TAR-binding protein	0.0262	0.2686	0.3703
Echinococcus granulosus	microtubule associated protein 2	0.076	0.8414	0.8755
Echinococcus granulosus	neuropeptide s receptor	0.0478	0.5168	0.5378
Entamoeba histolytica	hypothetical protein	0.0036	0.0084	0.0022
Onchocerca volvulus	Tankyrase homolog	0.0064	0.041	0.1091
Leishmania major	hypothetical protein, conserved	0.0113	0.0971	0.6927
Onchocerca volvulus	Pyruvate kinase homolog	0.0071	0.0492	0.1315
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0034	0.0062	0.00000055767
Schistosoma mansoni	tankyrase	0.0064	0.041	0.0414
Trichomonas vaginalis	glucosylceramidase, putative	0.0528	0.5749	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0099	0.0816	0.1117
Leishmania major	pyruvate kinase	0.0071	0.0492	0.0886
Brugia malayi	Pax transcription activation domain interacting protein	0.0034	0.0062	0.0052
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.2686	0.2785
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0565	0.4367
Echinococcus granulosus	tar DNA binding protein	0.0262	0.2686	0.2794
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0015	0.0009
Entamoeba histolytica	hypothetical protein	0.0036	0.0084	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.041	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0012	0.0005
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0475	0.5133	1
Echinococcus granulosus	vesicular acetylcholine transporter	0.0219	0.2195	0.2284
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0084	0.0074
Echinococcus granulosus	tankyrase	0.0064	0.041	0.0427
Schistosoma mansoni	microtubule-associated protein tau	0.076	0.8414	0.8753
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0134	0.1217	0.1266
Toxoplasma gondii	aldehyde dehydrogenase	0.0134	0.1214	0.1203
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0041	0.0029
Schistosoma mansoni	hypothetical protein	0.0069	0.0467	0.0474
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0864	0.9611	1
Brugia malayi	hypothetical protein	0.0034	0.0062	0.0052
Trypanosoma cruzi	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0113	0.0971	0.1792
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0034	0.0062	0.00000055767
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0134	0.1214	1
Onchocerca volvulus		0.003	0.0015	0.0007
Schistosoma mansoni	lamin	0.003	0.0015	0.0003
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.0834	0.0856
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0219	0.2195	0.2274
Echinococcus granulosus	WGR domain containing protein	0.0268	0.276	0.2872
Onchocerca volvulus		0.003	0.0015	0.0007
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0475	0.5133	0.5335
Chlamydia trachomatis	pyruvate kinase	0.0071	0.0492	0.8546
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.2686	0.2785
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0065	0.0422	0.0439
Schistosoma mansoni	lamin	0.003	0.0015	0.0003
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0219	0.2195	0.2274
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.041	0.0612
Entamoeba histolytica	hypothetical protein	0.0064	0.041	0.0364
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0071	0.0492	0.05
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0134	0.1217	0.1266
Loa Loa (eye worm)	pyruvate kinase	0.0071	0.0492	0.0669
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0099	0.0816	0.0849
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0134	0.1214	0.1252
Schistosoma mansoni	hypothetical protein	0.0032	0.0041	0.0029
Echinococcus granulosus	pyruvate kinase	0.0037	0.0094	0.0097
Loa Loa (eye worm)	pyruvate kinase	0.0071	0.0492	0.0669
Trichomonas vaginalis	glucosylceramidase, putative	0.0347	0.366	0.6326
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0041	0.0029
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.0834	0.0856
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0034	0.0062	0.0052
Trichomonas vaginalis	glucosylceramidase, putative	0.0347	0.366	0.6326

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	uM	Ability to displace [3H]-spiperone binding from anterior microM GTP ; ND means no data	ChEMBL.	3656361
IC50 (binding)	uM	Ability to displace [3H]-spiperone binding from anterior pituitary Dopamine receptor D2 in the absence of GTP; ND means no data	ChEMBL.	3656361
IC50 (binding)	0 uM	Ability to displace [3H]-spiperone binding from anterior pituitary Dopamine receptor D2 in the absence of GTP; ND means no data	ChEMBL.	3656361
IC50 (binding)	0 uM	Ability to displace [3H]-spiperone binding from anterior microM GTP ; ND means no data	ChEMBL.	3656361

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL54694

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 81206