Detailed information for compound 812204

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 394.575 | Formula: C20H34N4O2S
  • H donors: 3 H acceptors: 1 LogP: 2.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1NC(=S)N[C@@H](C1)C(=O)NCC1CCC2(O1)CCN(CC2)CC=C(C)C
  • InChi: 1S/C20H34N4O2S/c1-14(2)5-9-24-10-7-20(8-11-24)6-4-16(26-20)13-21-18(25)17-12-15(3)22-19(27)23-17/h5,15-17H,4,6-13H2,1-3H3,(H,21,25)(H2,22,23,27)/t15-,16?,17+/m1/s1
  • InChiKey: GQFHMSOYYYRLDZ-SKQWJGTPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0022 0.0018 0.0584
Trichomonas vaginalis taga, putative 0.0022 0.0018 0.1111
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0018 0.1111
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0033 0.0681
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0018 0.0165
Entamoeba histolytica P-glyco protein 6, putative 0.0022 0.0018 0.1111
Onchocerca volvulus 0.019 0.0313 1
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0018 0.0584
Schistosoma mansoni rab6-interacting 0.0022 0.0018 0.0591
Echinococcus granulosus cathepsin L cysteine protease 0.0029 0.003 0.0954
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0045 0.1451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.003 0.2068
Schistosoma mansoni hypothetical protein 0.0022 0.0018 0.0591
Echinococcus multilocularis pol protein 0.0644 0.1108 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0018 0.1111
Echinococcus multilocularis Solute carrier organic anion transporter family 0.019 0.0313 0.2824
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0077 0.5991
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0051 0.1047
Loa Loa (eye worm) hypothetical protein 0.0056 0.0077 0.2468
Schistosoma mansoni agrin 0.01 0.0155 0.4941
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.01 0.0155 0.4941
Loa Loa (eye worm) hypothetical protein 0.019 0.0313 1
Onchocerca volvulus 0.019 0.0313 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0018 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0033 0.1069
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.5715 1 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0022 0.0018 0.1111
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.01 0.0155 0.4941
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0377
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.01 0.0155 0.4941
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0018 0.1111
Echinococcus multilocularis follistatin 0.01 0.0155 0.1395
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.01 0.0155 0.4941
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0018 0.0165
Schistosoma mansoni lipoxygenase 0.0022 0.0018 0.0591
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Onchocerca volvulus 0.0083 0.0126 0.3644
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0077 0.5991
Toxoplasma gondii cathepsin CPL 0.0056 0.0077 0.2468
Loa Loa (eye worm) agrin synaptic family protein 0.01 0.0155 0.4941
Leishmania major cysteinyl-tRNA synthetase, putative 0.0083 0.0126 0.2558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0007 0.021
Onchocerca volvulus 0.0056 0.0077 0.2001
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0018 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Echinococcus granulosus leucyl tRNA synthetase 0.0083 0.0126 0.4015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0056 0.0077 0.0697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.003 0.2068
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.0491 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0222 0.4513
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0018 0.1111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0022 0.0018 0.0584
Onchocerca volvulus 0.019 0.0313 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0089 0.2835
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.007 0.2237
Brugia malayi secreted modular calcium-binding protein 1 0.01 0.0155 0.4941
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0018 0.1111
Mycobacterium ulcerans hypothetical protein 0.0154 0.0249 0.0249
Toxoplasma gondii hypothetical protein 0.0047 0.0062 0.1982
Brugia malayi sodium-independent organic anion transporter family protein 0.019 0.0313 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0018 0.0584
Onchocerca volvulus 0.0056 0.0077 0.2001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.0491 1
Brugia malayi Cytochrome P450 family protein 0.0033 0.0038 0.1206
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.007 0.2237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.007 0.2237
Loa Loa (eye worm) hypothetical protein 0.019 0.0313 1
Echinococcus granulosus organic anion transporting polypeptide 30B 0.019 0.0313 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.007 0.2237
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0027 0.1831
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0018 0.1111
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0018 0.1111
Loa Loa (eye worm) hypothetical protein 0.01 0.0155 0.4941
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0018 0.0584
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.003 0.0954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.003 0.0607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0018 0.0584
Schistosoma mansoni lipoxygenase 0.0062 0.0089 0.2835
Trypanosoma cruzi major cysteine proteinase, putative 0.0167 0.0272 0.5541
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0018 0.1111
Brugia malayi hypothetical protein 0.019 0.0313 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0018 0.1111
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0377
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.1435
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.01 0.0155 0.4941
Leishmania major cathepsin L-like protease 0.0056 0.0077 0.1572
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0027 0.0243
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0083 0.0126 1
Trypanosoma cruzi cysteine peptidase, putative 0.0212 0.0352 0.7164
Echinococcus multilocularis cathepsin L 0.0029 0.003 0.0269
Brugia malayi hypothetical protein 0.0022 0.0018 0.0591
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0033 0.0681
Leishmania major cathepsin L-like protease 0.0212 0.0352 0.7164
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.0491 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0018 0.1111
Trypanosoma cruzi cysteine peptidase, putative 0.0212 0.0352 0.7164
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0067 0.1368
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0083 0.0126 0.4015
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0077 0.2468
Echinococcus granulosus cathepsin l1 0.0056 0.0077 0.2468
Onchocerca volvulus 0.0056 0.0077 0.2001
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.003 0.0607
Leishmania major cathepsin L-like protease 0.0212 0.0352 0.7164
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.019 0.0313 0.2824
Loa Loa (eye worm) hypothetical protein 0.0136 0.0219 0.6985
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0022 0.0018 0.0571
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0012 0.024
Onchocerca volvulus Cathepsin L homolog 0.0056 0.0077 0.2001
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0089 0.0801
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0018 0.0584
Echinococcus multilocularis pol protein 0.0644 0.1108 1
Brugia malayi hypothetical protein 0.0038 0.0045 0.1451
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.003 0.0607
Schistosoma mansoni polycystin 1-related 0.0022 0.0018 0.0591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Brugia malayi sodium-independent organic anion transporter family protein 0.019 0.0313 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.0491 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0155 0.4941
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Echinococcus multilocularis cathepsin L cysteine protease 0.0056 0.0077 0.0697
Loa Loa (eye worm) hypothetical protein 0.01 0.0155 0.4941
Brugia malayi Cytochrome P450 family protein 0.0031 0.0033 0.1069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0018 0.1111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0045 0.3316
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.01 0.0155 0.4941
Onchocerca volvulus 0.0022 0.0018 0.0007
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.0045 0.1435
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0018 0.1111
Brugia malayi Cathepsin L-like precursor 0.0056 0.0077 0.2468
Plasmodium vivax vivapain-2 0.0056 0.0077 0.5755
Brugia malayi Cathepsin L-like precursor 0.0056 0.0077 0.2468
Schistosoma mansoni cathepsin F (C01 family) 0.0056 0.0077 0.2468
Onchocerca volvulus Putative organic anion transporter 0.019 0.0313 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0056 0.0077 0.2468
Toxoplasma gondii transporter, major facilitator family protein 0.019 0.0313 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0018 0.0591
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.1435
Trichomonas vaginalis abcb9, putative 0.0022 0.0018 0.1111
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0045 0.3316
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.1435
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0005 0.0099
Leishmania major p-glycoprotein 0.0022 0.0018 0.0372
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0018 0.0591
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0033 0.1069
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0018 0.1111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.007 0.0632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Loa Loa (eye worm) hypothetical protein 0.01 0.0155 0.4941
Entamoeba histolytica cysteine proteinase 2 0.0029 0.003 0.2068
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0056 0.0077 0.549
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0033 0.0681
Schistosoma mansoni loxhd1 0.0022 0.0018 0.0591
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.3356
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0018 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.003 0.0607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0077 0.5991
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0018 0.1111
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0045 0.1451
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0018 0.0584
Loa Loa (eye worm) multidrug resistance protein 3 0.0022 0.0018 0.0584
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0222 0.4513
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0083 0.0126 0.2558
Brugia malayi multidrug resistance protein 3 0.0022 0.0018 0.0584
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0051 0.1047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0051 0.1047
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0018 0.0584
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0194 0.032 0.6506
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0591
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Leishmania major cathepsin L-like protease 0.0212 0.0352 0.7164
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0083 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0377
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.0007 0.0059
Echinococcus granulosus agrin 0.01 0.0155 0.4941
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.007 0.2237
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0083 0.0126 0.1134
Plasmodium vivax unspecified product 0.0018 0.0012 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Onchocerca volvulus 0.0056 0.0077 0.2001
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0018 0.0591
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0018 0.1111
Echinococcus multilocularis cysteine protease 0.0056 0.0077 0.0697
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0045 0.041
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0083 0.0126 0.5
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0056 0.0077 0.549
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0005 0.0099
Loa Loa (eye worm) RecQ helicase 0.0027 0.0027 0.0862
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0083 0.0126 0.2558
Chlamydia trachomatis cysteine--tRNA ligase 0.0083 0.0126 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0077 0.5991
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0045 0.1435
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0083 0.0126 0.4015
Schistosoma mansoni multidrug resistance protein 0.0022 0.0018 0.0584
Entamoeba histolytica P-glycoprotein-2, putative 0.0022 0.0018 0.1111
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.3356
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0017 0.0543
Leishmania major cathepsin L-like protease 0.0056 0.0077 0.1572
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0021 0.0273
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0018 0.0165
Giardia lamblia Cysteinyl-tRNA synthetase 0.0083 0.0126 0.5
Plasmodium vivax vivapain-2 0.0056 0.0077 0.5755
Trichomonas vaginalis abcb9, putative 0.0022 0.0018 0.1111
Trypanosoma cruzi MFS transporter, putative 0.019 0.0313 0.637
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0083 0.0126 0.4015
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.003 0.0954
Onchocerca volvulus 0.019 0.0313 1
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0027 0.0862
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0018 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Brugia malayi Cathepsin L-like precursor 0.0056 0.0077 0.2468
Loa Loa (eye worm) fibroinase 0.0056 0.0077 0.2468
Schistosoma mansoni hypothetical protein 0.0038 0.0045 0.1451
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.007 0.2237
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0018 0.1111
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0011 0.0359
Brugia malayi SPARC precursor 0.01 0.0155 0.4941
Echinococcus granulosus cathepsin l1 0.0037 0.0045 0.1435
Leishmania major cathepsin L-like protease 0.0056 0.0077 0.1572
Onchocerca volvulus 0.0056 0.0077 0.2001
Onchocerca volvulus Putative organic anion transporter 0.019 0.0313 1
Brugia malayi prostaglandin transporter 0.019 0.0313 1
Brugia malayi Cathepsin L-like precursor 0.0056 0.0077 0.2468
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0056 0.0077 0.5991
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0022 0.0018 0.0584
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0012 0.024
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0056 0.0077 0.2468
Brugia malayi Cathepsin L-like precursor 0.0056 0.0077 0.2468
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0018 0.1111
Schistosoma mansoni multidrug resistance protein 0.0022 0.0018 0.0584
Echinococcus granulosus cysteinyl tRNA synthetase 0.0083 0.0126 0.4015
Echinococcus granulosus cathepsin L cysteine proteinase 0.0056 0.0077 0.2468
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.01 0.0155 0.4941
Brugia malayi Cathepsin L-like precursor 0.0037 0.0045 0.1435
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0018 0.1111
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.003 0.2068
Schistosoma mansoni rab6-interacting 0.0022 0.0018 0.0591
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0018 0.1111
Echinococcus multilocularis pol protein 0.0644 0.1108 1
Echinococcus multilocularis pol protein 0.0644 0.1108 1
Schistosoma mansoni multidrug resistance protein 0.0022 0.0018 0.0584
Echinococcus multilocularis cathepsin L cysteine protease 0.0056 0.0077 0.0697
Loa Loa (eye worm) hypothetical protein 0.019 0.0313 1
Brugia malayi Cathepsin L-like precursor 0.0037 0.0045 0.1435
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0083 0.0126 0.4015
Echinococcus granulosus cysteine protease 0.0029 0.003 0.0954
Echinococcus multilocularis expressed protein 0.01 0.0155 0.1395
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.5715 1 1
Brugia malayi hypothetical protein 0.0022 0.0018 0.0591
Echinococcus granulosus follistatin 0.01 0.0155 0.4941
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Schistosoma mansoni organic anion transporter 0.019 0.0313 1
Onchocerca volvulus Cathepsin L homolog 0.0056 0.0077 0.2001
Plasmodium vivax multidrug resistance protein 1, putative 0.0022 0.0018 0.0586
Echinococcus granulosus cathepsin L 0.0029 0.003 0.0954
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0007 0.021
Echinococcus granulosus Solute carrier organic anion transporter family 0.019 0.0313 1
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.3356
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.003 0.2068
Plasmodium vivax cysteine--tRNA ligase, putative 0.0083 0.0126 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0018 0.1111
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.01 0.0155 0.4941
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0005 0.0099
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0018 0.1111
Plasmodium vivax vivapain-3 0.0029 0.003 0.1599
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0018 0.0605
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0018 0.1111
Leishmania major cathepsin L-like protease 0.0056 0.0077 0.1572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.003 0.0607
Plasmodium falciparum cysteine--tRNA ligase 0.0083 0.0126 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0022 0.0018 0.0018
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0018 0.1111
Echinococcus granulosus cathepsin l cysteine peptidase 0.0056 0.0077 0.2468
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0077 0.5991
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0077 0.5991
Schistosoma mansoni cathepsin F (C01 family) 0.0056 0.0077 0.2468
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0077 0.5991
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0077 0.1572
Brugia malayi cathepsin L-like precursor 0.0037 0.0045 0.1435
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0022 0.0018 0.0372
Entamoeba histolytica cysteine proteinase 1, putative 0.0029 0.003 0.2068
Brugia malayi ABC transporter family protein 0.0022 0.0018 0.0584
Brugia malayi Cytochrome P450 family protein 0.0031 0.0033 0.1069
Schistosoma mansoni cathepsin s 0.0018 0.0012 0.0377
Schistosoma mansoni organic anion transporter 0.019 0.0313 1
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0033 0.0033
Leishmania major cathepsin L-like protease 0.0056 0.0077 0.1572
Toxoplasma gondii protease inhibitor PI2 0.01 0.0155 0.4941
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0007 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Loa Loa (eye worm) ctsf protein 0.0056 0.0077 0.2468
Trypanosoma cruzi cysteine protease, putative 0.0029 0.003 0.0607
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.003 0.0954
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.003 0.2068
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0018 0.1111
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0018 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0056 0.0077 0.5991
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0077 0.5991
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0018 0.1111
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.3356
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0056 0.0077 0.0697
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0083 0.0126 1
Leishmania major cysteine peptidase A (CPA) 0.0056 0.0077 0.1572
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0083 0.0126 0.2558
Loa Loa (eye worm) sodium-independent organic anion transporter 0.019 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0591
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0018 0.0591
Plasmodium vivax unspecified product 0.0029 0.003 0.1599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0012 0.0377
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0249 0.0249
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0045 0.3316
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0027 0.1831
Trypanosoma cruzi cruzipain precursor, putative 0.0212 0.0352 0.7164
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0018 0.1111
Loa Loa (eye worm) cysteine protease 0.0056 0.0077 0.2468
Echinococcus granulosus RUN 0.0022 0.0018 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Trypanosoma cruzi cysteine peptidase, putative 0.0212 0.0352 0.7164
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0222 0.4513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0018 0.0165
Entamoeba histolytica cysteine protease, putative 0.0056 0.0077 0.5991
Loa Loa (eye worm) hypothetical protein 0.019 0.0313 1
Echinococcus multilocularis cysteine protease 0.0056 0.0077 0.0697
Echinococcus granulosus bloom syndrome protein 0.0027 0.0027 0.0862
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0414
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0077 0.5991
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0018 0.1111
Trichomonas vaginalis abcb9, putative 0.0022 0.0018 0.1111
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0051 0.1047
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0018 0.1111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0077 0.5991
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0029 0.003 0.0607
Plasmodium vivax vivapain-1 0.0029 0.003 0.1599
Entamoeba histolytica P-glycoprotein-1 0.0022 0.0018 0.1111
Echinococcus multilocularis RUN 0.0022 0.0018 0.0167
Onchocerca volvulus 0.0022 0.0018 0.0007
Brugia malayi sodium-independent organic anion transporter family protein 0.019 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.019 0.0313 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0012 0.0377
Onchocerca volvulus 0.0037 0.0045 0.0904
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0033 0.1069
Brugia malayi hypothetical protein 0.019 0.0313 1
Echinococcus multilocularis agrin 0.01 0.0155 0.1395
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0018 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0212 0.0352 0.7164
Plasmodium falciparum cysteine proteinase falcipain 1 0.0029 0.003 0.1076
Loa Loa (eye worm) hypothetical protein 0.019 0.0313 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.003 0.0954
Echinococcus multilocularis ATP binding cassette sub family B 0.0022 0.0018 0.0161
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0018 0.002
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.01 0.0155 0.4941
Brugia malayi Cathepsin L-like precursor 0.0056 0.0077 0.2468
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.007 0.0632
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0077 0.5991
Treponema pallidum cysteinyl-tRNA synthetase 0.0083 0.0126 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0377
Onchocerca volvulus 0.01 0.0155 0.4627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Brugia malayi Doublecortin family protein 0.0022 0.0018 0.0591
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0083 0.0126 0.4015
Entamoeba histolytica cysteine protease, putative 0.0029 0.003 0.2068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0571
Leishmania major cytochrome p450-like protein 0.0031 0.0033 0.0681
Plasmodium falciparum cysteine--tRNA ligase 0.0083 0.0126 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0012 0.0377
Onchocerca volvulus 0.0056 0.0077 0.2001
Plasmodium falciparum cysteine proteinase falcipain 3 0.0056 0.0077 0.549
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.003 0.0954
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.003 0.2068
Schistosoma mansoni smdr2 0.0022 0.0018 0.0584
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.007 0.2237
Onchocerca volvulus 0.0056 0.0077 0.2001
Loa Loa (eye worm) hypothetical protein 0.0083 0.0126 0.4015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Onchocerca volvulus 0.019 0.0313 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0077 0.5991
Loa Loa (eye worm) hypothetical protein 0.019 0.0313 1
Entamoeba histolytica P-glycoprotein-5 0.0022 0.0018 0.1111
Onchocerca volvulus Cathepsin F homolog 0.0056 0.0077 0.2001
Schistosoma mansoni follistatin 0.01 0.0155 0.4941
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0038 0.1206
Onchocerca volvulus Putative organic anion transporter 0.019 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0584

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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