Detailed information for compound 812256

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.487 | Formula: C26H25FN2O3
  • H donors: 0 H acceptors: 2 LogP: 3.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CN1CCN(CCC1=O)C(=O)c1ccc(cc1)c1ccccc1F
  • InChi: 1S/C26H25FN2O3/c1-32-22-6-4-5-19(17-22)18-29-16-15-28(14-13-25(29)30)26(31)21-11-9-20(10-12-21)23-7-2-3-8-24(23)27/h2-12,17H,13-16,18H2,1H3
  • InChiKey: DJOXEAYEPHVQBO-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha glucosidase 0.0038 0.0141 0.0141
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0042 0.0162 0.107
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0097 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0163
Brugia malayi beta-lactamase family protein 0.0132 0.0627 0.0755
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1505 1
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0017 0.0105
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0002 0.0001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0132 0.0627 0.136
Mycobacterium tuberculosis Conserved protein 0.0132 0.0627 0.136
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.006 0.0255 0.1688
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0613 0.3093 1
Brugia malayi hypothetical protein 0.0014 0.0022 0.0026
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0002 0.0002
Schistosoma mansoni ets-related 0.001 0.0002 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0025 0.0029
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0077 0.0077
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0019 0.0044 0.0139
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0128
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0141 0.0169
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.006
Brugia malayi RNA recognition motif domain containing protein 0.0051 0.0212 0.0255
Schistosoma mansoni microtubule-associated protein tau 0.1959 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0141 0.0931
Mycobacterium leprae Probable lipase LipE 0.0132 0.0627 0.8711
Brugia malayi hypothetical protein 0.0022 0.0063 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0141 0.0931
Leishmania major mitochondrial DNA polymerase beta 0.0613 0.3093 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0002 0.0002
Brugia malayi beta-lactamase 0.0132 0.0627 0.0755
Entamoeba histolytica hypothetical protein 0.0029 0.0099 0.0645
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0132 0.0627 0.0627
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0063 0.0198
Trichomonas vaginalis rotamase, putative 0.0061 0.0263 0.1738
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0089 0.0089
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0141 0.0931
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0132 0.0627 0.0754
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0132 0.0627 0.0755
Schistosoma mansoni DNA helicase recq1 0.001 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1505 1
Brugia malayi Ets-domain containing protein 0.0072 0.0317 0.0381
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0041 0.016 0.1361
Trichomonas vaginalis hypothetical protein 0.003 0.0102 0.0667
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0074 0.0643
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0002 0.0002
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0141 0.0141
Echinococcus multilocularis Smad4 0.0015 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0263 0.1738
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1505 1
Schistosoma mansoni ets 0.001 0.0002 0.0002
Schistosoma mansoni rotamase 0.0061 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0132 0.0627 0.0754
Schistosoma mansoni smad1 5 8 and 0.0015 0.0025 0.0025
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0275 0.1359 0.309
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0077 0.0501
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0275 0.1359 0.1359
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0019 0.0044 0.0682
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0141 0.0453
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0132 0.0627 0.136
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0317 0.0317
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0074 0.0233
Brugia malayi Ets-domain containing protein 0.001 0.0002 0.0002
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0029 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0275 0.1359 0.1637
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0275 0.1359 0.1359
Mycobacterium tuberculosis Carboxylesterase LipT 0.0275 0.1359 0.309
Trichomonas vaginalis esterase, putative 0.0132 0.0627 0.4162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0098 0.0098
Mycobacterium ulcerans esterase/lipase LipP 0.0132 0.0627 0.3705
Toxoplasma gondii ABC1 family protein 0.0132 0.0627 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0052 0.0163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1505 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0074 0.014
Brugia malayi beta-lactamase family protein 0.0132 0.0627 0.0755
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0041 0.016 1
Echinococcus multilocularis expressed protein 0.0041 0.016 0.016
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0021 0.0062
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.1505 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1505 1
Mycobacterium tuberculosis Probable esterase LipL 0.0132 0.0627 0.136
Brugia malayi Pre-SET motif family protein 0.0029 0.0098 0.0117
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0052 0.0052
Echinococcus granulosus dna polymerase kappa 0.002 0.0052 0.0052
Onchocerca volvulus 0.0275 0.1359 1
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0002 0.0002
Loa Loa (eye worm) fli-1 protein 0.0218 0.1067 0.1285
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0002 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0052 0.0163
Echinococcus granulosus carboxylesterase 5A 0.1627 0.8295 0.8295
Brugia malayi Ets-domain containing protein 0.0072 0.0317 0.0381
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0132 0.0627 0.0754
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0061 0.0263 0.0315
Echinococcus granulosus para nitrobenzyl esterase 0.0275 0.1359 0.1359
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0317 0.0317
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0019 0.0044 0.0088
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0061 0.0263 0.0316
Loa Loa (eye worm) hypothetical protein 0.0061 0.0263 0.0315
Echinococcus granulosus Smad4 0.0015 0.0025 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0098 0.0098
Echinococcus multilocularis expressed protein 0.0061 0.0263 0.0263
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0086 0.0391 0.126
Trichomonas vaginalis rotamase, putative 0.006 0.0255 0.1688
Leishmania major hypothetical protein, conserved 0.0022 0.0063 0.0148
Echinococcus granulosus mothers against decapentaplegic 5 0.0015 0.0025 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0063 0.0198
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1627 0.8295 0.8295
Schistosoma mansoni BC026374 protein (S09 family) 0.0275 0.1359 0.1359
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0212 0.0212
Echinococcus granulosus neuroligin 0.0275 0.1359 0.1359
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0041 0.016 0.0256
Echinococcus multilocularis acetylcholinesterase 0.1627 0.8295 0.8295
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.006 0.0255 0.0821
Loa Loa (eye worm) hypothetical protein 0.0132 0.0627 0.0754
Trypanosoma brucei unspecified product 0.0014 0.002 0.0059
Echinococcus granulosus ferritin 0.0041 0.016 0.016
Echinococcus multilocularis dnaJ subfamily B 0.0425 0.2127 0.2127
Onchocerca volvulus 0.0098 0.0451 0.3213
Schistosoma mansoni hypothetical protein 0.0013 0.0017 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1505 1
Schistosoma mansoni elf1 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.1627 0.8295 1
Onchocerca volvulus 0.0086 0.0392 0.2772
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.006 0.0255 0.0821
Mycobacterium ulcerans carboxylesterase, LipT 0.0275 0.1359 0.8417
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0392 0.0392
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0002 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0132 0.0627 0.4162
Echinococcus multilocularis cpg binding protein 0.0032 0.0111 0.0111
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0063 0.8494
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.0816 0.0816
Onchocerca volvulus 0.0132 0.0627 0.4532
Schistosoma mansoni ets-related 0.0218 0.1067 0.1067
Echinococcus granulosus GPCR family 2 0.0013 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0029 0.0099 0.0645
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0017 0.0017
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0002 0.0001
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0141 0.0141
Schistosoma mansoni smad1 5 8 and 0.0015 0.0025 0.0025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0029 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0086 0.0392 0.047
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0002 0.0002
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0002 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Schistosoma mansoni gabp alpha 0.0072 0.0317 0.0317
Giardia lamblia DINP protein human, muc B family 0.002 0.0052 0.0333
Loa Loa (eye worm) carboxylesterase 0.0275 0.1359 0.1637
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0279 0.0279
Onchocerca volvulus 0.0275 0.1359 1
Mycobacterium tuberculosis Probable hydrolase 0.0132 0.0627 0.136
Brugia malayi MH2 domain containing protein 0.0015 0.0025 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0052 0.0163
Echinococcus multilocularis neuroligin 0.0275 0.1359 0.1359
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.0709 0.4233
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0021 0.0128
Onchocerca volvulus 0.0132 0.0627 0.4532
Loa Loa (eye worm) TAR-binding protein 0.0051 0.0212 0.0254
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0017 0.0105
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0141 0.0169
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0019 0.0044 0.0139
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0132 0.0627 0.3705
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.029 0.1437 0.4643
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0141 0.0931
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.1505 1
Schistosoma mansoni ferritin 0.0041 0.016 0.016
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0128
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0199 0.0969 0.1166
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0077 0.0091
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0021 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0017 0.0019
Schistosoma mansoni ferritin 0.0041 0.016 0.016
Loa Loa (eye worm) MH2 domain-containing protein 0.0219 0.107 0.1289
Brugia malayi MH1 domain containing protein 0.0015 0.0025 0.0029
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0074 0.1147
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0165 0.0198
Echinococcus granulosus acetylcholinesterase 0.1627 0.8295 0.8295
Schistosoma mansoni cpg binding protein 0.0032 0.0111 0.0111
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0275 0.1359 0.1359
Schistosoma mansoni Smad4 0.0015 0.0025 0.0025
Brugia malayi glutaminase DH11.1 0.0284 0.1404 0.1692
Brugia malayi Carboxylesterase family protein 0.0275 0.1359 0.1637
Brugia malayi Pre-SET motif family protein 0.0199 0.0969 0.1167
Onchocerca volvulus 0.003 0.0102 0.0607
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0002 0.0002
Trypanosoma brucei glucosidase, putative 0.0038 0.0141 0.0453
Brugia malayi Smad1 0.0015 0.0025 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.0132 0.0627 0.2024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1505 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0052 0.0163
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0052 0.006
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0002 0.0002
Brugia malayi Carboxylesterase family protein 0.0275 0.1359 0.1637
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0063 0.8494
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0098 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0128
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0052 0.0334
Schistosoma mansoni neuroligin 3 (S09 family) 0.0275 0.1359 0.1359
Echinococcus granulosus expressed protein 0.0041 0.016 0.016
Schistosoma mansoni tsg101-related 0.0051 0.021 0.021
Echinococcus multilocularis protein C ets 2 0.001 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.0032 0.0111 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0163
Loa Loa (eye worm) glutaminase 0.0284 0.1404 0.1692
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0132 0.0627 0.136
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0086 0.0391 0.126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0163
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0098 0.0098
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.1505 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0052 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0212 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.0059
Echinococcus granulosus BC026374 protein S09 family 0.0275 0.1359 0.1359
Schistosoma mansoni smad 0.0015 0.0025 0.0025
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0275 0.1359 0.309
Echinococcus multilocularis acetylcholinesterase 0.1627 0.8295 0.8295
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0061 0.0263 0.0263
Leishmania major hypothetical protein, conserved 0.002 0.0049 0.0104
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0141 0.0931
Onchocerca volvulus 0.0275 0.1359 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.0592 0.0712
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0021 0.0128
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0212 0.0212
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0052 0.0052
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0392 0.0392
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0098 0.154
Trichomonas vaginalis spcc417.12 protein, putative 0.0275 0.1359 0.9029
Trichomonas vaginalis penicillin-binding protein, putative 0.0132 0.0627 0.4162
Schistosoma mansoni gliotactin 0.0275 0.1359 0.1359
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0002 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0098 0.0098
Echinococcus multilocularis smad 0.0015 0.0025 0.0025
Echinococcus granulosus dnaJ subfamily B 0.0425 0.2127 0.2127
Echinococcus granulosus acetylcholinesterase 0.1627 0.8295 0.8295
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0017 0.0017
Loa Loa (eye worm) Smad1 0.0015 0.0025 0.0029
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0391 0.126
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0212 0.0212
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0128
Loa Loa (eye worm) transcription factor SMAD2 0.0219 0.107 0.1289
Brugia malayi transcription factor E74 isoform 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0116
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0034 0.0522
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0141 0.0931
Echinococcus multilocularis beta LACTamase domain containing family member 0.0132 0.0627 0.0627
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0019 0.0044 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.0132 0.0627 0.2024
Loa Loa (eye worm) carboxylesterase 0.1627 0.8295 1
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0002 0.0002
Echinococcus granulosus expressed protein 0.0061 0.0263 0.0263
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0816 0.0983
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0063 0.0461
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0029 0.0099 0.0099
Schistosoma mansoni DNA helicase recq5 0.001 0.0002 0.0002
Toxoplasma gondii hypothetical protein 0.0099 0.0456 0.7263
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0061 0.0263 0.0263
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.029 0.1437 0.4643
Mycobacterium ulcerans bacterioferritin BfrA 0.0041 0.016 0.0697
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0061 0.8298
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0074 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0132 0.0627 0.0627
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.1505 1
Schistosoma mansoni ferritin 0.0041 0.016 0.016
Leishmania major DNA polymerase eta, putative 0.002 0.0052 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0163
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0132 0.0627 0.0627
Onchocerca volvulus 0.0275 0.1359 1
Schistosoma mansoni apoferritin-2 0.0041 0.016 0.016
Echinococcus multilocularis mothers against decapentaplegic 5 0.0015 0.0025 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0132 0.0627 1
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.002 0.0049 0.0155
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0021 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0163
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0002 0.0002
Loa Loa (eye worm) RecQ helicase 0.0025 0.0077 0.0091
Entamoeba histolytica hypothetical protein 0.0024 0.0074 0.0479
Loa Loa (eye worm) hypothetical protein 0.0275 0.1359 0.1637
Trichomonas vaginalis set domain proteins, putative 0.0226 0.1109 0.7365
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.005 0.005
Schistosoma mansoni transcription factor LCR-F1 0.0029 0.0099 0.0099
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0816 0.0982
Schistosoma mansoni ferritin light chain 0.0041 0.016 0.016
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0132 0.0627 0.0754
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0141 0.0931
Brugia malayi MH2 domain containing protein 0.0015 0.0025 0.0029
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0002 0.0001
Loa Loa (eye worm) beta-lactamase 0.0132 0.0627 0.0754
Brugia malayi Carboxylesterase family protein 0.0275 0.1359 0.1637
Schistosoma mansoni tsg101-related 0.0051 0.021 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0163
Schistosoma mansoni apoferritin-2 0.0041 0.016 0.016
Echinococcus granulosus TGF beta signal transducer SmadC 0.0015 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0063 0.0074
Mycobacterium leprae conserved hypothetical protein 0.0132 0.0627 0.8711
Leishmania major hypothetical protein, conserved 0.0132 0.0627 0.1983
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0244 0.3874
Brugia malayi CXXC zinc finger family protein 0.003 0.0102 0.0122
Brugia malayi Carboxylesterase family protein 0.0275 0.1359 0.1637
Mycobacterium ulcerans lipase LipD 0.0132 0.0627 0.3705
Mycobacterium tuberculosis Probable lipase LipD 0.0132 0.0627 0.136
Echinococcus granulosus protein C ets 2 0.001 0.0002 0.0002
Echinococcus multilocularis tar DNA binding protein 0.0051 0.0212 0.0212
Brugia malayi Carboxylesterase family protein 0.1627 0.8295 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0613 0.3093 1
Loa Loa (eye worm) hypothetical protein 0.1627 0.8295 1
Brugia malayi TAR-binding protein 0.0051 0.0212 0.0255
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0392 0.0392
Trichomonas vaginalis glutaminase, putative 0.0284 0.1404 0.933
Brugia malayi MH1 domain containing protein 0.0015 0.0025 0.0029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0197
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0074 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0052 0.0163
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.0709 0.1554
Loa Loa (eye worm) carboxylesterase 0.0275 0.1359 0.1637
Echinococcus multilocularis GPCR, family 2 0.0013 0.0017 0.0017
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0052 0.0061
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0275 0.1359 0.1359
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0105 0.0488 0.1573
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0077 0.0501
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0141 0.0931
Schistosoma mansoni glutaminase 0.0284 0.1404 0.1404
Trypanosoma brucei unspecified product 0.0014 0.002 0.0059
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0845 0.4282 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0392 0.0471
Plasmodium vivax SET domain protein, putative 0.0029 0.0098 0.1059
Brugia malayi hypothetical protein 0.0029 0.0099 0.0117
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0074 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0132 0.0627 0.4162
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0052 0.0112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0165 0.0197
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0275 0.1359 0.9029
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0141 0.0931
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0023
Onchocerca volvulus 0.0275 0.1359 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0163
Mycobacterium tuberculosis Conserved hypothetical protein 0.0323 0.1605 0.3672
Brugia malayi RNA binding protein 0.0051 0.0212 0.0255
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0019
Echinococcus multilocularis dna polymerase eta 0.002 0.0052 0.0052
Mycobacterium ulcerans bacterioferritin BfrB 0.0041 0.016 0.0697
Schistosoma mansoni alpha-glucosidase 0.0146 0.0696 0.0696
Echinococcus granulosus dna polymerase eta 0.002 0.0052 0.0052
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.006 0.0255 0.0774
Trypanosoma brucei Vps23 core domain containing protein, putative 0.002 0.0049 0.0155
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.006 0.0255 0.0821
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1505 1
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0141 0.0404
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0052 0.0163
Echinococcus granulosus cpg binding protein 0.0032 0.0111 0.0111
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0102 0.0121
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0391 0.126
Echinococcus multilocularis ets variant gene 4 0.001 0.0002 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0141 0.0931
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0017 0.0051
Onchocerca volvulus 0.0132 0.0627 0.4532
Onchocerca volvulus 0.0226 0.1109 0.8131
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0029 0.0099 0.0645
Schistosoma mansoni hypothetical protein 0.0013 0.0017 0.0017
Schistosoma mansoni tsg101-related 0.0042 0.0162 0.0162
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.0709 1
Schistosoma mansoni smad1 5 8 and 0.0015 0.0025 0.0025
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0132 0.0627 0.136
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0063 0.0198
Schistosoma mansoni ferritin 0.0041 0.016 0.016
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0816 0.0816
Trypanosoma cruzi hypothetical protein, conserved 0.0132 0.0627 0.2024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Schistosoma mansoni acetylcholinesterase 0.0275 0.1359 0.1359
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0017 0.0017
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0317 0.0381
Loa Loa (eye worm) hypothetical protein 0.0275 0.1359 0.1637
Loa Loa (eye worm) hypothetical protein 0.0029 0.0097 0.0115
Loa Loa (eye worm) hypothetical protein 0.0275 0.1359 0.1637
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0132 0.0627 0.136
Schistosoma mansoni hypothetical protein 0.0013 0.0017 0.0017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0098 0.0098
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0021 0.0011
Schistosoma mansoni cpg binding protein 0.003 0.0102 0.0102
Echinococcus multilocularis carboxylesterase 5A 0.1627 0.8295 0.8295
Mycobacterium ulcerans glutaminase 0.0284 0.1404 0.8709
Loa Loa (eye worm) glutaminase 2 0.0284 0.1404 0.1692
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0275 0.1359 0.1359
Treponema pallidum bacterioferrin (TpF1) 0.0041 0.016 0.0604
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0052 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0052 0.0163
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0816 0.0816
Echinococcus multilocularis BC026374 protein (S09 family) 0.0275 0.1359 0.1359
Echinococcus multilocularis ferritin 0.0041 0.016 0.016
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0015 0.0025 0.0025
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0141 0.0931
Onchocerca volvulus 0.0029 0.0098 0.0578
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0074 0.1147
Loa Loa (eye worm) hypothetical protein 0.0061 0.0264 0.0316
Schistosoma mansoni hypothetical protein 0.0013 0.0017 0.0017
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0002 0.00000000038417
Loa Loa (eye worm) hypothetical protein 0.0132 0.0627 0.0754
Toxoplasma gondii peptidylprolyl isomerase 0.006 0.0255 0.4055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0098 0.0098
Trichomonas vaginalis D-aminoacylase, putative 0.0132 0.0627 0.4162
Mycobacterium ulcerans hypothetical protein 0.0132 0.0627 0.3705
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0052 0.0163
Brugia malayi Fli-1 protein 0.0218 0.1067 0.1285
Schistosoma mansoni DNA polymerase eta 0.002 0.0052 0.0052
Brugia malayi Carboxylesterase family protein 0.1627 0.8295 1
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0063 0.0974
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0051 0.0212 0.0254
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0021 0.0062
Schistosoma mansoni hypothetical protein 0.0029 0.0099 0.0099
Trichomonas vaginalis penicillin-binding protein, putative 0.0132 0.0627 0.4162
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0141 0.2234
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.0059
Schistosoma mansoni ferritin light chain 0.0041 0.016 0.016
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0052 0.0163
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0074 0.0183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0165 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0163
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0015 0.0025 0.0025
Mycobacterium ulcerans hypothetical protein 0.0323 0.1605 1
Echinococcus granulosus smad 0.0015 0.0025 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0163
Trichomonas vaginalis ferritin, putative 0.0041 0.016 0.1054
Brugia malayi hypothetical protein 0.0275 0.1359 0.1637
Leishmania major DNA polymerase kappa, putative 0.002 0.0052 0.0112
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.029 0.1437 0.4616
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0002 0.0001
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0074 0.014
Echinococcus granulosus bloom syndrome protein 0.0025 0.0077 0.0077
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0021 0.0128
Schistosoma mansoni alpha-glucosidase 0.0146 0.0696 0.0696
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0002 0.0002
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0425 0.2127 0.2127
Entamoeba histolytica hypothetical protein 0.0029 0.0099 0.0645
Mycobacterium tuberculosis Probable lipase LipE 0.0132 0.0627 0.136
Loa Loa (eye worm) RNA binding protein 0.0051 0.0212 0.0254
Loa Loa (eye worm) acetylcholinesterase 1 0.1627 0.8295 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0627 0.0754
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0017 0.002
Loa Loa (eye worm) hypothetical protein 0.0275 0.1359 0.1637
Echinococcus multilocularis microtubule associated protein 2 0.1959 1 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0041 0.016 0.0256
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0212 0.0212
Brugia malayi MH2 domain containing protein 0.0219 0.107 0.1289
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0052 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Trypanosoma brucei unspecified product 0.002 0.0052 0.0163
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0017 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0017 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0613 0.3093 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0052 0.0334
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0141 0.0453
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0052 0.0052
Echinococcus multilocularis para nitrobenzyl esterase 0.0275 0.1359 0.1359
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0074 0.2517
Brugia malayi hypothetical protein 0.0061 0.0263 0.0315
Echinococcus granulosus tar DNA binding protein 0.0051 0.0212 0.0212
Mycobacterium ulcerans beta-lactamase 0.0132 0.0627 0.3705
Loa Loa (eye worm) hypothetical protein 0.0275 0.1359 0.1637
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0021 0.0062
Loa Loa (eye worm) hypothetical protein 0.0275 0.1359 0.1637
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0025 0.0029

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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