TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 493.598 | Formula: C27H35N5O4
H donors: 2 H acceptors: 4 LogP: 3.86 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCC(n1cc(C(=O)NCCc2nc3c([nH]2)ccc(c3)OC)c(=O)c(c1)C(=O)N1CCCCCC1)C
InChi: 1S/C27H35N5O4/c1-4-18(2)32-16-20(25(33)21(17-32)27(35)31-13-7-5-6-8-14-31)26(34)28-12-11-24-29-22-10-9-19(36-3)15-23(22)30-24/h9-10,15-18H,4-8,11-14H2,1-3H3,(H,28,34)(H,29,30)
InChiKey: RFLQMQACAMDCHI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0251	0.039
Plasmodium falciparum	adenosylhomocysteinase	0.0536	0.645	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0377	0.0584
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0091	0.0984	0.1526
Echinococcus granulosus	cpg binding protein	0.0031	0.0238	0.037
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0167	0.0259
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.11	0.1705
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0377	0.0584
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0032	0.0246	0.0382
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0722	0.1119
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0081	0.0126
Plasmodium vivax	adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative	0.0536	0.645	1
Brugia malayi	Melibiase family protein	0.0067	0.0685	0.1063
Schistosoma mansoni	hypothetical protein	0.0416	0.4974	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0251	0.039
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0015	0.0038	0.0058
Echinococcus multilocularis	neuropeptide s receptor	0.047	0.5642	0.5642
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0342	0.1046
Loa Loa (eye worm)	adenosylhomocysteinase	0.0536	0.645	1
Schistosoma mansoni	adenosylhomocysteinase	0.0331	0.3938	0.6105
Brugia malayi	Heterochromatin protein 1	0.007	0.0722	0.1119
Schistosoma mansoni	hypothetical protein	0.0032	0.0251	0.039
Onchocerca volvulus		0.0011	0.000000017992	0.000000054936
Brugia malayi	intermediate filament protein	0.0054	0.0522	0.081
Brugia malayi	hypothetical protein	0.0037	0.0309	0.0479
Toxoplasma gondii	hypothetical protein	0.0032	0.0246	0.0382
Schistosoma mansoni	hypothetical protein	0.0032	0.0251	0.039
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0377	0.0584
Entamoeba histolytica	hypothetical protein	0.0037	0.0309	0.0479
Onchocerca volvulus		0.0278	0.3275	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0522	0.081
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0594	0.0357
Echinococcus multilocularis	peptidase Clp (S14 family)	0.006	0.0596	0.0596
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0309	0.0479
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.0685	0.1063
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0707	0.1096
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0984	0.5
Brugia malayi	Probable ClpP-like protease	0.0091	0.0984	0.1526
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0377	0.0584
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0047	0.0437	0.0678
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0379	0.0588
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0377	0.021
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0379	0.0588
Schistosoma mansoni	adenosylhomocysteinase	0.0331	0.3938	0.6105
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0214	0.0332
Echinococcus granulosus	Chromobox protein 3	0.0011	0.000000017992	0.000000027895
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0522	0.081
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0081	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0342	0.0531
Toxoplasma gondii	adenosylhomocysteinase, putative	0.0536	0.645	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0269	0.3169	0.4597
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0101	0.1098	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0238	0.0369
Toxoplasma gondii	ABC1 family protein	0.0042	0.0377	0.0584
Schistosoma mansoni	hypothetical protein	0.0171	0.1957	0.3034
Leishmania major	S-adenosylhomocysteine hydrolase	0.0536	0.645	1
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0536	0.645	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0081	0.0126
Schistosoma mansoni	hypothetical protein	0.0069	0.0707	0.1096
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0984	0.5
Onchocerca volvulus		0.0054	0.0522	0.1595
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0594	0.092
Entamoeba histolytica	adenosylhomocysteinase, putative	0.0536	0.645	1
Brugia malayi	Pre-SET motif family protein	0.0036	0.0296	0.0459
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0377	0.021
Echinococcus multilocularis	chromobox protein 1	0.007	0.0722	0.0722
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0296	0.0296
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0296	0.0459
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0342	0.0531
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0984	0.1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0101	0.1098	0.1703
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0251	0.039
Entamoeba histolytica	hypothetical protein	0.0037	0.0309	0.0479
Plasmodium vivax	SET domain protein, putative	0.0036	0.0296	0.0459
Mycobacterium tuberculosis	Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase)	0.0536	0.645	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0296	0.0459
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0309	0.0309
Echinococcus multilocularis	lamin	0.0054	0.0522	0.0522
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0296	0.0459
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0244	0.2861	0.4436
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0594	0.092
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0722	0.1119
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0081	0.0126
Schistosoma mansoni	adenosylhomocysteinase	0.0331	0.3938	0.6105
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0251	0.0251
Brugia malayi	SET domain containing protein	0.0013	0.0024	0.0037
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.0273	0.0423
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.006	0.0596	0.0361
Onchocerca volvulus		0.0042	0.0377	0.1151
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0377	0.0377
Brugia malayi	beta-lactamase family protein	0.0042	0.0377	0.0584
Echinococcus granulosus	chromobox protein 1	0.007	0.0722	0.1119
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0984	0.5
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0091	0.0984	0.1526
Schistosoma mansoni	cpg binding protein	0.0029	0.0218	0.0338
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0013	0.002	0.0032
Echinococcus multilocularis	lamin dm0	0.0054	0.0522	0.0522
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0377	0.0584
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0296	0.0459
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0522	0.081
Schistosoma mansoni	hypothetical protein	0.0032	0.0251	0.039
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0179	0.0179
Schistosoma mansoni	hypothetical protein	0.0171	0.1957	0.3034
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0377	0.0584
Brugia malayi	chromobox protein homolog 3	0.0039	0.0342	0.0531
Trichomonas vaginalis	set domain proteins, putative	0.0278	0.3275	0.5078
Schistosoma mansoni	lamin	0.0054	0.0522	0.081
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0015	0.0044	0.0068
Echinococcus granulosus	lamin dm0	0.0054	0.0522	0.081
Echinococcus granulosus	neuropeptide s receptor	0.047	0.5642	0.8748
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0251	0.039
Mycobacterium ulcerans	S-adenosyl-L-homocysteine hydrolase	0.0536	0.645	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0377	0.0584
Echinococcus granulosus	lamin	0.0054	0.0522	0.081
Onchocerca volvulus		0.0031	0.0238	0.0727
Echinococcus granulosus	geminin	0.0171	0.1957	0.3034
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0536	0.645	1
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0013	0.002	0.002
Onchocerca volvulus		0.0042	0.0377	0.1151
Schistosoma mansoni	lamin	0.0054	0.0522	0.081
Loa Loa (eye worm)	CHromoDomain protein family member	0.0013	0.002	0.0032
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0251	0.039
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0522	0.081
Loa Loa (eye worm)	hypothetical protein	0.0101	0.11	0.1705
Onchocerca volvulus		0.0054	0.0522	0.1595
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0377	0.0584
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0214	0.0332
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0984	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0081	0.0126
Echinococcus granulosus	adenosylhomocysteinase	0.0536	0.645	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0309	0.0479
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0379	0.1158
Onchocerca volvulus		0.0029	0.0218	0.0665
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.11	0.1705
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0594	0.092
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0091	0.0984	0.0984
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0536	0.645	1
Echinococcus granulosus	neuropeptide receptor A26	0.047	0.5642	0.8748
Entamoeba histolytica	hypothetical protein	0.0037	0.0309	0.0479
Trypanosoma brucei	S-adenosylhomocysteine hydrolase, putative	0.0536	0.645	1
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0201	0.0312
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.000000017992	0.000000017992
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0707	0.1096
Echinococcus granulosus	peptidase Clp S14 family	0.006	0.0596	0.0925
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0218	0.0338
Brugia malayi	beta-lactamase family protein	0.0042	0.0377	0.0584
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0251	0.0251
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0377	0.0584
Schistosoma mansoni	peptidase Clp (S14 family)	0.0091	0.0984	0.1526
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0101	0.1098	0.1703
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0377	0.0584
Schistosoma mansoni	hypothetical protein	0.0032	0.0251	0.039
Schistosoma mansoni	adenosylhomocysteinase	0.0536	0.645	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.006	0.0596	0.0564
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0081	0.0126
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0101	0.1098	0.1098
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0014	0.0034	0.0053
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0377	0.0584
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0218	0.0338
Echinococcus granulosus	intermediate filament protein	0.0054	0.0522	0.081
Toxoplasma gondii	melibiase subfamily protein	0.0101	0.1098	0.1703
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0179	0.0278
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0309	0.0479
Echinococcus multilocularis	dnaJ subfamily B	0.0416	0.4974	0.4974
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0013	0.002	0.0032
Echinococcus granulosus	dnaJ subfamily B	0.0416	0.4974	0.7712
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0201	0.0312
Echinococcus multilocularis	chromobox protein 1	0.007	0.0722	0.0722
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0091	0.0984	0.1189
Echinococcus multilocularis	geminin	0.0171	0.1957	0.1957
Mycobacterium leprae	putative S-adenosyl-L-homocysteine hydrolase SahH	0.0536	0.645	1
Schistosoma mansoni	chromobox protein	0.007	0.0722	0.1119
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0032	0.0246	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0522	0.081
Loa Loa (eye worm)	hypothetical protein	0.0053	0.051	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0685	0.1063
Echinococcus multilocularis	neuropeptide receptor A26	0.047	0.5642	0.5642
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0342	0.0531
Brugia malayi	beta-lactamase	0.0042	0.0377	0.0584
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0536	0.645	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0238	0.037
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0594	0.0594
Brugia malayi	CHD4 protein	0.0013	0.002	0.0032
Toxoplasma gondii	S-Adenosyl homocysteine hydrolase	0.0536	0.645	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.11	0.1705
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0167	0.0259
Brugia malayi	Adenosylhomocysteinase	0.0536	0.645	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0101	0.1098	0.1703
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0044	0.0068
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0091	0.0984	0.1526
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0067	0.0685	0.1063
Echinococcus granulosus	chromobox protein 1	0.007	0.0722	0.1119
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.006	0.0596	0.0361
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0984	0.1
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0101	0.1098	0.1703
Toxoplasma gondii	Alpha-galactosidase	0.0014	0.0034	0.0053
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0594	0.092
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0251	0.039
Echinococcus granulosus	GPCR family 2	0.0032	0.0251	0.039
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0377	0.0584
Schistosoma mansoni	adenosylhomocysteinase	0.0331	0.3938	0.6105
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0377	0.0584
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0377	0.0584
Trichomonas vaginalis	esterase, putative	0.0042	0.0377	0.0584
Echinococcus multilocularis	adenosylhomocysteinase	0.0536	0.645	0.645
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0594	0.0357
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0101	0.1098	0.1703
Echinococcus multilocularis	cpg binding protein	0.0031	0.0238	0.0238
Schistosoma mansoni	hypothetical protein	0.0037	0.0309	0.0479
Echinococcus multilocularis	musashi	0.0054	0.0522	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0296	0.0459
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0636	0.0987
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0091	0.0984	0.1526
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0555	0.0861
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0179	0.0278
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0296	0.0459
Onchocerca volvulus		0.0047	0.0437	0.1335
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0081	0.0126
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0594	0.0357
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0722	0.1119
Onchocerca volvulus		0.0042	0.0377	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0377	0.0584
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.0685	0.1063
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0594	0.0357
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0377	0.0584
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0984	0.1526
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0984	0.1526
Schistosoma mansoni	cpg binding protein	0.0031	0.0238	0.037
Schistosoma mansoni	chromobox protein	0.007	0.0722	0.1119
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0168	0.1928	0.2989
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0377	0.0584
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0377	0.0584
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0081	0.0126
Brugia malayi	Pre-SET motif family protein	0.0244	0.2861	0.4436
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0594	0.0357

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 812482