TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 374.517 | Formula: C22H34N2O3
H donors: 1 H acceptors: 1 LogP: 3.23 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1C)CN1CCC2(CC1)CCC(O2)CNC(=O)C(C)C
InChi: 1S/C22H34N2O3/c1-16(2)21(25)23-14-19-7-8-22(27-19)9-11-24(12-10-22)15-18-5-6-20(26-4)17(3)13-18/h5-6,13,16,19H,7-12,14-15H2,1-4H3,(H,23,25)
InChiKey: JOZXDSXESSIGIN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	EGF family domain-containing protein	0.0106	0.1938	0.5
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Schistosoma mansoni	notch	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	Calcium binding EGF domain containing protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Echinococcus multilocularis	neurogenic locus notch protein	0.0106	0.1938	0.1938
Echinococcus multilocularis	slit 2 protein	0.0106	0.1938	0.1938
Echinococcus multilocularis	neurogenic locus notch protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	EGF-like domain containing protein	0.0106	0.1938	0.1938
Echinococcus granulosus	delta-like protein 1	0.0106	0.1938	0.1938
Schistosoma mansoni	slit	0.0106	0.1938	0.1938
Echinococcus multilocularis	notch	0.0106	0.1938	0.1938
Echinococcus granulosus	protein jagged 1	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	Calcium binding EGF domain containing protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Schistosoma mansoni	notch	0.0106	0.1938	0.1938
Schistosoma mansoni	laminin gamma-3 chain	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Onchocerca volvulus	Peroxidasin homolog	0.033	1	1
Echinococcus granulosus	neurogenic locus protein delta	0.0106	0.1938	0.1938
Loa Loa (eye worm)	animal heme peroxidase	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Brugia malayi	EGF-like domain containing protein	0.0106	0.1938	0.1938
Echinococcus multilocularis	neural cadherin	0.0106	0.1938	0.1938
Echinococcus granulosus	neural cadherin	0.0106	0.1938	0.1938
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0266	0.7697	0.5
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	Cadherin domain containing protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	Animal haem peroxidase family protein	0.033	1	1
Schistosoma mansoni	cell polarity protein	0.0106	0.1938	0.1938
Schistosoma mansoni	hypothetical protein	0.0106	0.1938	0.1938
Schistosoma mansoni	septate junction protein	0.0106	0.1938	0.1938
Schistosoma mansoni	hypothetical protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Onchocerca volvulus	Peroxidase homolog	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	Peroxidasin	0.033	1	1
Brugia malayi	Cadherin domain containing protein	0.0106	0.1938	0.1938
Onchocerca volvulus		0.033	1	1
Schistosoma mansoni	peroxidasin	0.033	1	1
Echinococcus granulosus	neurogenic locus notch protein 4	0.0106	0.1938	0.1938
Brugia malayi	Animal haem peroxidase family protein	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Schistosoma mansoni	notch	0.0106	0.1938	0.1938
Brugia malayi	EGF-like domain containing protein	0.0106	0.1938	0.1938
Echinococcus multilocularis	protein jagged 1	0.0106	0.1938	0.1938
Onchocerca volvulus	Peroxidasin homolog	0.033	1	1
Schistosoma mansoni	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	Calcium binding EGF domain containing protein	0.0106	0.1938	0.1938
Echinococcus granulosus	neurogenic locus notch protein	0.0106	0.1938	0.1938
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0106	0.1938	0.1938
Brugia malayi	Delta serrate ligand family protein	0.0106	0.1938	0.1938
Schistosoma mansoni	notch	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	GCC2 and GCC3 family protein	0.0106	0.1938	0.1938
Schistosoma mansoni	hypothetical protein	0.0106	0.1938	0.1938
Schistosoma mansoni	hypothetical protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0106	0.1938	0.1938
Brugia malayi	Animal haem peroxidase family protein	0.033	1	1
Schistosoma mansoni	hypothetical protein	0.0106	0.1938	0.1938
Echinococcus multilocularis	peroxidasin	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Onchocerca volvulus		0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Brugia malayi	EGF-like domain containing protein	0.0106	0.1938	0.1938
Onchocerca volvulus	Peroxidase homolog	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0106	0.1938	0.1938
Schistosoma mansoni	peroxidasin	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	notch-like transmembrane receptor	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Echinococcus granulosus	protein jagged 1	0.0106	0.1938	0.1938
Echinococcus multilocularis	protein jagged 1	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Echinococcus granulosus	notch	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	EGF-like domain containing protein	0.0106	0.1938	0.1938
Onchocerca volvulus	Chorion peroxidase homolog	0.033	1	1
Giardia lamblia	High cysteine protein	0.0106	0.1938	0.5
Echinococcus granulosus	slit 2 protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	animal heme peroxidase	0.033	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.033	1	1
Echinococcus multilocularis	fibropellin Ia	0.0106	0.1938	0.1938
Schistosoma mansoni	hypothetical protein	0.0106	0.1938	0.1938
Echinococcus granulosus	fibropellin Ia	0.0106	0.1938	0.1938
Loa Loa (eye worm)	notch protein	0.0106	0.1938	0.1938
Brugia malayi	Animal haem peroxidase family protein	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Echinococcus multilocularis	protein jagged 2	0.0106	0.1938	0.1938
Brugia malayi	EGF-like domain containing protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	blistered cuticle protein 3	0.033	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.033	1	1
Brugia malayi	Muscle positioning protein 4	0.0106	0.1938	0.1938
Brugia malayi	EGF-like domain containing protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Onchocerca volvulus		0.033	1	1
Brugia malayi	Blistered cuticle protein 3	0.033	1	1
Echinococcus granulosus	peroxidasin	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Brugia malayi	Animal haem peroxidase family protein	0.033	1	1
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0106	0.1938	0.1938
Onchocerca volvulus	Dual oxidase homolog	0.033	1	1
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Schistosoma mansoni	notch	0.0106	0.1938	0.1938
Echinococcus multilocularis	neurogenic locus protein delta	0.0106	0.1938	0.1938
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0106	0.1938	0.1938
Echinococcus granulosus	protein jagged 2	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	Notch2	0.0106	0.1938	0.1938
Echinococcus granulosus	neurogenic locus notch protein	0.0106	0.1938	0.1938
Schistosoma mansoni	notch	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1938	0.1938
Loa Loa (eye worm)	hypothetical protein	0.033	1	1
Echinococcus granulosus	protein jagged 2	0.0106	0.1938	0.1938

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 812613