Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0493 | 0.3561 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0113 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0775 | 0.5944 | 0.5944 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0349 | 0.0349 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0113 | 0.0349 | 0.2519 |
Leishmania major | malonyl-coa decarboxylase-like protein | 0.0493 | 0.3561 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0822 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0113 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0113 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0349 | 0.0349 |
Brugia malayi | nuclear receptor NHR-88 | 0.0113 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0113 | 0.0349 | 0.0349 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0113 | 0.0349 | 0.0349 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0113 | 0.0349 | 0.425 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0113 | 0.0349 | 0.0349 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0113 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1387 | 0.1387 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0113 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0113 | 0.0349 | 0.0349 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0113 | 0.0349 | 0.2519 |
Echinococcus granulosus | geminin | 0.0169 | 0.0822 | 0.5927 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0349 | 0.0349 |
Schistosoma mansoni | thyroid hormone receptor | 0.0113 | 0.0349 | 0.425 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0113 | 0.0349 | 0.0349 |
Wolbachia endosymbiont of Brugia malayi | malonyl-CoA decarboxylase | 0.1255 | 1 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0113 | 0.0349 | 0.2519 |
Trypanosoma cruzi | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0493 | 0.3561 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0349 | 0.0349 |
Brugia malayi | steroid hormone receptor | 0.0113 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0349 | 0.0349 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0113 | 0.0349 | 0.2519 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0113 | 0.0349 | 0.2519 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0113 | 0.0349 | 0.0349 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0113 | 0.0349 | 0.425 |
Schistosoma mansoni | thyroid hormone receptor | 0.0113 | 0.0349 | 0.425 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0775 | 0.5944 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0113 | 0.0349 | 0.2519 |
Brugia malayi | nuclear hormone receptor | 0.0113 | 0.0349 | 0.0349 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0113 | 0.0349 | 0.425 |
Trypanosoma cruzi | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0493 | 0.3561 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0113 | 0.0349 | 0.425 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0113 | 0.0349 | 0.2519 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0113 | 0.0349 | 0.425 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0113 | 0.0349 | 0.0349 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0113 | 0.0349 | 0.425 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0113 | 0.0349 | 0.2519 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0113 | 0.0349 | 0.425 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0236 | 0.1387 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0113 | 0.0349 | 0.425 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0113 | 0.0349 | 0.2519 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0113 | 0.0349 | 0.2519 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0113 | 0.0349 | 0.0349 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0113 | 0.0349 | 0.0349 |
Echinococcus granulosus | FTZ F1 alpha | 0.0113 | 0.0349 | 0.2519 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0113 | 0.0349 | 0.2519 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0113 | 0.0349 | 0.0349 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0236 | 0.1387 | 1 |
Echinococcus multilocularis | geminin | 0.0169 | 0.0822 | 0.5927 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0113 | 0.0349 | 0.0349 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0113 | 0.0349 | 0.2519 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0113 | 0.0349 | 0.425 |
Brugia malayi | ecdysteroid receptor | 0.0775 | 0.5944 | 0.5944 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0113 | 0.0349 | 0.0349 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0113 | 0.0349 | 0.0349 |
Schistosoma mansoni | nuclear hormone receptor | 0.0113 | 0.0349 | 0.425 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0113 | 0.0349 | 0.2519 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0113 | 0.0349 | 0.0349 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0113 | 0.0349 | 0.0349 |
Brugia malayi | hypothetical protein | 0.0236 | 0.1387 | 0.1387 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0113 | 0.0349 | 0.2519 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0113 | 0.0349 | 0.0349 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0113 | 0.0349 | 0.2519 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0113 | 0.0349 | 0.0349 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0113 | 0.0349 | 0.0349 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0113 | 0.0349 | 0.425 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0113 | 0.0349 | 0.0349 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0113 | 0.0349 | 0.2519 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0822 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0113 | 0.0349 | 0.2519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.