Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1293 | 1 | 1 |
Leishmania major | malonyl-coa decarboxylase-like protein | 0.0508 | 0 | 0.5 |
Trypanosoma cruzi | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0508 | 0 | 0.5 |
Trypanosoma brucei | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0508 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0918 | 0.5224 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | malonyl-CoA decarboxylase | 0.1293 | 1 | 0.5 |
Trypanosoma cruzi | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0508 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.