Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0084 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0186 | 0.4285 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.2819 | 0.3329 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0039 | 0.0602 | 0.0409 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.024 | 0.5 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0048 | 0.0818 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0039 | 0.0602 | 0.1404 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.002 | 0.0137 | 0.0321 |
Loa Loa (eye worm) | glutamate receptor | 0.0031 | 0.0413 | 0.0782 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0048 | 0.0818 | 0.0623 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.024 | 0.0561 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.0818 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0329 | 0.7883 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.024 | 0.0372 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0098 | 0.2095 | 0.2401 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0027 | 0.0291 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.024 | 0.213 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.002 | 0.0137 | 0.0127 |
Loa Loa (eye worm) | glutamate receptor | 0.008 | 0.1631 | 0.3683 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.2819 | 0.6578 |
Onchocerca volvulus | 0.0046 | 0.077 | 0.1129 | |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0067 | 0.1305 | 0.1363 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0499 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.024 | 0.0034 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.024 | 0.0034 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0048 | 0.0818 | 0.0723 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.024 | 0.213 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.024 | 0.213 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.008 | 0.1631 | 0.3807 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.2819 | 0.6578 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.024 | 0.2391 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.024 | 0.0034 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0499 | 0.1163 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.2819 | 0.3351 |
Schistosoma mansoni | hypothetical protein | 0.0329 | 0.7883 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.024 | 0.213 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.024 | 0.213 |
Echinococcus granulosus | tumor protein p63 | 0.0312 | 0.7462 | 0.9447 |
Trichomonas vaginalis | set domain proteins, putative | 0.0211 | 0.4929 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.077 | 0.1632 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.024 | 0.0561 |
Onchocerca volvulus | 0.0027 | 0.0291 | 0.0109 | |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0048 | 0.0818 | 0.0623 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2819 | 0.3329 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0084 | 0.0332 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0072 | 0.1442 | 0.3366 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0067 | 0.1305 | 0.1336 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0207 | 1 |
Onchocerca volvulus | 0.0211 | 0.4929 | 1 | |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0027 | 0.0291 | 0.0032 |
Plasmodium vivax | SET domain protein, putative | 0.0027 | 0.0291 | 1 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0048 | 0.0818 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0027 | 0.0291 | 0.068 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0499 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0186 | 0.4285 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.0818 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2819 | 0.3329 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0067 | 0.1305 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2095 | 0.4787 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.2819 | 0.651 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0499 | 0.0273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2819 | 0.3329 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.024 | 0.213 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0499 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.024 | 0.2391 |
Brugia malayi | RNA binding protein | 0.0127 | 0.2819 | 0.6578 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2819 | 0.3329 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0291 | 0.0493 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0137 | 0.0127 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0091 | 0.1907 | 0.2128 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0499 | 0.0273 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0413 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.024 | 0.213 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0023 | 0.0207 | 0.5945 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0098 | 0.2095 | 0.2376 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.2819 | 0.651 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0046 | 0.077 | 0.063 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0048 | 0.0818 | 1 |
Echinococcus multilocularis | geminin | 0.0329 | 0.7883 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.024 | 0.213 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.024 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0207 | 0.0293 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.024 | 0.0561 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0413 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0499 | 0.0273 |
Echinococcus granulosus | geminin | 0.0329 | 0.7883 | 1 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.002 | 0.0137 | 0.0127 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0413 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0499 | 1 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0048 | 0.0818 | 1 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0048 | 0.0818 | 0.0623 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2819 | 0.3329 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0207 | 0.0484 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.2819 | 0.651 |
Echinococcus multilocularis | tumor protein p63 | 0.0312 | 0.7462 | 0.9445 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0207 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0048 | 0.0818 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.024 | 0.0372 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0048 | 0.0818 | 0.0693 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0499 | 0.0304 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.024 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.