Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Saccharomyces cerevisiae | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.013 | 0.0837 | 0.5 | |
Schistosoma mansoni | adenosylhomocysteinase | 0.0129 | 0.0826 | 0.0826 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5722 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0129 | 0.0826 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.0837 | 0.0013 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.0837 | 0.0837 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0129 | 0.0826 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0676 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0129 | 0.0826 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0676 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.0837 | 0.0013 |
Brugia malayi | thymidylate synthase | 0.013 | 0.0837 | 0.0013 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5722 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0421 | 0.5722 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0676 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0676 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5722 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0676 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.0837 | 0.0013 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5722 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5722 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.0837 | 0.0013 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0676 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0676 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0676 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.0837 | 0.0013 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.0837 | 0.0013 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0676 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.328 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 6.598 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 7.3098 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.049 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.049 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.049 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.049 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.16 uM | Inhibitory activity against rat liver dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.16 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.16 uM | Inhibitory activity against rat liver dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.16 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.47 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.47 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.47 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.47 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 6.3279 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 6.5979 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 7.3098 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
Selectivity (binding) | = 0.34 | Ratio of inhibitory concentration of rat liver and Pneumocystis carinii DHFR. | ChEMBL. | 8627607 |
Selectivity (binding) | = 3.3 | Ratio of inhibitory concentration of rat liver and Toxoplasma gondii DHFR | ChEMBL. | 8627607 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.