Detailed information for compound 81428

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 530.611 | Formula: C31H34N2O6
  • H donors: 3 H acceptors: 4 LogP: 3.11 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@@H]1CC[C@@]2(C34C1Oc1c4c(CC2N(CC3)CC2CC2)ccc1O)O)/C=C/C(=O)OCc1ccccc1
  • InChi: 1S/C31H34N2O6/c34-23-9-8-21-16-24-31(37)13-12-22(32-25(35)10-11-26(36)38-18-20-4-2-1-3-5-20)29-30(31,27(21)28(23)39-29)14-15-33(24)17-19-6-7-19/h1-5,8-11,19,22,24,29,34,37H,6-7,12-18H2,(H,32,35)/b11-10+/t22-,24?,29?,30?,31-/m1/s1
  • InChiKey: WFRPWLIRGBQZAG-VCCJEXIOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Opioid receptor   372 aa 320 aa 25.6 %
Onchocerca volvulus Opioid receptor   372 aa 386 aa 22.8 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Opioid receptor   372 aa 315 aa 28.6 %
Onchocerca volvulus Opioid receptor   372 aa 353 aa 21.0 %
Echinococcus multilocularis allatostatin A receptor Opioid receptor   372 aa 302 aa 28.5 %
Echinococcus granulosus thyrotropin releasing hormone receptor Opioid receptor   372 aa 330 aa 24.5 %
Brugia malayi ORL1-like opioid receptor Opioid receptor   372 aa 300 aa 24.7 %
Onchocerca volvulus Opioid receptor   372 aa 316 aa 26.9 %
Brugia malayi GnHR receptor homolog Opioid receptor   372 aa 313 aa 18.5 %
Onchocerca volvulus Opioid receptor   372 aa 349 aa 22.1 %
Echinococcus granulosus allatostatin A receptor Opioid receptor   372 aa 302 aa 27.8 %
Loa Loa (eye worm) neuropeptide F receptor Opioid receptor   372 aa 317 aa 23.3 %
Schistosoma mansoni peptide (allatostatin)-like receptor Opioid receptor   372 aa 353 aa 29.2 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Opioid receptor   372 aa 366 aa 22.7 %
Onchocerca volvulus Opioid receptor   372 aa 344 aa 22.1 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Opioid receptor   372 aa 331 aa 21.4 %
Echinococcus granulosus tm gpcr rhodopsin Opioid receptor   372 aa 334 aa 22.5 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Opioid receptor   372 aa 330 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus heat shock protein 0.0045 0.0179 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0062 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Brugia malayi Nuclear hormone receptor E75 0.002 0.002 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0097 0.0178
Schistosoma mansoni synaptotagmin 0.0026 0.0061 0.0083
Loa Loa (eye worm) hypothetical protein 0.0042 0.0159 0.0292
Brugia malayi conserved hypotetical protein 0.002 0.002 0.0033
Schistosoma mansoni protein kinase C 0.0166 0.0944 0.1294
Schistosoma mansoni atypical protein kinase C 0.0338 0.2032 0.2785
Brugia malayi Endoplasmin precursor 0.0045 0.0179 0.0315
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0084 0.069
Leishmania major calcium channel protein, putative,ion transporter, putative 0.016 0.0908 0.7019
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0048 0.0065
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0032 0.0098 0.0135
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0085 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Onchocerca volvulus 0.0026 0.0061 0.0306
Schistosoma mansoni voltage-gated potassium channel 0.0182 0.1047 0.1435
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0159 0.028
Brugia malayi Pleckstrin Homology Domain 0.014 0.078 0.1379
Mycobacterium ulcerans proteasome PrcA 0.0804 0.4967 1
Echinococcus granulosus otoferlin 0.0026 0.0061 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0176 0.0241
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0002 0.0002
Schistosoma mansoni nuclear receptor 0.002 0.002 0.0028
Echinococcus granulosus GPCR family 2 0.0031 0.0093 0.0128
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0137 0.0187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0666 0.1095
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0028 0.0073 0.0115
Loa Loa (eye worm) hypothetical protein 0.0083 0.0423 0.0776
Trypanosoma brucei protein kinase, putative 0.0055 0.0242 0.1499
Echinococcus granulosus smad 0.0032 0.0097 0.0133
Echinococcus granulosus extended synaptotagmin 2 0.0026 0.0061 0.0083
Onchocerca volvulus 0.014 0.078 0.4275
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0179 0.1089
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Echinococcus granulosus synaptotagmin 0.0026 0.0061 0.0083
Schistosoma mansoni synaptotagmin 12 0.0026 0.0061 0.0083
Loa Loa (eye worm) variant SH3 domain-containing protein 0.014 0.078 0.1431
Schistosoma mansoni zinc finger protein 0.002 0.002 0.0028
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0159 0.0292
Entamoeba histolytica C2 domain containing protein 0.0026 0.0061 0.0484
Echinococcus multilocularis serine:threonine protein kinase 38 0.0198 0.1149 0.1149
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0137 0.1151
Brugia malayi phospholipase C homolog 0.0026 0.0061 0.0105
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0078 0.0385 0.0385
Echinococcus multilocularis synaptotagmin 0.0026 0.0061 0.0061
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.002 0.0028
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Brugia malayi Blistered cuticle protein 3 0.0026 0.0057 0.0099
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0159 0.0218
Echinococcus granulosus dnaJ subfamily B 0.0401 0.2427 0.3326
Loa Loa (eye worm) hypothetical protein 0.014 0.078 0.1431
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0137 0.0974
Schistosoma mansoni peroxidasin 0.0026 0.0057 0.0078
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Schistosoma mansoni hypothetical protein 0.0033 0.0107 0.0147
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.014 0.078 0.1068
Onchocerca volvulus 0.0028 0.0074 0.0379
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0423 0.0579
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Onchocerca volvulus 0.0042 0.0159 0.0851
Leishmania major C-8 sterol isomerase-like protein 0.0217 0.1268 1
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.002 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0366 0.2806
Echinococcus multilocularis copine 9 0.0026 0.0061 0.0061
Trypanosoma brucei C-8 sterol isomerase, putative 0.0217 0.1268 1
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0179 0.0981
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0423 0.0579
Echinococcus multilocularis peroxidasin 0.0026 0.0057 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0137 0.0631
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0032 0.0098 0.0098
Echinococcus multilocularis serine:threonine protein kinase N2 0.0198 0.1149 0.1149
Schistosoma mansoni fer-1-related 0.0026 0.0061 0.0083
Brugia malayi diacylglycerol kinase 0.014 0.078 0.1379
Brugia malayi heat shock protein 90 0.0045 0.0179 0.0315
Loa Loa (eye worm) RhoGAP domain-containing protein 0.014 0.078 0.1431
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.002 0.0084
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0083 0.0423 0.0423
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0026 0.0061 0.0366
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0137 0.0187
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0159 0.0851
Onchocerca volvulus 0.0026 0.0057 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0085 0.0117
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0242 0.1499
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0242 0.0443
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Brugia malayi Protein kinase domain containing protein 0.0198 0.1149 0.2033
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0026 0.0061 0.0083
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0107 0.0147
Schistosoma mansoni hypothetical protein 0.1173 0.7297 1
Brugia malayi MH2 domain containing protein 0.0032 0.0097 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Schistosoma mansoni heat shock protein 0.003 0.0084 0.0115
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0179 0.1177
Brugia malayi hypothetical protein 0.015 0.084 0.1487
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0162 0.0052
Loa Loa (eye worm) hypothetical protein 0.009 0.0464 0.0852
Brugia malayi Protein kinase domain containing protein 0.0198 0.1149 0.2033
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0194 0.1123 0.2061
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0084 0.0436
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1149 0.1574
Loa Loa (eye worm) endoplasmin 0.0045 0.0179 0.0328
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0095 0.0496 0.068
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0137 0.0137
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Schistosoma mansoni diacylglycerol kinase theta 0.014 0.078 0.1068
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0135
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0026 0.0061 0.0000001381
Echinococcus granulosus protein kinase c eta type 0.014 0.078 0.1068
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0057 0.0105
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0032 0.0098 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0083 0.0421 0.3241
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0032 0.0098 0.0181
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0095 0.0496 1
Schistosoma mansoni hypothetical protein 0.0141 0.0786 0.1077
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0032 0.0098 0.0181
Brugia malayi RhoGAP domain containing protein 0.014 0.078 0.1379
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Schistosoma mansoni heat shock protein 0.0045 0.0179 0.0245
Echinococcus multilocularis serine threonine protein kinase 0.0965 0.5982 0.5982
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0137 0.024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0137 0.0251
Schistosoma mansoni hypothetical protein 0.0026 0.0061 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0061 0.0366
Brugia malayi Synapse defective protein 1 0.0026 0.0061 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0159 0.0901 0.1654
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0162 0.0771
Giardia lamblia Grp94/Hsp90 0.0042 0.0162 0.0694
Echinococcus granulosus sodium channel protein 0.016 0.0908 0.1244
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0026 0.0061 0.0061
Brugia malayi nuclear receptor RXR 0.002 0.002 0.0033
Brugia malayi protein kinase C3,putative 0.0145 0.0809 0.1432
Plasmodium falciparum telomerase reverse transcriptase 0.0083 0.0421 0.397
Onchocerca volvulus 0.0238 0.1395 0.7672
Schistosoma mansoni hypothetical protein 0.0031 0.0093 0.0128
Echinococcus multilocularis Niemann Pick C1 protein 0.0194 0.1123 0.1123
Echinococcus granulosus synaptotagmin 0.0026 0.0061 0.0083
Trypanosoma brucei heat shock protein, putative 0.0045 0.0179 0.0981
Echinococcus granulosus Rac GTPase activating protein 1 0.014 0.078 0.1068
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0032 0.0098 0.0172
Echinococcus multilocularis unc 13 (munc13) 0.0166 0.0944 0.0944
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Entamoeba histolytica protein kinase, putative 0.0198 0.1149 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0176 0.0309
Schistosoma mansoni transcription factor LCR-F1 0.0141 0.0786 0.1077
Schistosoma mansoni cpg binding protein 0.003 0.0084 0.0115
Echinococcus multilocularis neuropeptide receptor A26 0.0914 0.5664 0.5664
Loa Loa (eye worm) hypothetical protein 0.0267 0.1583 0.2905
Entamoeba histolytica hypothetical protein 0.0141 0.0786 0.6826
Brugia malayi Synaptotagmin protein 3 0.0026 0.0061 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.1105 0.6866 0.941
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0217 0.1268 0.2245
Loa Loa (eye worm) GABA receptor subunit 0.0017 0.0005 0.0009
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0159 0.0218
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0166 0.0944 0.1294
Echinococcus granulosus neuropeptide s receptor 0.0914 0.5664 0.7763
Brugia malayi nuclear hormone receptor 0.0042 0.0159 0.028
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0057 0.0105
Schistosoma mansoni copine 0.0026 0.0061 0.0083
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0026 0.0061 0.0083
Brugia malayi Pre-SET motif family protein 0.0206 0.1193 0.2112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0085 0.0117
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0166 0.0944 0.0944
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0179 0.1089
Schistosoma mansoni hypothetical protein 0.1173 0.7297 1
Brugia malayi RhoGAP domain containing protein 0.014 0.078 0.1379
Echinococcus granulosus heat shock protein 90 0.0038 0.0138 0.0189
Echinococcus multilocularis myotubularin protein 13 0.014 0.078 0.078
Echinococcus multilocularis calpain 5 0.0026 0.0061 0.0061
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0385 0.2959
Echinococcus multilocularis Diacylglycerol kinase theta 0.014 0.078 0.078
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0061 0.0366
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0024 0.0048 0.0048
Brugia malayi excitatory GABA receptor EXP-1A 0.0032 0.0098 0.0172
Plasmodium vivax heat shock protein 90, putative 0.003 0.0084 0.026
Schistosoma mansoni hypothetical protein 0.008 0.0404 0.0553
Brugia malayi Pre-SET motif family protein 0.003 0.0085 0.0149
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0083 0.0423 0.0747
Loa Loa (eye worm) RNA binding protein 0.0186 0.1069 0.1961
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0061 0.0484
Echinococcus multilocularis synaptotagmin 0.0026 0.0061 0.0061
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0366 0.281
Echinococcus granulosus Immunoglobulin E set 0.0026 0.0061 0.0083
Echinococcus granulosus nAChR subunit 0.0032 0.0098 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0198 0.1149 0.1149
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0032 0.0098 0.0135
Toxoplasma gondii RNA-directed DNA polymerase 0.0083 0.0421 0.3311
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0186 0.1069 0.1465
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0217 0.1268 1
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Onchocerca volvulus 0.0026 0.0061 0.0306
Schistosoma mansoni vesicular amine transporter 0.0024 0.0048 0.0065
Brugia malayi ecdysteroid receptor 0.0042 0.0159 0.028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0137 0.0974
Loa Loa (eye worm) MH2 domain-containing protein 0.0467 0.2845 0.522
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0159 0.0218
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0035 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Echinococcus multilocularis microtubule associated protein 2 0.0683 0.4208 0.4208
Echinococcus granulosus endoplasmin 0.0042 0.0162 0.0221
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0159 0.0218
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0145 0.0809 0.1432
Schistosoma mansoni diacylglycerol kinase theta 0.014 0.078 0.1068
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0098 0.0172
Schistosoma mansoni Mername-AA248 (C02 family) 0.0026 0.0061 0.0083
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0137 0.024
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0145 0.0809 0.1109
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0032 0.0098 0.0135
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0026 0.0061 0.0083
Entamoeba histolytica C2 domain containing protein 0.0026 0.0061 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0002 0.0002
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0026 0.0061 0.0061
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0159 0.028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0198 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Brugia malayi hypothetical protein 0.002 0.002 0.0033
Onchocerca volvulus 0.0032 0.0098 0.0515
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0366 0.3369
Onchocerca volvulus Putative nachr subunit 0.0032 0.0098 0.0515
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0519 0.0917
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0026 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0047 0.0191 0.0262
Loa Loa (eye worm) TAR-binding protein 0.0186 0.1069 0.1961
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0032 0.0098 0.0135
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0032 0.0098 0.0135
Brugia malayi tailless protein 0.002 0.002 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0159 0.028
Brugia malayi Protein kinase c protein 2 0.0911 0.5643 1
Toxoplasma gondii diacylglycerol kinase, putative 0.014 0.078 0.6609
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0095 0.0496 0.0496
Echinococcus granulosus Niemann Pick C1 protein 0.0278 0.1649 0.226
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0097 0.0133
Echinococcus granulosus glycine receptor subunit alpha 1 0.0032 0.0098 0.0135
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0105 0.0558 0.1023
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0175 0.1 0.1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0097 0.0133
Entamoeba histolytica hypothetical protein 0.0026 0.0061 0.0484
Echinococcus multilocularis synaptotagmin 15 0.0026 0.0061 0.0061
Echinococcus multilocularis nAChR subunit 0.0017 0.0005 0.0005
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0095 0.0496 0.068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0159 0.0292
Toxoplasma gondii isocitrate dehydrogenase 0.0078 0.0385 0.2987
Schistosoma mansoni nuclear hormone receptor 0.002 0.002 0.0028
Trypanosoma brucei rac serine-threonine kinase, putative 0.0198 0.1149 0.9012
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0666 0.0912
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0172
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0159 0.0159
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0032 0.0098 0.0135
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0242 0.1381
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0078 0.0385 0.0528
Echinococcus multilocularis calcium activated potassium channel 0.0021 0.003 0.003
Brugia malayi isocitrate dehydrogenase 0.0078 0.0385 0.0681
Onchocerca volvulus Peroxidase homolog 0.0026 0.0057 0.0287
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0003
Trypanosoma brucei heat shock protein, putative 0.0045 0.0179 0.0981
Schistosoma mansoni hypothetical protein 0.008 0.0404 0.0553
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0198 0.1149 0.1574
Loa Loa (eye worm) hypothetical protein 0.014 0.078 0.1431
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0135
Schistosoma mansoni vav2 0.014 0.078 0.1068
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Loa Loa (eye worm) C2 domain-containing protein 0.0026 0.0061 0.0111
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0005 0.0006
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0026 0.0061 0.0366
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1149 0.1574
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0666 0.0912
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0026 0.0061 0.0083
Brugia malayi hypothetical protein 0.0229 0.1341 0.2375
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Echinococcus multilocularis protein kinase c iota type 0.0338 0.2032 0.2032
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0666 0.0666
Plasmodium vivax SET domain protein, putative 0.003 0.0085 0.0275
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0093 0.0128
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0026 0.0061 0.00000014994
Schistosoma mansoni patched 1 0.0083 0.0423 0.0579
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0138 0.0189
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0095 0.0496 0.068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0172
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0061 0.0484
Onchocerca volvulus Huntingtin homolog 0.0242 0.1423 0.7824
Echinococcus multilocularis active breakpoint cluster region 0.0026 0.0061 0.0061
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.002 0.002
Brugia malayi RNA binding protein 0.0186 0.1069 0.1892
Entamoeba histolytica C2 domain containing protein 0.0026 0.0061 0.0484
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0162 0.0052
Loa Loa (eye worm) hypothetical protein 0.0166 0.0944 0.1732
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0141 0.0786 0.0786
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0141 0.0786 0.1077
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0097 0.0133
Echinococcus granulosus serine:threonine protein kinase N2 0.0141 0.0786 0.1077
Echinococcus multilocularis protein kinase c epsilon type 0.0501 0.3056 0.3056
Brugia malayi MH1 domain containing protein 0.0018 0.0007 0.001
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0026 0.0061 0.0083
Schistosoma mansoni Smad4 0.0032 0.0097 0.0133
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0105 0.0558 0.0764
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0159 0.0218
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0164 0.093 0.093
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.002 0.0084
Onchocerca volvulus 0.0267 0.1583 0.871
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0138 0.004
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0242 0.1811
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0024 0.0048 0.0065
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Echinococcus granulosus Niemann Pick C1 protein 0.0194 0.1123 0.1539
Schistosoma mansoni synaptotagmin-like protein 0.0026 0.0061 0.0083
Loa Loa (eye worm) nuclear factor I 0.0018 0.0007 0.0013
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0026 0.0061 0.0083
Echinococcus multilocularis X box binding protein 1 0.0284 0.1686 0.1686
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0198 0.1149 0.2108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0137 0.0974
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0026 0.0061 0.0083
Entamoeba histolytica protein kinase, putative 0.0031 0.009 0.0745
Brugia malayi Hsp90 protein 0.003 0.0084 0.0146
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0098 0.0135
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0035 0.006
Echinococcus granulosus unc 13 munc13 0.0166 0.0944 0.1294
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0078 0.0385 0.2959
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0032 0.0098 0.0172
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0172
Schistosoma mansoni smad1 5 8 and 0.0032 0.0097 0.0133
Echinococcus granulosus tar DNA binding protein 0.0186 0.1069 0.1465
Loa Loa (eye worm) RasGEF domain-containing protein 0.014 0.078 0.1431
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0242 0.1664
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0385 0.2692
Entamoeba histolytica DENN domain protein 0.0026 0.0061 0.0484
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0366 0.2806
Echinococcus granulosus calpain 5 0.0026 0.0061 0.0083
Onchocerca volvulus 0.0026 0.0057 0.0287
Schistosoma mansoni hypothetical protein 0.008 0.0404 0.0553
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0035 0.0035
Leishmania major heat shock protein, putative 0.003 0.0084 0.0195
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0078 0.0385 0.3581
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Onchocerca volvulus 0.002 0.002 0.0084
Schistosoma mansoni hypothetical protein 0.0401 0.2427 0.3326
Echinococcus granulosus peroxidasin 0.0026 0.0057 0.0078
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0083 0.0421 0.3241
Brugia malayi nuclear receptor NHR-88 0.0042 0.0159 0.028
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0032 0.0098 0.0181
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Echinococcus multilocularis neuropeptide s receptor 0.0914 0.5664 0.5664
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0666 0.5563
Onchocerca volvulus 0.0105 0.0558 0.305
Toxoplasma gondii Hsp90 domain-containing protein 0.017 0.0968 0.8341
Schistosoma mansoni protein kinase C mu 0.014 0.078 0.1068
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0159 0.0292
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.074 0.4566 0.4566
Echinococcus multilocularis potassium voltage gated channel protein 0.0024 0.0048 0.0048
Trypanosoma cruzi C2 domain containing protein, putative 0.0026 0.0061 0.0366
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Echinococcus multilocularis expressed conserved protein 0.0183 0.1049 0.1049
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0032 0.0098 0.0098
Echinococcus granulosus dna polymerase eta 0.0038 0.0137 0.0187
Echinococcus granulosus active breakpoint cluster region 0.0026 0.0061 0.0083
Onchocerca volvulus 0.0026 0.0057 0.0287
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.002 0.0033
Echinococcus granulosus short transient receptor potential channel 6 0.0017 0.0002 0.0002
Schistosoma mansoni coup transcription factor 0.0042 0.0159 0.0218
Schistosoma mansoni rho gtpase activating protein 0.0026 0.0061 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0179 0.0904
Loa Loa (eye worm) hypothetical protein 0.0242 0.1423 0.2611
Echinococcus multilocularis synaptotagmin 0.0026 0.0061 0.0061
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0179 0.1521
Echinococcus multilocularis glycine receptor subunit beta 0.0032 0.0098 0.0098
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.0026 0.0061 0.0484
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Schistosoma mansoni hypothetical protein 0.0133 0.0736 0.1009
Brugia malayi MH1 domain containing protein 0.0032 0.0097 0.0169
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0242 0.0331
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0057 0.0099
Loa Loa (eye worm) hypothetical protein 0.0038 0.0137 0.0251
Toxoplasma gondii isocitrate dehydrogenase 0.0078 0.0385 0.2987
Schistosoma mansoni hypothetical protein 0.0026 0.0061 0.0083
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0032 0.0098 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0061 0.0366
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0182 0.1047 0.1853
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0385 0.0385
Plasmodium falciparum heat shock protein 90, putative 0.017 0.0968 1
Schistosoma mansoni hypothetical protein 0.0067 0.0322 0.0441
Echinococcus granulosus NDR protein kinase 0.0198 0.1149 0.1574
Brugia malayi Synapse defective protein 1 0.0026 0.0061 0.0105
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0159 0.0159
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.002 0.0028
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0105 0.0558 0.0764
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0242 0.1381
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0048 0.0065
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0024 0.0048 0.0082
Schistosoma mansoni nuclear receptor 0.002 0.002 0.0028
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.014 0.078 0.1431
Echinococcus multilocularis raf serine:threonine protein kinase 0.014 0.078 0.078
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0162 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0159 0.028
Brugia malayi TAR-binding protein 0.0186 0.1069 0.1892
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0242 0.0242
Brugia malayi C1-like domain containing protein 0.0145 0.0809 0.1432
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1341 0.1341
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0057 0.0105
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0519 0.0953
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0101 0.0312
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Brugia malayi RNA recognition motif domain containing protein 0.0186 0.1069 0.1892
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0061 0.0366
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0501 0.3056 0.4189
Onchocerca volvulus Putative cc2d1b protein 0.0026 0.0061 0.0306
Loa Loa (eye worm) hypothetical protein 0.0074 0.0366 0.0672
Loa Loa (eye worm) hypothetical protein 0.014 0.078 0.1431
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0198 0.1149 0.2108
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0194 0.1119 0.8072
Brugia malayi MH2 domain containing protein 0.0467 0.2845 0.5039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0519 0.0917
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0035 0.0048
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0074 0.0136
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0666 0.1095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0176 0.0241
Brugia malayi nuclear hormone receptor 0.002 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0032 0.0098 0.0135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0159 0.028
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0064
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0032 0.0098 0.0172
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0078 0.0385 0.2692
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.002 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0061 0.0366
Echinococcus multilocularis protein piccolo 0.0026 0.0061 0.0061
Entamoeba histolytica diacylglycerol kinase, putative 0.014 0.078 0.6773
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0017 0.0005 0.0007
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0179 0.1312
Schistosoma mansoni cpg binding protein 0.003 0.0084 0.0115
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0179 0.1521
Brugia malayi Copine VIII 0.0026 0.0061 0.0105
Entamoeba histolytica diacylglycerol kinase, putative 0.014 0.078 0.6773
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0032 0.0098 0.0172
Entamoeba histolytica hypothetical protein 0.0141 0.0786 0.6826
Brugia malayi WW domain containing protein 0.0026 0.0061 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0804 0.4967 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0159 0.028
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0026 0.0061 0.0083
Treponema pallidum heat shock protein 90 0.0042 0.0162 0.5
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0057 0.0099
Loa Loa (eye worm) hypothetical protein 0.0095 0.0496 0.091
Schistosoma mansoni tar DNA-binding protein 0.0186 0.1069 0.1465
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0138 0.0592
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0171
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0085 0.0085
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.002 0.002
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0771 0.476 0.8735
Echinococcus granulosus glycine receptor subunit beta 0.0032 0.0098 0.0135
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0026 0.0061 0.0061
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0032 0.0098 0.0098
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Schistosoma mansoni hypothetical protein 0.0031 0.0093 0.0128
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0026 0.0061 0.0083
Onchocerca volvulus 0.0234 0.1373 0.755
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0159 0.028
Schistosoma mansoni synaptotagmin 0.0026 0.0061 0.0083
Echinococcus multilocularis cpg binding protein 0.003 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0423 0.2762
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Schistosoma mansoni hypothetical protein 0.008 0.0404 0.0553
Loa Loa (eye worm) hypothetical protein 0.0042 0.0159 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0159 0.028
Trypanosoma brucei heat shock protein, putative 0.0045 0.0179 0.0981
Brugia malayi MH1 domain containing protein 0.0018 0.0007 0.001
Brugia malayi Pax transcription factor protein 2 0.0238 0.1395 0.247
Echinococcus granulosus protein kinase C gamma type 0.0965 0.5982 0.8199
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0093 0.0163
Echinococcus multilocularis N chimaerin 0.014 0.078 0.078
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0005 0.0006
Brugia malayi CXXC zinc finger family protein 0.0028 0.0074 0.0128
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0242 0.0331
Loa Loa (eye worm) heat shock protein 75 0.003 0.0084 0.0154
Loa Loa (eye worm) hypothetical protein 0.0267 0.1583 0.2905
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0093 0.0171
Entamoeba histolytica hypothetical protein 0.0026 0.0061 0.0484
Entamoeba histolytica C2 domain containing protein 0.0026 0.0061 0.0484
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0098 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0032 0.0098 0.0098
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0242 0.1811
Echinococcus multilocularis jun protein 0.0164 0.093 0.093
Plasmodium falciparum endoplasmin, putative 0.0033 0.0101 0.0451
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0159 0.0159
Echinococcus granulosus potassium voltage gated channel protein 0.0182 0.1047 0.1435
Entamoeba histolytica C2 domain containing protein 0.0026 0.0061 0.0484
Schistosoma mansoni smad 0.0032 0.0097 0.0133
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0026 0.0061 0.0083
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0032 0.0098 0.0098
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0366 0.3369
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0048 0.0065
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0159 0.0218
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0159 0.0218
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0159 0.0218
Echinococcus granulosus RNA directed DNA polymerase 0.074 0.4566 0.6257
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0385 0.0385
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0159 0.0218
Brugia malayi hypothetical protein 0.0129 0.0708 0.1252
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0061 0.0366
Brugia malayi hypothetical protein 0.0048 0.02 0.0351
Loa Loa (eye worm) transcription factor SMAD2 0.0467 0.2845 0.522
Schistosoma mansoni synaptotagmin 0.0026 0.0061 0.0083
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0666 0.5013
Brugia malayi bZIP transcription factor family protein 0.0164 0.093 0.1645
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0159 0.0218
Echinococcus multilocularis sodium channel protein 0.016 0.0908 0.0908
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0159 0.0218
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0085 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Echinococcus granulosus cpg binding protein 0.003 0.0084 0.0115
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Echinococcus granulosus Smad4 0.0032 0.0097 0.0133
Brugia malayi hypothetical protein 0.0022 0.0035 0.006
Echinococcus granulosus protein kinase c epsilon type 0.0501 0.3056 0.4189
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0159 0.028
Onchocerca volvulus 0.0032 0.0098 0.0515
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0085 0.023
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0095 0.0496 0.0496
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0098 0.0135
Brugia malayi MH2 domain containing protein 0.0032 0.0097 0.0169
Echinococcus multilocularis endoplasmin 0.0042 0.0162 0.0162
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0048 0.0065
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0098 0.0172
Brugia malayi Telomerase reverse transcriptase 0.0221 0.1292 0.2288
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0005 0.0007
Echinococcus multilocularis protein kinase c eta type 0.014 0.078 0.078
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0135
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Loa Loa (eye worm) C2 domain-containing protein 0.0026 0.0061 0.0111
Echinococcus multilocularis dna polymerase eta 0.0038 0.0137 0.0137
Loa Loa (eye worm) synaptotagmin-1 0.0026 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.088 0.5449 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Loa Loa (eye worm) LGC-31 protein 0.0032 0.0098 0.0181
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0026 0.0061 0.0061
Echinococcus granulosus neuropeptide receptor A26 0.0914 0.5664 0.7763
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0137 0.0974
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.028 0.0384
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0057 0.0287
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0137 0.0631
Brugia malayi MAP kinase sur-1 0.0055 0.0242 0.0425
Trypanosoma brucei unspecified product 0.0038 0.0137 0.0631
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0666 0.1095
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Onchocerca volvulus 0.003 0.0085 0.0444
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0093 0.0163
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0024 0.0048 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1149 0.1574
Echinococcus multilocularis potassium voltage gated channel protein 0.0024 0.0048 0.0048
Echinococcus multilocularis Smad4 0.0032 0.0097 0.0097
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0078 0.0385 0.0528
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0407 0.2467 0.4527
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0242 0.1499
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0242 0.2918
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0093 0.0093
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Onchocerca volvulus 0.002 0.002 0.0084
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0385 0.2692
Brugia malayi NEDD4.2 0.0026 0.0061 0.0105
Loa Loa (eye worm) hypothetical protein 0.0042 0.0159 0.0292
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0809 0.1109
Entamoeba histolytica hypothetical protein 0.0026 0.0061 0.0484
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0032 0.0098 0.0172
Trypanosoma brucei unspecified product 0.0026 0.0062 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0159 0.028
Brugia malayi Copine family protein 0.0026 0.0061 0.0105
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.014 0.078 0.078
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0179 0.0981
Loa Loa (eye worm) pax transcription factor protein 2 0.0238 0.1395 0.256
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0159 0.0159
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0182 0.1047 0.1435
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0198 0.1149 0.2108
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Entamoeba histolytica hypothetical protein 0.0141 0.0786 0.6826
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0159 0.0218
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0242 0.1811
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0093 0.0128
Onchocerca volvulus 0.0026 0.0061 0.0306
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1149 0.1574
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0159 0.0159
Loa Loa (eye worm) DR-78 0.002 0.002 0.0037
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0017 0.0005 0.0007
Echinococcus multilocularis smad 0.0032 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.074 0.4566 0.8379
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0061 0.0105
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0032 0.0098 0.0098
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0093 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Schistosoma mansoni glut4 vesicle protein-related 0.0026 0.0061 0.0083
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0179 0.1306
Brugia malayi Variant SH3 domain containing protein 0.0026 0.0061 0.0105
Schistosoma mansoni unc-13 (munc13) 0.0026 0.0061 0.0083
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0026 0.0061 0.0083
Brugia malayi Cation transporter family protein 0.0032 0.0098 0.0172
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0137 0.0631
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0075 0.0103
Echinococcus granulosus protein piccolo 0.0026 0.0061 0.0083
Echinococcus granulosus copine 9 0.0026 0.0061 0.0083
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0804 0.4967 1
Schistosoma mansoni mctp-related 0.0026 0.0061 0.0083
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0242 0.1499
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Schistosoma mansoni synaptotagmin 0.0026 0.0061 0.0083
Plasmodium falciparum heat shock protein 90 0.0045 0.0179 0.1306
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1341 0.1838
Echinococcus granulosus X box binding protein 1 0.0284 0.1686 0.231
Loa Loa (eye worm) ACC-1 protein 0.0032 0.0098 0.0181
Brugia malayi nuclear receptor NHR-88 0.002 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0159 0.0218
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0198 0.1149 0.1574
Brugia malayi Variant SH3 domain containing protein 0.014 0.078 0.1379
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0179 0.1312
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0159 0.028
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0242 0.1381
Echinococcus multilocularis heat shock protein 90 0.0045 0.0179 0.0179
Schistosoma mansoni nuclear hormone receptor 0.002 0.002 0.0028
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0064
Onchocerca volvulus 0.0026 0.0061 0.0306
Loa Loa (eye worm) hypothetical protein 0.0267 0.1583 0.2905
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0032 0.0098 0.0181
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0159 0.0159
Echinococcus multilocularis intersectin 2 0.0026 0.0061 0.0061
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0057 0.0099
Schistosoma mansoni hypothetical protein 0.0031 0.0093 0.0128
Loa Loa (eye worm) AGC/PKN protein kinase 0.0198 0.1149 0.2108
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0032 0.0098 0.0098
Brugia malayi Niemann-Pick C1 protein precursor 0.0194 0.1123 0.1988
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0176 0.0176
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0084 0.0217
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0084 0.0115
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0026 0.0061 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0159 0.028
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.002 0.0037
Onchocerca volvulus 0.0026 0.0061 0.0306
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0242 0.1381
Loa Loa (eye worm) hypothetical protein 0.0229 0.1341 0.2462
Echinococcus multilocularis myoferlin 0.0026 0.0061 0.0061
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Entamoeba histolytica protein kinase, putative 0.0198 0.1149 1
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0179 0.1312
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0135
Echinococcus granulosus geminin 0.1173 0.7297 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0385 0.0385
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0026 0.0061 0.0061
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0159 0.0218
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0026 0.0061 0.0105
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0035 0.0048
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0179 0.1312
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0057 0.0287
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0137 0.0631
Brugia malayi Protein kinase domain containing protein 0.0198 0.1149 0.2033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Brugia malayi p70 ribosomal S6 kinase beta 0.0198 0.1149 0.2033
Onchocerca volvulus 0.0105 0.0558 0.305
Echinococcus granulosus synaptotagmin 15 0.0026 0.0061 0.0083
Loa Loa (eye worm) C2 domain-containing protein 0.0026 0.0061 0.0111
Schistosoma mansoni hypothetical protein 0.0026 0.0061 0.0083
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0137 0.0187
Entamoeba histolytica C2 domain protein, putative 0.0026 0.0061 0.0484
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0159 0.028
Brugia malayi nuclear receptor NHR-67 0.002 0.002 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0085 0.0085
Echinococcus granulosus glycine receptor subunit beta 0.0032 0.0098 0.0135
Brugia malayi hypothetical protein 0.0026 0.0057 0.0099
Echinococcus multilocularis transfer RNA-Gly 0.0024 0.0048 0.0048
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0084 0.0195
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Brugia malayi calpain 5 0.0026 0.0061 0.0105
Echinococcus multilocularis RNA directed DNA polymerase 0.074 0.4566 0.4566
Loa Loa (eye worm) hypothetical protein 0.0042 0.0159 0.0292
Echinococcus multilocularis nAChR subunit 0.0032 0.0098 0.0098
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0198 0.1149 0.1149
Loa Loa (eye worm) isocitrate dehydrogenase 0.0078 0.0385 0.0707
Trypanosoma brucei telomerase reverse transcriptase 0.0083 0.0421 0.2984
Leishmania major hypothetical protein, conserved 0.0026 0.0061 0.00000014994
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0145 0.0809 0.1485
Echinococcus multilocularis Rac GTPase activating protein 1 0.014 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.014 0.078 0.1431
Echinococcus granulosus glycine receptor subunit alpha 1 0.0032 0.0098 0.0135
Schistosoma mansoni hypothetical protein 0.0026 0.0061 0.0083
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0159 0.0218
Schistosoma mansoni hypothetical protein 0.0026 0.0061 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0176 0.0241
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0501 0.3056 0.5609
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.024 0.1646
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0172
Loa Loa (eye worm) AGC/NDR protein kinase 0.0198 0.1149 0.2108
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0061 0.0001
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0198 0.1149 0.2108
Loa Loa (eye worm) hypothetical protein 0.015 0.084 0.1542
Brugia malayi Cation transporter family protein 0.0105 0.0558 0.0986
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.014 0.078 0.1068
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0057 0.0105
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0666 0.0912
Loa Loa (eye worm) hypothetical protein 0.0217 0.1268 0.2327
Leishmania major hypothetical protein, conserved 0.0074 0.0366 0.2532
Toxoplasma gondii AGC kinase 0.0198 0.1149 1
Schistosoma mansoni unc-13 (munc13) 0.0166 0.0944 0.1294
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0026 0.0061 0.0061
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0101 0.0312
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Echinococcus granulosus N chimaerin 0.014 0.078 0.1068
Schistosoma mansoni hypothetical protein 0.014 0.078 0.1068
Schistosoma mansoni hypothetical protein 0.0284 0.1686 0.231
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0666 0.1095
Echinococcus multilocularis synaptotagmin 0.0026 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Loa Loa (eye worm) Smad1 0.0032 0.0097 0.0178
Schistosoma mansoni otoferlin 0.0026 0.0061 0.0083
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.002 0.0028
Echinococcus granulosus microtubule associated protein 2 0.0683 0.4208 0.5767
Schistosoma mansoni serine/threonine protein kinase 0.014 0.078 0.1068
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0026 0.0061 0.0061
Echinococcus granulosus neural cell expressed developmentally 0.0026 0.0061 0.0083
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0162 0.0837
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Echinococcus granulosus serine:threonine protein kinase N2 0.0198 0.1149 0.1574
Schistosoma mansoni endoplasmin 0.0045 0.0179 0.0245
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0159 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0097 0.0178
Onchocerca volvulus 0.0166 0.0944 0.5182
Loa Loa (eye worm) hypothetical protein 0.0182 0.1047 0.1922
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Echinococcus multilocularis shaker cognate 0.0024 0.0048 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0176 0.0241
Echinococcus granulosus Protein kinase C brain isozyme 0.1105 0.6866 0.941
Schistosoma mansoni serine/threonine kinase 0.0198 0.1149 0.1574
Brugia malayi RhoGEF domain containing protein 0.014 0.078 0.1379
Trypanosoma brucei heat shock protein, putative 0.0045 0.0179 0.0981
Echinococcus granulosus Diacylglycerol kinase theta 0.014 0.078 0.1068
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0026 0.0061 0.0366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0159 0.0292
Plasmodium vivax telomerase reverse transcriptase, putative 0.0083 0.0421 0.397
Loa Loa (eye worm) hypothetical protein 0.0042 0.0159 0.0292
Entamoeba histolytica protein kinase, putative 0.0198 0.1149 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0026 0.0061 0.0111
Brugia malayi hypothetical protein 0.002 0.002 0.0033
Entamoeba histolytica hypothetical protein 0.0026 0.0061 0.0484
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1371 1
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0024 0.0048 0.0082
Trichomonas vaginalis ion channel nompc, putative 0.0026 0.0061 0.0000001381
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0138 0.0986
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0176 0.0176
Brugia malayi Synaptotagmin I 0.0026 0.0061 0.0105
Schistosoma mansoni smad1 5 8 and 0.0032 0.0097 0.0133
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0194 0.1123 0.9776
Plasmodium vivax endoplasmin, putative 0.0045 0.0179 0.1306
Echinococcus granulosus heat shock protein 90 0.0045 0.0179 0.0245
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0017 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Echinococcus multilocularis glycine receptor subunit beta 0.0032 0.0098 0.0098
Onchocerca volvulus 0.0047 0.0191 0.1026
Entamoeba histolytica C2 domain containing protein 0.0026 0.0061 0.0484
Entamoeba histolytica protein kinase, putative 0.0198 0.1149 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0242 0.0331
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0242 0.1423 0.2611
Loa Loa (eye worm) ACC-1 protein 0.0032 0.0098 0.0181
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0097 0.0097
Echinococcus multilocularis heat shock protein 90 0.0038 0.0138 0.0138
Loa Loa (eye worm) voltage-gated potassium channel 0.0024 0.0048 0.0087
Loa Loa (eye worm) hypothetical protein 0.0099 0.0519 0.0953
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0135
Leishmania major DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Trypanosoma cruzi heat shock protein, putative 0.003 0.0084 0.0554
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0112 0.06 0.4956
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Brugia malayi Cation transporter family protein 0.0032 0.0098 0.0172
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0159 0.0292
Echinococcus granulosus protein kinase c iota type 0.0338 0.2032 0.2785
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0032 0.0098 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.1105 0.6866 0.941
Echinococcus granulosus myotubularin protein 13 0.014 0.078 0.1068
Echinococcus granulosus synaptotagmin protein 4 0.0026 0.0061 0.0083
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Echinococcus granulosus dna polymerase kappa 0.0038 0.0137 0.0187
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0083 0.0423 0.0776
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.002 0.0033
Schistosoma mansoni rabphilin-3a 0.0026 0.0061 0.0083
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0057 0.0099
Schistosoma mansoni peroxidasin 0.0026 0.0057 0.0078
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0366 0.3369
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0035 0.0048
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0032 0.0098 0.0181
Schistosoma mansoni unc-13 (munc13) 0.0175 0.1003 0.1375
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0032 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0137 0.0974
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.014 0.078 0.1068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0176 0.0241
Schistosoma mansoni microtubule-associated protein tau 0.0683 0.4208 0.5767
Entamoeba histolytica hypothetical protein 0.0141 0.0786 0.6826
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0026 0.0061 0.0083
Schistosoma mansoni DNA polymerase eta 0.0038 0.0137 0.0187
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0242 0.1811
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0057 0.0099
Loa Loa (eye worm) hypothetical protein 0.014 0.078 0.1431
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0172
Loa Loa (eye worm) hypothetical protein 0.014 0.078 0.1431
Trypanosoma brucei heat shock protein, putative 0.0045 0.0179 0.0981
Loa Loa (eye worm) hypothetical protein 0.0105 0.0558 0.1023
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.002 0.0033
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0084 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0186 0.1069 0.1465
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0176 0.0323
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0024 0.0048 0.0065
Loa Loa (eye worm) C2 domain-containing protein 0.0026 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Brugia malayi Smad1 0.0032 0.0097 0.0169
Brugia malayi LD23056p 0.0026 0.0061 0.0105
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.002 0.002
Echinococcus granulosus copine 9 0.0026 0.0061 0.0083
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0057 0.0287
Entamoeba histolytica hypothetical protein 0.0026 0.0061 0.0484
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Leishmania major telomerase reverse transcriptase, putative 0.0083 0.0421 0.2984
Echinococcus granulosus synaptotagmin 0.0026 0.0061 0.0083
Loa Loa (eye worm) hypothetical protein 0.014 0.078 0.1431
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0159 0.0218
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0097 0.0097
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0083 0.0423 0.058
Brugia malayi MH1 domain containing protein 0.0032 0.0097 0.0169
Trypanosoma cruzi cAMP binding protein, putative 0.0026 0.0061 0.0366
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0135
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0137 0.0137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.002 0.0028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0159 0.0218
Onchocerca volvulus Peroxidase homolog 0.0026 0.0057 0.0287
Trypanosoma brucei heat shock protein, putative 0.0045 0.0179 0.0981
Brugia malayi Nuclear hormone receptor E75 0.002 0.002 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0186 0.1069 0.1465
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.0048 0.0065
Echinococcus multilocularis isocitrate dehydrogenase 0.0078 0.0385 0.0385
Echinococcus granulosus synaptotagmin 2 0.0026 0.0061 0.0083
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Brugia malayi hypothetical protein 0.0074 0.0366 0.0646
Loa Loa (eye worm) hypothetical protein 0.014 0.078 0.1431
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0061 0.0366
Echinococcus granulosus intersectin 2 0.0026 0.0061 0.0083
Loa Loa (eye worm) hypothetical protein 0.014 0.078 0.1431
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0423 0.0776
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0162 0.0771
Brugia malayi diacylglycerol kinase 0.014 0.078 0.1379
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0145 0.0809 0.0809
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0026 0.0061 0.0111
Schistosoma mansoni heat shock protein 0.0045 0.0179 0.0245
Onchocerca volvulus 0.0026 0.0061 0.0306
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0026 0.0061 0.0083
Echinococcus multilocularis copine 9 0.0026 0.0061 0.0061
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.002 0.002
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0026 0.0061 0.0083
Onchocerca volvulus Huntingtin homolog 0.0242 0.1423 0.7824
Echinococcus granulosus raf serine:threonine protein kinase 0.014 0.078 0.1068
Schistosoma mansoni synaptotagmin 12 0.0026 0.0061 0.0083
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0107 0.0107
Trypanosoma brucei unspecified product 0.0026 0.0062 0.0013
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0242 0.0242
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0159 0.0218
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0159 0.0159
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.002 0.0037
Brugia malayi nuclear receptor RXR 0.0022 0.0035 0.006
Loa Loa (eye worm) C2 domain-containing protein 0.0026 0.0061 0.0111
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0026 0.0061 0.0061
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0048 0.0065
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0024 0.0048 0.0065
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0179 0.0328
Echinococcus multilocularis synaptotagmin protein 4 0.0026 0.0061 0.0061
Entamoeba histolytica C2 domain containing protein 0.0026 0.0061 0.0484
Entamoeba histolytica C2 domain containing protein 0.0026 0.0061 0.0484
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0035 0.0064
Loa Loa (eye worm) C2 domain-containing protein 0.0026 0.0061 0.0111
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.002 0.0028
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0186 0.1069 0.1961
Trypanosoma brucei heat shock protein, putative 0.0045 0.0179 0.0981
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0809 0.1109
Echinococcus multilocularis protein patched 0.0083 0.0423 0.0423
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0026 0.0061 0.0061
Plasmodium vivax heat shock protein, putative 0.017 0.0968 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1105 0.6866 0.6866
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0137 0.0631
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0032 0.0098 0.0181
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0159 0.0218
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0078 0.0385 0.0515
Echinococcus granulosus UNCoordinated family member unc 13 0.0026 0.0061 0.0083
Loa Loa (eye worm) hypothetical protein 0.0102 0.0541 0.0993
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0048 0.0065
Echinococcus granulosus synaptotagmin 0.0026 0.0061 0.0083
Echinococcus granulosus shaker cognate 0.0024 0.0048 0.0065
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0304 0.1817 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0335 0.2009 0.2009
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0026 0.0061 0.0083
Entamoeba histolytica hypothetical protein 0.014 0.078 0.6773
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1193 0.2189
Entamoeba histolytica hypothetical protein 0.0026 0.0061 0.0484
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0057 0.0105
Echinococcus multilocularis synaptotagmin 0.0026 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0031 0.0093 0.0128
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0026 0.0061 0.0111
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.002 0.0028
Echinococcus granulosus nAChR subunit 0.0017 0.0005 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0085 0.0117
Brugia malayi hypothetical protein 0.0141 0.0786 0.139
Brugia malayi Protein kinase domain containing protein 0.0145 0.0809 0.1432
Echinococcus granulosus jun protein 0.0164 0.093 0.1274
Brugia malayi ecdysone receptor 0.002 0.002 0.0033
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0197 0.1142 0.1565
Giardia lamblia Telomerase catalytic subunit 0.0083 0.0421 0.7908
Loa Loa (eye worm) hypothetical protein 0.0466 0.2836 0.5204
Loa Loa (eye worm) hypothetical protein 0.0067 0.0322 0.0591
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0366 0.2532
Brugia malayi Hr1 repeat family protein 0.0198 0.1149 0.2033
Echinococcus granulosus calcium activated potassium channel 0.0021 0.003 0.0041
Echinococcus multilocularis potassium voltage gated channel protein 0.0182 0.1047 0.1047
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Brugia malayi Isocitrate dehydrogenase 0.0078 0.0385 0.0681
Trypanosoma cruzi synaptotagmin, putative 0.0026 0.0061 0.0366
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0198 0.1149 0.1574
Loa Loa (eye worm) AGC/AKT protein kinase 0.0198 0.1149 0.2108
Echinococcus multilocularis protein dispatched 1 0.0095 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0037
Entamoeba histolytica calcium-binding protein, putative 0.0026 0.0061 0.0484
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0078 0.0385 0.3581
Brugia malayi Ras association domain family 1 isoform A 0.014 0.078 0.1379
Echinococcus multilocularis tar DNA binding protein 0.0186 0.1069 0.1069
Schistosoma mansoni synaptotagmin 0.0026 0.0061 0.0083
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.002 0.002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0098 0.0135
Brugia malayi protein kinase C II. 0.0501 0.3056 0.5414
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0191 0.0336
Schistosoma mansoni jun-related protein 0.0133 0.0736 0.1009
Brugia malayi C2 domain containing protein 0.0026 0.0061 0.0105
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0137 0.0581
Echinococcus granulosus glycine receptor subunit alpha 1 0.0032 0.0098 0.0135
Onchocerca volvulus 0.0032 0.0098 0.0515
Onchocerca volvulus 0.0026 0.0061 0.0306
Schistosoma mansoni tar DNA-binding protein 0.0186 0.1069 0.1465
Brugia malayi steroid hormone receptor 0.0042 0.0159 0.028
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1149 0.83
Echinococcus granulosus myoferlin 0.0026 0.0061 0.0083
Schistosoma mansoni rac gtpase activating protein 0.014 0.078 0.1068
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0157
Entamoeba histolytica C2 domain containing protein 0.0026 0.0061 0.0484
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.002 0.0028
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.0048 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0159 0.0292
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0138 0.0986
Entamoeba histolytica PH domain containing protein kinase, putative 0.0141 0.0786 0.6829
Schistosoma mansoni endoplasmin 0.0045 0.0179 0.0245
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0159 0.0218
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0159 0.028
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.002 0.0037
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Loa Loa (eye worm) hypothetical protein 0.0042 0.0159 0.0292
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0032 0.0098 0.0098
Trypanosoma cruzi synaptotagmin, putative 0.0026 0.0061 0.0366
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0026 0.0061 0.0306
Brugia malayi CHE-14 protein 0.0083 0.0423 0.0746
Echinococcus multilocularis neural cell expressed, developmentally 0.0026 0.0061 0.0061
Onchocerca volvulus 0.0129 0.0708 0.3879
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.016 0.0908 0.1244
Schistosoma mansoni transient receptor potential channel 0.0017 0.0002 0.0002
Brugia malayi Peroxidasin 0.0026 0.0057 0.0099
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.002 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0159 0.028
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0026 0.0061 0.0366
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0024 0.0048 0.0065
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.0048 0.0065
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0145 0.0809 0.1485
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0062 0.0013
Entamoeba histolytica protein kinase, putative 0.0031 0.009 0.0745
Loa Loa (eye worm) hypothetical protein 0.0042 0.0159 0.0292
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0179 0.1312
Echinococcus granulosus voltage gated potassium channel 0.0024 0.0048 0.0065
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0032 0.0098 0.0172
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0322 0.0568
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0164 0.093 0.1274
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0159 0.0851
Echinococcus multilocularis extended synaptotagmin 2 0.0026 0.0061 0.0061
Onchocerca volvulus 0.0105 0.0558 0.305
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0105
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Loa Loa (eye worm) Nedd4-PD 0.0026 0.0061 0.0111
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0002 0.0002
Leishmania major DNA polymerase eta, putative 0.0038 0.0137 0.0631
Schistosoma mansoni survival motor neuron protein 0.0047 0.0191 0.0262
Schistosoma mansoni synaptotagmin 0.0026 0.0061 0.0083
Loa Loa (eye worm) raf kinase 0.014 0.078 0.1431
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0062 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0064
Schistosoma mansoni smad1 5 8 and 0.0032 0.0097 0.0133
Schistosoma mansoni protein kinase C mu 0.0145 0.0809 0.1109
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0026 0.0061 0.0366
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0042 0.0159 0.0292
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0137 0.0581
Brugia malayi hypothetical protein 0.0242 0.1423 0.2519
Echinococcus multilocularis synaptotagmin 2 0.0026 0.0061 0.0061
Echinococcus granulosus synaptotagmin 0.0026 0.0061 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0159 0.0292
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Loa Loa (eye worm) copine family protein 0.0026 0.0061 0.0111
Echinococcus multilocularis short transient receptor potential channel 6 0.0017 0.0002 0.0002
Trypanosoma brucei heat shock protein, putative 0.0045 0.0179 0.0981
Echinococcus multilocularis heat shock protein 0.0045 0.0179 0.0179
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0026 0.0061 0.0083
Onchocerca volvulus 0.014 0.078 0.4275
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.2427 0.2427
Echinococcus granulosus expressed conserved protein 0.0183 0.1049 0.1437
Leishmania major heat shock protein 83-1 0.0045 0.0179 0.0981
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0032 0.0098 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0159 0.028
Onchocerca volvulus 0.015 0.084 0.461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0159 0.0292
Schistosoma mansoni voltage-gated potassium channel 0.0182 0.1047 0.1435
Brugia malayi hypothetical protein 0.0022 0.0035 0.006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0181
Echinococcus multilocularis 0.0026 0.0061 0.0061
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0159 0.0851
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0061 0.0001
Schistosoma mansoni cpg binding protein 0.0028 0.0074 0.0101
Echinococcus multilocularis Niemann Pick C1 protein 0.0278 0.1649 0.1649
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0005 0.0006
Echinococcus multilocularis GPCR, family 2 0.0031 0.0093 0.0093
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0179 0.0981
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0137 0.0631
Echinococcus multilocularis geminin 0.1173 0.7297 0.7297
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0024 0.0048 0.0048
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0057 0.0287

Activities

Activity type Activity value Assay description Source Reference
IC20 (functional) = 400 nM Compound was tested for irreversible antagonist activity against opioid receptor in mouse vas deferens expressed as IC20 of morphine divided by the compound ChEMBL. 3020246
IC20 (functional) = 400 nM Compound was tested for irreversible antagonist activity against opioid receptor in mouse vas deferens expressed as IC20 of morphine divided by the compound ChEMBL. 3020246
IC50 (binding) = 0.3 nM The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]-Dihydromorphine as the radioligand ChEMBL. 3020246
IC50 (binding) = 0.3 nM The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]-Dihydromorphine as the radioligand ChEMBL. 3020246
Inhibition (functional) = 57 % Compound was tested for agonist activity against opioid receptor in mouse vas deferens preparation at concentration of 1E-7 M ChEMBL. 3020246
Inhibition (functional) = 57 % Compound was tested for agonist activity against opioid receptor in mouse vas deferens preparation at concentration of 1E-7 M ChEMBL. 3020246
Potency ratio (functional) = 1.41 Compound was tested for agonist potency against opioid receptor in guinea pig ileal longitudinal muscle expressed as IC50 of morphine divided by the compound ChEMBL. 3020246
Ratio (functional) = 0 Compound was tested for irreversible antagonist activity against opioid receptor in mouse vas deferens in presence of morphine ChEMBL. 3020246
Ratio (functional) = 0.81 Irreversible antagonist activity against opioid receptor in mouse vas deferens at 200 nM relative to IC50 of nalorphine ChEMBL. 3020246
Ratio (functional) = 1.39 Compound was tested for irreversible antagonist activity against opioid receptor in mouse vas deferens expressed as IC50 of DADLE divided by the compound ChEMBL. 3020246
Ratio (functional) = 4.41 Irreversible antagonist activity against opioid receptor in mouse vas deferens at 200 nM relative to IC50 of nalorphine ChEMBL. 3020246
Ratio (functional) = 5.85 Compound was tested for irreversible antagonist activity against opioid receptor in mouse vas deferens at a concentration of 20 nM expressed as IC50 of morphine divided by the compound ChEMBL. 3020246
Ratio (functional) = 6.33 Compound was tested for irreversible antagonist activity against opioid receptor in mouse vas deferens at a concentration of 20 nM expressed as IC50 of morphine divided by the compound ChEMBL. 3020246
Ratio (functional) = 6.69 Irreversible antagonist activity against opioid receptor in mouse vas deferens at 200 nM relative to IC50 of nalorphine ChEMBL. 3020246

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.