Detailed information for compound 814325

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 496.6 | Formula: C30H32N4O3
  • H donors: 1 H acceptors: 4 LogP: 3.42 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC(CC1)C(N(C(=O)c1ccccn1)C)Cc1ccccc1)CC1NC(=O)c2c1cccc2
  • InChi: 1S/C30H32N4O3/c1-33(30(37)25-13-7-8-16-31-25)27(19-21-9-3-2-4-10-21)22-14-17-34(18-15-22)28(35)20-26-23-11-5-6-12-24(23)29(36)32-26/h2-13,16,22,26-27H,14-15,17-20H2,1H3,(H,32,36)
  • InChiKey: MYWNLIFHSZDZKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Onchocerca volvulus Alhambra homolog 0.0086 0.1244 0.1375
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0123 0.1884 0.3198
Toxoplasma gondii small ubiquitin family modifier, putative 0.009 0.1322 0.2377
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0278 0.459 0.4963
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0233 0.0144
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0204 0.009
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.028 0.4621 0.8279
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0239 0.0155
Chlamydia trachomatis phosphoglycerate kinase 0.0334 0.5563 0.5
Leishmania major DNA damage repair protein, putative 0.0049 0.0595 0.0813
Trypanosoma brucei DNA polymerase kappa, putative 0.0235 0.3832 0.68
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0233 0.0087
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0036 0.0384 0.0423
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0233 0.0087
Echinococcus multilocularis caspase 8 0.0026 0.0204 0.0061
Brugia malayi hypothetical protein 0.0023 0.0155 0.014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0233 0.0097
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0204 0.0051
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0204 0.0051
Brugia malayi Bloom's syndrome protein homolog 0.0068 0.0936 0.1001
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0569 0.9644 1
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.459 0.4674
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0023 0.0155 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0235 0.3832 0.68
Echinococcus granulosus chromobox protein 1 0.0068 0.094 0.0797
Loa Loa (eye worm) jmjC domain-containing protein 0.0177 0.2835 0.2999
Loa Loa (eye worm) hypothetical protein 0.0147 0.2312 0.2413
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0038 0.0419 0.0488
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Entamoeba histolytica phosphoglycerate kinase, putative 0.0334 0.5563 0.5768
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.017 0.0018
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0204 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.1957 0.3332
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0479 0.8079 0.8867
Brugia malayi Bromodomain containing protein 0.0086 0.1244 0.1342
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0132
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0235 0.3832 0.3875
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0334 0.5563 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0038 0.0419 0.0488
Echinococcus granulosus caspase 0.0026 0.0204 0.0049
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0038 0.0419 0.0488
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0233 0.0144
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0233 0.0098
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0204 0.0061
Leishmania major phosphoglycerate kinase C, glycosomal 0.0334 0.5563 1
Trypanosoma brucei chrX additional, unordered contigs 0.0049 0.0595 0.0813
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0233 0.0418
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0204 0.0051
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0239 0.0155
Schistosoma mansoni DNA polymerase IV / kappa 0.0049 0.0595 0.0492
Trypanosoma brucei unspecified product 0.0108 0.1626 0.272
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0419 0.0443
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0038 0.0419 0.0333
Plasmodium vivax metacaspase 1, putative 0.0026 0.0204 0.0042
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0036 0.0384 0.0423
Trichomonas vaginalis chromobox protein, putative 0.0068 0.094 0.0827
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.024 0.0233
Brugia malayi jmjC domain containing protein 0.0104 0.1559 0.1689
Trypanosoma brucei unspecified product 0.0108 0.1626 0.272
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0233 0.0098
Brugia malayi glutaminase DH11.1 0.0537 0.9091 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.3775 0.4051
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0023 0.0155 0.014
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.017 0.0148
Onchocerca volvulus 0.0032 0.03 0.0184
Plasmodium falciparum phd finger protein, putative 0.0086 0.1244 0.1976
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0038 0.0419 0.0488
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0204 0.0054
Trypanosoma cruzi metacaspase, putative 0.0026 0.0204 0.009
Trichomonas vaginalis ubiquitin, putative 0.0032 0.03 0.0153
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.009 0.1322 0.1306
Trypanosoma cruzi small ubiquitin protein, putative 0.009 0.1322 0.2159
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0038 0.0419 0.0431
Trypanosoma brucei phosphoglycerate kinase 0.0123 0.1884 0.3198
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0233 0.0098
Schistosoma mansoni DNA helicase recq1 0.0028 0.024 0.0095
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0281 0.4643 0.4559
Entamoeba histolytica serine/threonine protein kinase, putative 0.0278 0.459 0.476
Trypanosoma cruzi DNA damage repair protein, putative 0.0049 0.0595 0.0813
Trypanosoma cruzi DNA polymerase kappa, putative 0.0235 0.3832 0.68
Trypanosoma brucei DNA polymerase eta, putative 0.0231 0.3775 0.6694
Brugia malayi jmjC domain containing protein 0.0028 0.0233 0.0226
Leishmania major DNA polymerase kappa, putative 0.0049 0.0595 0.0813
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0533 0.0557
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0038 0.0419 0.0488
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0038 0.0419 0.0488
Trypanosoma cruzi metacaspase, putative 0.0026 0.0204 0.009
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0281 0.4643 0.5664
Onchocerca volvulus 0.0479 0.8079 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0181 0.0325
Trypanosoma brucei DNA polymerase IV, putative 0.0235 0.3832 0.68
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0038 0.0419 0.0488
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0133 0.2071 0.2254
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0204 0.0051
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0023 0.0155 0.0161
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0204 0.0051
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0096 0.1422 0.1474
Trypanosoma cruzi polo-like protein kinase, putative 0.0278 0.459 0.8202
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.459 0.4674
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0233 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.0209 0.3389 0.5981
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.094 0.0878
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.2146 0.2099
Trypanosoma brucei DNA polymerase IV, putative 0.0215 0.3494 0.6175
Schistosoma mansoni chromobox protein 0.0068 0.094 0.0878
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0271 0.0214
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0124 0.19 0.3415
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0204 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0533 0.0384
Brugia malayi ImpB/MucB/SamB family protein 0.0156 0.247 0.2694
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0239 0.0108
Echinococcus multilocularis dna polymerase kappa 0.0235 0.3832 0.4641
Brugia malayi Cell death protein 3 precursor 0.0026 0.0204 0.0193
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0417 0.0331
Leishmania major hypothetical protein, conserved 0.0028 0.0233 0.0144
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0468 0.033
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0038 0.0419 0.0488
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0038 0.0419 0.0488
Brugia malayi hypothetical protein 0.0023 0.0155 0.014
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0096 0.1422 0.2342
Loa Loa (eye worm) SMO-1 protein 0.009 0.1322 0.1306
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.024 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0086 0.1244 0.1976
Echinococcus multilocularis phosphoglycerate kinase 1 0.0334 0.5563 0.6825
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0204 0.0051
Echinococcus multilocularis PHD finger protein rhinoceros 0.0086 0.1244 0.1375
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0334 0.5563 1
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0233 0.0079
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0271 0.0214
Trypanosoma cruzi DNA damage repair protein, putative 0.0049 0.0595 0.0813
Leishmania major hypothetical protein, conserved 0.0209 0.3389 0.5981
Trichomonas vaginalis DNA helicase recq, putative 0.0036 0.0384 0.0241
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0233 0.0079
Echinococcus granulosus jumonji domain containing protein 0.012 0.1829 0.1701
Onchocerca volvulus Serine\/threonine kinase homolog 0.0278 0.459 0.5598
Brugia malayi Heterochromatin protein 1 0.0068 0.094 0.1006
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0204 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0235 0.3832 0.68
Echinococcus granulosus phd:f box containing protein 0.0028 0.0233 0.0079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0533 0.0477
Plasmodium falciparum phosphoglycerate kinase 0.0334 0.5563 1
Trypanosoma brucei metacaspase MCA3 0.0026 0.0204 0.009
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0096 0.1422 0.2342
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0038 0.0419 0.0488
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0479 0.8079 0.8048
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0038 0.0419 0.0488
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.459 0.4674
Trypanosoma cruzi metacaspase, putative 0.0026 0.0204 0.009
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0233 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.3389 0.5981
Loa Loa (eye worm) hypothetical protein 0.0254 0.4171 0.4494
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0543 0.0975
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0038 0.0419 0.0488
Echinococcus multilocularis lysine specific demethylase 5A 0.0104 0.1559 0.1771
Loa Loa (eye worm) PHD-finger family protein 0.0086 0.1244 0.1219
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0334 0.5563 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0086 0.1244 0.1219
Schistosoma mansoni jumonji/arid domain-containing protein 0.0104 0.1559 0.1571
Brugia malayi Pip kinase protein 2 0.0479 0.8079 0.8883
Loa Loa (eye worm) glutaminase 0.0537 0.9091 1
Schistosoma mansoni phosphoglycerate kinase 0.0334 0.5563 0.6052
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0204 0.0051
Echinococcus multilocularis chromobox protein 1 0.0068 0.094 0.099
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0223 0.0071
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0233 0.0098
Entamoeba histolytica recQ family helicase, putative 0.0036 0.0384 0.0398
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0278 0.459 0.5598
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0038 0.0419 0.0435
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0133 0.2071 0.2145
Brugia malayi Phosphoglycerate kinase 0.0123 0.1884 0.2048
Leishmania major hypothetical protein, conserved 0.0025 0.0181 0.0048
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0595 0.0813
Loa Loa (eye worm) hypothetical protein 0.0028 0.0239 0.0094
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.024 0.011
Loa Loa (eye worm) hypothetical protein 0.0032 0.03 0.0163
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0123 0.1884 0.3198
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0156 0.247 0.2351
Toxoplasma gondii PHD-finger domain-containing protein 0.0086 0.1244 0.2237
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0204 0.0051
Brugia malayi polk-prov protein 0.0127 0.1957 0.2128
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.024 0.0233
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0046 0.0552 0.069
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.1957 0.3332
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.459 0.4963
Echinococcus multilocularis chromobox protein 1 0.0068 0.094 0.099
Trichomonas vaginalis DNA polymerase eta, putative 0.0235 0.3832 0.3875
Trypanosoma cruzi DNA polymerase kappa, putative 0.0235 0.3832 0.68
Echinococcus granulosus ubiquitin 0.0032 0.03 0.0148
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.024 0.0107
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0038 0.0419 0.0296
Plasmodium falciparum DNA repair protein REV1, putative 0.0049 0.0595 0.0769
Trypanosoma brucei unspecified product 0.0215 0.3494 0.6175
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0239 0.0429
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0233 0.0098
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0038 0.0419 0.0488
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.247 0.435
Trypanosoma brucei DNA damage repair protein, putative 0.0049 0.0595 0.0813
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.028 0.4621 0.8249
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0028 0.0239 0.0429
Entamoeba histolytica deoxycytidyl transferase, putative 0.0156 0.247 0.2561
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0204 0.0054
Brugia malayi jmjC domain containing protein 0.0028 0.0233 0.0226
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0036 0.0384 0.0423
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.2146 0.2099
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0334 0.5563 1
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0233 0.0087
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0233 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0595 0.0813
Echinococcus granulosus Small ubiquitin modifier 2 0.009 0.1322 0.1186
Mycobacterium ulcerans phosphoglycerate kinase 0.0334 0.5563 0.6045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0104 0.1559 0.1571
Echinococcus multilocularis ubiquitin 0.0032 0.03 0.0184
Trypanosoma brucei DNA damage repair protein, putative 0.0049 0.0595 0.0813
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0038 0.0419 0.0753
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0032 0.031 0.0157
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0023 0.0155 0.0161
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.024 0.0157
Giardia lamblia DNA damage repair protein 0.0049 0.0595 0.0813
Plasmodium vivax JmjC domain containing protein 0.0028 0.0233 0.0097
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0123 0.1884 0.3198
Brugia malayi Protein-tyrosine phosphatase 0.0023 0.0155 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.1964 0.3345
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Schistosoma mansoni jumonji domain containing protein 0.0223 0.3637 0.3897
Entamoeba histolytica ubiquitin like protein 0.009 0.1322 0.1371
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0479 0.8079 0.8867
Schistosoma mansoni chromobox protein 0.0068 0.094 0.0878
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.1462 0.1377
Echinococcus multilocularis caspase 0.0026 0.0204 0.0061
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0181 0.0048
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0038 0.0419 0.0278
Leishmania major DNA polymerase eta, putative 0.0231 0.3775 0.6694
Echinococcus granulosus caspase 2 0.0026 0.0204 0.0049
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0023 0.0155 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.459 0.4674
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0038 0.0419 0.0753
Trypanosoma brucei metacaspase 0.0026 0.0204 0.009
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Trichomonas vaginalis glutaminase, putative 0.0537 0.9091 0.9418
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0204 0.0051
Loa Loa (eye worm) hypothetical protein 0.0334 0.5563 0.6052
Trichomonas vaginalis DNA helicase recq, putative 0.0068 0.0936 0.0823
Loa Loa (eye worm) hypothetical protein 0.0028 0.0233 0.0087
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0038 0.0419 0.0488
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0098 0.1462 0.1582
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0123 0.1884 0.3198
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.028 0.4621 0.8249
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0533 0.0423
Loa Loa (eye worm) hypothetical protein 0.0028 0.024 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0235 0.3832 0.68
Echinococcus granulosus lysine specific demethylase 5A 0.0104 0.1559 0.1426
Plasmodium falciparum metacaspase-like protein 0.0026 0.0204 0.0042
Schistosoma mansoni caspase-3 (C14 family) 0.0026 0.0204 0.0054
Echinococcus multilocularis bloom syndrome protein 0.0068 0.0936 0.0985
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0204 0.0051
Giardia lamblia Kinase, PLK 0.0278 0.459 0.8202
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0479 0.8079 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0235 0.3832 0.68
Plasmodium vivax small ubiquitin-related modifier, putative 0.009 0.1322 0.2121
Echinococcus granulosus expressed protein 0.0098 0.1462 0.1328
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0028 0.0239 0.0108
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.024 0.0431
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0038 0.0419 0.0268
Treponema pallidum phosphoglycerate kinase 0.0334 0.5563 1
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0233 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.459 0.4674
Echinococcus granulosus bloom syndrome protein 0.0068 0.0936 0.0793
Brugia malayi Protein-tyrosine phosphatase 1 0.0023 0.0155 0.014
Loa Loa (eye worm) RecQ helicase 0.0068 0.0936 0.0874
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.028 0.4621 0.4989
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0156 0.247 0.259
Brugia malayi AF-10 protein 0.0028 0.0239 0.0232
Brugia malayi chromobox protein homolog 3 0.0038 0.0417 0.0429
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0334 0.5563 0.5699
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0133 0.2071 0.2419
Loa Loa (eye worm) hypothetical protein 0.0026 0.0204 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0258 0.0115
Schistosoma mansoni hypothetical protein 0.0028 0.0239 0.0094
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0271 0.0214
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.459 0.4674
Brugia malayi hypothetical protein 0.0023 0.0155 0.014
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0204 0.0366
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0038 0.0419 0.0296
Loa Loa (eye worm) FYVE zinc finger family protein 0.0038 0.0419 0.0296
Trypanosoma cruzi metacaspase, putative 0.0026 0.0204 0.009
Mycobacterium ulcerans DNA polymerase IV 0.0235 0.3832 0.4105
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0038 0.0419 0.0443
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0278 0.459 0.8202
Brugia malayi jmjC domain containing protein 0.0281 0.4643 0.5092
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.024 0.0107
Loa Loa (eye worm) hypothetical protein 0.0038 0.0417 0.0293
Schistosoma mansoni DNA polymerase eta 0.0231 0.3775 0.4051
Echinococcus granulosus caspase 8 0.0026 0.0204 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0204 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0235 0.3832 0.68
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.024 0.0095
Entamoeba histolytica hypothetical protein 0.0032 0.03 0.0312
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0595 0.0813
Schistosoma mansoni glutaminase 0.0537 0.9091 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0068 0.0936 0.0823
Brugia malayi jmjC domain containing protein 0.0028 0.0233 0.0226
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0334 0.5563 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0123 0.1884 0.3198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0533 0.0423
Echinococcus granulosus chromobox protein 1 0.0068 0.094 0.0797
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0204 0.009
Brugia malayi Phosphoglycerate kinase 0.0334 0.5563 0.6107
Echinococcus multilocularis dna polymerase eta 0.0231 0.3775 0.4569
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0038 0.0419 0.0443
Trypanosoma brucei DNA polymerase IV, putative 0.0235 0.3832 0.68
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.3389 0.5981
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0233 0.0087
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0026 0.0204 0.0049
Echinococcus multilocularis jumonji domain containing protein 0.012 0.1829 0.2113
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0533 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0204 0.0051
Giardia lamblia PHD finger protein 15 0.0086 0.1244 0.2014
Echinococcus multilocularis peregrin 0.0095 0.1407 0.158
Trypanosoma brucei DNA polymerase kappa, putative 0.0235 0.3832 0.68
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0123 0.1884 0.3198
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.024 0.0431
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0468 0.033
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0038 0.0419 0.0296
Echinococcus multilocularis expressed protein 0.0098 0.1462 0.1649
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.024 0.0086
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0096 0.1422 0.2342
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.017 0.0015
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Trypanosoma cruzi polo-like protein kinase, putative 0.0278 0.459 0.8202
Onchocerca volvulus 0.003 0.0273 0.0149
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.003 0.0271 0.0487
Brugia malayi ImpB/MucB/SamB family protein 0.0231 0.3775 0.4134
Trypanosoma brucei DNA polymerase kappa, putative 0.0176 0.2808 0.4905
Echinococcus granulosus dna polymerase eta 0.0231 0.3775 0.3677
Brugia malayi Pip kinase protein 1 0.0038 0.0419 0.0431
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0204 0.0051
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0204 0.0366
Brugia malayi hypothetical protein 0.0023 0.0155 0.014
Entamoeba histolytica phosphoinositide kinase, putative 0.0038 0.0419 0.0435
Trypanosoma brucei phosphoglycerate kinase, putative 0.0123 0.1884 0.3198
Trichomonas vaginalis rotamase, putative 0.0098 0.1462 0.1377
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.017 0.0027
Trypanosoma brucei metacaspase MCA2 0.0026 0.0204 0.009
Brugia malayi hypothetical protein 0.0023 0.0155 0.014
Leishmania major metacaspase, putative 0.0026 0.0204 0.009
Loa Loa (eye worm) jmjC domain-containing protein 0.0104 0.1559 0.1571
Trypanosoma brucei phosphoglycerate kinase 0.0334 0.5563 1
Mycobacterium ulcerans hypothetical protein 0.0049 0.0595 0.0476
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0479 0.8079 0.8867
Echinococcus granulosus phosphoglycerate kinase 1 0.0334 0.5563 0.5493
Trypanosoma cruzi DNA polymerase kappa, putative 0.0235 0.3832 0.68
Toxoplasma gondii PHD-finger domain-containing protein 0.0086 0.1244 0.2237
Schistosoma mansoni rotamase 0.0098 0.1462 0.1463
Echinococcus multilocularis caspase 2 0.0026 0.0204 0.0061
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0032 0.031 0.0196
Trypanosoma brucei small ubiquitin-related modifier 0.009 0.1322 0.2159
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.03 0.0153
Loa Loa (eye worm) pip kinase 2 0.0479 0.8079 0.8867
Loa Loa (eye worm) hypothetical protein 0.0086 0.1244 0.1219
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.459 0.4674
Echinococcus granulosus PHD finger protein rhinoceros 0.0086 0.1244 0.1107
Leishmania major DNA polymerase eta, putative 0.0124 0.19 0.3226
Echinococcus granulosus dna polymerase kappa 0.0235 0.3832 0.3735
Mycobacterium ulcerans glutaminase 0.0537 0.9091 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0054 0.0686 0.0595
Brugia malayi Ubiquitin-like protein SMT3 0.009 0.1322 0.1428
Leishmania major small ubiquitin protein, putative 0.009 0.1322 0.2159
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0026 0.0204 0.0061
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0038 0.0419 0.0333
Plasmodium falciparum small ubiquitin-related modifier 0.009 0.1322 0.2121
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0098 0.1462 0.1463
Brugia malayi hypothetical protein 0.0025 0.0181 0.0168
Trypanosoma cruzi DNA polymerase eta, putative 0.0231 0.3775 0.6694
Loa Loa (eye worm) hypothetical protein 0.0026 0.0204 0.0054
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0133 0.2071 0.2145
Toxoplasma gondii peptidylprolyl isomerase 0.0096 0.1422 0.2556
Loa Loa (eye worm) glutaminase 2 0.0537 0.9091 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0233 0.0087
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0233 0.0079
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Trichomonas vaginalis rotamase, putative 0.0096 0.1422 0.1335
Trypanosoma brucei polo-like protein kinase 0.0278 0.459 0.8202
Giardia lamblia Sentrin 0.009 0.1322 0.2159
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0204 0.0054
Plasmodium vivax DNA repair protein REV1, putative 0.0049 0.0595 0.0769
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0068 0.0933 0.1676
Giardia lamblia DINP protein human, muc B family 0.0176 0.2808 0.4905
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0133 0.2071 0.2419
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0334 0.5563 1
Trypanosoma brucei phosphoglycerate kinase 0.0334 0.5563 1
Brugia malayi jmjC domain containing protein 0.0028 0.0233 0.0226
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0038 0.0419 0.0278
Loa Loa (eye worm) hypothetical protein 0.0028 0.0233 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0235 0.3832 0.68
Trypanosoma brucei DNA polymerase kappa, putative 0.0235 0.3832 0.68
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0038 0.0419 0.0753
Brugia malayi serine/threonine-protein kinase plk-2 0.0278 0.459 0.5034
Mycobacterium ulcerans DNA polymerase IV 0.0235 0.3832 0.4105
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0038 0.0419 0.0268
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0133 0.2071 0.1947
Schistosoma mansoni kinase 0.0141 0.221 0.23
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0133 0.2071 0.1947
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0417 0.0276
Leishmania major phosphoglycerate kinase B, cytosolic 0.0334 0.5563 1
Schistosoma mansoni DNA helicase recq5 0.0028 0.024 0.0095
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0181 0.0048
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0468 0.0395
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0176 0.2808 0.4905
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0038 0.0419 0.0296
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0096 0.1422 0.2342
Loa Loa (eye worm) hypothetical protein 0.0025 0.0181 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0181 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.1964 0.3345
Trypanosoma brucei DNA polymerase kappa, putative 0.0235 0.3832 0.68
Trypanosoma brucei Metacaspase-4 0.0026 0.0204 0.009
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0278 0.459 0.4505
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0233 0.0418
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0038 0.0419 0.0488
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0038 0.0419 0.0488
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.006 0.0792 0.1135
Schistosoma mansoni SET domain protein 0.0032 0.031 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0417 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.009 0.1322 0.123
Schistosoma mansoni phosphoglycerate kinase 0.0334 0.5563 0.6052
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0223 0.0071
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Echinococcus multilocularis Small ubiquitin modifier 2 0.009 0.1322 0.1473
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.017 0.0027
Schistosoma mansoni terminal deoxycytidyl transferase 0.0156 0.247 0.259
Echinococcus granulosus peregrin 0.0095 0.1407 0.1271
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0334 0.5563 1
Loa Loa (eye worm) pip kinase 1 0.0038 0.0419 0.0296
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Loa Loa (eye worm) hypothetical protein 0.0127 0.1957 0.2016
Trypanosoma cruzi small ubiquitin protein, putative 0.009 0.1322 0.2159
Brugia malayi hypothetical protein 0.0032 0.03 0.03
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0176 0.2808 0.4967
Mycobacterium tuberculosis Conserved protein 0.0024 0.017 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0533 0.0477
Giardia lamblia Hypothetical protein 0.0038 0.0419 0.0488
Brugia malayi Protein-tyrosine phosphatase 0.0023 0.0155 0.014
Trypanosoma cruzi DNA polymerase eta, putative 0.0124 0.19 0.3226
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0233 0.0144
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0204 0.0366
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0156 0.247 0.2921
Brugia malayi PHD-finger family protein 0.0086 0.1244 0.1342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0533 0.0384
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0569 0.9644 1
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0258 0.0253
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.0595 0.1069
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0271 0.0214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0533 0.0423
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0334 0.5563 0.5699
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0204 0.0051
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.1964 0.3345
Plasmodium vivax phosphoglycerate kinase, putative 0.0334 0.5563 1
Leishmania major DNA polymerase kappa, putative 0.0176 0.2808 0.4905
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0156 0.247 0.259
Schistosoma mansoni hypothetical protein 0.0086 0.1244 0.1219
Giardia lamblia Phosphoglycerate kinase 0.0334 0.5563 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0038 0.0419 0.0296
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0023 0.0155 0.014
Plasmodium falciparum metacaspase 1 0.0026 0.0204 0.0042
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.017 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0204 0.0042
Trichomonas vaginalis chromobox protein, putative 0.0068 0.094 0.0827
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0595 0.0813
Brugia malayi PHD-finger family protein 0.0028 0.0239 0.0232
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0038 0.0419 0.0488

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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