Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATPase, AAA family protein | 0.0139 | 0.0336 | 0.0925 |
Onchocerca volvulus | 0.0139 | 0.0336 | 0.5 | |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0139 | 0.0336 | 1 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0139 | 0.0336 | 0.0925 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0139 | 0.0336 | 0.5 |
Schistosoma mansoni | topbp1 | 0.0139 | 0.0336 | 0.0328 |
Treponema pallidum | DNA ligase (lig) | 0.0139 | 0.0336 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0139 | 0.0336 | 1 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0139 | 0.0336 | 1 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0139 | 0.0336 | 1 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0139 | 0.0336 | 1 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0139 | 0.0336 | 0.0328 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0139 | 0.0336 | 0.0925 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.0336 | 1 |
Brugia malayi | topoisomerase | 0.0139 | 0.0336 | 0.0328 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.0008 | 0.0228 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0842 | 0.3628 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2201 | 1 | 1 |
Echinococcus multilocularis | nibrin | 0.0139 | 0.0336 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.0336 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.0336 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0842 | 0.3628 | 1 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0139 | 0.0336 | 0.5 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0139 | 0.0336 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.0336 | 1 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0139 | 0.0336 | 0.0925 |
Brugia malayi | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Schistosoma mansoni | topbp1 | 0.0139 | 0.0336 | 0.0328 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.0336 | 1 |
Brugia malayi | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Brugia malayi | Dihydrofolate reductase | 0.2201 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2201 | 1 | 1 |
Schistosoma mansoni | DNA ligase IV | 0.0139 | 0.0336 | 0.0328 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.0336 | 0.0925 |
Echinococcus granulosus | nibrin | 0.0139 | 0.0336 | 0.0328 |
Brugia malayi | DKFZp564C0469 protein | 0.0139 | 0.0336 | 0.0328 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2201 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2201 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2201 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.2201 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2201 | 1 | 0.5 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0139 | 0.0336 | 0.0328 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0842 | 0.3628 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0842 | 0.3628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0139 | 0.0336 | 0.0328 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0842 | 0.3628 | 1 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0139 | 0.0336 | 0.0328 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.0336 | 0.0925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.0336 | 1 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0139 | 0.0336 | 0.0328 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0139 | 0.0336 | 0.0925 |
Trichomonas vaginalis | rotamase, putative | 0.0069 | 0.0008 | 0.0228 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0842 | 0.3628 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0336 | 0.0328 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.